Scientific Advisory Committee on Alternative Toxicological Methods Meeting Final Documents
September 17–18, 2024
Federal Register Notices September 17–18, 2024
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Meeting Materials
September 17–18, 2024
Presentation Abstracts and Background Materials
- Session 1: ICCVAM Biennial Report
- Session 2: Validation Updates, NAMs Pipeline, and Future Directions
- Session 3: Developmental Neurotoxicology
- Session 4: Computational Resources
Public Comments
| Agenda Topic | Name, Affiliation, Sponsorship | Technical and Scientific Public Comments |
|---|---|---|
| Session 2: Validation Updates/NAMs Pipeline and Future Directions | Shagun Krishna, Catharine Krebs, and Elizabeth Baker, Physicians Committee for Responsible Medicine | Public comment received September 11, 2024 |
| Session 2: Validation Updates/NAMs Pipeline and Future Directions | Amy Clippinger and Katherine Groff, People for the Ethical Treatment of Animals (PETA) | Public comment received September 11, 2024 |
| Session 1: ICCVAM Biennial Report | Vicki Katrinak, Humane Society of the United States (HSUS) | Public comment received September 11, 2024 |
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Presentations
September 17–18, 2024
September 17, 2024
ICCVAM Biennial Report
- ICCVAM 2022-2023 Biennial Report
Nicole Kleinstreuer, PhD, NIEHS/NICEATM
Validation Updates
- Updates to OECD Guidance Document 34 on Validation of New and Updated Test Methods
Charles Kovatch, U.S. Environmental Protection Agency - Reviewing the Method Developers Forum - Follow-on Activities from the VWG Report
Emily Reinke, PhD, Inotiv (contractor supporting NICEATM) - In Vitro Inhalation Toxicity: A Case Study in Building Confidence in New Methods
Amy Clippinger, PhD, PETA Science Consortium International
NAMs Pipeline - Future Directions
- Advisory Committee to the Director, NIH, Recommendations on Catalyzing the Development and Use of New Approach Methods (NAMs) to Advance Biomedical Research
Ellen Gadbois, PhD, National Institutes of Health - Complement-ARIE: Complement Animal Research in Experimentation
Margaret Ochocinska, PhD, National Institutes of Health - Novel Alternative Methods (NAMs) Validation and Qualification Network (VQN)
Stacey Adam, PhD, Foundation for the National Institutes of Health
September 18, 2024
Developmental Neurotoxicity
- International Efforts Implementing NAMs for Assessing Developmental Neurotoxicity in Chemical Risk Assessment
Iris Mangas, PhD, European Food Safety Authority - Integrated Approaches to Testing and Assessment (IATA) Case Study for DNT
Helena Hogberg, PhD, NIEHS/NICEATM - The DNT In Vitro Battery: Establishing Confidence in and Using Data from the Battery
Timothy Shafer, PhD, U.S. Environmental Protection Agency - Integrating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery to Identify Compounds for Future Study
Christopher McPherson, PhD, NIEHS - Transfer of and Data Generation from the Developmental Neurotoxicity In Vitro Battery
Megan Culbreth, PhD, U.S. Food and Drug Administration
Computational Resources
- NICEATM's Integrated Chemical Environment (ICE): Updates, Enhancements, and Advances
Brad Reisfeld, PhD, Inotiv (contractor supporting NICEATM) - Collaborative Modeling Project for Acute Inhalation Toxicity (CoMPAIT)
Kamel Mansouri, PhD, NIEHS/NICEATM - Collection of Alternative Methods for Regulatory Application (CAMERA): New Interactive Database of Validated NAMs
Nicole Kleinstreuer, PhD, NIEHS/NICEATM