September 21–22, 2022

Scientific Advisory Committee on Alternative Toxicological Methods Meeting

Federal Register Notices

September 21–22, 2022

• Federal Register notice: PDF HTML

Scientific Advisory Committee on Alternative Toxicological Methods Meeting Meeting Materials

September 21–22, 2022

Presentation Abstracts and Background Materials

• Session 1: Major ICCVAM Accomplishments in 2022 (Wednesday, September 21)
• Session 2a: Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics (Wednesday, September 21)
• Session 3: Validation and Establishing Scientific Confidence in New Approach Methodologies (Thursday, September 22)
• Session 4: Computational Resources (Thursday, September 22)

Public Comments

Scientific Advisory Committee on Alternative Toxicological Methods Meeting Presentations

September 21–22, 2022

Presentations

September 21, 2022

A Year in Review: ICCVAM Accomplishments in Advancing the 3Rs
John Gordon, PhD, U.S. Consumer Product Safety Commission

Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics

• Introduction
  Warren Casey, PhD, NIEHS/DTT
• Communicating Progress in Advancing Alternative Methods for Regulatory Use at the FDA
  Paul Brown, PhD, U.S. Food and Drug Administration
  
• U.S. Consumer Product Safety Commission Metrics on New Approach Methods Synopsis
  John Gordon, PhD, U.S. Consumer Product Safety Commission
  
• Animal Reduction Metrics Used by EPA Office of Pesticide Programs
  Monique Perron, PhD, U.S. Environmental Protection Agency
• Department of the Interior: Potential Metrics to Track and Encourage Use of Alternative Methods in Ecotoxicological Research and Testing
  Barnett Rattner, PhD, U.S. Department of the Interior
• Metrics Case Studies from Industry
  • Animal Metrics: Tracking NAMs Impacts on Animal Use
    Sue Marty, PhD, Dow Chemical
  • A Data-driven Decision Making Framework for the Selection, Application, and Development of Advanced In Vitro Models for Preclinical Drug Development
    Daniela Ortiz Franyuti, PhD, Roche
• Consideration of Alternative Methods Workgroup
  Jessie Carder, U.S. Department of Agriculture

September 22, 2022

Validation and Establishing Scientific Confidence in New Approach Methodologies (NAMs)

• ICCVAM Validation Work Group Update
  Suzanne Fitzpatrick, PhD, U.S. Food and Drug Administration
• Technical Framework for Enabling High Quality Measurements in NAMs
  Elijah Petersen, PhD, National Institute of Standards and Technology
• Scientific Confidence Framework
  • Biological Relevance: A Better Benchmark
    Nicole Kleinstreuer, PhD, NIEHS/DTT/NICEATM
  • Variability of Reference Data
    Agnes Karmaus, PhD, Inotiv (contractor supporting NICEATM)
  • Transparency, Data Integrity, and External Review
    João Barroso, PhD, European Union Reference Laboratory for Alternatives to Animal Testing
• Understanding Context of Use: Case Studies
  • Understanding Context of Use for Medical Devices
    Shelby Skoog, PhD, U.S. Food and Drug Administration
  • Context of Use of Mammalian LD50 in Ecological Assessment
    William Eckel, PhD, U.S. Environmental Protection Agency
    
  • Development of a Rapid Risk Assessment Process and Software Tools to Support Air Force Operational Decision-making and Technology Acquisition
    Rebecca Clewell, PhD, U.S. Air Force 

Update on NICEATM Computational Resources
Helena Hogberg, PhD, NIEHS/DTT/NICEATM