TDMS Study 61938-01 Pathology Tables
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
Facility: Battelle Northwest
Chemical CAS #: 5522-43-0
Lock Date: 06/05/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 12 12 12 12 12 12
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Special Study 2 2 2 2 2 2
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (3) (1) (4) (1) (10)
Hepatodiaphragmatic Nodule 2 (67%) 1 (100%) 4 (100%) 1 (100%) 1 (10%)
Inflammation, Chronic 1 (33%)
Inflammation, Chronic Active 1 (10%)
Necrosis 1 (10%)
Necrosis, Focal 1 (10%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 4 (40%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (1) (10)
Cyst 1 (10%) 1 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mediastinal (9) (1) (10)
Hemorrhage 1 (100%)
Spleen (10) (1) (10)
Fibrosis 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10)
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Epiglottis, Metaplasia, Squamous 4 (40%) 4 (40%) 10 (100%) 10 (100%) 10 (100%)
Lung (10) (10) (10) (10) (10) (10)
Hemorrhage 10 (100%) 8 (80%) 6 (60%) 9 (90%) 7 (70%) 9 (90%)
Inflammation, Chronic Active 5 (50%) 2 (20%) 2 (20%) 2 (20%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Bronchus, Metaplasia, Squamous 2 (20%) 3 (30%)
Nose (10) (10) (10) (10) (10) (10)
Olfactory Epithelium, Cytoplasmic Alteration 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Respiratory Epithelium, Cytoplasmic
Alteration 6 (60%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 12 12 12 12 12 12
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Special Study 2 2 2 2 2 2
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (2) (4) (1) (1) (10)
Hepatodiaphragmatic Nodule 2 (20%) 2 (100%) 4 (100%) 1 (100%) 1 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 6 (60%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (9) (10) (10) (9) (10) (10)
Hypospermia 9 (100%) 10 (100%) 10 (100%) 9 (100%) 10 (100%) 10 (100%)
Testes (10) (10) (10) (10) (10) (10)
Atrophy 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Mineralization 1 (10%) 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node (1) (1) (1)
Renal, Hemorrhage 1 (100%) 1 (100%) 1 (100%)
Lymph Node, Mediastinal (10) (1) (8)
Hemorrhage 1 (100%)
Thymus (10) (1) (10)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10) (10) (10) (10) (10)
Epiglottis, Metaplasia, Squamous 5 (50%) 10 (100%) 10 (100%) 10 (100%)
Lung (10) (8) (10) (10) (10) (10)
Hemorrhage 10 (100%) 8 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 3 (38%) 1 (10%) 2 (20%) 1 (10%)
Bronchus, Metaplasia, Squamous 1 (10%) 2 (20%) 5 (50%)
Nose (10) (10) (10) (10) (10) (10)
Olfactory Epithelium, Cytoplasmic Alteration 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Respiratory Epithelium, Cytoplasmic
Alteration 8 (80%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 61938-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:33:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 2.0 8.0 20.0 50.0
MG/M3 MG/M3 MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy 5 (50%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------