TR 346 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ETHYL CHLORIDE
NTP Experiment-Test: 05078-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 9 30
Natural Death 6 18
Accidently Killed 2
Survivors
Terminal Sacrifice 32 2
Missing 1
Animals Examined Microscopically 49 50
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ALIMENTARY SYSTEM
Gallbladder (39) (32)
Carcinoma, Metastatic 1 (3%)
Carcinoma, Metastatic, Uterus 1 (3%)
Intestine Large, Cecum (41) (41)
Intestine Large, Colon (47) (44)
Carcinoma, Metastatic, Uterus 2 (5%)
Intestine Large, Rectum (46) (44)
Intestine Small, Duodenum (44) (41)
Intestine Small, Ileum (44) (42)
Carcinoma, Metastatic, Uterus 1 (2%)
Intestine Small, Jejunum (44) (40)
Liver (49) (48)
Carcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma 3 (6%) 5 (10%)
Hepatocellular Carcinoma, Multiple 2 (4%)
Hepatocellular Adenoma 1 (2%)
Mesentery (12)
Carcinoma, Multiple, Metastatic, Uterus 2 (17%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (8%)
Carcinoma, Metastatic, Uterus 5 (42%)
Pancreas (48) (49)
Carcinoma, Metastatic, Uterus 7 (14%)
Salivary Glands (48) (47)
Stomach, Forestomach (48) (48)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (49) (47)
Carcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50)
Carcinoma, Multiple, Metastatic, Uterus 1 (2%)
Carcinoma, Metastatic, Uterus 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (48)
Capsule, Carcinoma, Metastatic, Uterus 4 (8%)
Adrenal Gland, Cortex (49) (48)
Carcinoma, Metastatic, Uterus 4 (8%)
Adrenal Gland, Medulla (49) (47)
Carcinoma, Metastatic, Uterus 1 (2%)
Pheochromocytoma NOS 1 (2%) 2 (4%)
Islets, Pancreatic (48) (49)
Pituitary Gland (49) (45)
Pars Distalis, Adenoma 11 (22%) 1 (2%)
Thyroid Gland (48) (48)
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (4)
Adenoacanthoma, Metastatic, Mammary Gland 1 (50%)
Carcinoma, Metastatic, Uterus 2 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (48)
Adenocarcinoma 1 (2%)
Carcinoma, Multiple, Metastatic, Uterus 1 (2%)
Carcinoma, Metastatic, Uterus 21 (44%)
Uterus (49) (50)
Carcinoma 1 (2%) 42 (84%)
Carcinoma, Multiple 1 (2%)
Fibrosarcoma 1 (2%)
Cervix, Polyp 1 (2%)
Endometrium, Polyp Stromal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50)
Lymph Node (46) (45)
Carcinoma, Metastatic, Uterus 1 (2%)
Mesenteric, Carcinoma, Metastatic, Uterus 1 (2%)
Renal, Carcinoma, Metastatic, Uterus 2 (4%)
Lymph Node, Bronchial (37) (38)
Adenoacanthoma, Metastatic, Mammary Gland 1 (3%)
Carcinoma, Multiple, Metastatic, Uterus 1 (3%)
Carcinoma, Metastatic, Uterus 13 (34%)
Lymph Node, Mandibular (41) (26)
Spleen (49) (49)
Carcinoma, Metastatic, Uterus 5 (10%)
Thymus (39) (25)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (38)
Adenoacanthoma 1 (2%) 1 (3%)
Adenocarcinoma 2 (5%)
Skin (48) (50)
Sarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Cranium, Osteosarcoma 1 (2%)
Skeletal Muscle (2) (2)
Adenoacanthoma, Metastatic, Mammary Gland 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (46) (49)
Lung (49) (50)
Adenoacanthoma, Multiple, Metastatic,
Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Page 4
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Multiple, Metastatic, Uncertain
Primary Site 1 (2%)
Carcinoma, Multiple, Metastatic, Uterus 11 (22%)
Carcinoma, Metastatic, Uterus 12 (24%)
Nose (49) (50)
Mucosa, Adenocarcinoma 1 (2%)
Trachea (46) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3)
Squamous Cell Carcinoma 1 (33%)
Pinna, Fibrosarcoma 1 (33%)
Harderian Gland (2) (2)
Adenocarcinoma 2 (100%)
Adenoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (47)
Carcinoma, Metastatic, Uterus 8 (17%)
Ureter (2)
Carcinoma, Metastatic, Uterus 1 (50%)
Urinary Bladder (46) (43)
Carcinoma, Metastatic, Uterus 7 (16%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50)
Leukemia Granulocytic 1 (2%)
Lymphoma Malignant 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 2 (4%)
Lymphoma Malignant Lymphocytic 2 (4%) 2 (4%)
Lymphoma Malignant Mixed 1 (2%) 3 (6%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 28 47
Total Primary Neoplasms 38 80
Total Animals with Benign Neoplasms 15 9
Total Benign Neoplasms 17 9
Total Animals with Malignant Neoplasms 18 47
Total Malignant Neoplasms 20 69
Total Animals with Metastatic Neoplasms 1 35
Total Metastatic Neoplasm 4 122
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2
Total Uncertain Neoplasms 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Natural Death 7 14
Moribund Sacrifice 15 25
Survivors
Terminal Sacrifice 28 11
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (48)
Squamous Cell Carcinoma 1 (2%)
Intestine Large, Colon (46) (45)
Intestine Small, Duodenum (45) (42)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Intestine Small, Ileum (44) (43)
Liver (50) (47)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 5 (10%) 6 (13%)
Hepatocellular Carcinoma, Multiple 4 (8%) 3 (6%)
Hepatocellular Adenoma 5 (10%) 2 (4%)
Hepatocellular Adenoma, Multiple 1 (2%)
Pancreas (49) (47)
Stomach, Forestomach (49) (48)
Stomach, Glandular (49) (48)
Tooth (2)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (48)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (47) (47)
Adrenal Gland, Cortex (46) (46)
Adenoma 1 (2%)
Islets, Pancreatic (49) (48)
Adenoma 1 (2%)
Thyroid Gland (49) (48)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (46) (39)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (38) (39)
Lymph Node, Bronchial (29) (30)
Fibrosarcoma, Metastatic, Skin 1 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%)
Spleen (49) (48)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (49)
Hemangiosarcoma 1 (2%)
Prepuce, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Head, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (48)
Cranium, Sternum, Fibrosarcoma, Metastatic,
Skin 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (48)
Alveolar/Bronchiolar Adenoma 3 (6%) 8 (17%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Page 8
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Nose (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (4)
Fibrosarcoma 1 (25%)
Pinna, Squamous Cell Carcinoma 1 (100%)
Harderian Gland (5) (4)
Adenocarcinoma 1 (20%)
Adenoma 2 (40%) 4 (100%)
Carcinoma 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49)
Ureter (1) (1)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Lymphoma Malignant Mixed 2 (4%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05078-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:10:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 27 20
Total Primary Neoplasms 31 34
Total Animals with Benign Neoplasms 12 11
Total Benign Neoplasms 13 17
Total Animals with Malignant Neoplasms 17 13
Total Malignant Neoplasms 18 17
Total Animals with Metastatic Neoplasms 3 1
Total Metastatic Neoplasm 7 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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