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https://ntp.niehs.nih.gov/go/iccvam-acutetox
Acute Systemic Toxicity Testing
Acute systemic toxicity tests are used to assess the toxicity of chemicals, medical products, and other substances resulting from different types of exposure. These tests are used to determine if substances need protective packaging, warning labels, and environmental release guides, or if protective equipment may be required for handling. Learn about alternatives to animal use for these tests.
The U.S. strategy and roadmap is guiding replacement of animal use for required acute systemic toxicity testing. Find out about related NICEATM and ICCVAM activities.
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NICEATM and collaborators have held workshops to consider how non-animal methods could be used to identify substances that are toxic when inhaled. Read more about the workshops.
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NICEATM coordinated a study of how in vitro cytotoxicity test methods could reduce animal use for acute toxicity testing. Read more about the study.
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