Workshop Report and Recommendations

Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

NIH Publication No. 01-4499
August 2001

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Complete Report

Main Body

Appendix A: Workshop Agenda

Appendix B: Summary Minutes and Public Comments (Plenary Sessions)

Appendix C: Guidance for Breakout Groups

Appendix D: Background Document for Workshop Participants 

  1. Preface
  2. Introduction
  3. In Vitro Test Methods for Predicting In Vivo Toxicity - General Strategies
  4. In Vitro Screening Methods for Assessing Acute Toxicity (Breakout Group 1)
  5. In Vitro Methods for Assessing Acute Toxicity - Toxicokinetic Determination
    (Breakout Group 2)
  6. In Vitro Methods for Assessing Acute Toxicity - Specific Organ Toxicity and Mechanism
    (Breakout Group 3)
  7. Chemical Data Sets for Validation of In Vitro Toxicity Tests (Breakout Group 4)
  8. Relevant General Databases
  9. References
  10. Glossary

Appenidix E: NICEATM Summary of The Multicenter Evaluation of In Vitro Cytotoxicity (MEIC)

Appendix F: Federal Regulations on Acute Toxicity

  1. U.S. EPA Classification and Labeling Regulations
  2. CPSC Regulations
  3. U.S. Department of Transportation
    1. Regulations
    2. Materials Assigned as Division 6.1 Materials
  4. OSHA Regulations

Appendix G: Workshop Participants

Appendix H: Federal Register Notices About the In Vitro Workshop

  1. 65 FR 37400 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Request for Data and Suggested Expert Scientists (June 14, 2000)
  2. 65 FR 57203 - Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Workshop Agenda and Registration Information (September 21, 2000)

Appendix I: ICCVAM Test Method Recommendations