Developmental & Reproductive Toxicity (DART) Reports

About Developmental & Reproductive Toxicity (DART) Reports

NTP has developed a range of techniques and testing regimes to evaluate the potential of environmental and occupational substances to affect development and damage reproductive systems.

Prenatal developmental toxicity studies identify substances that may pose a risk to the developing fetus if pregnant women are exposed. Regulatory agencies use the results of well-conducted animal studies to help set human exposure guidelines.

We have also developed methods for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily using rodent models.

Levels of Evidence for Developmental Toxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Given that developmental events are intertwined in the reproductive process, effects on developmental toxicity may be detected in reproductive studies. Evaluation of such developmental effects should be based on the NTP Criteria for Levels of Evidence for Developmental Toxicity. The Levels of Evidence are divided into five categories.

Categories for positive experimental results:

Clear Evidence of Developmental Toxicity
Some Evidence of Developmental Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Developmental Toxicity

Category for no observable effects:

No Evidence of Developmental Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Developmental Toxicity

Download graphic of NTP’s Level of Evidence Rating System for Developmental Toxicity Studies

Levels of Evidence for Reproductive Toxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Evaluation of reproductive effects are based on the NTP Criteria for Levels of Evidence for Reproductive Toxicity. The Levels of Evidence are divided into five categories.

Categories for positive experimental results:

Clear Evidence of Reproductive Toxicity
Some Evidence of Reproductive Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Reproductive Toxicity

Category for no observable effects:

No Evidence of Reproductive Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Reproductive Toxicity

Download graphic of NTP’s Level of Evidence Rating System for Reproductive Toxicity Studies

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Abstract	Full Text	Report Title	Year	Type
DART-08	PDF (5.82 MB)	Modified One-Generation Study of Bisphenol AF (CASRN 1478-61-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats with Prenatal, Reproductive Performance, and Subchronic Assessments in F1 Offspring	2022	Developmental & Reproductive Toxicity
DART-07	PDF (1.59 MB)	Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CASRN 95737-68-1) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:NZW SPF) Rabbits	2022	Developmental & Reproductive Toxicity
DART-06	PDF (5.17 MB)	Modified One-Generation Study of 2-Ethylhexyl p-Methoxycinnamate (CASRN 5466-77-3) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats with Prenatal, Reproductive Performance, and Subchronic Assessments in F1 Offspring	2022	Developmental & Reproductive Toxicity
DART-05	PDF (5.97 MB)	Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring	2022	Developmental & Reproductive Toxicity
DART-04	PDF (1006.3 KB)	Prenatal Development Studies of Dimethylaminoethanol Bitartrate (CASRN 5988-51-2) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies)	2020	Developmental & Reproductive Toxicity
DART-03	PDF (1.17 MB)	Prenatal Development Studies of Vinpocetine (CASRN 42971-09-5) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and New Zealand White (Hra:Nzw Spf) Rabbits (Gavage Studies)	2020	Developmental & Reproductive Toxicity
DART-02	PDF (1.09 MB)	Prenatal Development Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies)	2020	Developmental & Reproductive Toxicity
DART-01	PDF (937.57 KB)	Prenatal Development Studies of Tris(chloropropyl) Phosphate (CASRN 13674-84-5) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies)	2020	Developmental & Reproductive Toxicity