TR 346 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ETHYL CHLORIDE
NTP Experiment-Test: 05078-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 9 30
Natural Death 6 18
Accidently Killed 2
Survivors
Terminal Sacrifice 32 2
Missing 1
Animals Examined Microscopically 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50)
Hyperkeratosis 1 (2%)
Gallbladder (39) (32)
Inflammation, Chronic 2 (5%)
Inflammation, Suppurative 1 (3%)
Wall, Necrosis 1 (3%)
Intestine Large (48) (45)
Anus, Ulcer 1 (2%)
Intestine Large, Cecum (41) (41)
Inflammation, Acute 1 (2%)
Inflammation, Necrotizing 1 (2%)
Intestine Large, Colon (47) (44)
Inflammation, Necrotizing 1 (2%)
Intestine Small, Duodenum (44) (41)
Fibrosis 1 (2%)
Intestine Small, Ileum (44) (42)
Atrophy 1 (2%)
Liver (49) (48)
Basophilic Focus 1 (2%)
Eosinophilic Focus 2 (4%)
Focal Cellular Change 2 (4%)
Hematopoietic Cell Proliferation 7 (14%) 3 (6%)
Inclusion Body Intranuclear 2 (4%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 7 (15%)
Pancreas (48) (49)
Atrophy 2 (4%) 1 (2%)
Fibrosis 2 (4%)
Inflammation, Chronic 4 (8%) 2 (4%)
Inflammation, Necrotizing 2 (4%)
Karyomegaly 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (48) (47)
Inflammation, Chronic 12 (25%) 3 (6%)
Stomach, Forestomach (48) (48)
Acanthosis 1 (2%)
Hemorrhage, Acute 1 (2%)
Hyperkeratosis 1 (2%) 9 (19%)
Stomach, Glandular (49) (47)
Cyst 1 (2%)
Metaplasia, Focal, Squamous 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Ulcer 1 (2%)
Mucosa, Dilatation 1 (2%)
Tooth (1)
Peridontal Tissue, Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50)
Coronary Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Endocardium, Thrombosis 1 (2%)
Myocardium, Fibrosis 2 (4%)
Myocardium, Mineralization 1 (2%)
Myocardium, Necrosis 1 (2%)
Valve, Degeneration, Mucoid 7 (14%) 7 (14%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (48)
Capsule, Inflammation, Necrotizing 1 (2%) 1 (2%)
Subcapsular, Hyperplasia 45 (92%) 45 (94%)
Adrenal Gland, Cortex (49) (48)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration 40 (82%) 25 (52%)
Fibrosis 40 (82%) 21 (44%)
Hematopoietic Cell Proliferation 3 (6%)
Hemorrhage, Acute 1 (2%)
Hyperplasia 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Adrenal Gland, Medulla (49) (47)
Cyst 2 (4%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (48) (49)
Atrophy 3 (6%)
Inflammation, Chronic 1 (2%)
Pituitary Gland (49) (45)
Cyst 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 10 (20%) 4 (9%)
Pars Distalis, Hyperplasia, Focal 2 (4%)
Thyroid Gland (48) (48)
Atrophy 1 (2%)
Follicular Cell, Hyperplasia 2 (4%)
Follicular Cell, Hyperplasia, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Cyst Multilocular 1 (100%)
Ovary (49) (48)
Abscess 1 (2%)
Atrophy 1 (2%)
Cyst 17 (35%) 12 (25%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Liquifactive 1 (2%)
Corpus Luteum, Cyst 1 (2%)
Periovarian Tissue, Inflammation, Chronic 4 (8%) 1 (2%)
Uterus (49) (50)
Inflammation, Necrotizing 1 (2%)
Endometrium, Hyperplasia 2 (4%)
Endometrium, Hyperplasia, Cystic 39 (80%) 6 (12%)
Endometrium, Inflammation, Chronic 1 (2%)
Endometrium, Inflammation, Suppurative 3 (6%) 2 (4%)
Lymphatic, Ectasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50)
Hyperplasia 2 (4%)
Myelofibrosis 36 (73%) 6 (12%)
Lymph Node (46) (45)
Infiltration Cellular, Histiocyte 1 (2%)
Mediastinal, Hyperplasia, Chronic, Lymphoid 1 (2%)
Mesenteric, Edema, Acute 1 (2%)
Mesenteric, Hemorrhage, Acute 1 (2%)
Mesenteric, Infiltration Cellular, Histiocyte 1 (2%)
Sinus, Ectasia 1 (2%)
Lymph Node, Bronchial (37) (38)
Erythrophagocytosis 1 (3%)
Hemorrhage 1 (3%)
Hyperplasia, Lymphoid 3 (8%) 2 (5%)
Infiltration Cellular, Histiocyte 2 (5%) 2 (5%)
Lymph Node, Mandibular (41) (26)
Ectasia 1 (2%)
Erythrophagocytosis 2 (8%)
Hyperplasia, Lymphoid 3 (7%)
Infiltration Cellular, Histiocyte 14 (34%) 4 (15%)
Inflammation, Chronic 1 (4%)
Inflammation, Subacute 1 (4%)
Spleen (49) (49)
Atrophy 1 (2%)
Erythrophagocytosis 2 (4%)
Hematopoietic Cell Proliferation 11 (22%) 17 (35%)
Hyperplasia, Lymphoid 4 (8%) 2 (4%)
Thymus (39) (25)
Cyst 1 (3%) 1 (4%)
Infiltration Cellular 1 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (38)
Inflammation 2 (5%) 2 (5%)
Duct, Ectasia 3 (7%) 3 (8%)
Skin (48) (50)
Epidermis, Atrophy 1 (2%) 1 (2%)
Hair Follicle, Atrophy 14 (29%) 19 (38%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Histiocyte 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Cranium, Developmental Malformation 1 (2%)
Skeletal Muscle (2) (2)
Intercostal, Abscess 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Cerebrum, Infiltration Cellular, Histiocyte 1 (2%)
Thalamus, Mineralization 9 (18%) 10 (20%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (46) (49)
Epithelium, Hyperplasia, Focal 1 (2%)
Lung (49) (50)
Hemorrhage 5 (10%)
Inflammation, Acute 1 (2%) 12 (24%)
Inflammation, Chronic, Multifocal 23 (47%) 1 (2%)
Inflammation, Subacute 1 (2%)
Metaplasia, Osseous 1 (2%)
Thrombosis 2 (4%)
Alveolar Epithelium, Hyperplasia, Diffuse 1 (2%)
Alveolus, Adenomatosis, Focal 2 (4%)
Alveolus, Edema 1 (2%)
Alveolus, Erythrophagocytosis 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 6 (12%)
Bronchiole, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Bronchus, Inflammation, Suppurative 1 (2%)
Glands, Ectasia 2 (4%) 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%)
Interstitium, Inflammation, Subacute 1 (2%)
Pleura, Inflammation, Chronic 1 (2%)
Vein, Metaplasia, Focal, Osseous 1 (2%)
Nose (49) (50)
Glands, Dilatation 2 (4%)
Mucosa, Hyperplasia 1 (2%)
Mucosa, Inflammation, Suppurative 2 (4%) 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 2 (4%)
Submucosa, Inflammation, Chronic, Diffuse 1 (2%)
Trachea (46) (49)
Glands, Dilatation 1 (2%) 1 (2%)
Submucosa, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (47)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hydronephrosis 6 (13%)
Hypoplasia 1 (2%)
Inflammation, Chronic 8 (16%)
Inflammation, Suppurative 2 (4%)
Nephropathy 10 (20%) 20 (43%)
Capsule, Inflammation, Suppurative 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Renal Tubule, Karyomegaly 5 (11%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Pigmentation, Bile 2 (4%)
Ureter (2)
Transitional Epithelium, Necrosis 1 (50%)
Urinary Bladder (46) (43)
Edema 1 (2%)
Inflammation, Chronic 17 (37%) 5 (12%)
Inflammation, Necrotizing 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Natural Death 7 14
Moribund Sacrifice 15 25
Survivors
Terminal Sacrifice 28 11
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (48)
Hyperkeratosis 1 (2%)
Gallbladder (40) (31)
Inflammation, Chronic 1 (3%)
Mucosa, Hyperplasia 1 (3%)
Intestine Large (46) (45)
Anus, Necrosis, Focal 1 (2%)
Intestine Small, Duodenum (45) (42)
Ulcer 1 (2%)
Intestine Small, Ileum (44) (43)
Inflammation, Subacute 1 (2%)
Liver (50) (47)
Basophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Infiltration Cellular, Focal, Histiocyte 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization, Focal 1 (2%)
Necrosis 2 (4%) 5 (11%)
Hepatocyte, Cytomegaly 1 (2%)
Mesentery (3)
Inflammation, Suppurative 1 (33%)
Pancreas (49) (47)
Hyperplasia 2 (4%)
Salivary Glands (49) (48)
Inflammation, Chronic 7 (14%) 7 (15%)
Stomach, Forestomach (49) (48)
Hyperkeratosis 1 (2%) 2 (4%)
Epithelium, Hyperplasia 2 (4%)
Stomach, Glandular (49) (48)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Squamous 1 (2%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (2%)
Mucosa, Necrosis 1 (2%)
Tooth (2)
Abscess 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (48)
Coronary Artery, Inflammation, Chronic 2 (4%)
Coronary Artery, Mineralization 1 (2%)
Valve, Degeneration 2 (4%)
Valve, Degeneration, Mucoid 7 (14%) 8 (17%)
Valve, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (47) (47)
Capsule, Inflammation, Necrotizing 1 (2%)
Subcapsular, Hyperplasia 23 (49%) 27 (57%)
Adrenal Gland, Cortex (46) (46)
Degeneration, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Hypertrophy, Focal 1 (2%)
Adrenal Gland, Medulla (47) (47)
Cyst 1 (2%)
Islets, Pancreatic (49) (48)
Atrophy 1 (2%)
Pituitary Gland (47) (44)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (49) (48)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (3)
Hemorrhage, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (46) (39)
Inflammation, Necrotizing 1 (2%)
Penis (3) (8)
Inflammation, Suppurative 1 (33%) 2 (25%)
Necrosis 2 (67%) 6 (75%)
Endothelium, Hyperplasia,
Pseudoepitheliomatous 1 (13%)
Preputial Gland (19) (24)
Abscess 3 (16%) 1 (4%)
Cyst 6 (32%) 11 (46%)
Hyperplasia 2 (8%)
Inflammation, Chronic 1 (5%) 4 (17%)
Inflammation, Necrotizing 3 (13%)
Inflammation, Suppurative 5 (21%)
Prostate (49) (43)
Inflammation, Chronic 1 (2%) 2 (5%)
Inflammation, Suppurative 1 (2%) 2 (5%)
Seminal Vesicle (46) (41)
Dilatation 3 (7%) 10 (24%)
Inflammation, Chronic 2 (5%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Testes (48) (47)
Atrophy 4 (8%) 9 (19%)
Inflammation, Suppurative 1 (2%)
Vein, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (38) (39)
Infiltration Cellular, Histiocyte 1 (3%)
Mediastinal, Sinus, Infiltration Cellular 1 (3%)
Mesenteric, Infiltration Cellular, Histiocyte 1 (3%)
Renal, Inflammation, Acute 1 (3%)
Lymph Node, Bronchial (29) (30)
Infiltration Cellular, Histiocyte 1 (3%) 2 (7%)
Lymph Node, Mandibular (19) (22)
Ectasia 1 (5%)
Erythrophagocytosis 1 (5%)
Hyperplasia 1 (5%)
Hyperplasia, Lymphoid 1 (5%)
Infiltration Cellular, Histiocyte 4 (21%) 3 (14%)
Spleen (49) (48)
Atrophy 1 (2%) 1 (2%)
Congestion, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 9 (19%)
Hemorrhage 1 (2%)
Hemorrhage, Chronic 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Thymus (33) (33)
Cyst 1 (3%)
Necrosis, Multiple 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (18) (15)
Inflammation, Chronic 1 (6%)
Duct, Ectasia 1 (6%)
Skin (50) (49)
Hyperplasia, Lymphoid 1 (2%)
Hair Follicle, Atrophy 11 (22%) 6 (12%)
Hair Follicle, Degeneration 1 (2%)
Hair Follicle, Ectasia 1 (2%)
Prepuce, Abscess 3 (6%)
Prepuce, Cyst 1 (2%)
Prepuce, Hyperkeratosis 1 (2%)
Prepuce, Inflammation, Chronic 3 (6%)
Prepuce, Inflammation, Necrotizing 1 (2%) 2 (4%)
Prepuce, Inflammation, Suppurative 1 (2%) 4 (8%)
Prepuce, Ulcer 10 (20%) 18 (37%)
Subcutaneous Tissue, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Histiocyte 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2)
Inflammation, Necrotizing 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Suppurative 1 (2%)
Thalamus, Mineralization 19 (38%) 17 (35%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48)
Dilatation 1 (2%)
Submucosa, Cyst 1 (2%)
Submucosa, Inflammation, Chronic 1 (2%)
Lung (50) (48)
Bronchiectasis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic, Multifocal 9 (18%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolus, Adenomatosis, Focal 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Bronchiole, Hyperplasia, Multifocal 1 (2%)
Glands, Ectasia 3 (6%) 4 (8%)
Interstitium, Inflammation, Chronic 1 (2%)
Submucosa, Bronchus, Glands, Ectasia 1 (2%)
Nose (50) (49)
Glands, Cyst 2 (4%) 1 (2%)
Glands, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Septum, Developmental Malformation 1 (2%)
Submucosa, Inflammation, Chronic 3 (6%)
Trachea (50) (47)
Glands, Dilatation 4 (9%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2)
Cornea, Inflammation, Subacute 1 (50%)
Cornea, Necrosis, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (4%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Suppurative 2 (4%) 8 (16%)
Necrosis 3 (6%)
Nephropathy 27 (54%) 21 (43%)
Capsule, Inflammation, Necrotizing 1 (2%)
Pelvis, Inflammation, Suppurative 2 (4%) 1 (2%)
Renal Tubule, Karyomegaly 40 (82%)
Renal Tubule, Mineralization 1 (2%)
Ureter (1) (1)
Mucosa, Inflammation, Chronic 1 (100%)
Urinary Bladder (47) (47)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic 2 (4%) 3 (6%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%)
Lumen, Concretion 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
Transitional Epithelium, Necrosis 6 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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