TR 358 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OCHRATOXIN A
NTP Experiment-Test: 05036-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 02:27:31
Facility: Battelle Columbus Laboratory
Chemical CAS #: 303-47-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 80 80 80 80
Scheduled Sacrifice 30 29 30 30
Early Deaths
Moribund 10 22 11 11
Dead 7 3 4 4
Gavage Death 1 3
Survivors
Terminal Sacrifice 32 23 35 34
Dead 1
Animals Examined Microscopically 50 51 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (28) (15) (48)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (28) (14) (47)
Parasite Metazoan 1 (2%) 2 (4%)
Liver (50) (29) (19) (50)
Basophilic Focus, Multiple 41 (82%) 15 (52%) 11 (58%) 45 (90%)
Clear Cell Focus 4 (8%)
Cytoplasmic Alteration, Focal 2 (7%) 2 (11%) 4 (8%)
Cytoplasmic Alteration, Multifocal 1 (2%)
Eosinophilic Focus 1 (2%) 1 (2%)
Inflammation, Chronic Active, Multifocal 15 (30%) 3 (10%) 2 (11%) 8 (16%)
Necrosis, Acute 1 (2%)
Regeneration, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 13 (26%) 3 (10%) 2 (11%) 18 (36%)
Centrilobular, Degeneration 2 (4%)
Centrilobular, Vacuolization Cytoplasmic,
Diffuse 1 (2%) 3 (10%) 1 (5%)
Periportal, Fibrosis, Chronic, Multifocal 1 (2%)
Periportal, Vacuolization Cytoplasmic,
Diffuse 3 (6%) 2 (7%) 1 (2%)
Mesentery (1) (1) (1) (1)
Inflammation, Chronic Active 1 (100%) 1 (100%)
Perivascular, Inflammation, Chronic Active 1 (100%)
Pancreas (50) (29) (14) (50)
Acinus, Atrophy 12 (24%) 2 (7%) 2 (14%) 14 (28%)
Acinus, Degeneration, Multifocal 1 (2%)
Acinus, Focal Cellular Change 1 (2%)
Duct, Ectasia 3 (6%)
Perivascular, Inflammation, Chronic Active,
Multifocal 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (28) (15) (50)
Inflammation, Chronic Active, Multifocal 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Stomach, Forestomach (50) (28) (15) (49)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 1 (4%) 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (50) (28) (15) (49)
Ulcer 1 (2%)
Tongue (1) (1)
Epithelium, Hyperkeratosis, Focal 1 (100%)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (28) (15) (50)
Degeneration, Chronic, Multifocal 34 (68%) 10 (36%) 9 (60%) 41 (82%)
Epicardium, Inflammation, Chronic, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (29) (15) (50)
Accessory Adrenal Cortical Nodule 1 (7%)
Atrophy, Diffuse 1 (2%)
Degeneration 2 (4%)
Degeneration, Fatty 13 (26%) 3 (10%) 5 (33%) 13 (26%)
Degeneration, Fatty, Focal 1 (7%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hyperplasia 14 (28%) 6 (21%) 13 (26%)
Hypertrophy 2 (4%) 2 (7%) 3 (6%)
Necrosis, Acute 1 (3%) 2 (13%) 3 (6%)
Adrenal Gland, Medulla (50) (27) (15) (50)
Hyperplasia 1 (2%) 1 (4%) 1 (7%) 7 (14%)
Pituitary Gland (49) (41) (35) (49)
Pars Distalis, Cyst 21 (43%) 9 (22%) 9 (26%) 17 (35%)
Pars Distalis, Hyperplasia 15 (31%) 9 (22%) 8 (23%) 16 (33%)
Pars Nervosa, Hyperplasia, Glandular 1 (2%)
Rathke's Cleft, Cyst 3 (7%)
Thyroid Gland (50) (32) (18) (50)
C-Cell, Hyperplasia 24 (48%) 14 (44%) 9 (50%) 27 (54%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (29) (17) (47)
Hyperplasia 3 (6%) 8 (17%)
Infiltration Cellular, Focal, Lipocyte 1 (2%)
Inflammation, Chronic Active 1 (3%) 2 (12%) 6 (13%)
Duct, Cyst 1 (2%) 1 (3%) 1 (2%)
Duct, Hyperplasia, Multifocal, Squamous 1 (6%) 1 (2%)
Ovary (49) (29) (19) (50)
Edema, Diffuse 1 (2%)
Follicle, Cyst 2 (7%) 2 (4%)
Periovarian Tissue, Cyst 1 (2%) 3 (10%) 4 (21%) 1 (2%)
Uterus (49) (32) (19) (50)
Dilatation 1 (2%) 1 (3%)
Inflammation, Chronic Active 1 (3%)
Endometrium, Hyperplasia, Cystic, Glandular,
Multifocal 3 (6%) 4 (13%) 2 (11%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (28) (15) (50)
Femoral, Hyperplasia, Reticulum Cell 2 (4%)
Lymph Node (50) (27) (16) (50)
Lumbar, Cyst 1 (6%)
Lumbar, Inflammation, Chronic Active,
Multifocal 1 (6%)
Mesenteric, Hyperplasia, Lymphoid, Multifocal 1 (2%)
Mesenteric, Sinus, Ectasia 1 (4%)
Pancreatic, Inflammation, Chronic Active,
Multifocal 1 (2%)
Lymph Node, Mandibular (50) (26) (15) (50)
Hemorrhage, Multifocal 1 (2%)
Hyperplasia, Lymphoid, Multifocal 1 (7%)
Hyperplasia, Multifocal, Reticulum Cell 1 (2%)
Spleen (50) (29) (16) (50)
Degeneration, Fatty, Focal 1 (6%)
Depletion Lymphoid 1 (3%)
Edema, Diffuse 1 (2%)
Red Pulp, Fibrosis 1 (3%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 2 (4%) 3 (10%) 2 (13%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (43) (27) (11) (44)
Depletion Lymphoid, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (40) (34) (49)
Hyperplasia, Cystic, Multifocal 46 (98%) 22 (55%) 17 (50%) 48 (98%)
Skin (49) (31) (16) (50)
Acanthosis, Multifocal 1 (6%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Diffuse 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (28) (15) (50)
Femur, Hyperostosis 1 (2%)
Femur, Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (28) (15) (50)
Compression 5 (10%) 7 (25%) 2 (13%) 3 (6%)
Cyst 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Ventricle, Hydrocephalus 5 (10%) 7 (25%) 2 (13%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (32) (18) (50)
Foreign Body, Multifocal 4 (8%) 5 (16%) 1 (6%) 2 (4%)
Alveolar Epithelium, Hyperplasia 3 (9%) 1 (6%) 4 (8%)
Interstitium, Inflammation, Chronic Active,
Multifocal 30 (60%) 12 (38%) 8 (44%) 24 (48%)
Perivascular, Edema, Acute 4 (13%) 1 (2%)
Nose (50) (28) (15) (50)
Lumen, Foreign Body 7 (14%) 6 (12%)
Mucosa, Inflammation, Acute, Multifocal 5 (10%) 5 (10%)
Mucosa, Inflammation, Chronic Active,
Multifocal 2 (4%)
Nasolacrimal Duct, Inflammation, Acute,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (2) (5) (4)
Cornea, Hyperplasia 1 (50%)
Lens, Cataract 2 (50%) 1 (50%) 5 (100%) 4 (100%)
Retina, Atrophy, Diffuse 2 (50%) 1 (50%) 5 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (51) (50) (50)
Cyst 1 (2%) 25 (50%)
Cyst, Multiple 6 (12%)
Hydronephrosis 1 (2%)
Mineralization, Multifocal 1 (2%)
Nephropathy, Chronic, Diffuse 35 (70%) 40 (78%) 44 (88%) 46 (92%)
Cortex, Hemorrhage, Focal 1 (2%)
Pelvis, Epithelium, Hyperplasia, Multifocal 2 (4%)
Renal Tubule, Epithelium, Cytoplasmic
Alteration, Focal 1 (2%) 2 (4%)
Renal Tubule, Epithelium, Degeneration,
Multifocal 49 (98%) 49 (98%)
Renal Tubule, Epithelium, Hyperplasia, Focal 6 (12%) 12 (24%)
Renal Tubule, Epithelium, Hyperplasia,
Multifocal 6 (12%) 1 (2%)
Renal Tubule, Epithelium, Karyomegaly,
Multifocal 8 (16%) 50 (100%) 50 (100%)
Renal Tubule, Epithelium, Pigmentation,
Diffuse 1 (2%)
Renal Tubule, Epithelium, Proliferation,
Focal 1 (2%) 7 (14%)
Renal Tubule, Epithelium, Proliferation,
Multifocal 2 (4%) 9 (18%)
Urinary Bladder (50) (27) (15) (50)
Calculus Gross Observation 1 (7%)
Ectasia 2 (13%)
Hemorrhage 1 (4%)
Inflammation, Acute 1 (4%)
Mucosa, Hyperplasia, Diffuse 1 (7%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 80 80 80 80
Scheduled Sacrifice 30 29 29 30
Early Deaths
Gavage Death 4 6 2 1
Moribund 7 13 14 23
Dead 6 9 3
Survivors
Terminal Sacrifice 39 26 26 23
Animals Examined Microscopically 50 51 51 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (23) (20) (50)
Inflammation, Chronic Active, Diffuse 1 (5%)
Intestine Large, Colon (50) (25) (24) (50)
Parasite Metazoan 1 (2%) 2 (4%)
Intestine Large, Rectum (48) (23) (24) (47)
Parasite Metazoan 6 (13%) 2 (9%) 3 (6%)
Intestine Small, Duodenum (50) (25) (23) (50)
Necrosis, Acute, Focal 1 (2%)
Liver (50) (26) (26) (50)
Angiectasis, Multifocal 1 (2%)
Basophilic Focus, Multiple 40 (80%) 13 (50%) 8 (31%) 33 (66%)
Clear Cell Focus 9 (18%) 6 (12%)
Clear Cell Focus, Multiple 1 (2%)
Congestion 1 (2%) 1 (4%)
Cytoplasmic Alteration, Focal 1 (4%) 2 (4%)
Degeneration, Cystic, Focal 2 (4%) 1 (4%) 1 (4%) 1 (2%)
Eosinophilic Focus 2 (4%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%) 1 (2%)
Inflammation, Chronic Active, Multifocal 8 (16%) 1 (4%) 3 (6%)
Mixed Cell Focus 1 (4%)
Necrosis, Acute 1 (2%) 5 (19%) 1 (4%) 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia, Multifocal 38 (76%) 16 (62%) 14 (54%) 30 (60%)
Centrilobular, Vacuolization Cytoplasmic,
Diffuse 23 (46%) 5 (19%) 2 (8%) 13 (26%)
Periportal, Vacuolization Cytoplasmic,
Diffuse 1 (4%) 1 (4%) 1 (2%)
Mesentery (1) (7) (5) (11)
Inflammation, Chronic Active 3 (43%) 4 (80%) 3 (27%)
Pancreas (50) (26) (24) (50)
Inflammation, Acute, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic, Diffuse 1 (2%) 1 (2%)
Acinus, Atrophy 17 (34%) 8 (31%) 1 (4%) 14 (28%)
Acinus, Focal Cellular Change 6 (12%) 5 (10%)
Acinus, Hyperplasia, Focal 6 (12%) 2 (8%) 8 (16%)
Duct, Ectasia, Multifocal 1 (2%)
Perivascular, Inflammation, Chronic Active,
Multifocal 1 (4%) 3 (6%)
Salivary Glands (50) (26) (25) (49)
Acinus, Atrophy, Multifocal 2 (4%)
Stomach, Forestomach (50) (25) (25) (50)
Acanthosis 1 (4%) 8 (16%)
Acanthosis, Focal 1 (2%) 1 (2%)
Acanthosis, Multifocal 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Erosion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (8%) 2 (8%) 6 (12%)
Ulcer 1 (2%) 2 (8%) 2 (8%) 2 (4%)
Stomach, Glandular (50) (25) (25) (49)
Hyperplasia, Multifocal 1 (2%)
Inflammation, Acute 1 (4%)
Ulcer 4 (8%)
Tongue (3) (2) (2)
Epithelium, Hyperkeratosis, Focal 1 (50%)
Epithelium, Hyperplasia 1 (33%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (26) (25) (50)
Degeneration, Chronic, Multifocal 47 (94%) 26 (100%) 22 (88%) 47 (94%)
Inflammation, Chronic, Focal 1 (2%)
Epicardium, Fibrosis, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (25) (25) (50)
Cytoplasmic Alteration 1 (4%) 1 (2%)
Degeneration 2 (4%)
Degeneration, Fatty 6 (12%) 2 (8%) 3 (12%) 12 (24%)
Hyperplasia 18 (36%) 3 (12%) 2 (8%) 13 (26%)
Hyperplasia, Multifocal 1 (2%)
Hypertrophy 5 (10%) 1 (4%) 2 (4%)
Bilateral, Atrophy, Diffuse 1 (4%)
Adrenal Gland, Medulla (50) (25) (26) (49)
Hyperplasia 7 (14%) 2 (8%) 4 (15%) 10 (20%)
Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (26) (26) (50)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (50) (33) (27) (49)
Pars Distalis, Cyst 1 (2%) 1 (3%) 2 (7%) 3 (6%)
Pars Distalis, Hyperplasia 6 (12%) 4 (12%) 3 (11%) 14 (29%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Rathke's Cleft, Cyst, Multiple 1 (2%)
Thyroid Gland (50) (29) (26) (50)
C-Cell, Hyperplasia 24 (48%) 6 (21%) 10 (38%) 16 (32%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (2)
Inflammation, Chronic Active, Diffuse 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (26) (25) (50)
Atrophy, Diffuse 1 (4%)
Preputial Gland (50) (28) (25) (48)
Hyperplasia 1 (4%) 1 (4%)
Inflammation, Chronic Active, Multifocal 44 (88%) 11 (39%) 11 (44%) 38 (79%)
Duct, Ectasia 8 (16%) 1 (4%) 3 (6%)
Prostate (50) (26) (25) (50)
Atrophy, Diffuse 1 (4%)
Cyst 1 (2%)
Dilatation, Diffuse 1 (2%)
Inflammation, Acute 1 (4%)
Inflammation, Chronic Active, Multifocal 15 (30%) 2 (8%) 12 (24%)
Epithelium, Hyperplasia, Multifocal 1 (4%)
Seminal Vesicle (1) (1)
Dilatation 1 (100%)
Inflammation, Acute 1 (100%)
Testes (50) (50) (48) (50)
Inflammation, Chronic Active, Diffuse,
Necrotizing 1 (2%)
Germinal Epithelium, Atrophy 43 (86%) 1 (2%) 40 (83%) 33 (66%)
Interstitial Cell, Hyperplasia 22 (44%) 13 (26%) 14 (29%) 24 (48%)
Perivascular, Inflammation, Chronic,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (9)
Neutrophilia 5 (56%)
Bone Marrow (50) (25) (25) (50)
Femoral, Hyperplasia, Diffuse, Neutrophil 1 (4%) 1 (2%)
Lymph Node (50) (28) (25) (50)
Inguinal, Sinus, Ectasia 1 (4%)
Lumbar, Sinus, Ectasia 1 (4%)
Mediastinal, Congestion 1 (4%)
Mediastinal, Hemorrhage, Multifocal 1 (2%)
Mesenteric, Cyst 1 (2%)
Mesenteric, Inflammation, Chronic Active,
Multifocal 1 (2%)
Mesenteric, Sinus, Ectasia 1 (4%)
Lymph Node, Mandibular (49) (28) (23) (50)
Hemorrhage, Multifocal 2 (4%)
Infiltration Cellular, Plasma Cell 3 (11%) 1 (2%)
Necrosis, Acute, Multifocal 1 (2%)
Spleen (50) (29) (27) (50)
Angiectasis 1 (3%)
Depletion Lymphoid 3 (6%) 5 (17%)
Infiltration Cellular, Multifocal, Lipocyte 1 (2%)
Red Pulp, Fibrosis 2 (4%) 2 (7%) 1 (4%) 2 (4%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 3 (6%) 1 (3%) 1 (4%) 8 (16%)
Red Pulp, Infiltration Cellular, Multifocal,
Lipocyte 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (22) (23) (40)
Hyperplasia, Cystic, Multifocal 37 (95%) 18 (82%) 18 (78%) 38 (95%)
Skin (49) (32) (30) (49)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (3%) 1 (3%)
Subcutaneous Tissue, Fibrosis 1 (3%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (25) (25) (50)
Compression 1 (2%) 1 (4%) 1 (4%) 1 (2%)
Ventricle, Hydrocephalus 1 (2%) 2 (8%) 1 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (30) (27) (50)
Congestion 2 (4%) 2 (7%)
Edema, Acute, Diffuse 3 (6%)
Foreign Body, Multifocal 11 (22%) 9 (30%) 5 (19%) 6 (12%)
Mineralization, Focal 1 (2%)
Pigmentation 2 (7%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (3%) 2 (7%) 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 2 (7%) 1 (4%)
Interstitium, Inflammation, Chronic Active,
Multifocal 21 (42%) 5 (17%) 2 (7%) 14 (28%)
Perivascular, Edema, Acute 4 (13%)
Nose (50) (25) (24) (50)
Lumen, Foreign Body 2 (4%)
Nasolacrimal Duct, Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (4) (2)
Lens, Cataract 3 (100%) 1 (100%) 2 (50%) 2 (100%)
Retina, Atrophy, Diffuse 3 (100%) 1 (100%) 2 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (51) (51) (50)
Cyst 6 (12%)
Cyst, Multiple 1 (2%) 4 (8%)
Fibrosis, Focal 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Nephropathy, Chronic, Diffuse 48 (96%) 51 (100%) 51 (100%) 48 (96%)
Pelvis, Epithelium, Hyperplasia, Multifocal 1 (2%)
Pelvis, Epithelium, Hyperplasia, Multifocal,
Papillary 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Epithelium, Cytoplasmic
Alteration, Focal 1 (2%) 2 (4%) 7 (14%)
Renal Tubule, Epithelium, Cytoplasmic
Alteration, Multifocal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05036-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OCHRATOXIN A Date: 09/05/94
Route: GAVAGE Time: 02:27:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 UG/KG 21 UG/KG 70 UG/KG 210 UG/
KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Epithelium, Degeneration,
Multifocal 50 (98%) 49 (98%)
Renal Tubule, Epithelium, Hyperplasia, Focal 1 (2%) 11 (22%) 15 (30%)
Renal Tubule, Epithelium, Hyperplasia,
Multifocal 1 (2%) 5 (10%) 9 (18%)
Renal Tubule, Epithelium, Karyomegaly,
Multifocal 1 (2%) 51 (100%) 50 (100%)
Renal Tubule, Epithelium, Proliferation,
Focal 4 (8%) 13 (26%)
Renal Tubule, Epithelium, Proliferation,
Multifocal 6 (12%) 13 (26%)
Vein, Dilatation, Focal 1 (2%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Urinary Bladder (50) (23) (24) (50)
Calculus Micro Observation Only 2 (4%) 1 (2%)
Ectasia 1 (4%)
Inflammation, Acute 1 (4%)
Mucosa, Hyperplasia, Diffuse 1 (2%)
Serosa, Necrosis, Chronic Active, Multifocal 1 (2%)
Submucosa, Inflammation, Chronic Active,
Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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