National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/alt-links

Related Links


Information about testing regulations and guidelines

Information about funding opportunities for test method development

Disclaimer: The links below lead to pages outside the ICCVAM website. These links are for the convenience of visitors to our site, who may find them useful. NICEATM and ICCVAM are not responsible for the availability or content of these external sites, nor do we endorse, warrant or guarantee the products, services or information described or offered at these other sites.

International Cooperation on Alternative Test Methods (ICATM) Partner Organizations

Read more about ICATM

EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing) 
EURL ECVAM (formerly ECVAM) is the European Union's principal organisation for the scientific validation of alternative methods to animal testing. EURL ECVAM is actively involved in the search for test methods which replace, reduce or refine (the 'Three Rs') the use of laboratory animals in the test process. EURL ECVAM supports the post-validation regulatory acceptance process both at European Union level and also with international organisations such as the Organisation for Economic Co-operation and Development (OECD) and ICH (International Conference on Harmonisation).

JaCVAM (Japanese Center for the Validation of Alternative Methods) 
JaCVAM is part of the National Institute of Health Sciences within the Japanese Government. JaCVAM’s policy and mission is to promote the 3Rs in animal experiments for the evaluation of chemical substance safety in Japan and establish guidelines for new alternative experimental methods through international collaboration.

Health Canada 
Health Canada’s Environmental Health Science and Research Bureau coordinates the evaluation of alternative test methods in Canada.

KoCVAM (Korean Center for the Validation of Alternative Methods) 
The Korean Center for the Validation of Alternative Methods (KoCVAM) coordinates the evaluation of alternative test methods in South Korea. KoCVAM is part of the National Institute of Food and Drug Safety Evaluation of the South Korean Food and Drug Administration.


Other Organizations and Resources Relevant to Alternative Methods Development

U.S. Government Sites

ALTBIB: Resources for Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing 
ALTBIB provides access to PubMed®/MEDLINE® citations relevant to alternatives to the use of live vertebrates in biomedical research and testing. Many citations provide access to free full text.

USDA Animal Welfare Information Center Alternatives page has information about 3R's testing and the Animal Welfare Act, as well as links to relevant methods, journals and databases.

Links to other U.S. government resources are available on the ICCVAM Agencies page

International Government Sites

EURL ECVAM Database Service on Alternative Methods to Animal Experimentation (DB-ALM) 
DB-ALM was established in 1996 to establish, maintain and manage a database on alternative procedures to animal experiments. It provides ready-to-use information presented as evaluated data-sheets in the form of summary records and detailed information on various aspects of animal alternatives with focus on toxicology assessments.

TSAR: Tracking System for Alternative Test Methods Review, Validation and Approval in the Context of EU Regulations on Chemicals 
TSAR is a tool to provide a transparent view on the status of alternative methods as they progress from purely scientific protocols submitted for pre-validation to being actively used in a regulatory context. TSAR is administered by the European Commission Joint Research Centre (JRC) Institute for Health and Consumer Protection.

ZEBET: Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments 
ZEBET was established in 1989 within Germany's Federal Institute for Risk Assessment. The goal of ZEBET is to bring about the replacement of legally prescribed animal experiments with alternative test methods, to reduce the number of test animals to the absolutely necessary level and to alleviate the pain and suffering of animals used in experiments.

Academic and Non-Profit Organization Sites

ALTEX: Alternatives to Animal Experiments 
ALTEX is a scientific journal devoted to the publication of research on the development and promotion of alternatives to animal experiments. It is the official organ of CAAT and several other alternative methods groups. View ALTEX journal articles on the ALTWEB website

AltTox.org: Non-animal Methods for Toxicity Testing
AltTox.org is a website dedicated to advancing non-animal methods of toxicity testing through online discussion and information exchange. The site is developed and supported through a collaboration of the Procter & Gamble Company and The Humane Society of the United States.

CAAT - Johns Hopkins University Center for Alternatives to Animal Testing 
CAAT is an academic, science-based center affiliated with the Johns Hopkins University Bloomberg School of Public Health. The center provides a variety of resources for scientists, including grants, workshops and publications, and administers AltWeb, a global clearinghouse for information on alternatives to animal testing.

Canadian Council on Animal Care's (CCAC) Three Rs Microsite 
The CCAC is the national agency in Canada providing oversight for the use of animals in science. The CCAC Three Rs Microsite provides information on replacement, reduction and refinement alternatives for animal use in science. The information is available in both French and English.

EPAA: European Partnership for Alternative Approaches to Animal Testing
The EPAA is a joint initiative of the European Commission, European trade associations and individual companies from seven industry sectors. Its purpose is to promote the development and implementation of modern alternative approaches and new methods that will replace, reduce, and refine the use of animals in the field of safety testing.

FRAME: Fund for the Replacement of Animals in Medical Experiments 
FRAME is a United Kingdom charity founded in 1969 to promote the "Three Rs" (Reduce, Refine, Replace) as a way forward on the issue of animal experimentation. FRAME seeks to promote a moderate approach to the reduction of laboratory animal use by encouraging a realistic consideration of the ethical and scientific issues involved and the widest possible adoption of the Three Rs.

IVTIP (In Vitro Testing Industrial Platform) 
IVTIP is non-profit organization providing an informal forum of European companies with an active interest in in vitro methods to be used in regulatory/safety testing or in the compound discovery and development process. IVTIP suggests topics in the field of in vitro testing where more research is required and evaluating the results of the EU research projects, mainly from the industrial point of view.

NC3Rs (National Centre for Replacement, Refinement and Reduction of Animals in Research) 
The NC3Rs funds high-quality 3Rs research, develops a range of 3Rs information resources and guidelines, and organizes workshops and symposia to disseminate and advance the 3Rs. The Centre was established in the United Kingdom in May 2004 and is licensed under the Animals (Scientific Procedures) Act 1986, which regulates scientific procedures which may cause pain, suffering, distress or lasting harm to "protected animals."

PETA International Science Consortium
The PETA International Science Consortium, Ltd., promotes non-animal research methods and coordinates the scientific and regulatory expertise of its members. With an eye toward championing the best non-animal methods and replacing tests on animals, PISC brings scientific expertise and extensive knowledge of the international regulatory environment to the development of testing protocols.

Physicians Committee for Responsible Medicine
Since 1985, the Physicians Committee has been working tirelessly for alternatives to the use of animals in medical education and research and advocating for more effective scientific methods. Our priorities include shifting research from animal models to human-relevant studies, and working with policymakers and industry to adopt alternatives to chemical tests on animals.

University of California - Davis Center for Animal Alternatives Information
The UCDavis Center for Animal Alternatives places special emphasis on disseminating up-to-date information concerning animal alternatives through every level of public and private education. It also seeks to provide investigators who use animals with information on the most current methods for improving all aspects of animal care during their work.


Humane Care and Use of Laboratory Animals

U.S. Government Resources

National Institutes of Health Office of Extramural Research (OER) Office of Laboratory Animal Welfare (OLAW) 
The OER develops and implements NIH Grants Policy, monitors compliance with PHS policy on Humane Use and Care of Laboratory Animals, coordinates program guidelines, and develops and maintains information systems for grants administration.
Download the IACUC Guidebook from the OLAW web site

NIH Office of Animal Care and Use
Resource for NIH staff involved in the conduct of biomedical research at NIH

U.S. Department of Agriculture (USDA) Animal Welfare Information Center 
Maintained by the National Agricultural Library

USDA Animal and Plant Health Inspection Services Animal Welfare page

Other Resources

IACUC.ORG
An information resource for members and staff of institutional animal care and use committees.

Laboratory Animals Limited
Organization dedicated to promoting education and training in laboratory animal science.

Video on Humane Endpoints to Replace Lethal Parameters in Batch Potency Tests of Rabies Vaccines

This video, discussed at the October 2011 rabies vaccine workshop and the September 2010 ICCVAM vaccine workshop, is available on the Humane Endpoints in Laboratory Animal Experimentation website, which is administered by the Netherlands Center for Alternatives to Animal Use. Please note that the video is on the secured section of the website, which requires the user to register and receive approval for access.

Video credit: Klaus Cussler, Tamara Folz, Joachim Hartinger, Coenraad F.M. Hendriksen, Bjorn V.L. Steen and David A. Morton.  The HELP Group (Humane Endpoints – Lethal Parameters), Bilthoven, The Netherlands, 2001.


General Toxicology and In Vitro Methods

Society of Toxicology In Vitro and Alternative Methods Specialty Section
Members of the In Vitro and Alternative Methods Specialty Section have expertise in the application of in vitro techniques to problems of cellular toxicity, with a special emphasis on product safety evaluation.

Toxicology Education Foundation 
The Toxicology Education Foundation’s purpose is to encourage, support, and promote charitable and educational activities that increase the public understanding of toxicology. Support for the Toxicology Education Foundation comes from individuals, government, institutions and companies.

ToxTutor (National Library of Medicine)
ToxTutor is a self-paced tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. An update of ToxTutor released in October 2016 incorporates recent advances in the science of toxicology, provides more information on alternatives to animal testing, and features responsive design to support use on mobile devices.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.