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https://ntp.niehs.nih.gov/go/alt-funding

Funding Opportunities for Test Method Developers

NICEATM and ICCVAM seek to facilitate development of test methods that replace, reduce, and refine the use of animals in testing. In addition, both organizations are committed to the protection of human health, animal health, and the environment. This page lists announcements of funding opportunities intended to support the development of alternative test methods. If you are aware of a funding opportunity that could be included on this page, please contact NICEATM.

On April 17, 2020, the NIEHS SBIR/STTR program in coordination with NICEATM presented a webinar-based town hall meeting, "Development of New Approach Methodologies to Reduce Animal Use in Toxicity Testing." View presentations >>
SBIR and STTR Omnibus Grant Solicitations of the National Institutes of Health, Centers for Disease Control and Prevention, and Food and Drug Administration

NIEHS is offering funding for small businesses developing technologies of interest to the Tox21 program. These technologies include:

  • Tools for exposure assessment, including assessment of exposure to nanomaterials.
  • Improved or expanded testing methods for toxicity screening.
  • Computational approaches for predictive toxicology.
  • Technologies such as alternative or improved methods for fixing and preserving tissues.

The funding is being offered as part of the 2022 Omnibus Solicitation of the NIH, CDC, and Food and Drug Administration. This funding is available for small business grant applications to support development and commercialization of innovative technologies. View more information on the NIEHS website.

SBIR/STTR Omnibus Solicitations and Accompanying Resources

Next due date: January 5, 2023

For more information about this opportunity, contact:

NIH Funding Resources

The NIEHS SBIR/STTR Program Staff encourages applicants to submit grants at least one week before the deadline and to take advantage of the following resources:

Apply by December 5 for Grants to Support Development of Non-animal Research and Teaching Methods

Multiple grants are available from the Berlin Animal Protection Commissioner for the development and application of human-relevant, animal-free methods in research and teaching. The application deadline is December 5. Available awards and grants include:

  • The Early Career Scientist Award (€30,000) will fund a new project for the development and/or application of new approach methodologies (NAMs) in biomedical research. The project must have demonstrable potential to replace and reduce animal use in this field. National as well as international scientists can apply.
  • The Ongoing Project Award (€30,000) will fund a project that focuses on developing and/or using NAMs. The applicant needs to demonstrate how the additional funding will allow the project to reach its potential in helping to replace animal experiments in biomedical research. National as well as international scientists can apply.
  • Two awards will be given for the Development of New Animal-free Teaching Materials (€10,000 each) to replace the previously practiced use of animals for training or studies in the fields of anatomy, physiology, biochemistry, cell biology, clinical skills, surgery, and pharmacology. National as well as international lecturers and teaching material developers can apply.
  • Lecturers who train students and scientists in the use of animal-free NAMs can apply for a NAMs Teaching Grant (€5,000 each) to equip and run their teaching labs. The money may be used for setting up and running new hands-on training courses and workshops to train the next generation of NAMs scientists. These grants are reserved for lecturers who are teaching and training in Berlin.
Travel Awards Available for 2023 MPS World Summit

Students and postdoctoral researchers are eligible for 20 travel awards to attend the 2023 MPS World Summit. The meeting will focus on new developments in microphysiological systems (MPS) and application of MPS. European awardees will be reimbursed for $500 in travel costs and $300 in registration fee costs. International awardees will be reimbursed for $1,200 in travel costs and $300 in registration fee costs. Grants are being funded by the National Center for Advancing Translational Sciences of the National Institutes of Health. Apply by January 31, 2023.

NCATS and FDA Offering Grants to Develop Tissue Chips for Botulinum Toxin Testing

The National Center for Advancing Translational Sciences (NCATS) and U.S. Food and Drug Administration (FDA) are offering SBIR and STTR grants for the development of neuromuscular junction tissue chips to replace the mouse lethality bioassay as a potency assay for botulinum toxin. A main objective for this funding opportunity would be to position these tissue chips as an alternative test method as a standalone replacement for mouse lethality bioassay.

Applicants are encouraged to contact NCATS and FDA to ensure their study design, qualification plan and objectives are in line with the goals of the funding opportunity. Grantees will be expected to work with NCATS and FDA post-award to develop and implement the final validation plan for the proposed alternative test method.

The key dates are as follows:

  • Open Date (Earliest Submission Date): October 20
  • Letter of Intent Due Date: October 21
  • Application Due Date: November 21 by 5:00 p.m. local time of applicant organization

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. Application instructions are available on the NIH Grants website.

Grants Offered to Support Development of Animal-free Antibody Applications

PETA Science Consortium International e.V., the Physicians Committee for Responsible Medicine, and the Alternatives Research and Development Foundation are offering grants for free recombinant antibodies for use in research and testing. Awardees will receive commercially available recombinant antibodies to test in applications that currently use animal-derived antibodies. Applicants should submit a curriculum vitae and a proposal describing in detail the how the antibody will be used. Awardees will be expected to provide updates to grant sponsors on the progress of their work and publish their results. The offering has a rolling deadline, and grant amounts will vary based on details of the projects.

Grants Will Support Development of Tissue Models for Cancer Research

The National Cancer Institute is offering grants to support the development and characterization of state-of-the-art biomimetic tissue-engineered technologies for cancer research. Projects supported by this funding will become part of the Cancer Tissue Engineering Collaborative (TEC) Research Program. The goals of the Cancer TEC Program are to (1) catalyze the advancement of innovative, well-characterized in vitro and ex vivo systems available for cancer research, (2) expand the breadth of these systems to several cancer types, and (3) promote the exploration of cancer phenomena with biomimetic tissue-engineered systems.

Applications for funding were accepted beginning in May 2022, with applications due quarterly through February 2025. Grants of up to $400,000 will be awarded to fund projects that can continue up to five years. Eligibility for these grants is open to for-profit and nonprofit institutions within and outside the United States.