Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/849154

Defined Approaches for Endocrine Disruption

Defined approaches to testing and assessment combine data from multiple sources to support hazard evaluations. Defined approaches rely on:

  • Input data generated from specific sources
  • A data interpretation procedure such as a machine-learning model, flowchart, or decision tree, through which the input data is run
  • A simultaneous assessment of the input data to arrive at either a hazard prediction or a decision that more testing is needed

Defined approaches are a type of integrated approach to testing and assessment. These approaches answer a defined hazard characterization question within a specific regulatory context. Learn more >>

NICEATM and EPA scientists developed a defined approach (Browne et al. 2015) that combines data from 18 HTS assays to identify chemicals with the potential to interact with the estrogen receptor pathway. Use of this integrated testing strategy has been accepted by the EPA as an alternative to three assays currently used by the Tier 1 battery of the EPA Endocrine Disruptor Screening Program (EDSP).

Similarly, NICEATM and EPA scientists developed a defined approach (Kleinstreuer et al. 2017) that combines data from 11 HTS assays with a mathematical model to identify chemicals with the potential to interact with the androgen receptor pathway. The EPA is currently considering whether this approach is potentially useful for replacement of existing tests currently required in the EDSP.