TDMS Study 96017-06 Pathology Tables
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 10 13 13 11
Moribund Sacrifice 2 2 5 7
Survivors
Terminal Sacrifice 38 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (49) (48) (49)
Ulcer 1 (2%)
Intestine Large, Cecum (47) (46) (49) (46)
Edema 2 (4%) 1 (2%) 3 (7%)
Inflammation, Chronic 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (46) (48) (48) (45)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (46) (47) (49) (43)
Hyperplasia, Lymphoid 2 (4%) 2 (5%)
Intestine Small, Ileum (45) (47) (47) (46)
Inflammation, Chronic 1 (2%)
Liver (49) (50) (50) (49)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 1 (2%) 3 (6%) 3 (6%)
Clear Cell Focus 3 (6%) 1 (2%) 8 (16%) 5 (10%)
Eosinophilic Focus 7 (14%) 6 (12%) 10 (20%) 9 (18%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Hepatodiaphragmatic Nodule 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 7 (14%) 7 (14%) 4 (8%) 9 (18%)
Inflammation, Chronic Active 1 (2%)
Mixed Cell Focus 2 (4%) 6 (12%) 3 (6%) 1 (2%)
Necrosis, Focal 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Tension Lipidosis 1 (2%) 3 (6%)
Centrilobular, Necrosis 1 (2%) 4 (8%) 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 7 (14%) 4 (8%) 2 (4%)
Kupffer Cell, Pigmentation 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (28) (20) (16) (19)
Fat, Necrosis 22 (79%) 18 (90%) 11 (69%) 13 (68%)
Pancreas (49) (49) (49) (47)
Atrophy 1 (2%) 1 (2%) 3 (6%)
Cyst 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%)
Acinus, Cytoplasmic Alteration 1 (2%)
Salivary Glands (50) (49) (50) (50)
Hyperplasia, Lymphoid 15 (30%) 13 (27%) 16 (32%) 10 (20%)
Stomach, Forestomach (49) (50) (50) (49)
Erosion 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Epithelium, Hyperplasia 4 (8%) 5 (10%) 4 (8%)
Stomach, Glandular (49) (50) (50) (49)
Erosion 1 (2%) 1 (2%)
Pylorus, Epithelium, Hyperplasia, Atypical 1 (2%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Hypertrophy 1 (100%)
Inflammation, Chronic Active 1 (100%)
Heart (50) (49) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 9 (18%) 11 (22%) 6 (12%) 9 (18%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Hypertrophy, Focal 1 (2%)
Capsule, Hyperplasia 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (49) (49) (49) (46)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 2 (4%) 5 (10%) 3 (6%) 3 (7%)
Parathyroid Gland (45) (49) (47) (49)
Cyst 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Pituitary Gland (47) (49) (49) (49)
Pars Distalis, Angiectasis 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 4 (9%) 9 (18%) 4 (8%) 7 (14%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Degeneration, Cystic 10 (20%) 26 (52%) 16 (32%) 14 (28%)
Follicular Cell, Hyperplasia 8 (16%) 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (48) (49)
Cyst 1 (2%)
Ovary (49) (47) (47) (49)
Angiectasis 5 (10%) 3 (6%) 9 (19%) 7 (14%)
Cyst 14 (29%) 12 (26%) 14 (30%) 22 (45%)
Corpus Luteum, Hyperplasia 1 (2%) 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 4 (8%) 1 (2%) 2 (4%)
Hyperplasia, Cystic 44 (88%) 42 (84%) 44 (88%) 39 (78%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 20 (40%) 26 (52%) 24 (48%) 20 (40%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (12) (13) (11) (8)
Hyperplasia, Lymphoid 1 (8%)
Bronchial, Hemorrhage 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bronchial, Hyperplasia, Lymphoid 1 (8%)
Deep Cervical, Hemorrhage 1 (13%)
Iliac, Hematopoietic Cell Proliferation 1 (8%)
Iliac, Hemorrhage 1 (8%) 1 (13%)
Iliac, Hyperplasia, Lymphoid 1 (8%) 1 (8%) 1 (9%) 2 (25%)
Iliac, Pigmentation 1 (8%)
Inguinal, Hematopoietic Cell Proliferation 1 (8%)
Inguinal, Hyperplasia, Lymphoid 2 (15%)
Mediastinal, Hemorrhage 1 (8%)
Mediastinal, Hyperplasia, Lymphoid 1 (8%) 1 (8%) 1 (9%) 1 (13%)
Mediastinal, Pigmentation 1 (8%)
Pancreatic, Hyperplasia, Lymphoid 1 (9%)
Renal, Hyperplasia, Lymphoid 1 (8%) 1 (9%) 1 (13%)
Lymph Node, Mandibular (48) (49) (47) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (4%)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 13 (27%) 6 (12%) 8 (17%) 9 (18%)
Pigmentation 18 (38%) 25 (51%) 17 (36%) 23 (46%)
Lymph Node, Mesenteric (49) (49) (48) (45)
Angiectasis 1 (2%)
Atrophy 2 (4%) 1 (2%)
Ectasia 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 5 (11%)
Hyperplasia, Lymphoid 8 (16%) 9 (18%) 7 (15%) 5 (11%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (50) (50) (48)
Hematopoietic Cell Proliferation 34 (68%) 42 (84%) 35 (70%) 34 (71%)
Necrosis 1 (2%)
Pigmentation 5 (10%) 5 (10%) 1 (2%) 2 (4%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (4%) 2 (4%)
Lymphoid Follicle, Hyperplasia 8 (16%) 11 (22%) 14 (28%) 12 (25%)
Thymus (44) (47) (47) (48)
Atrophy 8 (18%) 9 (19%) 11 (23%) 13 (27%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 5 (10%) 6 (12%) 2 (4%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Ulcer 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Epidermis, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Myelofibrosis 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Skeletal Muscle (3) (4) (2) (5)
Inflammation, Chronic Active 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Compression 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Necrosis 1 (2%) 1 (2%)
Peripheral Nerve (1) (1) (1)
Atrophy 1 (100%)
Spinal Cord (1) (1) (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 2 (4%)
Hemorrhage 2 (4%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 5 (10%) 5 (10%) 1 (2%) 3 (6%)
Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Alveolar Epithelium, Hyperplasia 3 (6%) 3 (6%) 4 (8%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Atrophy 1 (2%)
Cataract 2 (4%) 2 (4%)
Inflammation, Chronic 2 (4%) 2 (4%) 3 (6%) 3 (6%)
Cornea, Hyperplasia 1 (2%) 4 (8%)
Cornea, Mineralization 1 (2%)
Harderian Gland (49) (50) (50) (50)
Hyperplasia, Focal 2 (4%) 4 (8%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 7 (14%) 2 (4%) 5 (10%) 8 (16%)
Infarct 3 (6%) 8 (16%) 6 (12%) 8 (16%)
Nephropathy 14 (29%) 8 (16%) 15 (30%) 12 (24%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Renal Tubule, Dilatation 2 (4%) 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 3 (6%) 1 (2%)
Urinary Bladder (50) (49) (50) (49)
Edema 2 (4%)
Hyperplasia, Lymphoid 3 (6%) 5 (10%) 3 (6%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 6 3 6
Natural Death 14 6 13 13
Survivors
Terminal Sacrifice 31 38 34 31
Other 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (43) (49) (48) (46)
Edema 2 (5%) 2 (4%) 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Duodenum (42) (50) (46) (48)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (44) (49) (46) (45)
Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 2 (4%)
Clear Cell Focus 10 (20%) 13 (26%) 23 (46%) 13 (26%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 15 (31%) 10 (20%) 15 (30%) 17 (34%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Mixed Cell Focus 3 (6%) 7 (14%) 8 (16%) 4 (8%)
Necrosis, Focal 8 (16%) 7 (14%) 3 (6%) 5 (10%)
Tension Lipidosis 1 (2%) 1 (2%) 2 (4%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Cyst Multilocular 1 (2%)
Centrilobular, Necrosis 4 (8%) 4 (8%) 5 (10%)
Hepatocyte, Vacuolization Cytoplasmic 8 (16%) 9 (18%) 4 (8%) 10 (20%)
Kupffer Cell, Pigmentation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Mesentery (7) (7) (10) (7)
Inflammation, Chronic 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 5 (71%) 6 (86%) 7 (70%) 4 (57%)
Pancreas (46) (50) (50) (49)
Necrosis 1 (2%)
Acinus, Cytoplasmic Alteration 2 (4%) 2 (4%) 2 (4%)
Salivary Glands (49) (50) (50) (50)
Atrophy 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 3 (6%) 4 (8%) 6 (12%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Diverticulum 2 (4%) 1 (2%)
Erosion 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 3 (6%) 1 (2%) 3 (6%) 6 (12%)
Ulcer 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Epithelium, Hyperplasia 4 (8%) 3 (6%) 4 (8%) 7 (14%)
Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%)
Stomach, Glandular (47) (50) (50) (50)
Erosion 2 (4%) 2 (4%) 1 (2%)
Glands, Hyperplasia 1 (2%)
Tooth (5) (6)
Malformation 5 (100%) 6 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 3 (6%) 2 (4%) 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 7 (14%) 5 (10%) 4 (8%) 6 (12%)
Hyperplasia, Focal 4 (8%) 7 (14%) 5 (10%) 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Hypertrophy, Focal 12 (24%) 11 (22%) 13 (26%) 6 (12%)
Capsule, Hyperplasia 7 (14%) 4 (8%) 1 (2%) 5 (10%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (46) (50) (50) (49)
Atrophy 1 (2%)
Hyperplasia 34 (74%) 32 (64%) 26 (52%) 13 (27%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (45) (47) (49) (47)
Cyst 2 (4%) 3 (6%) 4 (9%)
Pituitary Gland (45) (50) (48) (48)
Pars Distalis, Cyst 7 (16%) 7 (14%) 7 (15%) 5 (10%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (2%)
Thyroid Gland (48) (50) (50) (50)
Degeneration, Cystic 5 (10%) 8 (16%) 3 (6%) 6 (12%)
Follicular Cell, Hyperplasia 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Atypia Cellular 5 (10%) 4 (8%) 2 (4%) 6 (12%)
Granuloma Sperm 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Spermatocele 1 (2%) 1 (2%)
Preputial Gland (49) (50) (50) (50)
Cyst 25 (51%) 26 (52%) 33 (66%) 33 (66%)
Inflammation, Chronic 21 (43%) 30 (60%) 24 (48%) 28 (56%)
Prostate (48) (50) (50) (49)
Inflammation, Chronic 4 (8%) 1 (2%)
Seminal Vesicle (49) (50) (50) (50)
Degeneration 3 (6%) 5 (10%) 1 (2%)
Inflammation, Chronic 1 (2%)
Testes (49) (50) (50) (50)
Germinal Epithelium, Atrophy 9 (18%) 4 (8%) 4 (8%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (50) (50) (50)
Angiectasis 1 (2%)
Depletion Cellular 1 (2%)
Hyperplasia 22 (47%) 22 (44%) 28 (56%) 32 (64%)
Lymph Node (1) (2) (5) (1)
Bronchial, Hyperplasia, Lymphoid 1 (20%)
Iliac, Ectasia 1 (50%)
Inguinal, Hyperplasia, Lymphoid 1 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inguinal, Pigmentation 1 (50%)
Mediastinal, Hyperplasia, Lymphoid 1 (100%) 1 (20%)
Mediastinal, Pigmentation 1 (100%)
Pancreatic, Hyperplasia, Lymphoid 1 (20%)
Lymph Node, Mandibular (48) (50) (48) (48)
Atrophy 5 (10%) 2 (4%) 3 (6%) 7 (15%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 15 (31%) 14 (28%) 6 (13%) 7 (15%)
Pigmentation 7 (15%) 8 (16%) 1 (2%) 7 (15%)
Lymph Node, Mesenteric (46) (49) (49) (47)
Atrophy 4 (9%) 2 (4%) 1 (2%) 9 (19%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Hemorrhage 8 (17%) 5 (10%) 9 (18%) 7 (15%)
Hyperplasia, Lymphoid 2 (4%) 8 (16%) 3 (6%) 6 (13%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (47) (50) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 18 (38%) 20 (40%) 28 (56%) 38 (76%)
Pigmentation 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 4 (9%) 7 (14%) 3 (6%) 8 (16%)
Lymphoid Follicle, Hyperplasia 3 (6%) 6 (12%) 6 (12%) 6 (12%)
Thymus (42) (45) (46) (47)
Atrophy 14 (33%) 16 (36%) 12 (26%) 22 (47%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%)
Ulcer 3 (6%) 2 (4%) 3 (6%)
Epidermis, Hyperplasia 3 (6%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Hyperostosis 1 (2%)
Cranium, Hyperostosis 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (2) (2) (1)
Atrophy 1 (50%) 1 (100%)
Spinal Cord (2) (2) (1)
Gliosis 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Edema 2 (4%) 1 (2%) 2 (4%)
Hemorrhage 2 (4%) 4 (8%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 6 (12%) 3 (6%) 6 (12%)
Metaplasia, Osseous 1 (2%) 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 6 (12%) 6 (12%) 7 (14%)
Bronchiole, Hyperplasia 1 (2%)
Nose (48) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (50)
Atrophy 1 (2%)
Cataract 1 (2%) 1 (2%) 5 (10%)
Inflammation, Chronic 2 (4%) 2 (4%)
Bilateral, Cataract 1 (2%)
Cornea, Hyperplasia 1 (2%) 1 (2%)
Harderian Gland (49) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia, Focal 5 (10%) 1 (2%) 1 (2%) 1 (2%)
Lacrimal Gland (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 9 (18%) 13 (26%) 14 (28%) 11 (22%)
Hydronephrosis 4 (8%) 2 (4%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:07:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia, Lymphoid 5 (10%) 5 (10%) 6 (12%) 5 (10%)
Infarct 3 (6%) 7 (14%) 4 (8%) 5 (10%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Osseous 6 (12%) 3 (6%) 2 (4%) 2 (4%)
Nephropathy 36 (73%) 44 (88%) 42 (84%) 39 (78%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%)
Renal Tubule, Dilatation 1 (2%) 3 (6%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 3 (6%) 2 (4%) 7 (14%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urethra (3)
Angiectasis 3 (100%)
Inflammation, Chronic Active 3 (100%)
Urinary Bladder (49) (50) (50) (49)
Edema 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------