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Completed Substance Evaluations

The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that NTP prepares. Substances listed in the RoC were evaluated for cancer hazards using a formal process and established listing criteria.

Completed cancer hazard evaluations listed on this page include evaluations of substances since 1996, or the 8th report prepared by NTP. This list includes categories such as:

  • Substances listed in the Report on Carcinogens.
  • Substances reviewed by NTP but not listed in the Report on Carcinogens.
  • Substances previously listed which have been removed from the report.

For each substance, information relevant to the cancer hazard evaluation is provided, including scientific review document, substance profile, meetings and reports related to the review of the scientific document, and public comments.

Public comments and other meeting materials for evaluations completed prior to 2016 have been archived. Archived materials can be requested by using the corresponding link in the table.

List of completed substance evaluations
Substance Status Evaluation Materials
Alcoholic Beverage Consumption Known to be a human carcinogen
1-Amino-2,4,dibromoanthraquinone (ADBAQ) Reasonably anticipated to be a human carcinogen
2-Amino-3,4-dimethylimidazo[4-5-f]quinoline (MeIQ) Reasonably anticipated to be a human carcinogen
2-Amino-3,8-dimethylimidazo[4-5-f]quinoxaline (MeIQx) Reasonably anticipated to be a human carcinogen
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Reasonably anticipated to be a human carcinogen
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) Reasonably anticipated to be a human carcinogen
Aristolochic Acids Reasonably anticipated to be a human carcinogen
Azacitidine Reasonably anticipated to be a human carcinogen
Beryllium and Beryllium Compounds Known to be a human carcinogen
2,2-bis-(bromomethyl)-1,3-propanediol (BBMP) (Technical Grade) Reasonably anticipated to be a human carcinogen
1-Bromopropane Reasonably anticipated to be a human carcinogen
1,3-Butadiene Known to be a human carcinogen
Cadmium and Cadmium Compounds Known to be a human carcinogen
Captafol Reasonably anticipated to be a human carcinogen
Ceramic Fibers (Respirable Size) Reasonably anticipated to be a human carcinogen
Chloramphenicol Delisted
Chloroprene Reasonably anticipated to be a human carcinogen
p-Chloro-o-toluidine and its Hydrochloride Salt Reasonably anticipated to be a human carcinogen
Chlorozotocin (CZT) Reasonably anticipated to be a human carcinogen
Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo Reasonably anticipated to be a human carcinogen
Cobalt-Tungsten Carbide Powders and Hard Metals Reasonably anticipated to be a human carcinogen
Cumene Reasonably anticipated to be a human carcinogen
Cyclosporin A Known to be a human carcinogen
Danthron (1,8-Dihydroxyanthraquinone) Reasonably anticipated to be a human carcinogen
Diazoaminobenzene (DAAB) Reasonably anticipated to be a human carcinogen
2,3-Dibromo-1-propanol (DBP) Reasonably anticipated to be a human carcinogen
Diesel Exhaust Particulates Reasonably anticipated to be a human carcinogen
Diethanolamine (DEA) Reviewed but not listed in the Report on Carcinogens (RoC)
1,6-Dinitropyrene & 1,8-Dinitropyrene Reasonably anticipated to be a human carcinogen
Disperse Blue I Reasonably anticipated to be a human carcinogen
Dyes Metabolized to Benzidine (Benzidine Dyes as a Class) Known to be a human carcinogen
Dyes Metabolized to 3,3'-Dimethoxybenzidine (DMOB) Reasonably anticipated to be a human carcinogen
Dyes Metabolized to 3,3'-Dimethylbenzidine (DMB) Reasonably anticipated to be a human carcinogen
Epstein-Barr Virus Known to be a human carcinogen
Environmental Tobacco Smoke Known to be a human carcinogen
Estrogens, Steroidal Known to be a human carcinogen
Ethyl Acrylate Delisted
Ethylene Oxide Known to be a human carcinogen
Formaldehyde Known to be a human carcinogen
Furan Reasonably anticipated to be a human carcinogen
Gamma Radiation Reasonably anticipated to be a human carcinogen
Certain Glass Wool Fibers (Inhalable) Reasonably anticipated to be a human carcinogen
Heterocyclic Amines (Selected): PhIP, MeIQ, and MeIQx Reasonably anticipated to be a human carcinogen
Hepatitis B Virus (HBV) Known to be a human carcinogen
Hepatitis C Virus (HCV) Known to be a human carcinogen
Human Immunodeficiency Virus Type 1 (HIV-1) Known to be a human carcinogen
Human Papillomaviruses (HPV): Some Genital-Mucosal Types Known to be a human carcinogen
Human T-cell Lymphotrophic Virus Type 1 (HTLV-1) Known to be a human carcinogen
Isoprene Reasonably anticipated to be a human carcinogen
Kaposi Sarcoma-Associated Herpesvirus (KSHV) Known to be a human carcinogen
Lead and Lead Compounds Reasonably anticipated to be a human carcinogen
Merkel Cell Polyomavirus (MCV) Known to be a human carcinogen
Methyleugenol Reasonably anticipated to be a human carcinogen
Methyl-t-Butyl Ether (MtBE) Reviewed but not listed in the Report on Carcinogens (RoC)
Naphthalene Reasonably anticipated to be a human carcinogen
Neutrons Known to be a human carcinogen
Nickel Compounds Known to be a human carcinogen
Nickel (Metallic) Reasonably anticipated to be a human carcinogen
Nickel Alloys (Certain) Reviewed but not listed in the Report on Carcinogens (RoC)
o-Nitroanisole Reasonably anticipated to be a human carcinogen
Nitrobenzene Reasonably anticipated to be a human carcinogen
6-Nitrochrysene Reasonably anticipated to be a human carcinogen
Nitromethane Reasonably anticipated to be a human carcinogen
1-Nitropyrene Reasonably anticipated to be a human carcinogen
4-Nitropyrene Reasonably anticipated to be a human carcinogen
o-Nitrotoluene Reasonably anticipated to be a human carcinogen
Pentachlorophenol and By-products of Its Synthesis Reasonably anticipated to be a human carcinogen
Phenolphthalein Reasonably anticipated to be a human carcinogen
Riddelliine Reasonably anticipated to be a human carcinogen
Saccharin Delisted
Silica, Crystalline (Respirable Size) Known to be a human carcinogen
Smokeless Tobacco Known to be a human carcinogen
Solar Radiation & Exposure to Sunlamps or Sunbeds Reasonably anticipated to be a human carcinogen
Strong Inorganic Acid Mists Containing Sulfuric Acid Reasonably anticipated to be a human carcinogen
Styrene Reasonably anticipated to be a human carcinogen
Styrene-7,8-oxide Reasonably anticipated to be a human carcinogen
Tamoxifen Known to be a human carcinogen
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Known to be a human carcinogen
Tetrafluoroethylene Reasonably anticipated to be a human carcinogen
4,4'-Thiodianiline Reasonably anticipated to be a human carcinogen
Thiotepa Known to be a human carcinogen
Tobacco Smoking Known to be a human carcinogen
o-Toluidine Known to be a human carcinogen
Trichloroethylene (TCE) Known to be a human carcinogen
1,2,3-Trichloropropane Reasonably anticipated to be a human carcinogen
Ultraviolet (UV) Radiation, Broad Spectrum and UVA, UVB, and UVC Known to be a human carcinogen
Vinyl Bromide Reasonably anticipated to be a human carcinogen
Vinyl Fluoride Reasonably anticipated to be a human carcinogen
Wood Dust Known to be a human carcinogen
X-Radiation & Gamma Radiation and Neutrons Known to be a human carcinogen