TDMS Study 96006-06 Pathology Tables
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02
Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00
Final #1/Mice
Facility: BIORELIANCE
Chemical CAS #: 5407-04-5
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02
Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 2
Survivors
Terminal Sacrifice 10 10 10 10 10 7
Natural Death 1
Animals Examined Microscopically 10 1 1 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Salivary Glands (10) (8)
Infiltration Cellular, Focal, Lymphocyte 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (7)
Subcapsular, Hyperplasia, Focal 10 [1.0] 7 [1.0]
Thyroid Gland (10) (8)
Ectopic Thymus 2 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Uterus (10) (8)
Endometrium, Hyperplasia, Cystic 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02
Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (10) (7)
Hematopoietic Cell Proliferation 3 [1.0] 1 [1.0]
Thymus (10) (7)
Atrophy 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (8)
Hydronephrosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02
Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Stomach, Forestomach (10) (10)
Epithelium, Hyperplasia, Diffuse 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Subcapsular, Hyperplasia, Focal 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Hematopoietic Cell Proliferation 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02
Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Renal Tubule, Vacuolization Cytoplasmic,
Focal 9 [2.0] 8 [1.9]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------