Share This:
https://ntp.niehs.nih.gov/go/128

Developmental & Reproductive Toxicity

Mitosis of embryo under microscope

Study Overview

Study: Developmental toxicity, reproductive toxicity
Species: Rats, mice, rabbits

Description

NTP has developed a range of techniques and testing regimes for evaluating the potential of environmental and occupational substances to affect development and damage reproductive organ systems. Testing is focused on the following areas of study:

Prenatal Developmental Toxicity Studies

The prenatal developmental toxicity study (also known as embryo-fetal developmental study, teratology study, or Segment II study) is undertaken to identify sustances that may pose a risk to the developing fetus if pregnant women are exposed. Regulatory agencies use the results of well-conducted animal studies to help set human exposure guidelines. The experimental protocols, in general, are outlined by EPA Health Effects Test Guidelines OPPTS 870.3700.

Prenatal developmental toxicity studies are carried out using rodent models. Substances are tested in pregnant animals for their potential to cause birth defects and other signs of toxicity during embryo-fetal development. Pregnant females are usually exposed to the substance from implantation of the embryo in the uterus (gestation day 6 in the rodent) to the day before delivery. However, they may be exposed to the substance throughout pregnancy. This testing paradigm can also be used within a larger study to assess multigenerational responses. See Modified One-Generation design for details.

Modified One-Generation Studies

The classical study used to evaluate reproductive toxicity is the multigenerational reproduction experimental design. NTP has modified this study design to use fewer animals than the classical multigenerational study design, while generating information on the effects of substances on prenatal development, postnatal development, and reproduction.

NTP's Modified One-Generation Reproductive study design employs pregnant animals with dosing beginning at implantation and continued dosing of the dams throughout gestation and lactation. At weaning, the offspring are administered the test substance at the same dose level as their respective dam and are subsequently assigned to a number of different cohorts including:

  • a subchronic toxicity cohort – to evaluate target organ toxicity, pathology, clinical pathology
  • a teratology cohort – to evaluate prenatal development
  • a littering cohort – to evaluate breeding and littering for potential examination of the subsequent generation
  • a developmental neurotoxicity (DNT) cohort – to evaluate neurobehavioral end-points and neurohistopathology

Reproductive Studies

NTP has developed a range of techniques and testing regimes for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily using rodent models.

Protocols

Levels of Evidence Criteria

Levels of Evidence for Developmental Toxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Given that developmental events are intertwined in the reproductive process, effects on developmental toxicity may be detected in reproductive studies. Evaluation of such developmental effects should be based on the NTP Criteria for Levels of Evidence for Developmental Toxicity. The Levels of Evidence are divided into five categories.

Category for positive experimental results:

Clear Evidence of Developmental Toxicity
Some Evidence of Developmental Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Developmental Toxicity

Category for no observable effects:

No Evidence of Developmental Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Developmental Toxicity

Levels of Evidence for Reproductive Toxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Evaluation of reproductive effects are based on the NTP Criteria for Levels of Evidence for Reproductive Toxicity. The Levels of Evidence are divided into five categories.

Category for positive experimental results:

Clear Evidence of Reproductive Toxicity
Some Evidence of Reproductive Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Reproductive Toxicity

Category for no observable effects:

No Evidence of Reproductive Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Reproductive Toxicity

Non-Cancer Evaluation Criteria

NTP is working to bring the same rigorous standards used for categorizing the outcomes of its cancer studies to its non-cancer studies (developmental, immunotoxicity, and reproductive studies).

Non-Cancer Evaluation Categories

NTP uses the following five categories to describe the strength of the evidence for non-cancer study findings:

Clear Evidence
Some Evidence
Equivocal Evidence
No Evidence
Inadequate study

Specifications & Guidance

Abstracts & Reports

The following list of abstracts represents studies conducted by NTP beginning in 1985. These studies have not been evaluated by the levels of evidence criteria for reproductive or developmental toxicity established by NTP in March 2009. Because this is not a comprehensive list, contact CDM (or use our contact form) to inquire about other studies.

Drinking water report abstracts present results of studies conducted by contract laboratories for NTP. The screening studies were designed to provide broad toxicity information. The studies have limited experimental power and therefore should not be used as definitive information on reproductive or developmental toxicity outcomes. The findings were not evaluated in accordance with the levels of evidence for reproductive or developmental toxicity criteria established by NTP in March 2009. The findings and conclusions for these studies should not be construed to represent the views of NTP or the U.S. Government.

Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, contact CDM (or use our contact form) and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.

How to search with filtering and sorting

Search for particular reports by filtering or searching the table. As you type in the search box, the page will filter the table results as you type each letter.

Sort by clicking the up or down arrow in a column header. Click again to reverse the order. If only one arrow is displayed, that column is sorted in the direction of the arrow. Only one column can be sorted at a time.

Listing of all NTP study abstracts and reports
Abstract Full Text Report Title Report Year Type
TER87036 N/A Inhalation Developmental Toxicology Studies: Teratology Studies of Acetone (CAS No. 67-64-1) in Swiss (CD-1) Mice and Sprague Dawley Rats 1988 Developmental
TER87140 N/A Inhalation Developmental Toxicology Studies: Teratology Studies of Acetone (CAS No. 67-64-1) in Swiss (CD-1) Mice and Sprague Dawley Rats 1988 Developmental
TER91039 N/A Inhalation Development Toxicology Studies: Acetonitrile (CAS No.75-05-8) in Sprague Dawley Rats 1994 Developmental
TER88048 N/A Teratologic Evaluation of Acrylamide (CAS NO-. 791-06-1) Administered to Sprague Dawley (CD) Rats on Gestational Days 6 Through 20 1988 Developmental
TER89049 N/A Teratologic Evaluation of Acrylamide (CAS No.79-06-1) Administered to CD-1 (Swiss Mice) on Gestational Days 6 Through 17 1988 Developmental
TER87038 N/A Arsine (CAS No. 7784-42-1): Absence of Developmental Toxicity in Rats and Mice 1990 Developmental
TER97001 N/A Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2', 3'-Dideoxycytidine (AZT; CAS No. 30516-87-1 ddC; CAS No. 7481-89-2) Administered by Gavage to Swiss Albino (CD-1) Mice on Gestational Days 6-15 2002 Developmental
TER20203 N/A Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CAS No. 30516-87-1) and (-) 2', 3'-Dideoxy-3'-thiacytidine (3TC; CAS No. 134678-17-4) Co-administered by Gavage to Swiss Albino (CD-1) Mice on Gestational Days 6 Through 16 2004 Developmental
RACB98001 N/A Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CAS No. 30516-87-1) and Dapsone (CAS No. 80-08-0) Administered by Gavage to Swiss Albino (CD-1) Mice on Gestational Days 6 Through 15 2004 Developmental
TER84050 N/A Teratologic Evaluation of Bendectin (CAS No. 8064-77-5), in Sprague Dawley (CD) Rats 1984 Developmental
TER98005 N/A Developmental Toxicity Evaluation for Benzophenone (CAS No. 119-61-9) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 2002 Developmental
TER99001 N/A Developmental Toxicity Evaluation for Benzophenone (CAS No. 119-61-9) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 Through 29 2004 Developmental
TER99002 N/A Developmental Toxicity Evaluation of Berberine Chloride Dihydrate (CAS NO. 5956-60-5) Administered in the Feed to Swiss (CD-1) Mice on Gestational Days 6 to 17 2003 Developmental
TER98008 N/A Developmental Toxicity Evaluation for Berberine Chloride Dihydrate (CAS No. 5956-60-5) Administered in the Feed to Sprague Dawley (CD) Rats on Gestational Days 6 to 20 2003 Developmental
TER20102 N/A Developmental Toxicity Research Evaluation for Berberine Chloride Dihydrate (CAS No. 5956-60-5) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 2002 Developmental
TER20103 N/A Developmental Toxicity Research Evaluation for Berberine Chloride Dihydrate (CAS No. 5956-60-5) Administered by Gavage to Swiss (CD-1) Mice on Gestational Days 6 Through 16 2003 Developmental
TER85051 N/A Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD Rats on Gestational Days 6 Through 15 1985 Developmental
TER85052 N/A Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7), in CD-1 Mice on Gestational Days 6 Through 15 1985 Developmental
TER89027 N/A Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) Administered in Feed to Sprague Dawley (CD) Rats on Gestational Days 0 to 20 or 6 to 15 1990 Developmental
TER90123 N/A Evaluation of CNS Development in Sprague Dawley CD Rats Exposed to Boric Acid (CAS No. 10043-35-3) in Feed on Gestational Days 14-17 1994 Developmental
TER93138 N/A CNS Developmental Toxicity of Boric Acid (CAS No. 10043-35-3) in Sprague Dawley CD Rats Exposed on Gestation Days 6-15 1994 Developmental
TER89028 N/A Developmental Toxicity Evaluation of Boric Acid (CAS No. 10043-35-3) Administered in Feed to CD-1 Swiss Mice on Gestational Days 0 to 17 1989 Developmental
TER90003 N/A Developmental Toxicity Evaluation of Boric Acid (Cas No. 10043-35-3) Administered to New Zealand White Rabbits by Gavage on Gestational Days 6 Through 19 1991 Developmental
TER89041 N/A Inhalation Developmental Toxicology Studies of 1,3-Butadiene (CAS No. 106-99-0) in Sprague Dawley Rats 1987 Developmental
TER85144 N/A Inhalation Developmental Toxicology Studies: Teratology Study of 1,3-Butadiene (CAS No.106-99-0) in CD-1 Mice 1987 Developmental
TER90030 N/A Inhalation Developmental Toxicology Studies: Teratology Study of 1,4-Butanediol (CAS No. 110-63-4), in Swiss (CD-1) Mice 1994 Developmental
TER97004 N/A Developmental Toxicity Evaluation for 1,2,3,4-Butanetetracarboxylic Acid (CAS No. 1703-58-8) Administered by Gavage to Sprague Dawley (CD) Rats from Gestational Day 6 Through 19 1999 Developmental
TER89026 N/A Developmental Toxicity of Butyl benzyl phthalate (CAS No. 85-68-7) in CD-1 Swiss Mice 1990 Developmental
TER88025 N/A Developmental Toxicity of Butyl Benzyl Phthalate (CAS No. 85-68-7) Administered in Feed to CD Rats on Gestational Days 6 to 15 1989 Developmental
TER91018 N/A Developmental Toxicity of d-Camphor (CAS No. 464-49-3) in Sprague Dawley (CD) Rats 1992 Developmental
TER91019 N/A Developmental Toxicity of d-Camphor (CAS No. 464-49-3) in New Zealand White (NZW) Rabbits 1992 Developmental
TER84053 N/A Teratologic Evaluation of Carbon Disulfide (CAS No. 75-15-0) Administered to CD Rats on Gestational Days 6 Through 15 1984 Developmental
TER84054 N/A Teratologic Evaluation of Carbon Disulfide (CAS No. 75-15-0) Administered to New Zealand White Rabbits on Gestational Days 6 Through 19 1984 Developmental
TER91042 N/A Inhalation Developmental Toxicology Studies: Developmental Toxicity of Chloroprene (CAS No. 126-99-8) Vapors in New Zealand White Rabbits 1994 Developmental
TER82055 N/A Chlorpromazine Hydrochloride (CAS No. 69-09-0) Administered to Fischer/344 Rats on Gestational Days 6 Through 15 1983 Developmental
TER82056 N/A Chlorpromazine Hydrochloride (CAS No. 69-09-0) Administered to CD-1 Mice on Gestational Days 6 Through 15 1983 Developmental
TER90057 N/A Codeine (CAS No. 76-57-3) Administered to CD-1 Mice on Gestational Days 6 Through 15 1987 Developmental
TER90058 N/A Codeine (CAS No. 76-57-3) in LVG Hamsters on Gestational Days 5 Through 13 1987 Developmental
TER92136 N/A Developmental Toxicity of a-Cyclodextrin (CAS No. 10016-20-3) in Sprague Dawley CD Rats 1994 Developmental
TER92135 N/A Developmental Toxicity of a-Cyclodextrin (CAS No. 10016-20-3) in Swiss (CD-1) Mice (CAS No. 10016-20-3) 1994 Developmental
ORST800001 N/A Evaluation of 2,4-dichiorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in C57BL/6 mice: Reproduction and Fertility in Treated Male Mice and Evaluation of Congenital Malformations in Their Offspring (NTP CAS No. AGNTORANGEMX) 1980 Developmental
TER96001 N/A Developmental Toxicity Screen for Diethanolamine (CAS No. 111-42-2) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19: Evaluation of Dams and Pups Through Postnatal Day 21 1999 Developmental
TER88065 N/A Developmental Toxicity of Diethyl phthalate (CAS No. 84-66-2) Administered to CD Rats on Gestational Days 6 Through 15 1988 Developmental
TER89001 N/A Developmental Toxicity of Diethylene Glycol (CAS No. 111-46-6) in CD-1 Swiss Mice 1991 Developmental
TER86059 N/A Teratologic Evaluation Diethylene Glycol Diethyl Ether (CAS No.112-36-7) Administered to CD-1 Mice on Gestational Days 6 Through 15 1987 Developmental
TER87060 N/A Diethylene glycol diethyl ether (CAS No. 112-36-7) Administered to New Zealand White Rabbits on Gestational Days 6 Through 19 1987 Developmental
TER85061 N/A Teratologic Evaluation of Diethylene Glycol Dimethyl Ether (CAS NO. 111-96-6) Administered to CD-1 Mice on Gestational Days 6 Through 15 1985 Developmental
TER86062 N/A Diethylene glycol dimethyl ether (CAS No. 111-96-6) Administered to New Zealand White Rabbits on Gestation Days 6 Through 19 1987 Developmental
TER84063 N/A Teratologic Evaluation of Diethylhexyl Phthalate (CAS No. 117-81-7) in Fischer 344 Rats 1983 Developmental
TER84064 N/A Teratologic Evaluation of Diethylhexyl Phthalate (CAS No. 117-81-7) in CD-1 Mice 1983 Developmental
T0086E N/A Reproductive and Fertility Assessment of Diethylhexyl Phthalate (CAS No. 117-81-7) CD-1 Mice 1984 Developmental
TER93137 N/A Developmental Toxicity of Diethystilbestrol (CAS NO. 56-53-1) in Swiss (CD-1) Mice 1994 Developmental
TER88066 N/A Developmental Toxicity of Dimethyl phthalate (CAS No. 131-11-3) Administered to CD Rats on Gestational Days 6 Through 15 1989 Developmental
TER82067 N/A Teratologic Evaluation of Diphenhydramine Hydrochloride (CAS No. 147-24-0) in CD Rats 1983 Developmental
TER82068 N/A Teratologic Evaluation of Diphenhydramine Hydrochloride (CAS No. 147-24-0) Administered to CD-1 Mice on Gestational Days 11 Through 14 1982 Developmental
TER82069 N/A Teratologic Evaluation of Diphenhydramine Hydrochloride (CAS No. 147-24-0) in CD-1 Mice 1981 Developmental
TER91013 N/A Final Report on the Developmental Toxicity of Dipropylene Glycol (CAS No. 25265-71-8)in Sprague Dawley CD Rats 1992 Developmental
TER90014 N/A Developmental Toxicity of Dipropylene glycol (CAS No. 25265-71-8) in New Zealand White Rabbits 1992 Developmental
TER98003 N/A Developmental Toxicity Evaluation for Emodin Administered in the Feed to Sprague Dawley (CD) Rats on Gestational Days 6 to 17 2002 Developmental
TER99003 N/A Developmental Toxicity Evaluation for Emodin Administered in the Feed to Swiss (CD-1) Mice on Gestational Days 6 to 17 2002 Developmental
TER84070A N/A Teratologic Evaluation of Ethylene Chlorohydrin (CAS No. 107-07-3) in CD-1 Mice 1983 Developmental
TER84070B N/A Teratologic Evaluation of Ethylene Chlorohydrin (CAS No. 107-07-3) in CD-1 Mice 1983 Developmental
TER84070C N/A Teratologic Evaluation of Ethylene Chlorohydrin (CAS No. 107-07-3) in CD-1 Mice 1983 Developmental
TER84070D N/A Teratologic Evaluation of Ethylene Chlorohydrin (CAS No. 107-07-3) in CD-1 Mice 1983 Developmental
TER84071 N/A Teratologic Evaluation of Ethylene Chlorohydrin (CAS No. 107-07-3) in New Zealand White Rabbits 1983 Developmental
TER84073 N/A Teratologic Evaluation of Ethylene Glycol (CAS No. 107-21-1) Administered to CD-1 Mice on Gestational Days 6 Through 15 1984 Developmental
TER84128 N/A Developmental Toxicity of Ethylene Glycol (CAS No. 107-21-1) in CD Rats 1988 Developmental
TER90005 N/A Developmental Toxicity of Ethylene Glycol (CAS No 107-21-1) in New Zealand White Rabbits 1991 Developmental
TER89126 N/A Developmental Stages of the CD Rat Skeleton: Part II: Development after Maternal Exposure to Ethylene Glycol (CAS No. 107-21-1) 1990 Developmental
TER87074 N/A Ethylene Glycol Diethyl Ether (CAS No. 629-14-1) Administered to CD-1 Mice on Gestational Days 6 Through 15 1987 Developmental
TER90075 N/A Ethylene Glycol Diethyl Ether (CAS No. 629-14-1) Administered to New Zealand White Rabbits on Gestational Days 6 Through 19 1987 Developmental
TER88076 N/A Ethylene Glycol Monobutyl Ether (CAS No. 111-76-2) Administered to Fischer-344 Rats on Either Gestational Days 9-11 or Days 11-13 1989 Developmental
TER92020 N/A Developmental Toxicity Studies of Ethylenediamine (CAS No. 107-15-3) in New Zealand White Rabbits 1993 Developmental
TER82078 N/A Teratologic Evaluation of Ethylene oxide (CAS No. 75-21-8) in New Zealand White Rabbits 1983 Developmental
TER90029 N/A Developmental Toxicity of 2-Ethylhexanol (CAS NO. 104-76-7) in CD-1 Swiss Mice 1991 Developmental
TER97002 N/A Developmental Toxicity Evaluation of Formamide (CAS NO. 75-12-7) Administered by Gavage to Sprague Dawley (CD) Rats On Gestational Days 6 Through 19 1998 Developmental
TER98002 N/A Developmental Toxicity Evaluation Of Formamide (CAS No. 75-12-7) Administered By Gavage To New Zealand White Rabbits On Gestational Days 6 Through 29 2001 Developmental
TER89143 N/A Inhalation Developmental Toxicology Studies: Gallium Arsenide (CAS No. 1303-00-0) in Rats and Mice 1990 Developmental
TER90043 N/A Inhalation Developmental Toxicology Studies: Gallium Arsenide (CAS No. 1303-00-0) in Rats and Mice 1990 Developmental
TER82079 N/A Teratologic Evaluation of Gentian Violet (CAS No. 548-62-9) in CD Rats 1982 Developmental
TER82080 N/A Teratologic Evaluation of Gentian Violet (CAS No. 548-62-9) in New Zealand White Rabbits 1983 Developmental
TER92116 N/A Developmental Toxicity of Glyoxal Trimeric Dihydrate (CAS No. 4405-13-4) in Sprague Dawley (CD) Rats 1994 Developmental
TER92121 N/A Developmental Toxicity of Glyoxal Trimeric Dihydrate (CAS No. 4405-13-4) in New Zealand White (NZW) Rabbits 1993 Developmental
TER99004 N/A Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) Root Powder Administered in the Feed to Swiss (CD-1) Mice on Gestational Days 6-17 2002 Developmental
TER98007 N/A Developmental Toxicity Evaluation for Goldenseal Root Powder (Hydrastis Canadensis) Administered in the Feed to Sprague Dawley (CD) Rats on Gestational Days 6 to 20 2003 Developmental
T0166 N/A Peri/Postnatal Evaluation of Hexachloro-1,-Butadiene (HCBD) (CAS# 87-68-3) Toxicity in CD Rats 1990 Developmental
TER84084 N/A Teratologic Evaluation of Hydrochlorothiazide (Cas No. 58-93-5) Administered to CD Rats on Gestational Days 6 Through 15 1984 Developmental
TER84085 N/A Teratologic Evaluation of Hydrochlorothiazide (CAS NO. 58-93-5) Administered to CD-1 Mice on Gestational Days 6 Through 15 1984 Developmental
TER90082 N/A Inhalation Developmental Toxicology Studies: N-Hexane (CAS# 110-54-3) in Rats 1987 Developmental
TER90083 N/A N-Hexane (CAS# 110-54-3): Inhalation Developmental Toxicology Studies in Mice 1988 Developmental
TER82086 N/A Teratologic Evaluation of L-5-Hydroxytryptophan (CAS No. 4350-09-8) in Sprague Dawley CD Rats 1983 Developmental
TER97006 N/A Developmental Toxicity Evaluation for Isoeugenol (CAS NO. 97-54-1) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 1999 Developmental
TER88045 N/A Inhalation Developmental Toxicology Studies: Teratology Study of Isoprene (CAS No. 78-79-5) in Mice and Rats 1989 Developmental
TER88142 N/A Inhalation Developmental Toxicology Studies: Teratology Study of Isoprene (CAS No. 78-79-5) in Mice and Rats 1989 Developmental
TER82088 N/A Teratologic Evaluation of Isoproterenol Hydrochloride (CAS No. 51-30-9) in CD Rats 1982 Developmental
TER94001 N/A A Developmental Toxicity Study of 60 Hz Magnetic Fields (EMF) in Rats 1994 Developmental
TER96003 N/A Developmental Toxicity Evaluation of Melatonin (CAS NO. 73-31-4) administered by gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 1998 Developmental
TER90007 N/A Developmental Toxicity of Methacrylamide (CAS NO. 79-39-0) in CD-1 Swiss Mice 1991 Developmental
TER91016 N/A Developmental Toxicity of 8-Methyoxypsoralen (CAS No. 298-81-7) in New Zealand White (NZW) Rabbits 1994 Developmental
TER91017 N/A Developmental Toxicity Evaluation of 8-Methoxypsoralen (CAS NO. 298-81-7) administered by gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 1 N/A Developmental
TER85090 N/A Teratologic Evaluation of Alpha-Methyldopa (CAS No. 555-30-6) Administered to CD Rats on Gestational Days 6 Through 20 1986 Developmental
TER86091 N/A Teratologic Evaluation of Alpha-Methyldopa (CAS No. 555-30-6) Administered to CD-1 Mice on Gestational Days 6 Through 17 1987 Developmental
TER92124 N/A Developmental Toxicity of Methylene Blue Trihydrate (CAS No. 7220-79-3) in Sprague Dawley (CD) Rats 1993 Developmental
TER92125 N/A Developmental Toxicity of Methylene Blue Trihydrate (CAS No. 7220-79-3) in New Zealand White (NZW) Rabbits 1994 Developmental
TER88046 N/A Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone (CAS No. 78-93-3) in Mice 1989 Developmental
TER90008 N/A Developmental Toxicity Evaluation of N,N'-methylenebisacrylamide (CAS NO. 110-26-9) in Swiss (CD-1) Mice 1992 Developmental
TER97007 N/A Developmental Toxicity Evaluation For Methyleugenol (CAS No. 93-15-2) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 to 19 2004 Developmental
TER90002 N/A Developmental Toxicity of Mono(2-ethylhexyl)phthalate (MEHP) (CAS No. 4376-20-9) in CD-1 Swiss Mice 1991 Developmental
TER91006 N/A Developmental Toxicity Studies of Naphthalene (CAS No. 91-20-3) in Sprague Dawley (CD) Rats N/A Developmental
TER91006 N/A Developmental Toxicity of Naphthalene (CAS No. 91-20-3) in New Zealand White (NZW) Rabbits 1991 Developmental
TER85092 N/A Teratologic Evaluation of Nitrofurazone (CAS NO. 59-87-0) Administered to CD-1 Mice on Gestational Days 6 Through 15 1985 Developmental
TER87093 N/A Teratologic Evaluation of Nitrofurazone (CAS No. 59-87-0) Administered to New Zealand White Rabbits on Gestational Days 6 Through 19 1987 Developmental
TER82094 N/A Teratologic Evaluation of Oxytetracycline Hydrochloride (CAS No. 2058-46-0) in CD Rats 1983 Developmental
TER82095 N/A Teratologic Evaluation of Oxytetracycline Hydrochloride (CAS No. 2058-46-0) in CD-1 Mice 1982 Developmental
TER90031 N/A Developmental Toxicology of Pesticide/Fertilizer Mixture-California (CAS #PestFertMix2) in Sprague Dawley (CD) Rats 1992 Developmental
TER91032 N/A Developmental Toxicology of Iowa Pesticide/Fertilizer Mixture (CAS #PestFertMix3) in Sprague Dawley (CD) Rats 1992 Developmental
TER81104 N/A Teratologic Evaluation of Phenol (CAS NO. 108-95-2) In CD Rats 1983 Developmental
TER80129 N/A Teratologic Evaluation of Phenol (CAS NO. 108-95-2) in CD-1 Mice 1983 Developmental
TER91010 N/A Developmental Toxicology of Polyoxyethylene Sorbitan Monolaurate (CAS #9005-64-5) in Sprague Dawley CD Rats 1992 Developmental
TER91009 N/A Developmental Toxicology of Polyoxyethylene Sorbitan Monooleate (CAS #9005-65-6) in Sprague Dawley CD Rats 1992 Developmental
TER85106 N/A Scopolamine Hydrobromide (CAS NO. 114-49-8) Administered to CD Rats on Gestational Days 6 Through 15 1987 Developmental
TER91009 N/A Teratologic Evaluation of Scopolamine Hydrobromide (CAS NO. 114-49-8) Administered to CD-1 Mice on Gestational Days 6 Through 15 1987 Developmental
TER85107 N/A Teratologic Evaluation of Scopolamine Hydrobromide (CAS NO. 114-49-8) Administered to CD-1 Mice on Gestational Days 6 Through 15 1987 Developmental
TER20001 N/A Developmental Toxicity Evaluation for Silver Acetate (CAS NO. 563-63-3) Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6-19 2002 Developmental
TER97005 N/A Developmental Toxicity Evaluation for Sodium Chlorate (Cas No. 7775-09-9) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 Through 29 2002 Developmental
TER91022 N/A Developmental Toxicity of Sodium Flouride (CAS No. 7681-49-4) in Sprague Dawley CD Rats 1994 Developmental
TER91033 N/A Developmental Toxicity of Sodium Flouride (CAS No. 7681-49-4) in New Zealand White (NZW) Rabbits 1993 Developmental
TER99005 N/A Developmental Toxicity Evaluation for Sodium Thioglycolate (Cas No. 367-51-1) Administered Topically to New Zealand White Rabbits gestational days 6 Through 29 2001 Developmental
TER98009 N/A Developmental Toxicity Evaluation for Sodium Thioglycolate (Cas No. 367-51-1) Administered Topically to Sprague Dawley Rats on Gestational Days 6 Through 19 2001 Developmental
TER20002 N/A Developmental Toxicity Evaluation for Alpha-Solanine (CAS No. 20562-02-1) Administered by Gavage to Swiss (CD-1) Mice on Gestational Days 6-16 2002 Developmental
TER81108 N/A Addendum to Final Report: Teratologic Evaluation of Sulfamethazine (CAS No. 57-68-1) in CD Rats 1985 Developmental
TER81109 N/A Teratologic Evaluation of Sulfamethazine (CAS No. 57-68-1) in New Zealand White Rabbits 1984 Developmental
TER84001 N/A Developmental Toxicity Evaluation of Sulfamethazine (Cas No. 57-68-1) in Feed to Fischer 344 Rats 1987 Developmental
TER88047 N/A Inhalation Developmental Toxicology Studies: Teratology Study of Tetrahydrofuran (CAS No. 109-99-9) in Mice and Rats 1988 Developmental
TER92133 N/A Developmental Toxicity of Thiophenol (CAS No. 108-98-5) in Sprague Dawley (CD) Rats 1994 Developmental
TER92134 N/A Developmental Toxicity of Thiophenol (CAS No. 108-98-5) in New Zealand White Rabbits 1994 Developmental
TER84110 N/A Teratologic Evaluation of Theophylline (CAS NO. 58-55-9) Administered to CD Rats on Gestational Days 6 Through 15 1985 Developmental
T0179 N/A Developmental Toxicity Evaluation of 1,1,1-Trichloroethane (CAS No. 71-55-6) Administered in Drinking Water to CD Rats 1987 Developmental
T0151 N/A Developmental Toxicity Evaluation of 1,1,1-Trichloroethane (CAS NO. 71-55-6) Administered to CD Rats 1987 Developmental
TER84112 N/A Teratologic Evaluation of Triethylene Glycol Dimethyl Ether (CAS No. 112-49-2) Administered to CD-1 Mice on Gestational Days 6 Through 15 1985 Developmental
TER85113 N/A Teratologic Evaluation of Triethylene Glycol Dimethyl Ether (CAS No. 112-49-2) Administered to New Zealand White Rabbits on Gestational Days 6 Through 19 1987 Developmental
TER87119 N/A Teratologic Evaluation of Corn Oil (CAS No. 8001-30-7) and Distilled Water Administered by Gavage to CD-1 Mice on Gestational Days 6 Through 15 1988 Developmental
TER87118 N/A Teratologic Evaluation of Corn Oil (CAS No. 8001-30-7) or Distilled Water Administered to CD Rats on Gestational Days 6 Through 15 1989 Developmental
RACB83079 N/A Acetaminophen : (CAS # 103-90-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed 1984 Reproductive
RACB90022 N/A Acrylamide (CAS No. 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice 1993 Reproductive
RACB88127 N/A Alternate Task 3 Design in CD Sprague-Dawley Rats 1992 Reproductive
RACB84042 N/A Reproduction and Fertility Assessment of 9-Aminoacridine Hydrochloride (CAS# 134-50-9) in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB98003 N/A Azidothymidine(AZT) CAS# 30516-87-1: Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Swiss CD-1® Mice by Gavage 2003 Reproductive
RACB92023 N/A Reproductive/Developmental/General Toxicity Study of 3'-Azido-3'-Deoxythymidine (AZT)/Methadone Hydrochloride Combinations in CD-1 Mice 1992 Reproductive
RACB82081 N/A Bisphenol A: (CAS No. 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic® Implants 1984 Reproductive
RACB84080 N/A Bisphenol A: (CAS No. 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed 1985 Reproductive
RACB88034 N/A Reproductive Toxicity of Boric Acid (CAS No. 10043-35-3) in CD-1 Swiss Mice 1990 Reproductive
RACB87111 N/A Bromoform (Tribromomethane) (CAS No. 75-25-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage 1989 Reproductive
RACB85043 N/A 2, 2-bis(bromomethyl)-1,3-propanediol (CAS #3296-90-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed 1986 Reproductive
RACB94006 N/A Reproductive Toxicity of Caffeine (CAS No: 58-08-2) Administered by Gavage to Sprague-Dawley Rats 1996 Reproductive
RACB81078 N/A Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water 1984 Reproductive
RACB84044 N/A Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1984 Reproductive
RACB88037 N/A Reproductive Toxicity of Carisoprodol (CAS No. 78-44-4) in CD-1 Swiss Mice 1991 Reproductive
RACB88036 N/A Reproductive Toxicity of a Chemical Mixture (NTP CAS No. CHEMMIXH2O) in CD-1 Swiss Mice 1990 Reproductive
RACB90062 N/A Reproductive Toxicity of a Mixture of Ground Water Contaminants (CAS No. CHEMMIXH2O) in Sprague-Dawley Rats 1991 Reproductive
RACB87045 N/A Chloroform (CAS No. 67-66-3): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage 1988 Reproductive
RACB90011 N/A Reproductive Toxicity of 2-Chloronitrobenzene (CAS No. 88-73-3) in CD-1 Swiss Mice 1992 Reproductive
RACB19077 N/A Reproductive Toxicity of 4-Chloronitrobenzene (CAS No. 100-00-5) in CD-1 Swiss Mice 1991 Reproductive
RACB88075 N/A 1-Chloro-2-propanol (CAS No. 127-00-4): Reproduction and Fertility Assessment In CD Sprague-Dawley Rats Via Drinking Water 1990 Reproductive
RACB90001 N/A Reproductive Toxicity of Ortho-Cresol (OCRE), CAS No. 95-48-7, in CD-1 Swiss Mice 1992 Reproductive
RACB90003 N/A Reproductive Toxicity of Meta-/Para-Cresol (MPCRE) (CAS No. 1319-77-3) in CD-1 Swiss Mice 1992 Reproductive
RACB90014 N/A Reproductive Toxicity of Diazepam (CAS No. 439-14-5) in CD Sprague-Dawley Rats 1992 Reproductive
RACB82083 N/A Dibromochloropropane (CAS #96-12-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage 1984 Reproductive
RACB97003 N/A DiButyl Phthalate (CAS No. 84-74-2): Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats in the Diet 2002 Reproductive
RACB98004 N/A Multigenerational Reproductive Assessment by Continuous Breeding when Diethylhexylphthalate (CAS 117-81-7) was Administered to Sprague Dawley Rats in the Diet 2005 Reproductive
RACB83086 N/A Diethylene Glycol (CAS #111-46-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water 1984 Reproductive
RACB83088 N/A Reproductive and Fertility Assessment of Diethylene Glycol Monoethyl Ether (CAS No. 111-90-0) in CD-1 Mice when Administered in Drinking Water 1984 Reproductive
RACB83092 N/A Diethyl Phthalate (CAS #84-66-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed 1984 Reproductive
RACB84118 N/A Diethylhexyl Phthalate (CAS No. 117-81-7): Reproduction & Fertility Evaluation in F344 Rats Exposed During Gestation 1986 Reproductive
RACB83046 N/A Diethylstilbestrol (CAS #56-53-1): Fertility Assessment in CD-1 Mice When Administered in Feed 1984 Reproductive
RACB83094 N/A Reproductive and Fertility Assessment of Trans-Diethylstilbestrol (DES) (CAS No. 56-53-1) in CD-1 Mice When Administered in the Feed 1983 Reproductive
RACB90023 N/A Reproductive Toxicity of N,N-Dimethyl Formamide (CAS No. 68-12-2) in CD-1 Swiss Mice 1992 Reproductive
RACB83084 N/A Di(n-butyl) Phthalate (CAS No. 84-74-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed 1984 Reproductive
RACB89012 N/A Reproductive Toxicity of Di-N-Butyl Phthalate (CAS No. 84-74-2) in Sprague-Dawley Rats 1991 Reproductive
RACB84093 N/A Di-(n-hexyl)phthalate (CAS #84-75-3): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB84049 N/A Di-N-Propylphthalate (CAS #131-16-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB85047 N/A Dioctyl Phthalate (CAS #117-84-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB94012 N/A Reproductive Toxicity of Elmiron (CAS No. 37319-17-8) Administered by Gavage to Sprague-Dawley Rats 1997 Reproductive
RACB84095 N/A Ethanol (CAS # 64-17-5): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB84052 N/A Ethoxyacetic Acid (CAS #627-03-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB84051 N/A Ethylene Glycol (CAS #107-21-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1984 Reproductive
RACB84096 N/A Ethylene Glycol (CAS #107-21-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1986 Reproductive
RACB85053 N/A Ethylene Glycol Monobutyl Ether (CAS #111-76-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB84050 N/A Ethylene Glycol Monoethyl Ether (CAS No. 110-80-5): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Water 1984 Reproductive
RACB85054 N/A Ethylene Glycol Monoethyl Ether Acetate (CAS #111-15-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB86057 N/A Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Wate 1988 Reproductive
RACB87058 N/A Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in C57Bl/6 Mice When Administered in Drinking Water 1988 Reproductive
RACB86099 N/A Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in C3H Mice When Administered in Drinking Water 1989 Reproductive
RACB88100 N/A Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS #109-86-4) in Sprague-Dawley Rats, Litter Five 1990 Reproductive
RACB89056 N/A Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS No. 109-86-4) in Sprague-Dawley Rats, Litter Two 1990 Reproductive
RACB84055 N/A Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB83098 N/A Ethylene Glycol Monomethyl Ether: (CAS# 109-86-4) Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB83101 N/A Reproduction and Fertility Assessment of Ethylene Glycol Monophenyl Ether (CAS #122-99-6) in CD-1 Mice When Administered in Feed 1984 Reproductive
RACB88120 N/A Reproductive Toxicity of Dietary Restriction (NTP CAS No. FEED RESTRICT) in CD-1 Swiss Mice 1990 Reproductive
RACB89121 N/A Reproductive Toxicity Associated with Feed Restriction (CAS No. FEEDRESTRICT) in CD-1 Swiss Mice 1992 Reproductive
RACB89041 N/A Reproductive Toxicity Associated with Feed Restriction (CAS No. FEEDRESTRICT) in Sprague-Dawley Rats 1991 Reproductive
RACB90005 N/A Reproductive Toxicity of Formamide (FORM) (CAS No. 75-12-7) in CD-1 Swiss Mice 1992 Reproductive
RACB88076 N/A 2-Hydroxy-4-Methoxybenzophenone (CAS No. 131-57-7): Reproductive Toxicity in CD-1 Swiss Mice; Dose 1.25, 2.5 & 5% in Feed 1990 Reproductive
RACB97004 N/A Isoeugenol (CAS No. 97-54-1): Reproductive Assessment by Continuous Breeding when Administered to Sprague-Dawley Rats by Gavage 2002 Reproductive
RACB82102 N/A Lead Acetate Trihydrate (CAS #301-04-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water 1984 Reproductive
RACB84059 N/A Lead Acetate Trihydrate (CAS # 301-04-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB94009 N/A Reproductive Toxicity of in Lead Acetate Trihydrate (CAS #6080-56-4) in Sprague-Dawley Rats 1996 Reproductive
RACB94019 N/A Reproductive Toxicity of Methacrylonitrile (CAS No. 126-98-7) Administered in Diet to Sprague-Dawley Rats 1997 Reproductive
RACB84103 N/A Methoxyacetic Acid (CAS #625-45-6): Reproductive and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water 1986 Reproductive
RACB90018 N/A Reproductive Toxicity of Methacrylamide (CAS # 79-39-0) in CD-1 Mice Administered in Drinking Water 1992 Reproductive
RACB90016 N/A Reproductive Toxicity of N,N'-Methylenebisacrylamide (CAS# 110-26-9) in CD-1 Swiss Mice 1993 Reproductive
RACB90017 N/A Reproductive Toxicity of N-Methylolacrylamide (CAS No. 924-42-5) in CD-1 Swiss Mice 1993 Reproductive
RACB88060 N/A Methylphenidate Hydrochloride (CAS No. 298-59-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed 1989 Reproductive
RACB82104 N/A Methyl Salicylate, CAS #119-36-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage 1984 Reproductive
RACB85061 N/A Methyl Salicylate (CAS 119-36-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage 1985 Reproductive
RACB88105 N/A m-Nitrobenzoic Acid (CAS #121-92-6): Reproductive Toxicity in CD-1 Swiss Mice 1990 Reproductive
RACB90065 N/A Reproductive Toxicity of para-Nitrobenzoic Acid (CAS No. 62-23-7) in CD-1 Swiss Mice 1990 Reproductive
RACB89063 N/A Nitrofurantoin (CAS No. 67-20-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered via Feed 1989 Reproductive
RACB89020 N/A Reproductive Toxicity of Nitrofurazone (CAS No. 59-87-0) in CD-1 Swiss Mice 1992 Reproductive
RACB94021 N/A Nonylphenol: Multigenerational Reproductive Effects in Sprague-Dawley Rats when Exposed to Nonylphenol (CASRN: 84852-15-3) in the Diet 1997 Reproductive
RACB84064 N/A Oxalic Acid (CAS #144-62-7): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB84048 N/A Di-N-Pentylphthalate (CAS# 131-18-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed 1985 Reproductive
RACB90027 N/A Reproductive Toxicity of Pesticide/Fertilizer Mixture II (CAS No. PESTFERTMIX2) in CD-1 Swiss Mice 1992 Reproductive
RACB90029 N/A Reproductive Toxicity of Iowa Pesticide/Fertilizer Mixture (CAS No. PESTFERTMIX3) in CD-1 Swiss Mice 1992 Reproductive
RACB89066 N/A Reproductive Toxicity of Phenolphthalein (CAS No. 77-09-8) in CD-1 Swiss Mice 1990 Reproductive
RACB95002 N/A Reproductive Toxicity (Testicular) of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice 1996 Reproductive
RACB95001 N/A Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to SD Rats 1996 Reproductive
RACB94014 N/A Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice 1997 Reproductive
RACB90009 N/A Reproductive Toxicity of Primaclone (CAS No. 125-33-7) in CD-1 Swiss Mice 1991 Reproductive
RACB20103 N/A Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive
RACB20104 N/A Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive
RACB20105 N/A Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive
RACB20106 N/A Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive
RACB20203 N/A Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage 2004 Reproductive
RACB84068 N/A Propylene Glycol (CAS No. 57-55-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB84067 N/A Propantheline Bromide (CAS# 50-34-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB85069 N/A Propylene Glycol Monomethyl Ether (CAS #107-98): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1986 Reproductive
RACB20102 N/A Two-Generation Reproduction Toxicity Study of Propylthiouracil (CAS#51-52-5) when Administered to Sprague-Dawley Rats in the Drinking Water 2003 Reproductive
RACB90002 N/A Reproductive Toxicity of Salicylazosulfapyridine (CAS No. 599-79-1) in CD Sprague-Dawley Rats 1992 Reproductive
RACB88071 N/A Reproductive Toxicity of Sodium Nitrite (CAS No. 7632-00-0) in CD-1 Swiss Mice 1990 Reproductive
RACB83072 N/A Sodium Saccharin (CAS # 128-44-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1985 Reproductive
RACB82108 N/A Sulfamethazine (CAS #57-68-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered via the Diet 1984 Reproductive
RACB95003 N/A Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats 1997 Reproductive
RACB20101 N/A Abstract for NTP Study of Reproductive Assessment by Continuous Breeding when 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09-7) was Administered to Sprague Dawley Rats by Oral Gavage 2004 Reproductive
RACB89010 N/A Reproductive Toxicity of 1,2,4,5-Tetrachlorobenzene (CAS No. 95-94-3) in CD-1 Swiss Mice 1991 Reproductive
RACB83073 N/A Reproduction and Fertility Assessment of Theobromine (CAS No. 83-67-0) in CD-1 Mice When Administered in Feed 1984 Reproductive
RACB84074 N/A Theophylline (CAS # 58-55-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water/Feed 1985 Reproductive
RACB94001 N/A Reproductive Toxicity of Thiophenol II (CAS No: 108-98-5) Administered by Gavage to Sprague-Dawley Rats 1996 Reproductive
RACB84112 N/A Trichloroethylene (CAS # 79-01-6): Reproduction and Fertility Assessment in F344 Rats When Administered in Feed 1986 Reproductive
RACB84113 N/A Trichloroethylene (CAS # 79-01-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed 1985 Reproductive
RACB83115 N/A Reproductive and Fertility Assessment of Triethylene Glycol (CAS #112-27-6) in CD-1 Mice when Administered in Drinking Water 1984 Reproductive
RACB84116 N/A Triethylene Glycol Diacetate (CAS #111-21-7): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water 1986 Reproductive
RACB83117 N/A Reproductive and Fertility Assessment of Triethylene Glycol Dimethyl Ether (CAS #112-49-2) in CD-1 Mice when Administered in Drinking Water 1984 Reproductive
RACB91039 N/A Reproductive Toxicity of 1,2,3-Trichloropropane (CAS No. 96-18-4) Administered by Gavage in CD-1 Swiss Mice 1990 Reproductive
RACB92040 N/A Reproductive Toxicity of Tris(2-chloroethyl)phosphate (CAS No. 115-96-8) in CD-1 Swiss Mice 1991 Reproductive
RACB90035 N/A Reproductive Toxicity of 4-Vinylcyclohexene (CAS No. 100-40-3) in CD-1 Swiss Mice 1991 Reproductive
RDGT94013 N/A Short-Term Reproductive and Developmental Toxicity of Bromoacetonitrile (CAS No. 590-17-0) Administered in Drinking Water to Sprague Dawley Rats 1997 Drinking Water
RDGT96001 N/A Short-Term Reproductive and Developmental Toxicity of Bromochloroacetic Acid (CAS No. 5589-96-8) Administered in the Drinking Water to Sprague Dawley Rats 1998 Drinking Water
RDGT94017 N/A Short-Term Reproductive and Developmental Toxicity of Bromodichloromethane (CAS No. 75-27-4) Administered in the Drinking Water to Sprague Dawley Rats 1998 Drinking Water
RDGT94003 N/A Short-Term Reproductive Developmental Toxicity of Chlorodibromomethane (CAS No. 124-48-1) Administered in Drinking Water to Sprague Dawley Rats 1996 Drinking Water
RDGT94014 N/A Reproductive Toxicity of Dibromoacetonitrile (CAS No. 3252-43-5) Administered to Sprague Dawley Rats in the Drinking Water 1997 Drinking Water
RDGT98001 N/A Short-Term Reproductive and Developmental Toxicity Study of Dibromochloroacetic Acid (CAS No. 5278-95-5) Administered to Sprague Dawley Rats in the Drinking Water 2000 Drinking Water
RDGT94008 N/A Short-Term Reproductive and Developmental Toxicity Study of Hexachloroacetone (CAS No. 116-16-5) Administered to Sprague Dawley Rats in the Drinking Water 1997 Drinking Water
RDGT94007 N/A Sodium Bromate (CAS No. 7789-38-0): Short-Term Reproductive and Developmental Toxicity Study When Administered to Sprague Dawley Rats in the Drinking Water 1996 Drinking Water
RDGT94011 N/A Sodium Selenate (CAS No. 13410-01-0): Short-Term Reproductive and Developmental Toxicity Study When Administered to Sprague Dawley Rats in the Drinking Water 1996 Drinking Water
RDGT94009 N/A Short-Term Reproductive and Developmental Toxicity of Tribromoacetic Acid (CAS No. 75-96-7) Administered in Drinking Water to Sprague Dawley Rats 1998 Drinking Water

Short-Term Reproductive and Developmental Toxicity Studies of Water Disinfection By-Products

These studies assessed the general reproductive and developmental toxicities of several water disinfection by-products in rats using the Short Term Reproductive and Developmental Toxicity Screening design (Harris, et al, 1992). The study approach sought to identify the body systems that are the most sensitive to exposure from these substances.

The water disinfection by-products studies focused on the following:

  • Development
  • Female reproduction
  • Male reproduction
  • Various somatic organs or processes

The data generated from these studies identified water disinfection by-products (and related compounds) that require further investigation.

Protocol

This short-term test for reproductive and developmental toxicity provided preliminary data on the toxicity of substances about which little or no data existed.

Mice were mated for 3 days prior to substance exposure to produce time-mated females for gestational exposure and to ascertain fertility of the untreated males. The group of time-mated females were treated during gestation days (GD) 8-14 and allowed to litter for observations through postnatal day (PND) 4. Observations included:

  • Pup number and body weights on PND 0, 1, and 4
  • Number of uterine implantation sites on PND 4

A second group of females were dosed daily for 19 days. After 7 days, these females were housed with males who had been treated for 5 days prior to the second mating. Daily chemical dosing continued during the 5-day cohabitation.

This second group of females were humanely euthanized after 19 days of treatment. The following data were recorded:

  • The number of live fetuses
  • The number of dead fetuses
  • The number of implantation sites

After 17 days of dosing, the males were humanely euthanized and their reproductive systems were evaluated. Observations included:

  • Organ weights
  • Testicular histology
  • Total epididymal sperm counts and motility