TDMS Study 88138-03 Pathology Tables
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
FINAL #1 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 9 13
Natural Death 2 2 4 3
Survivors
Terminal Sacrifice 32 38 37 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation 1 (2%)
Periesophageal Tissue, Necrosis, Fatty 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Inflammation 1 (2%)
Metaplasia, Mucous 1 (2%)
Parasite Metazoan 1 (2%) 3 (6%) 2 (4%) 3 (6%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 8 (16%) 8 (16%) 14 (28%) 6 (12%)
Ulcer 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Inflammation 1 (2%)
Mineralization 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Hyperplasia 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Inflammation 1 (2%) 2 (4%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 5 (10%) 1 (2%)
Basophilic Focus 48 (96%) 48 (96%) 41 (82%) 43 (86%)
Clear Cell Focus 15 (30%) 13 (26%) 10 (20%) 10 (20%)
Degeneration, Cystic 1 (2%) 3 (6%) 4 (8%)
Eosinophilic Focus 6 (12%) 6 (12%) 9 (18%)
Fatty Change, Diffuse 11 (22%) 8 (16%) 9 (18%) 20 (40%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 6 (12%) 4 (8%) 2 (4%)
Hepatodiaphragmatic Nodule 5 (10%) 6 (12%) 6 (12%) 6 (12%)
Inflammation, Chronic Active 46 (92%) 38 (76%) 29 (58%) 30 (60%)
Mixed Cell Focus 10 (20%) 11 (22%) 5 (10%) 5 (10%)
Necrosis 12 (24%) 6 (12%) 11 (22%) 12 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 10 (20%) 35 (70%) 39 (78%) 40 (80%)
Hepatocyte, Centrilobular, Hypertrophy 27 (54%) 30 (60%) 33 (66%)
Oval Cell, Hyperplasia 3 (6%)
Mesentery (12) (18) (10) (6)
Fat, Necrosis 11 (92%) 18 (100%) 10 (100%) 4 (67%)
Oral Mucosa (4) (8) (4) (4)
Hyperplasia, Squamous 1 (25%)
Gingival, Inflammation 4 (100%) 7 (88%) 4 (100%) 4 (100%)
Pancreas (50) (50) (50) (50)
Basophilic Focus 1 (2%) 1 (2%)
Inflammation 12 (24%) 3 (6%) 2 (4%) 6 (12%)
Acinus, Atrophy 17 (34%) 10 (20%) 11 (22%) 12 (24%)
Salivary Glands (50) (50) (50) (50)
Atrophy 2 (4%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Inflammation 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 2 (4%) 2 (4%) 2 (4%) 4 (8%)
Inflammation 4 (8%) 2 (4%) 2 (4%) 3 (6%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%) 1 (2%) 1 (2%)
Inflammation 2 (4%) 3 (6%)
Mineralization 2 (4%) 2 (4%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Atrophy 1 (2%)
Tooth (3) (3)
Inflammation 3 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 46 (92%) 46 (92%) 48 (96%) 46 (92%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Angiectasis 42 (84%) 36 (72%) 18 (36%) 24 (48%)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 3 (6%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Hyperplasia 6 (12%) 10 (20%) 6 (12%) 6 (12%)
Hypertrophy 7 (14%) 5 (10%) 5 (10%) 8 (16%)
Karyomegaly 1 (2%)
Necrosis 5 (10%) 7 (14%) 5 (10%) 2 (4%)
Vacuolization Cytoplasmic 14 (28%) 16 (32%) 15 (30%) 20 (40%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Necrosis 2 (4%)
Vacuolization Cytoplasmic 1 (2%)
Parathyroid Gland (47) (48) (44) (48)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 30 (60%) 30 (60%) 23 (46%) 23 (46%)
Cyst 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 23 (46%) 24 (48%) 20 (40%) 18 (36%)
Inflammation 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 34 (68%) 11 (22%) 13 (26%) 8 (16%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicle, Hyperplasia 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 3 (6%) 2 (4%) 1 (2%)
Hyperplasia 6 (12%) 1 (2%) 2 (4%)
Hyperplasia, Squamous 1 (2%)
Inflammation 2 (4%) 2 (4%) 2 (4%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 6 (12%) 13 (26%) 10 (20%) 9 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis, Focal 1 (2%)
Inflammation 1 (2%)
Cervix, Hypertrophy 1 (2%)
Endometrium, Hyperplasia, Cystic 12 (24%) 20 (40%) 20 (40%) 20 (40%)
Endometrium, Hyperplasia, Adenomatous 1 (2%) 1 (2%) 1 (2%)
Serosa, Inflammation, Granulomatous 2 (4%)
Vagina (1) (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Myelofibrosis 2 (4%) 2 (4%) 6 (12%)
Necrosis 1 (2%) 1 (2%)
Erythroid Cell, Hyperplasia 8 (16%) 6 (12%) 7 (14%) 2 (4%)
Myeloid Cell, Hyperplasia 11 (22%) 13 (26%) 20 (40%) 13 (26%)
Lymph Node (8) (8) (11) (12)
Axillary, Right, Ectasia 1 (9%)
Axillary, Right, Infiltration Cellular,
Plasma Cell 1 (9%)
Deep Cervical, Ectasia 1 (13%)
Deep Cervical, Hemorrhage 1 (13%)
Deep Cervical, Infiltration Cellular, Plasma
Cell 3 (38%) 2 (17%)
Deep Cervical, Infiltration Cellular,
Histiocyte 3 (38%)
Mediastinal, Hemorrhage 2 (17%)
Mediastinal, Infiltration Cellular, Plasma
Cell 2 (25%) 1 (13%) 4 (36%) 2 (17%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (9%) 1 (8%)
Pancreatic, Hemorrhage 2 (25%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (38%) 1 (8%)
Pancreatic, Pigmentation, Hemosiderin 2 (25%)
Renal, Infiltration Cellular, Histiocyte 1 (13%) 1 (8%)
Renal, Pigmentation 1 (8%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 50 (100%) 49 (98%) 48 (96%) 49 (98%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (49) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Autolysis 2 (4%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 47 (96%) 45 (90%) 40 (80%) 45 (90%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Infarct 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 48 (98%) 50 (100%) 49 (98%) 49 (98%)
Lymphoid Follicle, Atrophy 5 (10%)
Red Pulp, Hyperplasia 1 (2%)
Thymus (50) (49) (46) (50)
Atrophy 49 (98%) 48 (98%) 44 (96%) 49 (98%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Atrophy 1 (2%)
Galactocele 7 (14%) 3 (6%) 2 (4%) 2 (4%)
Hyperplasia 3 (6%) 4 (8%) 1 (2%) 3 (6%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%)
Skeletal Muscle (1) (1) (3) (1)
Inflammation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
Hydrocephalus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Inflammation 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Granulomatous 12 (24%) 5 (10%) 9 (18%) 7 (14%)
Metaplasia, Squamous 1 (2%)
Alveolar Epithelium, Hyperplasia 18 (36%) 18 (36%) 13 (26%) 15 (30%)
Alveolus, Infiltration Cellular, Histiocyte 50 (100%) 50 (100%) 50 (100%) 50 (100%)
Interstitium, Fibrosis 1 (2%)
Nose (50) (50) (50) (50)
Inflammation 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Thrombosis 2 (4%)
Trachea (50) (50) (50) (50)
Inflammation 4 (8%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Lens, Cataract 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Optic Nerve, Fibrosis 1 (2%)
Retina, Degeneration 2 (4%) 2 (4%) 4 (8%) 4 (8%)
Retina, Dysplasia 1 (2%)
Harderian Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 14 (28%) 10 (20%) 6 (12%) 9 (18%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Infarct 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Nephropathy 47 (94%) 49 (98%) 48 (96%) 49 (98%)
Cortex, Inflammation 1 (2%)
Cortex, Mineralization 2 (4%) 1 (2%) 4 (8%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Medulla, Fibrosis 1 (2%)
Medulla, Mineralization 43 (86%) 49 (98%) 49 (98%) 46 (92%)
Pelvis, Inflammation 1 (2%) 4 (8%) 2 (4%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Renal Tubule, Cyst 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 25 12 16 44
Natural Death 3 11 3 4
Survivors
Terminal Sacrifice 22 27 31 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Erosion 1 (2%)
Inflammation 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 6 (12%) 6 (12%) 8 (16%) 5 (10%)
Intestine Large, Cecum (50) (50) (50) (50)
Erosion 1 (2%) 1 (2%) 1 (2%)
Inflammation 4 (8%)
Mineralization 2 (4%)
Ulcer 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 24 (48%) 25 (50%) 32 (64%) 19 (38%)
Clear Cell Focus 19 (38%) 19 (38%) 18 (36%)
Congestion 1 (2%)
Degeneration, Cystic 8 (16%) 11 (22%) 20 (40%) 15 (30%)
Eosinophilic Focus 5 (10%) 14 (28%) 10 (20%) 9 (18%)
Fatty Change, Diffuse 22 (44%) 20 (40%) 22 (44%) 15 (30%)
Hematopoietic Cell Proliferation 4 (8%) 1 (2%) 2 (4%) 4 (8%)
Hepatodiaphragmatic Nodule 2 (4%) 6 (12%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic Active 22 (44%) 21 (42%) 35 (70%) 33 (66%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Mineralization 1 (2%)
Mixed Cell Focus 9 (18%) 17 (34%) 22 (44%) 4 (8%)
Necrosis 19 (38%) 19 (38%) 9 (18%) 14 (28%)
Bile Duct, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 49 (98%) 46 (92%) 48 (96%) 50 (100%)
Hepatocyte, Multinucleated 1 (2%) 1 (2%)
Hepatocyte, Centrilobular, Hypertrophy 17 (34%) 31 (62%) 19 (38%)
Hepatocyte, Centrilobular, Necrosis 1 (2%)
Vein, Inflammation 1 (2%)
Mesentery (9) (12) (8) (4)
Inflammation 1 (11%) 1 (13%) 1 (25%)
Fat, Necrosis 7 (78%) 7 (58%) 7 (88%) 3 (75%)
Oral Mucosa (8) (8) (5) (7)
Gingival, Hyperplasia 1 (20%)
Gingival, Inflammation 8 (100%) 6 (75%) 5 (100%) 5 (71%)
Pharyngeal, Inflammation 1 (14%)
Pancreas (50) (50) (50) (50)
Basophilic Focus 1 (2%)
Cyst 3 (6%)
Inflammation 14 (28%) 16 (32%) 6 (12%) 9 (18%)
Metaplasia, Hepatocyte 1 (2%)
Acinus, Atrophy 20 (40%) 21 (42%) 22 (44%) 10 (20%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (49) (50) (50) (49)
Atrophy 1 (2%) 1 (2%) 3 (6%)
Inflammation 2 (4%)
Stomach, Forestomach (50) (49) (49) (50)
Autolysis 1 (2%)
Hyperplasia, Squamous 7 (14%) 4 (8%) 10 (20%) 17 (34%)
Inflammation 8 (16%) 6 (12%) 8 (16%) 12 (24%)
Mineralization 1 (2%) 1 (2%) 3 (6%)
Ulcer 4 (8%) 1 (2%) 8 (16%) 8 (16%)
Stomach, Glandular (50) (50) (49) (50)
Erosion 5 (10%) 2 (4%) 3 (6%) 3 (6%)
Hyperplasia 1 (2%)
Inflammation 5 (10%) 5 (10%) 4 (8%) 7 (14%)
Mineralization 5 (10%) 15 (30%)
Ulcer 1 (2%) 1 (2%) 4 (8%)
Tooth (3) (5) (2) (3)
Inflammation 1 (33%) 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Inflammation 1 (2%)
Mineralization 1 (2%) 1 (2%) 11 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Pulmonary Artery, Pulmonary Vein, Hypertrophy 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 48 (96%) 48 (96%) 47 (94%) 49 (98%)
Mineralization 2 (4%) 6 (12%)
Aorta, Tunic, Media, Mineralization 1 (2%)
Atrium, Thrombosis 3 (6%) 5 (10%) 2 (4%) 1 (2%)
Endocardium, Hyperplasia 2 (4%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Angiectasis 4 (8%) 4 (8%) 2 (4%) 1 (2%)
Atrophy 1 (2%)
Cytoplasmic Alteration 1 (2%)
Degeneration, Cystic 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 2 (4%)
Hyperplasia 1 (2%) 4 (8%) 11 (22%) 4 (8%)
Hypertrophy 8 (16%) 2 (4%) 3 (6%) 3 (6%)
Necrosis 1 (2%) 4 (8%) 1 (2%)
Vacuolization Cytoplasmic 27 (54%) 27 (55%) 31 (62%) 27 (54%)
Adrenal Medulla (50) (49) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 6 (12%) 8 (16%) 11 (22%) 5 (10%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (45) (48) (49)
Hyperplasia 2 (4%) 1 (2%) 19 (40%) 32 (65%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 4 (8%) 10 (20%) 11 (22%) 3 (6%)
Cyst 6 (12%) 3 (6%) 1 (2%) 5 (10%)
Hyperplasia 16 (32%) 21 (42%) 12 (24%) 13 (26%)
Inflammation 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Ultimobranchial Cyst 2 (4%) 1 (2%)
C-Cell, Hyperplasia 17 (34%) 8 (16%) 8 (16%) 5 (10%)
Follicle, Cyst 1 (2%)
Follicle, Degeneration 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%) 2 (4%)
Inflammation 3 (6%) 4 (8%) 1 (2%)
Preputial Gland (50) (50) (50) (49)
Atrophy 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Atrophy 4 (8%) 7 (14%) 8 (16%) 4 (8%)
Hyperplasia 2 (4%) 3 (6%) 4 (8%)
Inflammation 18 (36%) 17 (34%) 26 (52%) 26 (52%)
Seminal Vesicle (50) (50) (50) (49)
Atrophy 3 (6%) 7 (14%) 8 (16%) 4 (8%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Mineralization 4 (8%)
Testes (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%)
Necrosis 2 (4%)
Germinal Epithelium, Degeneration 6 (12%) 5 (10%) 6 (12%) 7 (14%)
Interstitial Cell, Hyperplasia 15 (30%) 12 (24%) 14 (28%) 22 (44%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia, Megakaryocyte 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Myelofibrosis 1 (2%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
Erythroid Cell, Hyperplasia 13 (26%) 3 (6%) 10 (20%) 10 (20%)
Myeloid Cell, Hyperplasia 21 (42%) 27 (55%) 20 (40%) 14 (28%)
Lymph Node (19) (20) (16) (19)
Deep Cervical, Ectasia 2 (11%) 1 (5%)
Deep Cervical, Infiltration Cellular, Plasma
Cell 1 (5%) 2 (10%) 2 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Ectasia 3 (16%) 4 (25%) 3 (16%)
Mediastinal, Hemorrhage 1 (5%) 1 (6%) 2 (11%)
Mediastinal, Hyperplasia 1 (6%) 2 (11%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (5%) 2 (13%) 3 (16%)
Mediastinal, Infiltration Cellular,
Histiocyte 2 (11%)
Mediastinal, Inflammation 1 (6%)
Pancreatic, Ectasia 2 (13%) 2 (11%)
Pancreatic, Hemorrhage 1 (6%) 1 (5%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (5%) 1 (5%) 2 (13%)
Pancreatic, Inflammation 3 (19%) 1 (5%)
Renal, Ectasia 1 (5%)
Renal, Infiltration Cellular, Histiocyte 1 (5%)
Lymph Node, Mandibular (5) (1) (2)
Ectasia 1 (20%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Atrophy 1 (2%) 6 (12%)
Ectasia 4 (8%) 2 (4%) 5 (10%) 4 (8%)
Infiltration Cellular, Histiocyte 47 (94%) 41 (82%) 48 (96%) 46 (92%)
Inflammation 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%)
Autolysis 1 (2%)
Fibrosis 1 (2%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 45 (90%) 42 (84%) 45 (90%) 41 (82%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 2 (4%) 9 (18%) 4 (8%)
Inflammation, Granulomatous 1 (2%) 3 (6%) 7 (14%) 1 (2%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Pigmentation, Hemosiderin 39 (78%) 43 (86%) 44 (88%) 43 (86%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 2 (4%)
Thymus (48) (48) (48) (48)
Atrophy 44 (92%) 42 (88%) 47 (98%) 46 (96%)
Ectopic Parathyroid Gland 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (50) (50)
Fibrosis 1 (2%)
Galactocele 2 (4%) 1 (2%)
Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation 2 (4%)
Subcutaneous Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 4 (8%)
Osteosclerosis 1 (2%)
Skeletal Muscle (2) (2) (1)
Degeneration 1 (50%) 1 (50%) 1 (100%)
Inflammation 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 5 (10%) 5 (10%) 2 (4%) 5 (10%)
Necrosis 2 (4%) 4 (8%)
Peripheral Nerve (1)
Infiltration Cellular, Mononuclear Cell 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Inflammation, Acute 2 (4%) 2 (4%) 5 (10%) 7 (14%)
Inflammation, Granulomatous 2 (4%) 4 (8%) 5 (10%) 2 (4%)
Metaplasia, Squamous 1 (2%)
Mineralization 2 (4%) 10 (20%)
Necrosis 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 16 (32%) 5 (10%) 13 (26%) 7 (14%)
Alveolus, Infiltration Cellular, Histiocyte 46 (92%) 47 (96%) 49 (98%) 50 (100%)
Bronchiole, Hyperplasia 1 (2%) 3 (6%)
Interstitium, Fibrosis 2 (4%)
Nose (50) (50) (50) (50)
Inflammation 7 (14%) 7 (14%) 8 (16%) 9 (18%)
Thrombosis 1 (2%) 2 (4%) 1 (2%)
Olfactory Epithelium, Degeneration 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:17:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Trachea (50) (50) (50) (50)
Inflammation 2 (4%) 1 (2%) 8 (16%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Anterior Chamber, Inflammation 1 (2%)
Ciliary Body, Inflammation 1 (2%)
Cornea, Inflammation 1 (2%)
Iris, Fibrosis 1 (2%) 1 (2%)
Iris, Inflammation 1 (2%) 1 (2%)
Lens, Cataract 2 (4%) 1 (2%)
Lens, Mineralization 1 (2%)
Retina, Atrophy 1 (2%)
Retina, Degeneration 5 (10%) 2 (4%) 5 (10%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphoid 9 (18%) 4 (8%) 9 (18%) 3 (6%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 4 (8%) 1 (2%) 4 (8%) 2 (4%)
Hyperplasia, Oncocytic 1 (2%)
Infarct 1 (2%) 3 (6%)
Nephropathy 50 (100%) 45 (90%) 50 (100%) 50 (100%)
Artery, Inflammation 1 (2%)
Cortex, Mineralization 1 (2%) 4 (8%) 14 (28%)
Medulla, Mineralization 47 (94%) 49 (98%) 47 (94%) 49 (98%)
Papilla, Transitional Epithelium, Hyperplasia 1 (2%)
Pelvis, Inflammation 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 11 (22%) 29 (58%) 34 (68%)
Renal Tubule, Cyst 1 (2%) 9 (18%)
Renal Tubule, Hyperplasia 1 (2%) 5 (10%) 20 (40%) 23 (46%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 2 (4%)
Urinary Bladder (50) (50) (50) (50)
Calculus Gross Observation 1 (2%) 1 (2%)
Inflammation 3 (6%) 2 (4%) 2 (4%)
Muscularis, Degeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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