TDMS Study 05135-05 Pathology Tables
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:06
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 40 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 30 30 29 30 30 30
Animals Examined Microscopically 40 40 40 40 40 40
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Pharynx (40) (10) (11) (10) (10) (40)
Palate, Papilloma 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (38) (10) (12) (10) (10) (40)
Ganglioneuroma 1 (8%)
Pituitary Gland (40) (18) (14) (14) (14) (40)
Adenoma 6 (15%) 7 (39%) 3 (21%) 4 (29%) 3 (21%) 8 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (40) (10) (12) (10) (11) (40)
Mesothelioma Benign 1 (8%) 1 (3%)
Mesothelioma NOS 1 (9%)
Testes (40) (40) (40) (40) (39) (40)
Page 2
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leukemia Mononuclear 2 (5%)
Interstitial Cell, Adenoma 3 (8%) 3 (8%) 4 (10%) 7 (18%) 8 (21%) 8 (20%)
Interstitial Cell, Adenoma, Multiple 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (40) (13) (12) (13) (13) (40)
Leukemia Mononuclear 2 (15%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (3) (10) (10) (11) (10) (3)
Fibroadenoma 1 (9%)
Skin (40) (10) (11) (12) (10) (40)
Sarcoma 1 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (40) (40) (40) (40) (40) (40)
Alveolar/Bronchiolar Adenoma 1 (3%) 1 (3%) 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(40) *(40) *(40) *(40) *(40) *(40)
Leukemia Mononuclear 2 (5%)
Mesothelioma Benign 1 (3%) 1 (3%)
Mesothelioma NOS 1 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 13 10 11 11 15
Total Primary Neoplasms 10 13 10 12 12 20
Total Animals with Benign Neoplasms 9 11 9 11 11 15
Total Benign Neoplasms 10 11 9 12 11 20
Total Animals with Malignant Neoplasms 2 1
Total Malignant Neoplasms 2 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------