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Measuring Progress

Adoption of Alternatives and Reduction of Animal Use

Federal agencies promote the use of alternative methods for biomedical research and testing to evaluate toxicity. Implementation of alternatives can:

  • Replace animals with non-animal systems or one animal species with a phylogenetically lower one.
  • Reduce the number of animals required to provide scientifically valid results.
  • Refine procedures to decrease pain and distress.

ICCVAM was established to promote chemical hazard evaluation methods that protect human health and the environment while reducing animal use. ICCVAM’s 2018 strategic roadmap called for the identification of appropriate metrics for monitoring progress and measuring success in adopting alternatives.

In responses to a request by Congress, the U.S. Government Accountability Office (GAO) investigated and reported on how federal agencies ensure that alternative methods are being considered and used. The GAO found that federal agencies actively promote the use of alternative methods in a variety of ways, including:

  • Modifying regulations and policies.
  • Incorporating new methods into guidances.
  • Inspecting testing facilities.
  • Providing training on the use of alternative methods.
  • Developing new strategic plans to minimize the use of animals.

However, the GAO also found that federal agencies have not routinely developed or reported metrics that demonstrate how their efforts to encourage the use of alternative methods affect animal use.

Metrics Workgroup

The GAO report recommended that ICCVAM establish a workgroup to develop metrics that ICCVAM member agencies could use to assess progress made toward replacing, reducing, or refining animal use in testing. Furthermore, the report recommended that such metrics be incorporated into ICCVAM Biennial Progress Reports.

In response, ICCVAM established its Metrics Workgroup in early 2020. The workgroup includes members from nine ICCVAM agencies. It is determining how agencies can best address the GAO report’s recommendations within the context of the ICCVAM Authorization Act. Reports of the workgroup’s activities will be posted on this page as they become available.

Agency Activities to Measure Success

In coordination with the ICCVAM Metrics Workgroup, ICCVAM agencies are developing webpages to inform their stakeholders about progress on adoption of alternatives and reduction of animal use. Links to those pages are available below.