TR 371 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 03 TIME: 15:06:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: 0570101 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 03 TIME: 15:06:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 0570101 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 03 TIME: 15:06:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 0570101 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TOLUENE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Spleen Hemangiosarcoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Thyroid Gland: Follicular Cell
Adenoma
All Organs Hemangiosarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/58 (0%) 0/58 (0%) 0/59 (0%) | 1/49 (2%) 1/50 (2%) 1/49 (2%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.3% 3.0% 4.2% 6.0% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 1/30 (3%) 1/33 (3%) 1/24 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 729 (T) 729 (T) 729 (T) 715 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.342 P=0.741N P=0.712 P=0.518 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.316 P=0.741N P=0.712 P=0.437 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.331 P=0.741N P=0.712 P=0.488 |
|COCHRAN-ARMITAGE | (e) | P=0.326 |
|FISHER EXACT | (e) (e) (e) | P=0.747N P=0.753N P=0.484 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/58 (0%) 0/58 (0%) 0/59 (0%) | 1/49 (2%) 2/50 (4%) 1/49 (2%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.3% 5.4% 4.2% 6.0% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 1/30 (3%) 1/33 (3%) 1/24 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 729 (T) 599 729 (T) 715 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.467 P=0.514 P=0.712 P=0.518 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.483 P=0.377 P=0.712 P=0.437 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.458 P=0.502 P=0.712 P=0.488 |
|COCHRAN-ARMITAGE | (e) | P=0.459 |
|FISHER EXACT | (e) (e) (e) | P=0.508 P=0.753N P=0.484 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 0/60 (0%) 2/60 (3%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 8.1% 0.0% 8.2% | 0.0% 6.1% 4.2% 3.1% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 1/19 (5%) | 0/30 (0%) 2/33 (6%) 1/24 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- 400 --- 633 | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.491 P=0.152 (e) P=0.275 | P=0.569 P=0.259 P=0.455 P=0.513 |
|INCIDENTAL TUMOR | P=0.375 P=0.123 (e) P=0.213 | P=0.569 P=0.259 P=0.455 P=0.513 |
|LOGISTIC REGRESSION | P=0.472 P=0.107 (e) P=0.253 | P=0.569 P=0.259 P=0.455 P=0.513 |
|COCHRAN-ARMITAGE | P=0.477 | P=0.558 |
|FISHER EXACT | P=0.122 (e) P=0.248 | P=0.247 P=0.500 P=0.485 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 1/60 (2%) 2/60 (3%) | 0/50 (0%) 2/50 (4%) 2/50 (4%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 8.1% 4.2% 8.2% | 0.0% 6.1% 8.3% 6.3% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 1/19 (5%) | 0/30 (0%) 2/33 (6%) 2/24 (8%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | --- 400 639 633 | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.459 P=0.152 P=0.500 P=0.275 | P=0.280 P=0.259 P=0.190 P=0.252 |
|INCIDENTAL TUMOR | P=0.319 P=0.123 P=0.461 P=0.213 | P=0.280 P=0.259 P=0.190 P=0.252 |
|LOGISTIC REGRESSION | P=0.431 P=0.107 P=0.485 P=0.253 | P=0.280 P=0.259 P=0.190 P=0.252 |
|COCHRAN-ARMITAGE | P=0.437 | P=0.260 |
|FISHER EXACT | P=0.122 P=0.500 P=0.248 | P=0.247 P=0.247 P=0.232 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/59 (2%) | 1/49 (2%) 0/50 (0%) 0/50 (0%) 0/47 (0%) |
|ADJUSTED (b) | 8.2% 0.0% 0.0% 3.2% | 2.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/17 (6%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 0/30 (0%) 0/33 (0%) 0/24 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 543 --- --- 638 | 681 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.525N P=0.199N P=0.261N P=0.458N | P=0.367N P=0.505N P=0.539N P=0.516N |
|INCIDENTAL TUMOR | P=0.591N P=0.231N P=0.240N P=0.567N | P=0.386N P=0.571N P=0.448N P=0.638N |
|LOGISTIC REGRESSION | P=0.540N P=0.223N P=0.253N P=0.498N | P=0.357N P=0.498N P=0.497N P=0.510N |
|COCHRAN-ARMITAGE | P=0.534N | P=0.357N |
|FISHER EXACT | P=0.248N P=0.248N P=0.506N | P=0.495N P=0.495N P=0.510N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 10/60 (17%) 9/60 (15%) 11/59 (19%) | 3/49 (6%) 7/50 (14%) 6/50 (12%) 7/47 (15%) |
|ADJUSTED (b) | 24.1% 33.2% 34.4% 34.3% | 10.0% 19.7% 22.5% 20.0% |
|TERMINAL (d) | 2/17 (12%) 5/22 (23%) 4/16 (25%) 3/19 (16%) | 3/30 (10%) 5/33 (15%) 5/24 (21%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 446 501 319 297 | 729 (T) 683 509 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246 P=0.475 P=0.332 P=0.305 | P=0.235 P=0.190 P=0.153 P=0.181 |
|INCIDENTAL TUMOR | P=0.237 P=0.334 P=0.379 P=0.178 | P=0.180 P=0.160 P=0.163 P=0.152 |
|LOGISTIC REGRESSION | P=0.226 P=0.347 P=0.377 P=0.212 | P=0.208 P=0.147 P=0.225 P=0.136 |
|COCHRAN-ARMITAGE | P=0.241 | P=0.210 |
|FISHER EXACT | P=0.301 P=0.395 P=0.210 | P=0.167 P=0.254 P=0.142 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/60 (22%) 8/60 (13%) 9/60 (15%) 8/59 (14%) | 4/49 (8%) 2/50 (4%) 2/50 (4%) 7/47 (15%) |
|ADJUSTED (b) | 44.5% 27.1% 32.7% 27.1% | 11.1% 5.0% 6.3% 19.4% |
|TERMINAL (d) | 4/17 (24%) 4/22 (18%) 2/16 (13%) 2/19 (11%) | 2/30 (7%) 0/33 (0%) 1/24 (4%) 4/32 (13%) |
|FIRST INCIDENCE (DAYS) | 436 526 425 366 | 631 477 578 589 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263N P=0.088N P=0.315N P=0.138N | P=0.090 P=0.337N P=0.407N P=0.264 |
|INCIDENTAL TUMOR | P=0.231N P=0.117N P=0.292N P=0.160N | P=0.101 P=0.468N P=0.229N P=0.234 |
|LOGISTIC REGRESSION | P=0.261N P=0.119N P=0.293N P=0.165N | P=0.078 P=0.336N P=0.328N P=0.232 |
|COCHRAN-ARMITAGE | P=0.242N | P=0.078 |
|FISHER EXACT | P=0.168N P=0.240N P=0.179N | P=0.329N P=0.329N P=0.238 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 17/60 (28%) 18/60 (30%) 19/59 (32%) | 7/49 (14%) 9/50 (18%) 8/50 (16%) 13/47 (28%) |
|ADJUSTED (b) | 57.9% 51.0% 57.9% 53.2% | 20.6% 23.7% 28.3% 34.5% |
|TERMINAL (d) | 6/17 (35%) 8/22 (36%) 6/16 (38%) 5/19 (26%) | 5/30 (17%) 5/33 (15%) 6/24 (25%) 8/32 (25%) |
|FIRST INCIDENCE (DAYS) | 436 501 319 297 | 631 477 509 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432 P=0.210N P=0.537 P=0.457N | P=0.093 P=0.435 P=0.358 P=0.124 |
|INCIDENTAL TUMOR | P=0.449 P=0.335N P=0.563N P=0.548 | P=0.077 P=0.308 P=0.491 P=0.090 |
|LOGISTIC REGRESSION | P=0.400 P=0.326N P=0.573N P=0.566 | P=0.070 P=0.390 P=0.503 P=0.081 |
|COCHRAN-ARMITAGE | P=0.438 | P=0.072 |
|FISHER EXACT | P=0.421N P=0.500N P=0.553 | P=0.410 P=0.517 P=0.086 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 17/60 (28%) 18/60 (30%) 19/59 (32%) | 7/49 (14%) 9/50 (18%) 8/50 (16%) 13/47 (28%) |
|ADJUSTED (b) | 57.9% 51.0% 57.9% 53.2% | 20.6% 23.7% 28.3% 34.5% |
|TERMINAL (d) | 6/17 (35%) 8/22 (36%) 6/16 (38%) 5/19 (26%) | 5/30 (17%) 5/33 (15%) 6/24 (25%) 8/32 (25%) |
|FIRST INCIDENCE (DAYS) | 436 501 319 297 | 631 477 509 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432 P=0.210N P=0.537 P=0.457N | P=0.093 P=0.435 P=0.358 P=0.124 |
|INCIDENTAL TUMOR | P=0.449 P=0.335N P=0.563N P=0.548 | P=0.077 P=0.308 P=0.491 P=0.090 |
|LOGISTIC REGRESSION | P=0.400 P=0.326N P=0.573N P=0.566 | P=0.070 P=0.390 P=0.503 P=0.081 |
|COCHRAN-ARMITAGE | P=0.438 | P=0.072 |
|FISHER EXACT | P=0.421N P=0.500N P=0.553 | P=0.410 P=0.517 P=0.086 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 1/60 (2%) 2/60 (3%) 8/60 (13%) | 5/50 (10%) 0/50 (0%) 3/50 (6%) 4/47 (9%) |
|ADJUSTED (b) | 32.9% 4.5% 8.4% 26.2% | 14.8% 0.0% 10.3% 11.7% |
|TERMINAL (d) | 3/17 (18%) 1/22 (5%) 1/16 (6%) 3/19 (16%) | 3/30 (10%) 0/33 (0%) 1/24 (4%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 613 729 (T) 450 366 | 681 --- 702 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.228 P=0.010N** P=0.068N P=0.516N | P=0.354 P=0.031N* P=0.477N P=0.489N |
|INCIDENTAL TUMOR | P=0.179 P=0.011N* P=0.068N P=0.565 | P=0.314 P=0.040N* P=0.343N P=0.581N |
|LOGISTIC REGRESSION | P=0.210 P=0.010N** P=0.062N P=0.591N | P=0.335 P=0.036N* P=0.409N P=0.545N |
|COCHRAN-ARMITAGE | P=0.224 | P=0.334 |
|FISHER EXACT | P=0.016N* P=0.047N* P=0.605N | P=0.028N* P=0.357N P=0.540N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 1/60 (2%) | 0/50 (0%) 3/50 (6%) 1/50 (2%) 3/47 (6%) |
|ADJUSTED (b) | 8.5% 4.5% 0.0% 3.0% | 0.0% 8.6% 4.2% 7.8% |
|TERMINAL (d) | 0/17 (0%) 1/22 (5%) 0/16 (0%) 0/19 (0%) | 0/30 (0%) 2/33 (6%) 1/24 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 618 729 (T) --- 587 | --- 686 729 (T) 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385N P=0.429N P=0.252N P=0.472N | P=0.228 P=0.134 P=0.455 P=0.118 |
|INCIDENTAL TUMOR | P=0.381N P=0.483N P=0.261N P=0.514N | P=0.202 P=0.112 P=0.455 P=0.115 |
|LOGISTIC REGRESSION | P=0.381N P=0.451N P=0.257N P=0.492N | P=0.210 P=0.114 P=0.455 P=0.114 |
|COCHRAN-ARMITAGE | P=0.374N | P=0.211 |
|FISHER EXACT | P=0.500N P=0.248N P=0.500N | P=0.121 P=0.500 P=0.110 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 1/60 (2%) 2/60 (3%) 9/60 (15%) | 5/50 (10%) 3/50 (6%) 4/50 (8%) 7/47 (15%) |
|ADJUSTED (b) | 36.4% 4.5% 8.4% 28.4% | 14.8% 8.6% 14.2% 18.9% |
|TERMINAL (d) | 3/17 (18%) 1/22 (5%) 1/16 (6%) 3/19 (16%) | 3/30 (10%) 2/33 (6%) 2/24 (8%) 4/32 (13%) |
|FIRST INCIDENCE (DAYS) | 613 729 (T) 450 366 | 681 686 702 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205 P=0.005N** P=0.042N* P=0.508N | P=0.182 P=0.331N P=0.627N P=0.386 |
|INCIDENTAL TUMOR | P=0.167 P=0.006N** P=0.040N* P=0.574 | P=0.141 P=0.396N P=0.505N P=0.305 |
|LOGISTIC REGRESSION | P=0.187 P=0.005N** P=0.037N* P=0.584N | P=0.156 P=0.375N P=0.567N P=0.330 |
|COCHRAN-ARMITAGE | P=0.200 | P=0.157 |
|FISHER EXACT | P=0.008N** P=0.027N* P=0.601N | P=0.357N P=0.500N P=0.336 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/50 (4%) 0/50 (0%) 2/50 (4%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.3% 0.0% 6.1% 3.1% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 1/30 (3%) 0/33 (0%) 0/24 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 716 --- 659 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.598 P=0.226N P=0.620 P=0.485N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.545 P=0.267N P=0.646N P=0.563N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.594 P=0.242N P=0.681 P=0.512N |
|COCHRAN-ARMITAGE | (e) | P=0.594 |
|FISHER EXACT | (e) (e) (e) | P=0.247N P=0.691N P=0.523N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 2/58 (3%) 1/58 (2%) 0/56 (0%) | 12/49 (24%) 19/48 (40%) 21/49 (43%) 15/46 (33%) |
|ADJUSTED (b) | 0.0% 7.5% 6.7% 0.0% | 36.9% 51.0% 58.0% 46.9% |
|TERMINAL (d) | 0/17 (0%) 1/22 (5%) 1/15 (7%) 0/18 (0%) | 10/30 (33%) 15/33 (45%) 10/24 (42%) 15/32 (47%) |
|FIRST INCIDENCE (DAYS) | --- 633 729 (T) --- | 653 653 398 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.365N P=0.297 P=0.475 (e) | P=0.410 P=0.146 P=0.014 * P=0.382 |
|INCIDENTAL TUMOR | P=0.408N P=0.275 P=0.475 (e) | P=0.325 P=0.091 P=0.038 * P=0.325 |
|LOGISTIC REGRESSION | P=0.367N P=0.266 P=0.475 (e) | P=0.344 P=0.066 P=0.033 * P=0.278 |
|COCHRAN-ARMITAGE | P=0.367N | P=0.367 |
|FISHER EXACT | P=0.244 P=0.496 (e) | P=0.084 P=0.043 * P=0.258 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/47 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 8.0% 2.9% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 0/30 (0%) 0/33 (0%) 1/24 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 725 715 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.213 (e) P=0.196 P=0.506 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.147 (e) P=0.242 P=0.362 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.200 (e) P=0.194 P=0.487 |
|COCHRAN-ARMITAGE | (e) | P=0.194 |
|FISHER EXACT | (e) (e) (e) | (e) P=0.247 P=0.485 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 3/59 (5%) | 1/50 (2%) 1/50 (2%) 0/49 (0%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% 15.8% | 3.3% 3.0% 0.0% 5.6% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 1/16 (6%) 3/19 (16%) | 1/30 (3%) 1/33 (3%) 0/24 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) 729 (T) | 729 (T) 729 (T) --- 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * (e) P=0.488 P=0.137 | P=0.367 P=0.741N P=0.545N P=0.501 |
|INCIDENTAL TUMOR | P=0.016 * (e) P=0.488 P=0.137 | P=0.396 P=0.741N P=0.545N P=0.489 |
|LOGISTIC REGRESSION | P=0.016 * (e) P=0.488 P=0.137 | P=0.354 P=0.741N P=0.545N P=0.475 |
|COCHRAN-ARMITAGE | P=0.017 * | P=0.354 |
|FISHER EXACT | (e) P=0.500 P=0.119 | P=0.753N P=0.505N P=0.477 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 3/50 (6%) 1/50 (2%) 1/50 (2%) 3/47 (6%) |
|ADJUSTED (b) | 5.9% 4.5% 5.0% 0.0% | 10.0% 3.0% 4.2% 9.4% |
|TERMINAL (d) | 1/17 (6%) 1/22 (5%) 0/16 (0%) 0/19 (0%) | 3/30 (10%) 1/33 (3%) 1/24 (4%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 689 --- | 729 (T) 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.301N P=0.704N P=0.748 P=0.478N | P=0.439 P=0.271N P=0.387N P=0.634N |
|INCIDENTAL TUMOR | P=0.257N P=0.704N P=0.754 P=0.478N | P=0.439 P=0.271N P=0.387N P=0.634N |
|LOGISTIC REGRESSION | P=0.295N P=0.704N P=0.748 P=0.478N | P=0.439 P=0.271N P=0.387N P=0.634N |
|COCHRAN-ARMITAGE | P=0.303N | P=0.418 |
|FISHER EXACT | P=0.752N P=0.752N P=0.500N | P=0.309N P=0.309N P=0.631 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 0/59 (0%) | 0/50 (0%) 0/50 (0%) 4/50 (8%) 0/47 (0%) |
|ADJUSTED (b) | 5.9% 7.3% 0.0% 0.0% | 0.0% 0.0% 12.0% 0.0% |
|TERMINAL (d) | 1/17 (6%) 1/22 (5%) 0/16 (0%) 0/19 (0%) | 0/30 (0%) 0/33 (0%) 1/24 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 611 --- --- | --- --- 629 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.143N P=0.577 P=0.512N P=0.478N | P=0.405 (e) P=0.050 * (e) |
|INCIDENTAL TUMOR | P=0.157N P=0.573 P=0.512N P=0.478N | P=0.388 (e) P=0.090 (e) |
|LOGISTIC REGRESSION | P=0.137N P=0.551 P=0.512N P=0.478N | P=0.404 (e) P=0.063 (e) |
|COCHRAN-ARMITAGE | P=0.136N | P=0.404 |
|FISHER EXACT | P=0.500 P=0.500N P=0.504N | (e) P=0.059 (e) |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 0/59 (0%) | 1/50 (2%) 0/50 (0%) 4/50 (8%) 0/47 (0%) |
|ADJUSTED (b) | 5.9% 7.3% 0.0% 0.0% | 3.3% 0.0% 12.0% 0.0% |
|TERMINAL (d) | 1/17 (6%) 1/22 (5%) 0/16 (0%) 0/19 (0%) | 1/30 (3%) 0/33 (0%) 1/24 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 611 --- --- | 729 (T) --- 629 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.143N P=0.577 P=0.512N P=0.478N | P=0.592 P=0.481N P=0.140 P=0.487N |
|INCIDENTAL TUMOR | P=0.157N P=0.573 P=0.512N P=0.478N | P=0.592 P=0.481N P=0.214 P=0.487N |
|LOGISTIC REGRESSION | P=0.137N P=0.551 P=0.512N P=0.478N | P=0.593 P=0.481N P=0.178 P=0.487N |
|COCHRAN-ARMITAGE | P=0.136N | P=0.594 |
|FISHER EXACT | P=0.500 P=0.500N P=0.504N | P=0.500N P=0.181 P=0.515N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 2/50 (4%) 1/50 (2%) 2/47 (4%) |
|ADJUSTED (b) | | 10.0% 5.9% 3.8% 6.3% |
|TERMINAL (d) | | 3/30 (10%) 1/33 (3%) 0/24 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 722 713 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.422N P=0.457N P=0.393N P=0.470N |
|INCIDENTAL TUMOR | | P=0.451N P=0.497N P=0.342N P=0.470N |
|LOGISTIC REGRESSION | | P=0.429N P=0.490N P=0.369N P=0.470N |
|COCHRAN-ARMITAGE | | P=0.435N |
|FISHER EXACT | | P=0.500N P=0.309N P=0.530N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 2/47 (4%) |
|ADJUSTED (b) | 0.0% 2.8% 4.2% 0.0% | 6.7% 3.0% 0.0% 5.8% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 2/30 (7%) 1/33 (3%) 0/24 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- 607 639 --- | 729 (T) 729 (T) --- 696 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529N P=0.530 P=0.500 (e) | P=0.563 P=0.467N P=0.288N P=0.676N |
|INCIDENTAL TUMOR | P=0.631N P=0.522 P=0.461 (e) | P=0.541 P=0.467N P=0.288N P=0.653 |
|LOGISTIC REGRESSION | P=0.541N P=0.502 P=0.485 (e) | P=0.550 P=0.467N P=0.288N P=0.676 |
|COCHRAN-ARMITAGE | P=0.536N | P=0.548 |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.500N P=0.247N P=0.668 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 5/60 (8%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 6/47 (13%) |
|ADJUSTED (b) | 8.2% 0.0% 6.3% 23.6% | 5.8% 6.1% 3.3% 17.0% |
|TERMINAL (d) | 1/17 (6%) 0/22 (0%) 1/16 (6%) 4/19 (21%) | 1/30 (3%) 2/33 (6%) 0/24 (0%) 4/32 (13%) |
|FIRST INCIDENCE (DAYS) | 543 --- 729 (T) 638 | 681 729 (T) 708 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.199N P=0.530N P=0.264 | P=0.054 P=0.670N P=0.569N P=0.142 |
|INCIDENTAL TUMOR | P=0.022 * P=0.231N P=0.507N P=0.211 | P=0.041 * P=0.688 P=0.465N P=0.090 |
|LOGISTIC REGRESSION | P=0.032 * P=0.223N P=0.531N P=0.250 | P=0.044 * P=0.684 P=0.519N P=0.112 |
|COCHRAN-ARMITAGE | P=0.031 * | P=0.043 * |
|FISHER EXACT | P=0.248N P=0.500N P=0.219 | P=0.691N P=0.500N P=0.115 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 2/60 (3%) 5/60 (8%) | 4/50 (8%) 3/50 (6%) 1/50 (2%) 8/47 (17%) |
|ADJUSTED (b) | 8.2% 2.8% 10.2% 23.6% | 12.3% 9.1% 3.3% 22.2% |
|TERMINAL (d) | 1/17 (6%) 0/22 (0%) 1/16 (6%) 4/19 (21%) | 3/30 (10%) 3/33 (9%) 0/24 (0%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 543 607 639 638 | 681 729 (T) 708 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066 P=0.440N P=0.670 P=0.264 | P=0.078 P=0.457N P=0.251N P=0.194 |
|INCIDENTAL TUMOR | P=0.040 * P=0.480N P=0.670 P=0.211 | P=0.058 P=0.483N P=0.188N P=0.116 |
|LOGISTIC REGRESSION | P=0.064 P=0.484N P=0.664 P=0.250 | P=0.063 P=0.514N P=0.208N P=0.143 |
|COCHRAN-ARMITAGE | P=0.065 | P=0.062 |
|FISHER EXACT | P=0.500N P=0.691N P=0.219 | P=0.500N P=0.181N P=0.149 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/47 (2%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 3.8% | 0.0% 0.0% 8.3% 2.9% |
|TERMINAL (d) | 0/17 (0%) 0/22 (0%) 0/16 (0%) 0/19 (0%) | 0/30 (0%) 0/33 (0%) 2/24 (8%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 543 --- --- 691 | --- --- 729 (T) 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.541 P=0.477N P=0.527N P=0.737N | P=0.211 (e) P=0.190 P=0.494 |
|INCIDENTAL TUMOR | P=0.601 P=0.539N P=0.489N P=0.731N | P=0.181 (e) P=0.190 P=0.362 |
|LOGISTIC REGRESSION | P=0.531 P=0.519N P=0.491N P=0.761N | P=0.199 (e) P=0.190 P=0.486 |
|COCHRAN-ARMITAGE | P=0.536 | P=0.194 |
|FISHER EXACT | P=0.500N P=0.500N P=0.752N | (e) P=0.247 P=0.485 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 10/60 (17%) 8/60 (13%) 5/60 (8%) | 22/50 (44%) 10/50 (20%) 19/50 (38%) 12/47 (26%) |
|ADJUSTED (b) | 29.0% 36.4% 41.2% 24.1% | 60.5% 26.6% 51.9% 35.0% |
|TERMINAL (d) | 4/17 (24%) 6/22 (27%) 6/16 (38%) 4/19 (21%) | 16/30 (53%) 6/33 (18%) 8/24 (33%) 10/32 (31%) |
|FIRST INCIDENCE (DAYS) | 543 556 319 691 | 624 599 398 670 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.259N P=0.373 P=0.335 P=0.420N | P=0.228N P=0.007N** P=0.510 P=0.023N* |
|INCIDENTAL TUMOR | P=0.193N P=0.283 P=0.371 P=0.385N | P=0.228N P=0.024N* P=0.328N P=0.046N* |
|LOGISTIC REGRESSION | P=0.241N P=0.303 P=0.311 P=0.410N | P=0.227N P=0.010N* P=0.377N P=0.039N* |
|COCHRAN-ARMITAGE | P=0.249N | P=0.231N |
|FISHER EXACT | P=0.211 P=0.389 P=0.500N | P=0.009N** P=0.342N P=0.045N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 10/60 (17%) 8/60 (13%) 4/60 (7%) | 22/50 (44%) 10/50 (20%) 17/50 (34%) 11/47 (23%) |
|ADJUSTED (b) | 27.2% 36.4% 41.2% 21.1% | 60.5% 26.6% 45.9% 33.1% |
|TERMINAL (d) | 4/17 (24%) 6/22 (27%) 6/16 (38%) 4/19 (21%) | 16/30 (53%) 6/33 (18%) 6/24 (25%) 10/32 (31%) |
|FIRST INCIDENCE (DAYS) | 701 556 319 729 (T) | 624 599 398 670 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.218N P=0.262 P=0.230 P=0.425N | P=0.147N P=0.007N** P=0.473N P=0.012N* |
|INCIDENTAL TUMOR | P=0.169N P=0.195 P=0.252 P=0.393N | P=0.135N P=0.024N* P=0.181N P=0.023N* |
|LOGISTIC REGRESSION | P=0.172N P=0.205 P=0.258 P=0.393N | P=0.138N P=0.010N* P=0.227N P=0.022N* |
|COCHRAN-ARMITAGE | P=0.211N | P=0.142N |
|FISHER EXACT | P=0.135 P=0.279 P=0.500N | P=0.009N** P=0.206N P=0.027N* |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 18/60 (30%) 14/60 (23%) 19/60 (32%) | 19/50 (38%) 28/50 (56%) 29/50 (58%) 29/47 (62%) |
|ADJUSTED (b) | 57.0% 50.5% 55.2% 55.8% | 56.9% 70.0% 74.9% 78.2% |
|TERMINAL (d) | 7/17 (41%) 7/22 (32%) 7/16 (44%) 7/19 (37%) | 16/30 (53%) 21/33 (64%) 15/24 (63%) 24/32 (75%) |
|FIRST INCIDENCE (DAYS) | 446 400 319 297 | 653 534 398 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.471N P=0.514N P=0.487 | P=0.069 P=0.105 P=0.007 ** P=0.048 * |
|INCIDENTAL TUMOR | P=0.326 P=0.540 P=0.481N P=0.317 | P=0.018 * P=0.052 P=0.022 * P=0.014 * |
|LOGISTIC REGRESSION | P=0.348 P=0.531 P=0.514N P=0.360 | P=0.025 * P=0.025 * P=0.025 * P=0.009 ** |
|COCHRAN-ARMITAGE | P=0.392 | P=0.033 * |
|FISHER EXACT | P=0.420 P=0.417N P=0.344 | P=0.054 P=0.036 * P=0.016 * |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 21/60 (35%) 16/60 (27%) 17/60 (28%) 17/60 (28%) | 26/50 (52%) 17/50 (34%) 27/50 (54%) 27/47 (57%) |
|ADJUSTED (b) | 69.4% 52.7% 63.8% 60.1% | 66.2% 40.9% 66.8% 64.3% |
|TERMINAL (d) | 9/17 (53%) 9/22 (41%) 8/16 (50%) 9/19 (47%) | 17/30 (57%) 9/33 (27%) 11/24 (46%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 436 526 319 366 | 624 477 398 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386N P=0.074N P=0.377N P=0.183N | P=0.139 P=0.055N P=0.213 P=0.537 |
|INCIDENTAL TUMOR | P=0.309N P=0.110N P=0.336N P=0.204N | P=0.048 * P=0.118N P=0.580 P=0.233 |
|LOGISTIC REGRESSION | P=0.388N P=0.098N P=0.392N P=0.211N | P=0.083 P=0.091N P=0.459 P=0.335 |
|COCHRAN-ARMITAGE | P=0.353N | P=0.070 |
|FISHER EXACT | P=0.215N P=0.278N P=0.278N | P=0.053N P=0.500 P=0.369 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 120 PPM 600 PPM 1200 PPM | 0 PPM 120 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/60 (48%) 29/60 (48%) 26/60 (43%) 33/60 (55%) | 33/50 (66%) 36/50 (72%) 42/50 (84%) 38/47 (81%) |
|ADJUSTED (b) | 83.4% 74.5% 87.9% 85.8% | 80.3% 83.7% 93.3% 88.4% |
|TERMINAL (d) | 12/17 (71%) 13/22 (59%) 13/16 (81%) 14/19 (74%) | 22/30 (73%) 26/33 (79%) 21/24 (88%) 27/32 (84%) |
|FIRST INCIDENCE (DAYS) | 436 400 319 297 | 624 477 398 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.269 P=0.229N P=0.507N P=0.505 | P=0.151 P=0.507 P=0.009 ** P=0.296 |
|INCIDENTAL TUMOR | P=0.217 P=0.386N P=0.457N P=0.320 | P=0.018 * P=0.149 P=0.027 * P=0.028 * |
|LOGISTIC REGRESSION | P=0.181 P=0.380N P=0.533N P=0.307 | P=0.038 * P=0.130 P=0.017 * P=0.040 * |
|COCHRAN-ARMITAGE | P=0.272 | P=0.040 * |
|FISHER EXACT | P=0.572N P=0.357N P=0.292 | P=0.333 P=0.032 * P=0.077 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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