National Toxicology Program

National Toxicology Program

Reference Data for Evaluation of In Vitro Test Methods and Computational Models

NICEATM is assembling high-quality data from in vivo testing of chemicals for potential endocrine disruptor activity. These data have potential utility for developing adverse outcome pathways or models of estrogenic activity, prioritizing chemicals for further testing, or evaluating species-specific responses to chemicals.

Curated Database of Rodent Uterotrophic Bioactivity

Reference: Kleinstreuer NC, Ceger PC, Allen DG, Strickland J, Chang X, Hamm JT, Casey WM. A curated database of rodent uterotrophic bioactivity. Environ Health Perspect 124(5):556-62.

NICEATM performed a search of the peer-reviewed literature for uterotrophic assay data on the 1812 ToxCast compounds. The initial search yielded over 1000 papers, of which 670 were deemed potentially relevant based on the inclusion of uterine weight as a measured endpoint. From these 670 manuscripts, 2615 individual chemical/study/protocol combinations were extracted, yielding results on 235 chemicals with unique CASRNs.
View data from initial search: 2615 experiments 

Only study design protocols which met all six minimum criteria to be considered guideline-like (GL) were included in the GL-UTDB. The GL-UTDB contains information from 458 GL studies extracted from 93 publications, providing high-quality in vivo estrogenic bioactivity data on 118 chemicals with unique CASRNs (103 of which are in the ToxCast/Tox21 inventory). We included all chemicals in the studies returned by our search, some of which were not in the ToxCast library but were included in publications that also examined ToxCast chemicals. We performed an additional round of manual quality assurance on all study information in the GL-UTDB to confirm data entry accuracy.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.