TR 346 Mouse Pathology Tables
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
| 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anus, Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | M M + M + + + M M + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 2 1 2|
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Metaplasia, Focal, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 3 |
Valve, Degeneration, Mucoid | 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Necrotizing | 4|
Subcapsular, Hyperplasia | 3 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 3 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
| 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Atrophy | 4 |
Degeneration | 2 1 1 2 2 1 2 1 1 2 1 1 2 2 1 2 2 1 1 2|
Fibrosis | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 2|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + M M M + M M + + + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 |
Pars Distalis, Hyperplasia | 2 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Follicular Cell, Hyperplasia, Focal | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst Multilocular | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 |
Cyst | 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis, Liquifactive | 4|
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 1 2 2 2 2 3 2 2 3 2 2 2 2|
Endometrium, Hyperplasia | |
Endometrium, Inflammation, Chronic | |
Endometrium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 2 3 2 1 3 2 2 2 3 3 1 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
| 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + M + + +|
Infiltration Cellular, Histiocyte | 1 |
Mediastinal, Hyperplasia, Chronic, | |
Lymphoid | |
Mesenteric, Edema, Acute | 3 |
Mesenteric, Hemorrhage, Acute | 3 |
Mesenteric, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + M M M M + M + M + + +|
Hyperplasia, Lymphoid | 3|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + M + + + + M + + +|
Ectasia | 1 |
Hyperplasia, Lymphoid | 2 3 2 |
Infiltration Cellular, Histiocyte | 2 1 1 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Erythrophagocytosis | |
Hematopoietic Cell Proliferation | 2 2 1 3|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + M + + + + + + + + + M M M + + +|
Inflammation | 2|
Duct, Ectasia | 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Atrophy | 3 |
Hair Follicle, Atrophy | 2 2 2 2 3 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Abscess | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Cerebrum, Infiltration Cellular, | |
Histiocyte | 1 |
Thalamus, Mineralization | 2 2 2 2 2 2|
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|
| 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3|
Inflammation, Chronic, Multifocal | 2 2 3 2 2 2 2 2 1 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Hyperplasia, Multifocal | |
Bronchus, Inflammation, Suppurative | |
Glands, Ectasia | 2 2|
Vein, Metaplasia, Focal, Osseous | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
Submucosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hypoplasia | 4 |
Inflammation, Chronic | 2 2 2 2 2 2 2 |
Inflammation, Suppurative | |
Nephropathy | 1 1 2 2 1 2|
Capsule, Inflammation, Suppurative | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic | 2 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5| |
| 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | M + A + A A M A A + + M + + A + + + + M + + + +| 39 |
Inflammation, Chronic | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Anus, Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + M| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + A +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + M + A + + + A + + + + + + + + + + + + + A +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + A + + + A + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + A + + + A + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + A + + + A + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 1 | 7 1.6|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 4 | 2 3.5|
Inflammation, Chronic | 2 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 2 2 2 2 | 12 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 1.0|
Metaplasia, Focal, Squamous | | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
Valve, Degeneration, Mucoid | 1 2 | 7 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5| |
| 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Necrotizing | | 1 4.0|
Subcapsular, Hyperplasia | 3 2 2 2 2 2 1 2 2 3 2 2 2 1 2 2 3 3 2 2 2 2| 45 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 4.0|
Degeneration | 1 1 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 2 1| 40 1.6|
Fibrosis | 1 1 1 2 1 1 1 2 2 1 1 2 2 2 2 2 1 1 1 1| 40 1.3|
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + I + + + + + + + +| 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + + M M M + M M M + M M + + + + M + M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 1.5|
Pars Distalis, Hyperplasia | 2 2 2 3 3 2 | 10 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Focal | 1 | 2 1.5|
Follicular Cell, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Cyst Multilocular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Atrophy | | 1 2.0|
Cyst | 4 2 2 2 4 2 3 3 | 17 2.4|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis, Liquifactive | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5| |
| 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 3 2 2 2 2 4 2 1 2 2| 39 2.1|
Endometrium, Hyperplasia | 2 2 | 2 2.0|
Endometrium, Inflammation, Chronic | 1 | 1 1.0|
Endometrium, Inflammation, | | |
Suppurative | 3 2 4 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 2 2 3 2 1 2 2 2 2 2 2 1 1 2 2 2 1| 36 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Histiocyte | | 1 1.0|
Mediastinal, Hyperplasia, Chronic, | | |
Lymphoid | 2 | 1 2.0|
Mesenteric, Edema, Acute | | 1 3.0|
Mesenteric, Hemorrhage, Acute | | 1 3.0|
Mesenteric, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + + + + + + + + M + + M + + + + I| 37 |
Hyperplasia, Lymphoid | 4 2 | 3 3.0|
Infiltration Cellular, Histiocyte | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + M + + M + + + + M + + + + + +| 41 |
Ectasia | | 1 1.0|
Hyperplasia, Lymphoid | | 3 2.3|
Infiltration Cellular, Histiocyte | 2 1 2 2 2 1 2 2 2| 14 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Erythrophagocytosis | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 3 2 3 3 2 3 | 11 2.5|
Hyperplasia, Lymphoid | 4 3 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + M + + + M + + + M + + + M M M| 39 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation | 2 | 2 2.0|
Duct, Ectasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Skin | + + I + + + + + + + + + + + + + + + + + + + + +| 48 |
Epidermis, Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5| |
| 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hair Follicle, Atrophy | 2 2 2 2 | 14 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranium, Developmental Malformation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Intercostal, Abscess | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | | 1 3.0|
Cerebrum, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Thalamus, Mineralization | 2 1 2 | 9 1.9|
Ventricle, Dilatation | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + I + + + M + + + + + + + + + + + I + + + + +| 46 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 1 2 | 23 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Bronchiole, Hyperplasia, Multifocal | 3 | 1 3.0|
Bronchus, Inflammation, Suppurative | 2 | 1 2.0|
Glands, Ectasia | | 2 2.0|
Vein, Metaplasia, Focal, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Inflammation, Suppurative | 2 3 | 2 2.5|
Respiratory Epithelium, Hyperplasia | 3 2| 2 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + I + + + + + I + + + + + + I + + + + + + + +| 46 |
Glands, Dilatation | | 1 2.0|
Submucosa, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 3 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5| |
| 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hypoplasia | | 1 4.0|
Inflammation, Chronic | 1 | 8 1.9|
Inflammation, Suppurative | 3 2 | 2 2.5|
Nephropathy | 1 1 1 1 | 10 1.3|
Capsule, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + I + + + + + + + + + + + + +| 46 |
Inflammation, Chronic | 2 2 2 2 1 2 2 1 1 | 17 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|
DAY ON TEST | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|
| 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + I + + A + A + + + M + + A + M + + + A A|
Inflammation, Suppurative | 3 |
Wall, Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + A M|
Inflammation, Acute | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + A +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + A + + + A + + + + + + + + + +|
Fibrosis | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + A + + + + + + + + + + + + + +|
Eosinophilic Focus | 3 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 4 |
Inclusion Body Intranuclear | 2 |
Infarct | 4 |
Necrosis | 1 4 4 3 3|
__________________________________________________________________________|
Mesentery | + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 2 |
Inflammation, Chronic | 2 2|
Inflammation, Necrotizing | |
Karyomegaly | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + M|
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + A + + + + + + + + + +|
Acanthosis | 2 |
Hemorrhage, Acute | |
Hyperkeratosis | 2 1 2 2 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + A + + + + + + + + + +|
Metaplasia, Focal, Squamous | |
Necrosis, Coagulative | 2 |
Mucosa, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|
DAY ON TEST | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|
| 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 2 |
Endocardium, Thrombosis | 3 |
Myocardium, Fibrosis | |
Myocardium, Mineralization | |
Myocardium, Necrosis | |
Valve, Degeneration, Mucoid | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + A + + + A + + + + + + + + + +|
Capsule, Inflammation, Necrotizing | |
Subcapsular, Hyperplasia | 2 2 3 3 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + A + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | |
Cyst | |
Degeneration | 1 1 2 1 2 2 1 2 1 1 2 2 2 1 2|
Fibrosis | 1 1 1 1 1 1 1 1 2 1 2 1|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Acute | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + A + + + A + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 3|
__________________________________________________________________________|
Parathyroid Gland | M + M M M M + M + M M + M M + M M M M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + A + + + + + + + + + +|
Cyst | X |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X 2 X |
Inflammation, Chronic | |
Corpus Luteum, Cyst | |
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|
DAY ON TEST | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|
| 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Endometrium, Hyperplasia, Cystic | 2 2 3 |
Endometrium, Inflammation, | |
Suppurative | |
Lymphatic, Ectasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Myelofibrosis | 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + + + + M + + + + M + +|
Sinus, Ectasia | 4|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + A + + + + + + M + + I + M + M|
Erythrophagocytosis | 1 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + A M M + + + M M I + M + M M M|
Erythrophagocytosis | 1 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 4 3 3 3 3 3 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + M M + M M M M + A + + M M + + + M + + + + I M|
Cyst | X |
Infiltration Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + M + + M + + + + M + + + M + M + + M + +|
Inflammation | 2 |
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Atrophy | 4 |
Hair Follicle, Atrophy | 2 3 1 3 3 3 2 3 3 2 3 4 2|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Infiltration | |
Cellular, Histiocyte | 1|
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|
DAY ON TEST | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|
| 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Thalamus, Mineralization | 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 4 2 |
Inflammation, Acute | 2 2 2 3 3 3 |
Inflammation, Chronic, Multifocal | |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Thrombosis | 3 X |
Alveolar Epithelium, Hyperplasia, | |
Diffuse | |
Alveolus, Adenomatosis, Focal | 1 |
Alveolus, Edema | |
Alveolus, Erythrophagocytosis | 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 3 |
Bronchiole, Hyperplasia, Multifocal | |
Glands, Ectasia | 3 |
Interstitium, Inflammation, Chronic | 2 |
Interstitium, Inflammation, Subacute | 2 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | |
Mucosa, Hyperplasia | |
Mucosa, Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 |
Submucosa, Inflammation, Chronic, | |
Diffuse | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|
DAY ON TEST | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|
| 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + + A + + + + + + + + + +|
Cyst | 2 |
Hematopoietic Cell Proliferation | |
Hydronephrosis | 3 3 |
Nephropathy | 2 3 3 2 3 2 2 2 2 |
Glomerulus, Amyloid Deposition | |
Renal Tubule, Karyomegaly | 1 1 1 1 |
Renal Tubule, Mineralization | 3|
Renal Tubule, Pigmentation, Bile | 2 3 |
__________________________________________________________________________|
Ureter | |
Transitional Epithelium, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + A + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 1 2 1 |
Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + M + + M A + + + M + + A + M + M M A + + + + +| 32 |
Inflammation, Suppurative | | 1 3.0|
Wall, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | A + + + + A A + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + A A + + A + + + + + + M + + + + + M + +| 41 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + A A + + + + + + + + + + + + M + + + + +| 44 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + A + A A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small | A + + A + A A + + A + + + + + + + + + A + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + A A + + A + + + + + + + + + M + + + + +| 41 |
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + A A + + A + + + + + + + + + A + + + + +| 42 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + A A + + A + + + + + + + + + A + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Eosinophilic Focus | 1 | 2 2.0|
Focal Cellular Change | 1 | 2 1.5|
Hematopoietic Cell Proliferation | 1 1 | 3 2.0|
Inclusion Body Intranuclear | 2 | 2 2.0|
Infarct | | 1 4.0|
Necrosis | 2 3 | 7 2.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Fibrosis | 2 | 2 2.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Necrotizing | 4 4 | 2 4.0|
Karyomegaly | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | | 1 2.0|
Hemorrhage, Acute | 2 | 1 2.0|
Hyperkeratosis | 3 2 | 9 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Metaplasia, Focal, Squamous | 2 | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
Mucosa, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
Endocardium, Thrombosis | | 1 3.0|
Myocardium, Fibrosis | 2 1 | 2 1.5|
Myocardium, Mineralization | 2 | 1 2.0|
Myocardium, Necrosis | 3 | 1 3.0|
Valve, Degeneration, Mucoid | 2 1 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Inflammation, Necrotizing | 4 | 1 4.0|
Subcapsular, Hyperplasia | 2 2 3 1 2 2 2 2 2 2 3 2 2 2 2 2 2 3 3 2 2 2| 45 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 1 |
Congestion | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Degeneration | 2 2 1 1 1 2 2 2 2 2 | 25 1.6|
Fibrosis | 1 2 1 1 1 1 2 2 2 | 21 1.3|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Hemorrhage, Acute | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Cyst | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M M M M M + M + + + + M + M M + M + M M M M| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + + + + + + M + I + + + + +| 45 |
Cyst | | 1 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 3 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + M + + + + + + + + + + + + + M + + + + +| 48 |
Cyst | 4 2 X X 4 | 12 3.0|
Inflammation, Chronic | 4 | 1 4.0|
Corpus Luteum, Cyst | X | 1 |
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Necrotizing | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 1 | 6 2.3|
Endometrium, Inflammation, | | |
Suppurative | 2 3 | 2 2.5|
Lymphatic, Ectasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
Myelofibrosis | 2 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + M| 45 |
Sinus, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + + M + + + + + + + + + + + + M + + M + + M| 38 |
Erythrophagocytosis | | 1 1.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + M + + + M + + + M M + + M + + M M M M M| 26 |
Erythrophagocytosis | | 2 1.5|
Infiltration Cellular, Histiocyte | 2 1 2 1 | 4 1.5|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 3| 17 2.6|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + I + M + M I M + I + M + + + I + + M + + I M M| 25 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + + + + + + + + + M + + M +| 38 |
Inflammation | 2 | 2 2.0|
Duct, Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Atrophy | | 1 4.0|
Hair Follicle, Atrophy | 3 2 2 2 3 4 | 19 2.6|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Histiocyte | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | 2 2 2 | 10 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 3 | 5 2.8|
Inflammation, Acute | 2 3 2 2 2 3 | 12 2.4|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Subacute | 3 | 1 3.0|
Metaplasia, Osseous | 1 | 1 1.0|
Thrombosis | | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Diffuse | 3 | 1 3.0|
Alveolus, Adenomatosis, Focal | 2 | 2 1.5|
Alveolus, Edema | 3 | 1 3.0|
Alveolus, Erythrophagocytosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 2 | 6 2.8|
Bronchiole, Hyperplasia, Multifocal | 2 | 1 2.0|
Glands, Ectasia | | 1 3.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
Interstitium, Inflammation, Subacute | | 1 2.0|
Pleura, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Dilatation | 2 3 | 2 2.5|
Mucosa, Hyperplasia | 2 | 1 2.0|
Mucosa, Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
Submucosa, Inflammation, Chronic, | | |
Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Cyst | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hydronephrosis | 3 2 2 2 | 6 2.5|
Nephropathy | 3 3 3 2 2 2 2 2 2 2 3| 20 2.4|
Glomerulus, Amyloid Deposition | 3 | 1 3.0|
Renal Tubule, Karyomegaly | 1 | 5 1.0|
Renal Tubule, Mineralization | | 1 3.0|
Renal Tubule, Pigmentation, Bile | | 2 2.5|
__________________________________________________________________________|____________|
Ureter | + + | 2 |
Transitional Epithelium, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A M + M + + + A + + + + + A + + + + +| 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5| |
DAY ON TEST | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9| |
| 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Edema | 4 | 1 4.0|
Inflammation, Chronic | 2 1 | 5 1.4|
Inflammation, Necrotizing | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|
| 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + A + + + M + + + M + M + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A A + + + + + M M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A + + + + + M A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 3 |
Necrosis | 4 |
Hepatocyte, Cytomegaly | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 2|
Cyst | 2 |
Hyperplasia | 2 |
Metaplasia, Squamous | 1 |
Mucosa, Necrosis | |
__________________________________________________________________________|
Tooth | + |
Abscess | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 3 2 |
Coronary Artery, Mineralization | 2 |
Valve, Degeneration, Mucoid | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + I + A + + + + + + + I + + + + + + +|
Capsule, Inflammation, Necrotizing | |
Subcapsular, Hyperplasia | 1 1 2 1 2 2 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + I + A + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|
| 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + I + A + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M + + + M I M + + M M + + M + + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + M + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + M + + + + + + A + + + + + + + + + + + M + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Penis | + + + |
Inflammation, Suppurative | 4 |
Necrosis | 4 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Abscess | 4 4 |
Cyst | X 3 4 3 3|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 |
Vein, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + M M + + + + I M + + + M + + + + + + M + M I|
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M M + + + M M M + + M + + + + M + M + M I|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + I M I M + + M M M + M M + M M M M M|
Ectasia | |
Infiltration Cellular, Histiocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|
| 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 1 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 2 2 3 |
Hemorrhage, Chronic | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Thymus | M + + M M + + + I M + M + M + + + + + + M + M + M|
Necrosis, Multiple | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M + + + + M M M + M + M + M M + + M M M M|
Inflammation, Chronic | 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 2 3 3 2|
Hair Follicle, Degeneration | 3 |
Hair Follicle, Ectasia | 3 |
Prepuce, Abscess | 4 |
Prepuce, Inflammation, Necrotizing | 4 |
Prepuce, Inflammation, Suppurative | |
Prepuce, Ulcer | 4 4 4 4 4 3 |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 4 |
Subcutaneous Tissue, Infiltration | |
Cellular, Histiocyte | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|
DAY ON TEST | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|
| 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Dilatation | |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Acute | |
Inflammation, Chronic, Multifocal | 2 2 2 |
Inflammation, Chronic Active | 4 |
Alveolus, Adenomatosis, Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Glands, Ectasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
Glands, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Subacute | 2 |
Cornea, Necrosis, Focal | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 |
Nephropathy | 1 1 2 1 1 1 1 3 1 1 1 1 1 3 2 2|
Capsule, Inflammation, Necrotizing | |
Pelvis, Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + A + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5| |
DAY ON TEST | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7| |
| 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + I M + + + + + A + A + + + + + + + +| 40 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + + + M + + + + A + + + M + M + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + M + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + + + + M + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 3.0|
Necrosis | 3 | 2 3.5|
Hepatocyte, Cytomegaly | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Cyst | | 1 2.0|
Hyperplasia | | 1 2.0|
Metaplasia, Squamous | | 1 1.0|
Mucosa, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 2 2.5|
Coronary Artery, Mineralization | | 1 2.0|
Valve, Degeneration, Mucoid | 2 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5| |
DAY ON TEST | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7| |
| 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Capsule, Inflammation, Necrotizing | 4 | 1 4.0|
Subcapsular, Hyperplasia | 2 1 2 1 2 2 1 2 2 2 | 23 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M I M + M + + + M M M + M M + M M M + + + M M M| 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | | 3 |
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + +| 19 |
Abscess | 4 | 3 4.0|
Cyst | 3 | 6 3.2|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Dilatation | 3 2 | 3 3.0|
Inflammation, Necrotizing | 4 | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 1| 4 2.0|
Vein, Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5| |
DAY ON TEST | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7| |
| 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M + + I I + + + + I + + + + + +| 38 |
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + I M M + M + M I I + + + I I + + + + + +| 29 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + + + + M + + M I M M M + I I M + M M M| 19 |
Ectasia | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 1.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 | 6 2.0|
Hemorrhage, Chronic | | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + M + I + I + M + M + M + + + +| 33 |
Necrosis, Multiple | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M M M M M M M M M M M M + M M + M M + + + +| 18 |
Inflammation, Chronic | | 1 3.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | 2 3 3 2 2 3 2 | 11 2.5|
Hair Follicle, Degeneration | | 1 3.0|
Hair Follicle, Ectasia | | 1 3.0|
Prepuce, Abscess | 3 3| 3 3.3|
Prepuce, Inflammation, Necrotizing | | 1 4.0|
Prepuce, Inflammation, Suppurative | 3 | 1 3.0|
Prepuce, Ulcer | 3 3 3 3 | 10 3.5|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 4.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Histiocyte | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5| |
DAY ON TEST | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7| |
| 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 2 2| 19 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 1 3.0|
Submucosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchiectasis | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 | 9 2.0|
Inflammation, Chronic Active | | 1 4.0|
Alveolus, Adenomatosis, Focal | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Glands, Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Cyst | 2 2 | 2 2.0|
Glands, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5| |
DAY ON TEST | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7| |
| 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 2 4.0|
Nephropathy | 1 1 2 1 2 2 2 1 1 1 1 | 27 1.4|
Capsule, Inflammation, Necrotizing | 4 | 1 4.0|
Pelvis, Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 1 2 | 2 1.5|
Inflammation, Suppurative | | 2 3.5|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|
DAY ON TEST | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|
| 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | M M M I M M + + + + + + + + A + M + M M A A M + +|
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A A + + + + + A + + + +|
Anus, Necrosis, Focal | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M A A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + M A A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M A A + + + + + A + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M A A + + + + + A + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + M A A + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + A + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 1 2 |
Inflammation, Acute | 2 |
Mineralization, Focal | 1 |
Necrosis | 4 4 3 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + A + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperkeratosis | 2 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | |
Metaplasia, Squamous | 2 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + A + + + + + + + + + +|
Valve, Degeneration | 2 2 |
Valve, Degeneration, Mucoid | 1 1 1 2 1 |
Valve, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|
DAY ON TEST | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|
| 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + M + + + + + + + + + + + + A + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 1 2 2 2 1 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + A + + + + + + + + + +|
Degeneration, Focal | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M M M M M M + + M M + M M + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + M A + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + M M + M + + + + + + + + + A + + + + + + M +|
__________________________________________________________________________|
Penis | + + + + |
Inflammation, Suppurative | 4 |
Necrosis | 4 2 4 4 |
Endothelium, Hyperplasia, | |
Pseudoepitheliomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Abscess | |
Cyst | X 1 4 X X |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Necrotizing | 4|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | I + + + + M + + + + + M + + A + + + + + A + + + M|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + M |
Dilatation | 4 3 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | 2 3 2 2 2 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|
DAY ON TEST | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|
| 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M M M + M M +|
Mediastinal, Sinus, Infiltration | |
Cellular | 2 |
Mesenteric, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + A + + + M M M M M M +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M + M + + + + + M M M A M M + M M M + M M M|
Erythrophagocytosis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | 3 |
Congestion, Acute | |
Hematopoietic Cell Proliferation | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + I M + M + + M + M M M + A + + + + + A + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M + M M M + + M +|
__________________________________________________________________________|
Mammary Gland, Mandibular | + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hair Follicle, Atrophy | 3 2 |
Prepuce, Cyst | X |
Prepuce, Hyperkeratosis | 4 |
Prepuce, Inflammation, Chronic | 1 2 |
Prepuce, Inflammation, Necrotizing | 4|
Prepuce, Inflammation, Suppurative | 4 |
Prepuce, Ulcer | 2 3 3 3 3 4 4 |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|
DAY ON TEST | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|
| 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +|
Submucosa, Cyst | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | 3|
Inflammation, Chronic, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Bronchiole, Hyperplasia, Multifocal | 2 |
Glands, Ectasia | 2 |
Interstitium, Inflammation, Chronic | 2 |
Submucosa, Bronchus, Glands, Ectasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | X |
Olfactory Epithelium, Hyperplasia | 2 |
Septum, Developmental Malformation | X |
Submucosa, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
Glands, Dilatation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1|
Infarct | 3 3 |
Inflammation, Chronic | 1 2 |
Inflammation, Suppurative | 4 4 3 2 |
Necrosis | 4 2 |
Nephropathy | 1 1 2 1 4 1 1 1 1 2 2 1 |
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Karyomegaly | 2 2 1 1 1 1 1 2 2 2 2 2 2 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|
DAY ON TEST | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|
| 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Ureter | |
Mucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + A + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Necrotizing | 4 |
Inflammation, Suppurative | 3 2 |
Lumen, Concretion | 2|
Transitional Epithelium, Hyperplasia | 1 |
Transitional Epithelium, Necrosis | 4 1 4 2|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4| |
DAY ON TEST | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0| |
| 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + M + M + + + + + + + A + M + + A + + + M + + +| 31 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + A + + + +| 45 |
Anus, Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + M + A + + + + + A + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + A + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + A + + A + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + A + + A + + A + + + +| 42 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A + + A + + + +| 43 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A + + A + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Basophilic Focus | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Inflammation, Acute | | 1 2.0|
Mineralization, Focal | | 1 1.0|
Necrosis | 1 3 | 5 3.0|
__________________________________________________________________________|____________|
Mesentery | A + | 3 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hyperkeratosis | 2 | 2 2.0|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Cyst | | 1 |
Inflammation, Chronic | 2 | 1 2.0|
Metaplasia, Squamous | 2 2 | 4 1.8|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4| |
DAY ON TEST | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0| |
| 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Valve, Degeneration | | 2 2.0|
Valve, Degeneration, Mucoid | 2 2 2 | 8 1.5|
Valve, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 1 1 1 1 1 2 | 27 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + A + + + + + + + + + +| 46 |
Degeneration, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M M M + + M M M M M M + M + M M M M| 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M A + + A + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + M M + + + + + + + A + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Penis | + + + +| 8 |
Inflammation, Suppurative | 2 | 2 3.0|
Necrosis | 2 2| 6 3.0|
Endothelium, Hyperplasia, | | |
Pseudoepitheliomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + +| 24 |
Abscess | 3 | 1 3.0|
Cyst | X 2 4 3 2 3 | 11 2.7|
Hyperplasia | 2 3 | 2 2.5|
Inflammation, Chronic | 2 2 4 2 | 4 2.5|
Inflammation, Necrotizing | 4 4 | 3 4.0|
Inflammation, Suppurative | 2 3 4 3| 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + A + + + + + + + + + +| 43 |
Inflammation, Chronic | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4| |
DAY ON TEST | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0| |
| 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + +| 41 |
Dilatation | 3 4 3 3 3 2 | 10 2.9|
Inflammation, Chronic | 3 | 2 2.5|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + M + + + + + + + + + A + + + + + + + + + +| 47 |
Atrophy | 3 2 1 | 9 2.1|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M M + + + + + + A M + + + + + M + + +| 39 |
Mediastinal, Sinus, Infiltration | | |
Cellular | | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + M M M + + M + + A M M + + + M M M M +| 30 |
Infiltration Cellular, Histiocyte | 3 1| 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M M M + + + + M M A M + M + + + M M + M| 22 |
Erythrophagocytosis | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
Congestion, Acute | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + M M + + M M + M + + + + M + + +| 33 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + + M + + M M + M M M + M + + M M M M + +| 15 |
__________________________________________________________________________|____________|
Mammary Gland, Mandibular | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Hair Follicle, Atrophy | 4 2 2 3 | 6 2.7|
Prepuce, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4| |
DAY ON TEST | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0| |
| 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Prepuce, Hyperkeratosis | | 1 4.0|
Prepuce, Inflammation, Chronic | 3 | 3 2.0|
Prepuce, Inflammation, Necrotizing | 4 | 2 4.0|
Prepuce, Inflammation, Suppurative | 3 4 4 | 4 3.8|
Prepuce, Ulcer | 4 3 4 3 3 4 3 4 4 4 3| 18 3.4|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2| 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Submucosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic, Multifocal | 1 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Bronchiole, Hyperplasia, Multifocal | | 1 2.0|
Glands, Ectasia | 2 2 2| 4 2.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
Submucosa, Bronchus, Glands, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Glands, Cyst | | 1 |
Olfactory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05078-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:49:45
__________________________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4| |
DAY ON TEST | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0| |
| 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Septum, Developmental Malformation | | 1 |
Submucosa, Inflammation, Chronic | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Glands, Dilatation | 2 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 4 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hydronephrosis | | 1 1.0|
Infarct | | 2 3.0|
Inflammation, Chronic | | 2 1.5|
Inflammation, Suppurative | 4 2 3 3 | 8 3.1|
Necrosis | 4 | 3 3.3|
Nephropathy | 2 1 1 1 1 1 1 2 2 | 21 1.4|
Pelvis, Inflammation, Suppurative | 1 | 1 1.0|
Renal Tubule, Karyomegaly | 2 2 2 2 2 2 1 1 1 1 2 1 2 2 2 1 2 1 2 1| 40 1.6|
Renal Tubule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Mucosa, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Inflammation, Acute | 2 4 | 2 3.0|
Inflammation, Chronic | 3 4 3 | 3 3.3|
Inflammation, Necrotizing | | 1 4.0|
Inflammation, Suppurative | | 2 2.5|
Lumen, Concretion | | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 2 1.5|
Transitional Epithelium, Necrosis | 4 4 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 371012-371012/371012
--multipart-boundary--