On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/niceatm-training

Integrated Chemical Environment Training 2024

May 22, 2024 
Natcher Conference Center, National Institutes of Health, Bethesda, MD

View slides presented at the training.

NICEATM hosted a training session focused on the Integrated Chemical Environment (ICE), including opportunities to learn about its latest updates. ICE is a globally used platform that provides user-friendly access to high-quality data and tools to support the evaluation of chemical toxicity. This training provided a general overview of ICE, its data and curated chemical lists, and live demonstrations of different ICE tools, including:

  • Search Tool – Explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest.
  • Chemical Quest Tool - Identify structurally similar chemicals.
  • Chemical Characterization Tool - Compare chemical properties and chemical use categories.
  • Curve Surfer Tool - Explore concentration-response curves and bioactivity with curated high-throughput screening data.
  • PBPK Tool - Predict tissue-specific chemical concentration profiles following a dosing event.
  • IVIVE Tool - Estimate the in vivo equivalent administered dose from in vitro data.

Agenda

Time (EDT) Topic
1:00-1:50 p.m. Introduction to ICE
Data Sets and Curated Chemical Lists in ICE
Search Tool: explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest 
1:50-2:00 p.m. Break
2:00-2:50 p.m. Chemical Quest Tool: identify structurally similar chemicals
Chemical Characterization Tool: compare chemical properties and chemical use categories
Curve Surfer Tool: explore concentration-response curves and bioactivity with curated high-throughput screening data
2:50-3:00 p.m. Break
3:00-3:50 p.m. PBPK Tool: predict tissue-specific chemical concentration profiles following a dosing event 
IVIVE Tool: estimate the in vivo equivalent administered dose from in vitro data 
Q&A