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Endocrine Disruptor Test Method Evaluations

Endocrine disruptors are substances that can interfere with the normal function of the endocrine (hormone) system, and often these interactions are with hormone receptors. It's not yet clear what effects these types of substances might have in humans, but there is evidence suggesting endocrine disruptors could cause human health problems. NICEATM is working with federal agencies to develop non-animal test methods and approaches to identify potential endocrine disruptors.


Principal Component Analysis plot with pipet tips

Defined Approaches for Endocrine Disruption

Defined approaches to testing and assessment combine data from multiple sources to support hazard evaluations. Read about NICEATM projects here. Go
Two female and one male scientists reviewing data on a laptop

Data to Support Evaluation of In Vitro Methods & Computer Models

NICEATM created a database to help evaluate in vitro tests and computer models of estrogenic activity. Go
Diagram of estrogen responsive elements

Validation of the VM7Luc Test Method

ICCVAM recommended that the VM7Luc test method could be used to identify substances that induce or inhibit estrogen receptors in vitro. Go
3D rendering of a molecular strands

Review of In Vitro Endocrine Disruptor Screening Assays

ICCVAM evaluated four types of in vitro methods proposed to replace animal use in a U.S. Environmental Protection Agency program. Go