ICCVAM Annual and Biennial Reports

The ICCVAM Authorization Act of 2000 directed ICCVAM to prepare a progress report on its first anniversary and every other year thereafter. The latest ICCVAM Biennial Progress Report describes ICCVAM and ICCVAM agency activities from January 2022 through December 2023.

• ICCVAM Authorization Act of 2000
• ICCVAM 2022-2023 Biennial Report

The report highlights ICCVAM member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of new approach methodologies. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized in the report include:

• Development of an updated document on “Validation, Qualification, and Regulatory Acceptance of New Approach Methodologies,” by the ICCVAM Validation Workgroup.
• Publication of articles describing U.S. and international information needs and testing requirements for nanomaterials, ecotoxicity, and acute systemic toxicity. An ICCVAM workgroup also published an award-winning article describing federal agency application of in vitro to in vivo extrapolation.
• Curation and publication of a human skin sensitization database.
• Broadening applicability of defined approaches for skin sensitization.
• Establishment of an ICCVAM workgroup to provide expertise in identifying and evaluating NAMs to predict toxicity of per- and polyfluoroalkyl substances (PFAS).
• Expansion of the Integrated Chemical Environment, and descriptions of web tools and data resources for chemical exploration and toxicity prediction provided by NIEHS, the U.S. Environmental Protection Agency, and others.

In the website edition of the Biennial Report, menu items allow users to view articles by agency or find articles relevant to topics such as in vitro to in vivo extrapolation, cardiotoxicity, or mixtures toxicity. Reference pages list publications of interest as well as providing glossary terms and acronyms relevant to ICCVAM agencies and activities.