Scientific Advisory Committee on Alternative Toxicological Methods Meeting Final Documents
September 21–22, 2022
Federal Register Notices September 21–22, 2022
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Meeting Materials
September 21–22, 2022
Presentation Abstracts and Background Materials
- Session 1: Major ICCVAM Accomplishments in 2022 (Wednesday, September 21)
- Session 2a: Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics (Wednesday, September 21)
- Session 3: Validation and Establishing Scientific Confidence in New Approach Methodologies (Thursday, September 22)
- Session 4: Computational Resources (Thursday, September 22)
Public Comments
| Agenda Topic | Name, Affiliation, Sponsorship | Technical and Scientific Public Comments |
|
Implementing the Strategic Roadmap: |
Joseph Manuppello, Physicians Committee for Responsible Medicine | Presentation given September 21, 2022 |
|
Major ICCVAM Accomplishments in 2022 Implementing the Strategic Roadmap: Validation and Establishing Scientific Confidence in NAMs |
Frank Barile, Humane Society of the United States/Humane Society Legislative Fund | Public comment received September 15, 2022 |
| Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics |
Ashley Haugen, That Water Bead Lady, Inc. | Public comment received September 15, 2022 |
| Validation and Establishing Scientific Confidence in NAMs | Ashley Haugen, That Water Bead Lady, Inc. | Public comment received September 15, 2022 |
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Presentations
September 21–22, 2022
Presentations
September 21, 2022
A Year in Review: ICCVAM Accomplishments in Advancing the 3Rs
John Gordon, PhD, U.S. Consumer Product Safety Commission
Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics
- Introduction
Warren Casey, PhD, NIEHS/DTT - Communicating Progress in Advancing Alternative Methods for Regulatory Use at the FDA
Paul Brown, PhD, U.S. Food and Drug Administration - U.S. Consumer Product Safety Commission Metrics on New Approach Methods Synopsis
John Gordon, PhD, U.S. Consumer Product Safety Commission - Animal Reduction Metrics Used by EPA Office of Pesticide Programs
Monique Perron, PhD, U.S. Environmental Protection Agency - Department of the Interior: Potential Metrics to Track and Encourage Use of Alternative Methods in Ecotoxicological Research and Testing
Barnett Rattner, PhD, U.S. Department of the Interior - Metrics Case Studies from Industry
- Animal Metrics: Tracking NAMs Impacts on Animal Use
Sue Marty, PhD, Dow Chemical - A Data-driven Decision Making Framework for the Selection, Application, and Development of Advanced In Vitro Models for Preclinical Drug Development
Daniela Ortiz Franyuti, PhD, Roche
- Animal Metrics: Tracking NAMs Impacts on Animal Use
- Consideration of Alternative Methods Workgroup
Jessie Carder, U.S. Department of Agriculture
September 22, 2022
Validation and Establishing Scientific Confidence in New Approach Methodologies (NAMs)
- ICCVAM Validation Work Group Update
Suzanne Fitzpatrick, PhD, U.S. Food and Drug Administration - Technical Framework for Enabling High Quality Measurements in NAMs
Elijah Petersen, PhD, National Institute of Standards and Technology - Scientific Confidence Framework
- Biological Relevance: A Better Benchmark
Nicole Kleinstreuer, PhD, NIEHS/DTT/NICEATM - Variability of Reference Data
Agnes Karmaus, PhD, Inotiv (contractor supporting NICEATM) - Transparency, Data Integrity, and External Review
João Barroso, PhD, European Union Reference Laboratory for Alternatives to Animal Testing
- Biological Relevance: A Better Benchmark
- Understanding Context of Use: Case Studies
- Understanding Context of Use for Medical Devices
Shelby Skoog, PhD, U.S. Food and Drug Administration - Context of Use of Mammalian LD50 in Ecological Assessment
William Eckel, PhD, U.S. Environmental Protection Agency - Development of a Rapid Risk Assessment Process and Software Tools to Support Air Force Operational Decision-making and Technology Acquisition
Rebecca Clewell, PhD, U.S. Air Force
- Understanding Context of Use for Medical Devices
Update on NICEATM Computational Resources
Helena Hogberg, PhD, NIEHS/DTT/NICEATM