Test Method Evaluations
Acute systemic toxicity tests assess the likelihood of chemical or medical products to cause illness following a single exposure. Read about evaluations of approaches that reduce animal use for these tests.
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Biologics are medical products derived from biological sources. Learn more about methods that use fewer or no animals to evaluate the safety of biologics.
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Cardiotoxicity is a major cause of failure of new drugs. NICEATM is supporting an initiative to design non-animal approaches to assess cardiotoxicity hazard.
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Developmental toxicity tests assess how substances interfere with normal development and impact offspring. Learn more about alternatives to traditional animal studies for developmental toxicity.
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Endocrine disruptors are substances that mimic or inhibit the function of hormones. Read about non-animal approaches to identify endocrine disruptors.
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NICEATM evaluates the use of microphysiological systems, or tissue chips, to replace, reduce, or refine animal use in testing.
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Ocular and dermal toxicity tests examine how substances interact with eyes and skin. Learn more about evaluations of non-animal testing approaches.
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Pyrogens are substances that can produce a fever. Learn more about ICCVAM evaluation of test methods proposed as replacements for the rabbit pyrogen test.
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Skin sensitizers can cause allergic skin rashes. Read about how NICEATM and ICCVAM have developed approaches to identify these substances without using animals.
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