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Research & Testing

NTP immunotoxicity, neurobehavioral, reproductive, and toxicology/carcinogenicity studies, as well as general chemistry and modified one-generation protocols, are conducted according to the specifications listed below.

Chemistry

Chemistry Specifications and Criteria
Specification/Criteria Last Updated
Chemistry Specifications 2017

Developmental & Reproductive Toxicity

Developmental and Reproductive Toxicity Specifications and Criteria
Specification/Criteria Last Updated
Explanation of Levels of Evidence for Developmental Toxicity 2009
Explanation of Levels of Evidence for Reproductive Toxicity 2009
NTP Reproductive Specifications 2011

Health Effects Assessments

Health Effects Assessments Specifications and Criteria
Specification/Criteria Last Updated
Handbook for Conducting Systematic Reviews for Noncancer Health Effects Evaluations 2019
Handbook for Preparing Report on Carcinogens Monographs 2015
Report on Carcinogens Listing Criteria 2016
Risk of Bias Tool 2015

Immunotoxicity

Immunotoxicity Specifications and Criteria
Specification/Criteria Last Updated
Explanation of Levels of Evidence for Immune System Toxicity 2009
NTP Immunotoxicity Study Pathology Specifications 2016

Modified One-Generation

Modified One-Generation Specifications and Criteria
Specification/Criteria Last Updated
Modified One-Generation Guidance Document 2015

Neurotoxicity

Neurotoxicity Specifications and Criteria
Specification/Criteria Last Updated
NTP Neurobehavioral Testing Specifications 2015

Statistical Procedures

Statistical Procedures Specifications and Criteria
Specification/Criteria Last Updated
Statistical Procedures 2019

Toxicology/Carcinogenicity

Toxicology/Carcinogenicity Specifications and Criteria
Specification/Criteria Last Updated
Explanation of Levels of Evidence of Carcinogenic Activity 1986
NTP Specifications for Toxicology/Carcinogenicity Studies 2011

Transcriptomics

Transcriptomics Specifications and Criteria
Specification/Criteria Last Updated
NTP Approach to Genomic Dose-Response Modeling 2018