TDMS Study 88004-06 Pathology Tables
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 FINAL #1 MICE Facility: Battelle Northwest Chemical CAS #: 1321-74-0 Lock Date: 06/17/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 11 12 8 7 Natural Death 6 3 3 1 Accidently Killed 1 Survivors Terminal Sacrifice 33 35 38 42 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Infiltration Cellular, Mixed Cell 1 (2%) Gallbladder (45) (41) (36) (41) Hemorrhage, Chronic 1 (2%) Inflammation, Acute 1 (3%) Inflammation, Chronic 1 (2%) Intestine Large, Rectum (46) (48) (50) (50) Artery, Inflammation, Chronic Active 1 (2%) Liver (49) (50) (50) (50) Angiectasis 1 (2%) Basophilic Focus 4 (8%) 2 (4%) 2 (4%) Clear Cell Focus 4 (8%) 2 (4%) 3 (6%) Eosinophilic Focus 12 (24%) 8 (16%) 3 (6%) 4 (8%) Fatty Change 2 (4%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) Infarct 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Granulomatous 1 (2%) 1 (2%) Mixed Cell Focus 1 (2%) Necrosis 1 (2%) 3 (6%) 1 (2%) Tension Lipidosis 1 (2%) 5 (10%) 2 (4%) 4 (8%) Vacuolization Cytoplasmic, Focal 1 (2%) Centrilobular, Hypertrophy 1 (2%) Mesentery (17) (16) (4) (5) Artery, Inflammation, Chronic Active 1 (6%) Fat, Congestion 1 (6%) Fat, Hemorrhage 1 (25%) Fat, Necrosis 17 (100%) 15 (94%) 3 (75%) 5 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pancreas (48) (50) (50) (50) Atrophy 2 (4%) 1 (2%) Basophilic Focus 1 (2%) Duct, Cyst 2 (4%) Stomach, Forestomach (50) (50) (50) (50) Hyperplasia, Squamous 3 (6%) 5 (10%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) Ulcer 1 (2%) 1 (2%) Stomach, Glandular (49) (50) (49) (49) Hemorrhage 1 (2%) Necrosis 1 (2%) Tooth (9) (13) (8) (15) Incisor, Dysplasia 9 (100%) 13 (100%) 8 (100%) 15 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Aorta, Mineralization 1 (100%) Heart (50) (50) (50) (50) Cardiomyopathy 3 (6%) 6 (12%) 1 (2%) 1 (2%) Infiltration Cellular, Polymorphonuclear 1 (2%) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) 1 (2%) 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) Artery, Inflammation, Chronic Active 2 (4%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 1 (2%) 2 (4%) 5 (10%) 4 (8%) Hypertrophy 3 (6%) 2 (4%) 8 (16%) Adrenal Medulla (49) (50) (49) (50) Hyperplasia 1 (2%) 1 (2%) 2 (4%) Necrosis 1 (2%) Islets, Pancreatic (48) (49) (49) (50) Hyperplasia 1 (2%) Pituitary Gland (47) (50) (49) (45) Cyst 1 (2%) Pars Distalis, Angiectasis 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Hyperplasia 8 (17%) 16 (32%) 6 (12%) 5 (11%) Thyroid Gland (49) (49) (50) (48) C-Cell, Hyperplasia 1 (2%) Follicular Cell, Hyperplasia 1 (2%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (48) (50) (49) (49) Angiectasis 2 (4%) 3 (6%) Cyst 9 (19%) 14 (28%) 10 (20%) 9 (18%) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) Uterus (49) (50) (50) (49) Angiectasis 1 (2%) 2 (4%) 1 (2%) Endometrium, Hyperplasia, Cystic 2 (4%) 8 (16%) 5 (10%) 8 (16%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (9) (3) (5) (2) Ectasia 1 (11%) Deep Cervical, Hyperplasia, Lymphoid 1 (11%) Deep Cervical, Infiltration Cellular, Plasma Cell 1 (50%) Iliac, Angiectasis 1 (50%) Iliac, Ectasia 1 (11%) Lumbar, Angiectasis 1 (20%) Renal, Angiectasis 1 (20%) Lymph Node, Mesenteric (49) (50) (49) (49) Angiectasis 1 (2%) Ectasia 1 (2%) Inflammation, Granulomatous 1 (2%) Spleen (49) (50) (49) (49) Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 3 (6%) 1 (2%) Inflammation, Acute 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Necrosis 1 (2%) Sinusoid, Dilatation 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Inflammation, Chronic Active 3 (6%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Degeneration, Focal 1 (2%) Hemorrhage 1 (2%) Meninges, Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (48) (50) (50) (49) Hyperplasia, Squamous 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Lung (50) (50) (50) (49) Hemorrhage 1 (2%) Infiltration Cellular, Polymorphonuclear 1 (2%) Inflammation, Acute 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 4 (8%) 3 (6%) 4 (8%) 8 (16%) Alveolus, Granuloma 1 (2%) Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 6 (12%) 9 (18%) 17 (35%) Bronchiole, Hyperplasia 1 (2%) Bronchiole, Hyperplasia, Atypical 39 (78%) 45 (90%) 48 (98%) Nose (50) (50) (50) (49) Inflammation, Suppurative 1 (2%) 50 (100%) 49 (98%) 49 (100%) Glands, Respiratory Epithelium, Metaplasia 3 (6%) 50 (100%) 50 (100%) 49 (100%) Olfactory Epithelium, Atrophy 8 (16%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 50 (100%) 40 (80%) 8 (16%) Olfactory Epithelium, Respiratory Epithelium, Metaplasia 50 (100%) 50 (100%) 49 (100%) Trachea (49) (50) (50) (50) Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (50) (50) (49) Cataract 1 (2%) 2 (4%) 1 (2%) Inflammation 1 (2%) Phthisis Bulbi 1 (2%) 1 (2%) Cornea, Hyperplasia, Squamous 1 (2%) Cornea, Inflammation, Chronic Active 1 (2%) 3 (6%) 3 (6%) Cornea, Inflammation, Suppurative 1 (2%) Cornea, Mineralization 6 (12%) Harderian Gland (50) (50) (50) (50) Hyperplasia 1 (2%) 4 (8%) 2 (4%) 3 (6%) Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Amyloid Deposition 1 (2%) Infarct 1 (2%) Inflammation, Suppurative 2 (4%) 2 (4%) Metaplasia, Osseous 2 (4%) 3 (6%) 3 (6%) 1 (2%) Mineralization 1 (2%) Nephropathy 25 (51%) 31 (62%) 22 (44%) 17 (34%) Artery, Inflammation, Chronic Active 1 (2%) Urinary Bladder (49) (50) (50) (49) Inflammation, Suppurative 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 7 6 5 4 Natural Death 2 6 3 3 Survivors Terminal Sacrifice 41 38 42 43 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (50) (50) (50) (50) Angiectasis 1 (2%) Basophilic Focus 3 (6%) 6 (12%) 7 (14%) 4 (8%) Clear Cell Focus 9 (18%) 11 (22%) 6 (12%) 5 (10%) Eosinophilic Focus 8 (16%) 7 (14%) 2 (4%) Fatty Change 2 (4%) 1 (2%) Infarct 2 (4%) 1 (2%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) Mixed Cell Focus 2 (4%) 1 (2%) 2 (4%) 1 (2%) Necrosis 1 (2%) 2 (4%) 2 (4%) 2 (4%) Tension Lipidosis 2 (4%) 1 (2%) 2 (4%) 1 (2%) Vacuolization Cytoplasmic, Focal 2 (4%) Mesentery (11) (4) (4) (5) Fat, Necrosis 10 (91%) 4 (100%) 4 (100%) 5 (100%) Pancreas (49) (48) (50) (50) Duct, Cyst 2 (4%) Stomach, Forestomach (49) (50) (49) (50) Hyperplasia, Squamous 1 (2%) 4 (8%) 2 (4%) 4 (8%) Inflammation 1 (2%) Inflammation, Acute 2 (4%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%) Mineralization 1 (2%) Ulcer 2 (4%) 1 (2%) 1 (2%) Stomach, Glandular (48) (48) (47) (49) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) 1 (2%) Tooth (41) (43) (41) (35) Incisor, Dysplasia 41 (100%) 43 (100%) 41 (100%) 35 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (49) (50) (50) Cardiomyopathy 14 (28%) 5 (10%) 5 (10%) 5 (10%) Mineralization 1 (2%) 1 (2%) 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (49) (50) (50) Hyperplasia 9 (18%) 10 (20%) 6 (12%) 5 (10%) Hypertrophy 24 (49%) 25 (51%) 26 (52%) 24 (48%) Adrenal Medulla (49) (49) (50) (50) Hyperplasia 1 (2%) 2 (4%) 2 (4%) Parathyroid Gland (35) (39) (36) (35) Hyperplasia 1 (3%) Pituitary Gland (48) (47) (47) (46) Cyst 1 (2%) Pars Distalis, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%) Thyroid Gland (49) (49) (50) (50) Follicular Cell, Hyperplasia 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Granuloma Sperm 1 (2%) 2 (4%) Penis (1) Inflammation, Acute 1 (100%) Preputial Gland (50) (50) (50) (50) Ectasia 1 (2%) 3 (6%) 2 (4%) 1 (2%) Inflammation, Chronic Active 2 (4%) Seminal Vesicle (49) (48) (50) (49) Inflammation, Chronic 1 (2%) Testes (50) (50) (50) (50) Atrophy 2 (4%) Mineralization 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Interstitial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (50) (50) Necrosis 1 (2%) Spleen (49) (48) (50) (50) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic Active 3 (6%) 1 (2%) 2 (4%) Inflammation, Granulomatous 1 (2%) Subcutaneous Tissue, Cyst Epithelial Inclusion 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Necrosis, Focal 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Inflammation, Suppurative 1 (2%) Lung (49) (49) (49) (49) Hemorrhage 1 (2%) 1 (2%) Mineralization 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 5 (10%) 5 (10%) 7 (14%) Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 4 (8%) 5 (10%) 1 (2%) Bronchiole, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC DIVINYLBENZENE Date: 08/14/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:01:09 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Bronchiole, Hyperplasia, Atypical 38 (78%) 46 (94%) 46 (94%) Bronchiole, Inflammation, Chronic Active 1 (2%) Nose (50) (50) (49) (50) Inflammation, Suppurative 3 (6%) 47 (94%) 49 (100%) 49 (98%) Glands, Necrosis 1 (2%) Glands, Respiratory Epithelium, Metaplasia 12 (24%) 50 (100%) 49 (100%) 50 (100%) Olfactory Epithelium, Atrophy 14 (28%) Olfactory Epithelium, Degeneration, Hyaline 5 (10%) 50 (100%) 48 (98%) 11 (22%) Olfactory Epithelium, Respiratory Epithelium, Metaplasia 1 (2%) 50 (100%) 49 (100%) 50 (100%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) Sinus, Foreign Body 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (49) (47) (47) (50) Phthisis Bulbi 1 (2%) 1 (2%) Cornea, Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%) Cornea, Mineralization 2 (4%) Harderian Gland (50) (49) (50) (50) Hyperplasia 2 (4%) 2 (4%) 3 (6%) 2 (4%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 1 (2%) 2 (4%) Infarct 1 (2%) 2 (4%) 1 (2%) Inflammation, Suppurative 1 (2%) Metaplasia, Osseous 7 (14%) 3 (6%) 5 (10%) 1 (2%) Nephropathy 45 (90%) 43 (86%) 40 (80%) 34 (68%) Capsule, Fibrosis 1 (2%) Papilla, Necrosis 1 (2%) Pelvis, Dilatation 1 (2%) Renal Tubule, Hyperplasia 2 (4%) 1 (2%) Renal Tubule, Necrosis 1 (2%) Urinary Bladder (48) (48) (49) (49) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------