National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16647

TDMS Study 61938-01 Pathology Tables

NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57




       Facility:  Battelle Northwest

       Chemical CAS #:  5522-43-0

       Lock Date:  06/05/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          12           12           12           12           12           12           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Special Study                                        2            2            2            2            2            2           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (3)          (1)          (4)          (1)          (10)         
      Hepatodiaphragmatic Nodule                                    2 (67%)      1 (100%)     4 (100%)     1 (100%)     1 (10%)     
      Inflammation, Chronic                                         1 (33%)                                                         
      Inflammation, Chronic Active                                                                                      1 (10%)     
      Necrosis                                                                                                          1 (10%)     
      Necrosis, Focal                                  1 (10%)      1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   4 (40%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                   (1)                       (10)         
      Cyst                                             1 (10%)                                1 (100%)                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mediastinal                            (9)          (1)                                                 (10)         
      Hemorrhage                                                    1 (100%)                                                        
   Spleen                                             (10)                      (1)                                    (10)         
      Fibrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Epiglottis, Metaplasia, Squamous                              4 (40%)      4 (40%)     10 (100%)    10 (100%)    10 (100%)    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                      10 (100%)     8 (80%)      6 (60%)      9 (90%)      7 (70%)      9 (90%)     
      Inflammation, Chronic Active                                  5 (50%)      2 (20%)                   2 (20%)      2 (20%)     
      Alveolar Epithelium, Hyperplasia                 1 (10%)                                                                      
      Bronchus, Metaplasia, Squamous                                                                       2 (20%)      3 (30%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Olfactory Epithelium, Cytoplasmic Alteration    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Respiratory Epithelium, Cytoplasmic                                                                                           
        Alteration                                                                            6 (60%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      1 (10%)                                                          1 (10%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          12           12           12           12           12           12           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Special Study                                        2            2            2            2            2            2           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (2)          (4)          (1)          (1)          (10)         
      Hepatodiaphragmatic Nodule                       2 (20%)      2 (100%)     4 (100%)     1 (100%)     1 (100%)     1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   6 (60%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (9)          (10)         (10)         (9)          (10)         (10)         
      Hypospermia                                      9 (100%)    10 (100%)    10 (100%)     9 (100%)    10 (100%)    10 (100%)    
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                         10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Mineralization                                   1 (10%)                                             2 (20%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node                                         (1)                       (1)                       (1)                       
      Renal, Hemorrhage                                1 (100%)                  1 (100%)                  1 (100%)                 
   Lymph Node, Mediastinal                            (10)                      (1)                                    (8)          
      Hemorrhage                                                                 1 (100%)                                           
   Thymus                                             (10)                      (1)                                    (10)         
      Hemorrhage                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Epiglottis, Metaplasia, Squamous                                           5 (50%)     10 (100%)    10 (100%)    10 (100%)    
   Lung                                               (10)         (8)          (10)         (10)         (10)         (10)         
      Hemorrhage                                      10 (100%)     8 (100%)    10 (100%)     9 (90%)     10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                  3 (38%)      1 (10%)      2 (20%)      1 (10%)                  
      Bronchus, Metaplasia, Squamous                                                          1 (10%)      2 (20%)      5 (50%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Olfactory Epithelium, Cytoplasmic Alteration    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Respiratory Epithelium, Cytoplasmic                                                                                           
        Alteration                                                                            8 (80%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 61938-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   1-NITROPYRENE                                       Date: 10/18/04    
Route: RESPIRATORY EXPOSURE NASAL                                                                                 Time: 08:33:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5          2.0          8.0          20.0         50.0            
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      5 (50%)                                                          5 (50%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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