Scientific Advisory Committee on Alternative Toxicological Methods Meeting Final Documents
September 21 - 22 , 2022
Federal Register Notices September 21 - 22 , 2022
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Meeting Materials
September 21 - 22 , 2022
Presentation Abstracts and Background Materials
- Session 1: Major ICCVAM Accomplishments in 2022 (Wednesday, September 21)
- Session 2a: Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics (Wednesday, September 21)
- Session 3: Validation and Establishing Scientific Confidence in New Approach Methodologies (Thursday, September 22)
- Session 4: Computational Resources (Thursday, September 22)
Public Comments
| Agenda Topic | Name, Affiliation, Sponsorship | Technical and Scientific Public Comments |
|
Implementing the Strategic Roadmap: |
Joseph Manuppello, Physicians Committee for Responsible Medicine | Presentation given September 21, 2022 |
|
Major ICCVAM Accomplishments in 2022 Implementing the Strategic Roadmap: Validation and Establishing Scientific Confidence in NAMs |
Frank Barile, Humane Society of the United States/Humane Society Legislative Fund | Public comment received September 15, 2022 |
| Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics |
Ashley Haugen, That Water Bead Lady, Inc. | Public comment received September 15, 2022 |
| Validation and Establishing Scientific Confidence in NAMs | Ashley Haugen, That Water Bead Lady, Inc. | Public comment received September 15, 2022 |
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Presentations
September 21 - 22 , 2022
Presentations
September 21, 2022
A Year in Review: ICCVAM Accomplishments in Advancing the 3Rs
John Gordon, PhD, U.S. Consumer Product Safety Commission
Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics
- Introduction
Warren Casey, PhD, NIEHS/DTT - Communicating Progress in Advancing Alternative Methods for Regulatory Use at the FDA
Paul Brown, PhD, U.S. Food and Drug Administration - U.S. Consumer Product Safety Commission Metrics on New Approach Methods Synopsis
John Gordon, PhD, U.S. Consumer Product Safety Commission - Animal Reduction Metrics Used by EPA Office of Pesticide Programs
Monique Perron, PhD, U.S. Environmental Protection Agency - Department of the Interior: Potential Metrics to Track and Encourage Use of Alternative Methods in Ecotoxicological Research and Testing
Barnett Rattner, PhD, U.S. Department of the Interior - Metrics Case Studies from Industry
- Animal Metrics: Tracking NAMs Impacts on Animal Use
Sue Marty, PhD, Dow Chemical - A Data-driven Decision Making Framework for the Selection, Application, and Development of Advanced In Vitro Models for Preclinical Drug Development
Daniela Ortiz Franyuti, PhD, Roche
- Animal Metrics: Tracking NAMs Impacts on Animal Use
- Consideration of Alternative Methods Workgroup
Jessie Carder, U.S. Department of Agriculture
September 22, 2022
Validation and Establishing Scientific Confidence in New Approach Methodologies (NAMs)
- ICCVAM Validation Work Group Update
Suzanne Fitzpatrick, PhD, U.S. Food and Drug Administration - Technical Framework for Enabling High Quality Measurements in NAMs
Elijah Petersen, PhD, National Institute of Standards and Technology - Scientific Confidence Framework
- Biological Relevance: A Better Benchmark
Nicole Kleinstreuer, PhD, NIEHS/DTT/NICEATM - Variability of Reference Data
Agnes Karmaus, PhD, Inotiv (contractor supporting NICEATM) - Transparency, Data Integrity, and External Review
João Barroso, PhD, European Union Reference Laboratory for Alternatives to Animal Testing
- Biological Relevance: A Better Benchmark
- Understanding Context of Use: Case Studies
- Understanding Context of Use for Medical Devices
Shelby Skoog, PhD, U.S. Food and Drug Administration - Context of Use of Mammalian LD50 in Ecological Assessment
William Eckel, PhD, U.S. Environmental Protection Agency - Development of a Rapid Risk Assessment Process and Software Tools to Support Air Force Operational Decision-making and Technology Acquisition
Rebecca Clewell, PhD, U.S. Air Force
- Understanding Context of Use for Medical Devices
Update on NICEATM Computational Resources
Helena Hogberg, PhD, NIEHS/DTT/NICEATM