Completed RoC Evaluations

The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that NTP prepares. Substances listed in the RoC were evaluated for cancer hazards using a formal process and established listing criteria.

Completed cancer hazard evaluations listed on this page include evaluations of substances since 1996, or the 8th report prepared by NTP. This list includes categories such as:

Substances listed in the Report on Carcinogens.
Substances reviewed by NTP but not listed in the Report on Carcinogens.
Substances previously listed which have been removed from the report.

For each substance, information relevant to the cancer hazard evaluation is provided, including scientific review document, substance profile, meetings and reports related to the review of the scientific document, and public comments.

RoC monographs (a type of scientific review document) were initiated in 2013 are listed on the monograph webpage and in the table below.

Public comments and other meeting materials for evaluations completed prior to 2018 have been archived. Archived materials can be requested by using the corresponding link in the table.

List of completed substance evaluations
Substance	Status	Evaluation Materials

Alcoholic Beverage Consumption	Known to be a human carcinogen	Background Document Appendix B Request Archived Materials
1-Amino-2,4,dibromoanthraquinone (ADBAQ)	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
2-Amino-3,4-dimethylimidazo[4-5-f]quinoline (MeIQ)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
2-Amino-3,8-dimethylimidazo[4-5-f]quinoxaline (MeIQx)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ)	Reasonably anticipated to be a human carcinogen	Background Document Appendix Request Archived Materials
Antimony Trioxide	Reasonably anticipated to be a human carcinogen	RoC Review of Antimony trioxide
Aristolochic Acids	Known to be a human carcinogen	Background Document Request Archived Materials
Azacitidine	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Beryllium and Beryllium Compounds	Known to be a human carcinogen	Background Document Appendix Request Archived Materials
2,2-bis-(bromomethyl)-1,3-propanediol (BBMP) (Technical Grade)	Reasonably anticipated to be a human carcinogen	Background Document Appendix Request Archived Materials
1-Bromopropane	Reasonably anticipated to be a human carcinogen	RoC Review of 1-Bromopropane
1,3-Butadiene	Known to be a human carcinogen	Background Document Request Archived Materials
Cadmium and Cadmium Compounds	Known to be a human carcinogen	Background Document Request Archived Materials
Captafol	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Ceramic Fibers (Respirable Size)	Reasonably anticipated to be a human carcinogen	Request Archived Materials
Chloramphenicol	Delisted	Background Document Appendix Request Archived Materials
Chloroprene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
p-Chloro-o-toluidine and its Hydrochloride Salt	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Chlorozotocin (CZT)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo	Reasonably anticipated to be a human carcinogen	RoC Review of Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo
Cobalt-Tungsten Carbide Powders and Hard Metals	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Cumene	Reasonably anticipated to be a human carcinogen	RoC Review of Cumene
Cyclosporin A	Known to be a human carcinogen	Background Document Request Archived Materials
Danthron (1,8-Dihydroxyanthraquinone)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Diazoaminobenzene (DAAB)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
2,3-Dibromo-1-propanol (DBP)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Diesel Exhaust Particulates	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Diethanolamine (DEA)	Reviewed but not listed in the Report on Carcinogens (RoC)	Background Document Appendix A Appendix B Appendix C Request Archived Materials
1,6-Dinitropyrene & 1,8-Dinitropyrene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Disperse Blue I	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Dyes Metabolized to Benzidine (Benzidine Dyes as a Class)	Known to be a human carcinogen	Background Document Request Archived Materials
Dyes Metabolized to 3,3'-Dimethoxybenzidine (DMOB)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Dyes Metabolized to 3,3'-Dimethylbenzidine (DMB)	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Appendix C Appendix D Request Archived Materials
Epstein-Barr Virus	Known to be a human carcinogen	RoC Review of Epstein-Barr Virus
Environmental Tobacco Smoke	Known to be a human carcinogen	Background Document Appendix 3A Appendix 3B Appendix 3C Request Archived Materials
Estrogens, Steroidal	Known to be a human carcinogen	Background Document Appendix A Appendix B Appendix C Request Archived Materials
Ethyl Acrylate	Delisted	Background Document Appendix A Request Archived Materials
Ethylene Oxide	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Formaldehyde	Known to be a human carcinogen	Background Document Request Archived Materials
Furan	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Certain Glass Wool Fibers (Inhalable)	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Haloacetic Acids	Reasonably anticipated to be a human carcinogen	RoC Review of Haloacetic Acids Found as Water Disinfection By-products
Helicobacter pylori (H. pylori)	Known to be a human carcinogen	RoC Review of Helicobacter pylori (H. pylori)
Heterocyclic Amines (Selected): PhIP, MeIQ, and MeIQx	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Hepatitis B Virus (HBV)	Known to be a human carcinogen	Background Document Request Archived Materials
Hepatitis C Virus (HCV)	Known to be a human carcinogen	Background Document Request Archived Materials
Human Immunodeficiency Virus Type 1 (HIV-1)	Known to be a human carcinogen	Roc Review of Human Immunodeficiency Virus Type 1 (HIV-1)
Human Papillomaviruses (HPV): Some Genital-Mucosal Types	Known to be a human carcinogen	Background Document Request Archived Materials
Human T-cell Lymphotrophic Virus Type 1 (HTLV-1)	Known to be a human carcinogen	RoC Review of Human T-cell Lymphotrophic Virus Type 1 (HTLV-1)
Isoprene	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
Kaposi Sarcoma-Associated Herpesvirus (KSHV)	Known to be a human carcinogen	RoC Review of Kaposi Sarcoma-Associated Herpesvirus (KSHV)
Lead and Lead Compounds	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Merkel Cell Polyomavirus (MCV)	Known to be a human carcinogen	RoC Review of Merkel Cell Polyomavirus (MCV)
Methyleugenol	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
Methyl-t-Butyl Ether (MtBE)	Reviewed but not listed in the Report on Carcinogens (RoC)	Background Document Request Archived Materials
Naphthalene	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
Neutrons	Known to be a human carcinogen	Background Document Request Archived Materials
Nickel Compounds	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Nickel (Metallic)	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Appendix C Request Archived Materials
Nickel Alloys (Certain)	Reviewed but not listed in the Report on Carcinogens (RoC)	Background Document Appendix A Appendix B Appendix C Request Archived Materials
o-Nitroanisole	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Nitrobenzene	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
6-Nitrochrysene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Nitromethane	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
1-Nitropyrene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
4-Nitropyrene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
o-Nitrotoluene	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Pentachlorophenol and By-products of Its Synthesis	Reasonably anticipated to be a human carcinogen	RoC Review of Pentachlorophenol and By-products of Its Synthesis
Phenolphthalein	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
Riddelliine	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Saccharin	Delisted	Background Document Appendix A Appendix B Appendix C Request Archived Materials
Silica, Crystalline (Respirable Size)	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Smokeless Tobacco	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Solar Radiation & Exposure to Sunlamps or Sunbeds (two listings)	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Strong Inorganic Acid Mists Containing Sulfuric Acid	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Styrene	Reasonably anticipated to be a human carcinogen	Background Document Erratum and Addendum Request Archived Materials
Styrene-7,8-oxide	Reasonably anticipated to be a human carcinogen	Background Documents Appendix A Appendix B Appendix C Appendix D Appendix E Request Archived Materials
Tamoxifen	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
Tetrafluoroethylene	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
4,4'-Thiodianiline	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
Thiotepa	Known to be a human carcinogen	Background Document Request Archived Materials
Tobacco Smoking	Known to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
o-Toluidine	Known to be a human carcinogen	RoC Review of o-Toluidine
Trichloroethylene (TCE)	Known to be a human carcinogen	Background Document RoC Review of Trichloroethylene (TCE)
1,2,3-Trichloropropane	Reasonably anticipated to be a human carcinogen	Background Document Request Archived Materials
Ultraviolet (UV) Radiation, Broad Spectrum	Known to be a human carcinogen	Background Document Appendix A Request Archived Materials
UVA, UVB, and UVC (three listings)	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Request Archived Materials
Vinyl Bromide	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Appendix C Appendix D Appendix E Appendix F Request Archived Materials
Vinyl Fluoride	Reasonably anticipated to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
Wood Dust	Known to be a human carcinogen	Background Document Appendix A Appendix B Request Archived Materials
X-Radiation & Gamma Radiation (two listings)	Known to be a human carcinogen	Background Document Request Archived Materials