TR 364 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94
EXPERIMENT: 05048 TEST: 02 TIME: 01:46:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122
PATHOLOGIST: R. THOMPSON CAS: 989-38-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94
EXPERIMENT: 05048 TEST: 02 TIME: 01:46:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122
PATHOLOGIST: R. THOMPSON CAS: 989-38-8
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94
EXPERIMENT: 05048 TEST: 02 TIME: 01:46:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122
PATHOLOGIST: R. THOMPSON CAS: 989-38-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF RHODAMINE 6G
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
====================================================================================================
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 19.4% 6.3% 5.3% | 0.0% 11.0% 0.0% |
|TERMINAL (d) | 7/36 (19%) 2/32 (6%) 2/38 (5%) | 0/39 (0%) 3/35 (9%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | --- 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.037N* P=0.108N P=0.067N | P=0.595 P=0.052 (e) |
|INCIDENTAL TUMOR | P=0.037N* P=0.108N P=0.067N | P=0.593 P=0.061 (e) |
|LOGISTIC REGRESSION | P=0.037N* P=0.108N P=0.067N | P=0.606 P=0.054 (e) |
|COCHRAN-ARMITAGE | P=0.042N* | P=0.622 |
|FISHER EXACT | P=0.080N P=0.080N | P=0.059 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/49 (0%) 0/48 (0%) | 0/50 (0%) 1/48 (2%) 2/48 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 2.0% 5.3% |
|TERMINAL (d) | 0/36 (0%) 0/32 (0%) 0/38 (0%) | 0/39 (0%) 0/35 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 546 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.140 P=0.496 P=0.228 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.150 (e) P=0.200 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.146 P=0.775 P=0.224 |
|COCHRAN-ARMITAGE | (e) | P=0.136 |
|FISHER EXACT | (e) (e) | P=0.490 P=0.237 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/49 (0%) 0/48 (0%) | 0/50 (0%) 2/48 (4%) 2/48 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 4.8% 5.3% |
|TERMINAL (d) | 0/36 (0%) 0/32 (0%) 0/38 (0%) | 0/39 (0%) 1/35 (3%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 546 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.170 P=0.226 P=0.228 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.188 P=0.478 P=0.200 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.178 P=0.314 P=0.224 |
|COCHRAN-ARMITAGE | (e) | P=0.168 |
|FISHER EXACT | (e) (e) | P=0.237 P=0.237 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 7/49 (14%) 5/50 (10%) | 5/50 (10%) 3/50 (6%) 1/49 (2%) |
|ADJUSTED (b) | 13.9% 20.8% 13.2% | 12.8% 8.1% 2.8% |
|TERMINAL (d) | 5/36 (14%) 6/32 (19%) 5/38 (13%) | 5/39 (13%) 2/35 (6%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 663 729 (T) | 729 (T) 693 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.525N P=0.299 P=0.597N | P=0.087N P=0.415N P=0.121N |
|INCIDENTAL TUMOR | P=0.537N P=0.311 P=0.597N | P=0.087N P=0.394N P=0.121N |
|LOGISTIC REGRESSION | P=0.538N P=0.323 P=0.597N | P=0.080N P=0.397N P=0.121N |
|COCHRAN-ARMITAGE | P=0.548N | P=0.073N |
|FISHER EXACT | P=0.380 P=0.617N | P=0.357N P=0.107N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/49 (20%) 6/49 (12%) 6/50 (12%) | 3/50 (6%) 1/50 (2%) 4/49 (8%) |
|ADJUSTED (b) | 23.2% 16.7% 14.3% | 7.4% 2.1% 11.1% |
|TERMINAL (d) | 5/36 (14%) 3/32 (9%) 3/38 (8%) | 2/39 (5%) 0/35 (0%) 4/36 (11%) |
|FIRST INCIDENCE (DAYS) | 546 666 522 | 695 581 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162N P=0.285N P=0.207N | P=0.385 P=0.338N P=0.461 |
|INCIDENTAL TUMOR | P=0.173N P=0.154N P=0.266N | P=0.409 P=0.307N P=0.452 |
|LOGISTIC REGRESSION | P=0.361N P=0.205N P=0.613N | P=0.405 P=0.251N P=0.474 |
|COCHRAN-ARMITAGE | P=0.151N | P=0.402 |
|FISHER EXACT | P=0.207N P=0.194N | P=0.309N P=0.489 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 12/49 (24%) 11/50 (22%) | 8/50 (16%) 4/50 (8%) 5/49 (10%) |
|ADJUSTED (b) | 30.7% 32.8% 26.5% | 19.9% 10.0% 13.9% |
|TERMINAL (d) | 8/36 (22%) 8/32 (25%) 8/38 (21%) | 7/39 (18%) 2/35 (6%) 5/36 (14%) |
|FIRST INCIDENCE (DAYS) | 546 663 522 | 695 581 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.559 P=0.379N | P=0.258N P=0.233N P=0.326N |
|INCIDENTAL TUMOR | P=0.380N P=0.474N P=0.474N | P=0.244N P=0.203N P=0.332N |
|LOGISTIC REGRESSION | P=0.362N P=0.509N P=0.464 | P=0.234N P=0.181N P=0.309N |
|COCHRAN-ARMITAGE | P=0.342N | P=0.225N |
|FISHER EXACT | P=0.500N P=0.385N | P=0.178N P=0.290N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 12/49 (24%) 11/50 (22%) | 8/50 (16%) 4/50 (8%) 5/49 (10%) |
|ADJUSTED (b) | 30.7% 32.8% 26.5% | 19.9% 10.0% 13.9% |
|TERMINAL (d) | 8/36 (22%) 8/32 (25%) 8/38 (21%) | 7/39 (18%) 2/35 (6%) 5/36 (14%) |
|FIRST INCIDENCE (DAYS) | 546 663 522 | 695 581 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332N P=0.559 P=0.379N | P=0.258N P=0.233N P=0.326N |
|INCIDENTAL TUMOR | P=0.380N P=0.474N P=0.474N | P=0.244N P=0.203N P=0.332N |
|LOGISTIC REGRESSION | P=0.362N P=0.509N P=0.464 | P=0.234N P=0.181N P=0.309N |
|COCHRAN-ARMITAGE | P=0.342N | P=0.225N |
|FISHER EXACT | P=0.500N P=0.385N | P=0.178N P=0.290N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 4/50 (8%) | 3/50 (6%) 5/50 (10%) 3/49 (6%) |
|ADJUSTED (b) | 16.1% 15.6% 10.5% | 7.7% 13.5% 8.3% |
|TERMINAL (d) | 5/36 (14%) 5/32 (16%) 4/38 (11%) | 3/39 (8%) 4/35 (11%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 705 729 (T) 729 (T) | 729 (T) 667 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.280N P=0.582N P=0.338N | P=0.533 P=0.303 P=0.626 |
|INCIDENTAL TUMOR | P=0.291N P=0.567N P=0.360N | P=0.529 P=0.321 P=0.626 |
|LOGISTIC REGRESSION | P=0.277N P=0.562N P=0.339N | P=0.550 P=0.324 P=0.626 |
|COCHRAN-ARMITAGE | P=0.309N | P=0.565 |
|FISHER EXACT | P=0.500N P=0.370N | P=0.357 P=0.651 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 8.3% 5.3% 2.6% | 2.3% 2.9% 0.0% |
|TERMINAL (d) | 3/36 (8%) 1/32 (3%) 1/38 (3%) | 0/39 (0%) 1/35 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 621 729 (T) | 693 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.216N P=0.545N P=0.286N | P=0.345N P=0.740 P=0.505N |
|INCIDENTAL TUMOR | P=0.272N P=0.523N P=0.286N | P=0.351N P=0.748N P=0.527N |
|LOGISTIC REGRESSION | P=0.228N P=0.514N P=0.286N | P=0.337N P=0.761 P=0.490N |
|COCHRAN-ARMITAGE | P=0.222N | P=0.335N |
|FISHER EXACT | P=0.500N P=0.309N | P=0.753N P=0.505N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 7/50 (14%) 5/50 (10%) | 4/50 (8%) 6/50 (12%) 3/49 (6%) |
|ADJUSTED (b) | 24.2% 20.6% 13.2% | 9.8% 16.3% 8.3% |
|TERMINAL (d) | 8/36 (22%) 6/32 (19%) 5/38 (13%) | 3/39 (8%) 5/35 (14%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 705 621 729 (T) | 693 667 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.136N P=0.488N P=0.164N | P=0.474N P=0.312 P=0.539N |
|INCIDENTAL TUMOR | P=0.168N P=0.461N P=0.177N | P=0.483N P=0.344 P=0.548N |
|LOGISTIC REGRESSION | P=0.148N P=0.452N P=0.161N | P=0.456N P=0.338 P=0.526N |
|COCHRAN-ARMITAGE | P=0.157N | P=0.442N |
|FISHER EXACT | P=0.393N P=0.194N | P=0.370 P=0.511N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 5.3% 5.6% |
|TERMINAL (d) | 0/36 (0%) 0/32 (0%) 0/38 (0%) | 0/39 (0%) 1/35 (3%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 693 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.166 P=0.220 P=0.221 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.157 P=0.252 P=0.221 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.169 P=0.234 P=0.221 |
|COCHRAN-ARMITAGE | (e) | P=0.176 |
|FISHER EXACT | (e) (e) | P=0.247 P=0.247 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/41 (0%) 0/44 (0%) 0/45 (0%) | 4/49 (8%) 4/44 (9%) 6/46 (13%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.5% 11.4% 17.1% |
|TERMINAL (d) | 0/30 (0%) 0/31 (0%) 0/37 (0%) | 4/38 (11%) 3/33 (9%) 6/35 (17%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 693 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.261 P=0.569 P=0.317 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.245 P=0.564 P=0.317 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.261 P=0.558 P=0.317 |
|COCHRAN-ARMITAGE | (e) | P=0.269 |
|FISHER EXACT | (e) (e) | P=0.581 P=0.330 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/41 (0%) 0/44 (0%) 0/45 (0%) | 4/49 (8%) 5/44 (11%) 6/46 (13%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.5% 13.4% 17.1% |
|TERMINAL (d) | 0/30 (0%) 0/31 (0%) 0/37 (0%) | 4/38 (11%) 3/33 (9%) 6/35 (17%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 666 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.268 P=0.427 P=0.317 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.236 P=0.414 P=0.317 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.264 P=0.415 P=0.317 |
|COCHRAN-ARMITAGE | (e) | P=0.273 |
|FISHER EXACT | (e) (e) | P=0.431 P=0.330 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 12.0% 5.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 3/32 (9%) 2/38 (5%) | 0/39 (0%) 0/35 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- 707 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244 P=0.052 P=0.250 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.224 P=0.058 P=0.250 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.236 P=0.053 P=0.250 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.222 | (e) |
|FISHER EXACT | P=0.059 P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/50 (24%) 6/50 (12%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 23.9% 32.3% 14.7% | 0.0% 2.2% 2.8% |
|TERMINAL (d) | 5/36 (14%) 8/32 (25%) 4/38 (11%) | 0/39 (0%) 0/35 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 639 573 433 | --- 640 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.182N P=0.310 P=0.200N | P=0.318 P=0.496 P=0.484 |
|INCIDENTAL TUMOR | P=0.283N P=0.400 P=0.284N | P=0.406 P=0.500 P=0.484 |
|LOGISTIC REGRESSION | P=0.190N P=0.388 P=0.209N | P=0.346 P=0.592 P=0.484 |
|COCHRAN-ARMITAGE | P=0.185N | P=0.331 |
|FISHER EXACT | P=0.405 P=0.207N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 17/50 (34%) 9/50 (18%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 31.6% 42.7% 21.6% | 0.0% 2.2% 2.8% |
|TERMINAL (d) | 6/36 (17%) 10/32 (31%) 6/38 (16%) | 0/39 (0%) 0/35 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 579 573 433 | --- 640 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161N P=0.244 P=0.172N | P=0.318 P=0.496 P=0.484 |
|INCIDENTAL TUMOR | P=0.324N P=0.344 P=0.338N | P=0.406 P=0.500 P=0.484 |
|LOGISTIC REGRESSION | P=0.367N P=0.316 P=0.425N | P=0.346 P=0.592 P=0.484 |
|COCHRAN-ARMITAGE | P=0.154N | P=0.331 |
|FISHER EXACT | P=0.333 P=0.171N | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 14/50 (28%) 7/50 (14%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 31.6% 35.6% 16.7% | 0.0% 2.2% 2.8% |
|TERMINAL (d) | 6/36 (17%) 8/32 (25%) 4/38 (11%) | 0/39 (0%) 0/35 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 579 573 433 | --- 640 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.463 P=0.078N | P=0.318 P=0.496 P=0.484 |
|INCIDENTAL TUMOR | P=0.156N P=0.563N P=0.159N | P=0.406 P=0.500 P=0.484 |
|LOGISTIC REGRESSION | P=0.194N P=0.591N P=0.240N | P=0.346 P=0.592 P=0.484 |
|COCHRAN-ARMITAGE | P=0.062N | P=0.331 |
|FISHER EXACT | P=0.588N P=0.070N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.4% 4.8% 2.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 0/32 (0%) 0/38 (0%) | 0/39 (0%) 0/35 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 579 635 699 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.126N P=0.382N P=0.182N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.243N P=0.277N P=0.387N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.352N P=0.339N P=0.176N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.118N | (e) |
|FISHER EXACT | P=0.339N P=0.181N | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 3.1% 2.6% | 2.6% 2.9% 0.0% |
|TERMINAL (d) | 2/36 (6%) 1/32 (3%) 1/38 (3%) | 1/39 (3%) 1/35 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363N P=0.541N P=0.481N | P=0.351N P=0.738 P=0.516N |
|INCIDENTAL TUMOR | P=0.363N P=0.541N P=0.481N | P=0.351N P=0.738 P=0.516N |
|LOGISTIC REGRESSION | P=0.363N P=0.541N P=0.481N | P=0.351N P=0.738 P=0.516N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.331N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/49 (6%) 3/50 (6%) | 1/50 (2%) 2/50 (4%) 1/48 (2%) |
|ADJUSTED (b) | 0.0% 9.4% 7.9% | 2.6% 5.7% 2.8% |
|TERMINAL (d) | 0/36 (0%) 3/32 (9%) 3/38 (8%) | 1/39 (3%) 2/35 (6%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.116 P=0.101 P=0.131 | P=0.595 P=0.462 P=0.744 |
|INCIDENTAL TUMOR | P=0.116 P=0.101 P=0.131 | P=0.595 P=0.462 P=0.744 |
|LOGISTIC REGRESSION | P=0.116 P=0.101 P=0.131 | P=0.595 P=0.462 P=0.744 |
|COCHRAN-ARMITAGE | P=0.102 | P=0.609 |
|FISHER EXACT | P=0.117 P=0.121 | P=0.500 P=0.742 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/49 (8%) 3/50 (6%) | 1/50 (2%) 2/50 (4%) 1/48 (2%) |
|ADJUSTED (b) | 0.0% 12.5% 7.9% | 2.6% 5.7% 2.8% |
|TERMINAL (d) | 0/36 (0%) 4/32 (13%) 3/38 (8%) | 1/39 (3%) 2/35 (6%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 P=0.049 * P=0.131 | P=0.595 P=0.462 P=0.744 |
|INCIDENTAL TUMOR | P=0.135 P=0.049 * P=0.131 | P=0.595 P=0.462 P=0.744 |
|LOGISTIC REGRESSION | P=0.135 P=0.049 * P=0.131 | P=0.595 P=0.462 P=0.744 |
|COCHRAN-ARMITAGE | P=0.119 | P=0.609 |
|FISHER EXACT | P=0.056 P=0.121 | P=0.500 P=0.742 |
|=================================================================================================================================|
| |
|Uterus |
| Leiomyoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 5.4% 0.0% |
|TERMINAL (d) | | 0/39 (0%) 1/35 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 706 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.650 P=0.220 (e) |
|INCIDENTAL TUMOR | | P=0.649 P=0.252 (e) |
|LOGISTIC REGRESSION | | P=0.662 P=0.228 (e) |
|COCHRAN-ARMITAGE | | P=0.669 |
|FISHER EXACT | | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.8% 0.0% 0.0% | 5.1% 0.0% 2.6% |
|TERMINAL (d) | 1/36 (3%) 0/32 (0%) 0/38 (0%) | 2/39 (5%) 0/35 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 729 (T) --- 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267N P=0.523N P=0.489N | P=0.380N P=0.262N P=0.522N |
|INCIDENTAL TUMOR | P=0.267N P=0.523N P=0.489N | P=0.386N P=0.262N P=0.534N |
|LOGISTIC REGRESSION | P=0.267N P=0.523N P=0.489N | P=0.377N P=0.262N P=0.520N |
|COCHRAN-ARMITAGE | P=0.269N | P=0.360N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% | 5.1% 0.0% 2.6% |
|TERMINAL (d) | 2/36 (6%) 0/32 (0%) 0/38 (0%) | 2/39 (5%) 0/35 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 729 (T) --- 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.264N P=0.226N | P=0.380N P=0.262N P=0.522N |
|INCIDENTAL TUMOR | P=0.095N P=0.264N P=0.226N | P=0.386N P=0.262N P=0.534N |
|LOGISTIC REGRESSION | P=0.095N P=0.264N P=0.226N | P=0.377N P=0.262N P=0.520N |
|COCHRAN-ARMITAGE | P=0.095N | P=0.360N |
|FISHER EXACT | P=0.247N P=0.247N | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 3/50 (6%) | 16/50 (32%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | 12.9% 9.1% 7.6% | 34.5% 20.5% 16.7% |
|TERMINAL (d) | 4/36 (11%) 0/32 (0%) 2/38 (5%) | 9/39 (23%) 5/35 (14%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 474 479 705 | 630 440 459 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.545N P=0.342N | P=0.037N* P=0.100N P=0.056N |
|INCIDENTAL TUMOR | P=0.271N P=0.380N P=0.282N | P=0.012N* P=0.025N* P=0.015N* |
|LOGISTIC REGRESSION | P=0.280N P=0.508N P=0.359N | P=0.012N* P=0.038N* P=0.018N* |
|COCHRAN-ARMITAGE | P=0.290N | P=0.018N* |
|FISHER EXACT | P=0.500N P=0.357N | P=0.050N P=0.028N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 3/50 (6%) | 16/50 (32%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | 12.9% 9.1% 7.6% | 34.5% 20.5% 16.7% |
|TERMINAL (d) | 4/36 (11%) 0/32 (0%) 2/38 (5%) | 9/39 (23%) 5/35 (14%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 474 479 705 | 630 440 459 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.545N P=0.342N | P=0.037N* P=0.100N P=0.056N |
|INCIDENTAL TUMOR | P=0.271N P=0.380N P=0.282N | P=0.012N* P=0.025N* P=0.015N* |
|LOGISTIC REGRESSION | P=0.280N P=0.508N P=0.359N | P=0.012N* P=0.038N* P=0.018N* |
|COCHRAN-ARMITAGE | P=0.290N | P=0.018N* |
|FISHER EXACT | P=0.500N P=0.357N | P=0.050N P=0.028N* |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 17/50 (34%) 15/50 (30%) | 13/50 (26%) 20/50 (40%) 11/50 (22%) |
|ADJUSTED (b) | 48.6% 49.7% 39.5% | 33.3% 49.5% 29.7% |
|TERMINAL (d) | 17/36 (47%) 15/32 (47%) 15/38 (39%) | 13/39 (33%) 15/35 (43%) 10/36 (28%) |
|FIRST INCIDENCE (DAYS) | 705 663 729 (T) | 729 (T) 546 725 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.226N P=0.499 P=0.257N | P=0.467N P=0.053 P=0.494N |
|INCIDENTAL TUMOR | P=0.245N P=0.529 P=0.270N | P=0.447N P=0.092 P=0.499N |
|LOGISTIC REGRESSION | P=0.223N P=0.547 P=0.250N | P=0.420N P=0.071 P=0.475N |
|COCHRAN-ARMITAGE | P=0.298N | P=0.371N |
|FISHER EXACT | P=0.500N P=0.335N | P=0.101 P=0.408N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 25/50 (50%) 16/50 (32%) | 21/50 (42%) 17/50 (34%) 18/50 (36%) |
|ADJUSTED (b) | 62.4% 55.1% 36.3% | 44.5% 38.4% 41.6% |
|TERMINAL (d) | 18/36 (50%) 12/32 (38%) 10/38 (26%) | 13/39 (33%) 9/35 (26%) 11/36 (31%) |
|FIRST INCIDENCE (DAYS) | 474 479 433 | 630 440 459 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011N* P=0.420N P=0.011N* | P=0.406N P=0.402N P=0.447N |
|INCIDENTAL TUMOR | P=0.009N** P=0.119N P=0.007N** | P=0.269N P=0.193N P=0.337N |
|LOGISTIC REGRESSION | P=0.034N* P=0.145N P=0.036N* | P=0.261N P=0.193N P=0.315N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.303N |
|FISHER EXACT | P=0.211N P=0.004N** | P=0.268N P=0.341N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05048 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- RHODAMINE 6G
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.1% 0.2% | UNTREATD 0.05% 0.1% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 33/50 (66%) 29/50 (58%) | 29/50 (58%) 33/50 (66%) 25/50 (50%) |
|ADJUSTED (b) | 81.2% 73.1% 65.9% | 61.6% 71.4% 57.9% |
|TERMINAL (d) | 27/36 (75%) 20/32 (63%) 23/38 (61%) | 21/39 (54%) 22/35 (63%) 18/36 (50%) |
|FIRST INCIDENCE (DAYS) | 474 479 433 | 630 440 459 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.040N* P=0.417N P=0.040N* | P=0.400N P=0.170 P=0.422N |
|INCIDENTAL TUMOR | P=0.052N P=0.106N P=0.038N* | P=0.246N P=0.349 P=0.315N |
|LOGISTIC REGRESSION | P=0.114N P=0.118N P=0.122N | P=0.229N P=0.307 P=0.287N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.239N |
|FISHER EXACT | P=0.133N P=0.026N* | P=0.268 P=0.274N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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