TR 373 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
SUCCINIC ANHYDRIDE
NTP Experiment-Test: 05041-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 13:16:42
Facility: Microbiological Associates
Chemical CAS #: 108-30-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Dead 10 11 10
Moribund 18 15 14
Gavage Death 1 6 9
Accident 1
Survivors
Terminal Sacrifice 30 27 26
Dead 1
Moribund 1
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (45) (60)
Hemorrhage 1 (2%)
Inflammation, Chronic 3 (5%)
Adventitia, Fibrosis 1 (2%)
Muscularis, Regeneration 1 (2%) 2 (3%)
Intestine Large, Colon (55) (44) (55)
Inflammation, Acute 1 (2%)
Intestine Large, Rectum (53) (35) (53)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Liver (60) (52) (60)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%)
Basophilic Focus, Multiple 27 (45%) 16 (31%) 25 (42%)
Congestion 2 (4%) 3 (5%)
Cytologic Alterations 1 (2%) 1 (2%) 6 (10%)
Cytologic Alterations, Multiple 1 (2%) 1 (2%)
Fibrosis, Focal 6 (10%) 12 (23%) 10 (17%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 5 (8%) 12 (23%) 14 (23%)
Hyperplasia, Nodular 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 16 (27%) 15 (29%) 15 (25%)
Necrosis, Focal 1 (2%) 1 (2%)
Necrosis, Multifocal 3 (6%) 2 (3%)
Vacuolization Cytoplasmic 6 (10%) 3 (6%) 4 (7%)
Bile Duct, Hyperplasia 19 (32%) 6 (12%) 9 (15%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Fibrosis, Multifocal 1 (2%)
Centrilobular, Necrosis 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Vacuolization Cytoplasmic 5 (8%) 1 (2%) 1 (2%)
Hepatocyte, Inclusion Body Intranuclear 1 (2%)
Mesentery (6) (6) (3)
Hemorrhage 1 (17%) 1 (33%)
Inflammation, Chronic 1 (17%) 1 (33%)
Fat, Necrosis 3 (50%) 4 (67%) 2 (67%)
Pancreas (59) (44) (59)
Cyst 1 (2%)
Ectopic Tissue 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Acinus, Atrophy, Diffuse 2 (3%)
Acinus, Atrophy, Focal 10 (17%) 5 (11%) 5 (8%)
Acinus, Hyperplasia 1 (2%)
Stomach, Forestomach (58) (44) (57)
Edema 1 (2%)
Erosion, Acute 1 (2%)
Foreign Body 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Acute 2 (5%)
Inflammation, Chronic 3 (5%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Stomach, Glandular (58) (45) (54)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Epithelium, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Foreign Body 1 (100%)
Aorta, Inflammation, Chronic Active 1 (100%)
Heart (60) (45) (60)
Cardiomyopathy 38 (63%) 18 (40%) 21 (35%)
Foreign Body 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Epicardium, Foreign Body 2 (3%)
Epicardium, Inflammation, Acute 2 (3%)
Epicardium, Inflammation, Chronic 2 (4%)
Epicardium, Inflammation, Chronic Active 1 (2%) 3 (5%)
Epicardium, Necrosis 2 (4%) 2 (3%)
Pericardium, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (45) (59)
Angiectasis 1 (2%)
Congestion 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 4 (7%) 2 (3%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis, Focal 2 (3%) 5 (11%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 6 (10%)
Adrenal Gland, Medulla (59) (43) (54)
Hyperplasia 11 (19%) 3 (7%) 9 (17%)
Pituitary Gland (60) (55) (60)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 9 (15%) 9 (16%) 8 (13%)
Pars Distalis, Concretion 1 (2%)
Pars Distalis, Cyst 4 (7%) 3 (5%)
Pars Distalis, Degeneration, Focal 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (3%) 2 (4%) 7 (12%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (59) (45) (60)
C-Cell, Hyperplasia 8 (14%) 4 (9%) 5 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (27) (53)
Dilatation 2 (5%) 1 (4%) 1 (2%)
Hyperplasia 1 (3%)
Inflammation, Acute 1 (3%) 1 (4%) 1 (2%)
Ovary (59) (44) (60)
Atrophy 2 (3%)
Congestion 2 (3%)
Cyst 4 (7%) 4 (9%) 2 (3%)
Hemorrhage 1 (2%)
Uterus (59) (48) (60)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 4 (7%) 3 (6%)
Vagina (1)
Inflammation, Acute 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (45) (60)
Hyperplasia 3 (5%) 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%) 2 (4%) 1 (2%)
Hypoplasia 1 (2%)
Lymph Node (59) (45) (60)
Mediastinal, Foreign Body 2 (3%)
Mediastinal, Giant Cell, Multiple 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Lymph Node, Mandibular (54) (43) (55)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 2 (5%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (59) (43) (59)
Edema 1 (2%) 2 (5%)
Hemorrhage 3 (5%)
Pigmentation 1 (2%)
Spleen (59) (46) (60)
Congestion 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 6 (10%) 3 (7%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Pigmentation 10 (17%) 7 (15%) 9 (15%)
Thymus (48) (41) (52)
Hemorrhage 2 (4%)
Necrosis 2 (5%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (55) (59)
Dilatation 8 (14%) 4 (7%) 1 (2%)
Hyperplasia 2 (3%) 3 (5%) 2 (3%)
Skin (60) (44) (60)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (45) (60)
Cranium, Hemorrhage 1 (2%)
Cranium, Femur, Hyperostosis 2 (3%)
Skeletal Muscle (1) (1)
Inflammation, Chronic Active 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (45) (60)
Abscess 1 (2%)
Hemorrhage 3 (7%)
Thrombosis, Focal 1 (2%)
Thrombosis, Multifocal 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%)
Pons, Vacuolization Cytoplasmic 1 (2%)
Thalamus, Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (44) (60)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Lung (60) (49) (60)
Congestion 2 (3%) 5 (10%) 9 (15%)
Edema 1 (2%) 2 (3%)
Fibrosis, Focal 1 (2%)
Foreign Body 2 (3%) 7 (14%) 8 (13%)
Hemorrhage 3 (5%) 3 (6%) 3 (5%)
Hyperplasia, Adenomatous 4 (7%) 4 (8%) 4 (7%)
Infiltration Cellular, Histiocyte 23 (38%) 13 (27%) 24 (40%)
Inflammation, Acute 2 (3%) 3 (6%) 3 (5%)
Inflammation, Chronic 1 (2%) 2 (3%)
Inflammation, Granulomatous 1 (2%)
Pigmentation 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Bronchiole, Foreign Body 1 (2%)
Bronchiole, Inflammation, Acute 2 (3%)
Bronchiole, Inflammation, Subacute 1 (2%)
Mediastinum, Foreign Body 1 (2%) 1 (2%)
Mediastinum, Hemorrhage 1 (2%)
Mediastinum, Inflammation, Acute 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%) 3 (5%)
Mediastinum, Necrosis 1 (2%)
Pleura, Fibrosis 3 (5%)
Pleura, Foreign Body 1 (2%)
Pleura, Inflammation, Acute 1 (2%)
Pleura, Inflammation, Chronic 2 (3%)
Pleura, Inflammation, Chronic Active 2 (3%)
Pleura, Necrosis 5 (10%) 4 (7%)
Nose (59) (50) (57)
Foreign Body 1 (2%)
Sinus, Foreign Body 1 (2%) 2 (4%) 5 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Sinus, Fungus 1 (2%) 2 (4%)
Sinus, Hemorrhage 1 (2%)
Sinus, Inflammation, Acute 2 (3%) 7 (14%) 9 (16%)
Turbinate, Inflammation, Chronic 2 (3%) 1 (2%)
Turbinate, Inflammation, Subacute 2 (4%)
Turbinate, Necrosis 1 (2%)
Trachea (60) (44) (60)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 5 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (8) (4)
Abscess 1 (25%)
Lens Capsule, Cataract 1 (25%) 4 (50%) 4 (100%)
Retina, Atrophy 3 (75%) 5 (63%) 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Nephropathy 20 (33%) 15 (25%) 9 (15%)
Pigmentation 2 (3%) 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Pelvis, Mineralization 5 (8%) 3 (5%) 3 (5%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (56) (41) (60)
Angiectasis 1 (2%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Moribund 15 16 10
Dead 8 9 14
Gavage Death 1 2 4
Survivors
Terminal Sacrifice 36 33 32
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (28) (60)
Fibrosis, Focal 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis 1 (4%)
Muscularis, Regeneration 1 (2%)
Intestine Large (54) (27) (54)
Circumanal Gland, Hyperplasia 2 (4%)
Intestine Large, Cecum (52) (24) (53)
Inflammation, Acute 1 (4%)
Parasite Protozoan 1 (4%) 1 (2%)
Intestine Small, Ileum (53) (24) (51)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%)
Liver (60) (47) (60)
Angiectasis 3 (5%) 3 (6%) 1 (2%)
Basophilic Focus 4 (7%) 7 (15%) 2 (3%)
Basophilic Focus, Multiple 15 (25%) 5 (11%) 19 (32%)
Congestion 4 (9%) 3 (5%)
Cytologic Alterations 2 (3%) 4 (9%) 1 (2%)
Cytologic Alterations, Multiple 5 (8%) 1 (2%)
Fibrosis, Focal 5 (8%) 4 (9%) 4 (7%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 6 (10%) 9 (19%) 6 (10%)
Hyperplasia, Focal 2 (3%) 4 (9%)
Hyperplasia, Nodular 1 (2%) 1 (2%)
Inflammation, Chronic 6 (10%) 1 (2%) 4 (7%)
Necrosis, Focal 1 (2%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Vacuolization Cytoplasmic 6 (10%) 7 (15%) 4 (7%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 42 (70%) 28 (60%) 46 (77%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (4%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Vacuolization Cytoplasmic 2 (3%) 3 (5%)
Mesentery (13) (14) (12)
Inflammation, Chronic 2 (15%)
Artery, Inflammation, Multifocal 1 (8%)
Fat, Necrosis 12 (92%) 10 (71%) 11 (92%)
Pancreas (59) (26) (59)
Cyst 2 (8%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%) 1 (4%)
Acinus, Atrophy, Focal 22 (37%) 2 (8%) 17 (29%)
Acinus, Hyperplasia, Focal 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Pharynx (1)
Developmental Malformation 1 (100%)
Salivary Glands (58) (27) (58)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Vacuolization Cytoplasmic 1 (4%)
Stomach, Forestomach (59) (29) (58)
Edema 1 (3%)
Fungus 1 (3%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Ulcer 2 (3%) 2 (7%) 1 (2%)
Stomach, Glandular (58) (31) (59)
Atrophy 1 (3%)
Dilatation 1 (3%)
Edema 1 (2%) 1 (3%)
Erosion 1 (3%)
Tooth (1) (1)
Peridontal Tissue, Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (29) (59)
Cardiomyopathy 47 (78%) 22 (76%) 43 (73%)
Atrium, Thrombosis 3 (5%) 1 (3%) 2 (3%)
Endocardium, Fibrosis 1 (2%)
Epicardium, Fibrosis 1 (3%)
Epicardium, Inflammation, Chronic 1 (3%) 2 (3%)
Epicardium, Inflammation, Chronic Active 1 (2%)
Myocardium, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (59)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 6 (10%) 3 (5%) 4 (7%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 4 (7%) 8 (13%) 3 (5%)
Adrenal Gland, Medulla (58) (58) (58)
Hyperplasia 21 (36%) 9 (16%) 14 (24%)
Necrosis 1 (2%)
Islets, Pancreatic (59) (27) (60)
Hyperplasia 2 (3%) 3 (5%)
Parathyroid Gland (51) (26) (51)
Hyperplasia 1 (2%)
Pituitary Gland (57) (59) (60)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 3 (5%) 5 (8%)
Pars Distalis, Cyst 2 (3%) 2 (3%)
Pars Distalis, Hyperplasia 8 (14%) 11 (19%) 11 (18%)
Pars Distalis, Inflammation, Chronic 1 (2%)
Pars Distalis, Thrombosis 1 (2%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Thyroid Gland (60) (60) (58)
Cyst 2 (3%) 2 (3%)
Fibrosis 1 (2%)
Inflammation, Chronic 2 (3%)
C-Cell, Hyperplasia 11 (18%) 6 (10%) 4 (7%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (29) (59)
Inflammation, Acute 1 (3%)
Inflammation, Chronic 1 (2%)
Serosa, Hyperplasia, Focal 1 (2%)
Preputial Gland (48) (23) (51)
Dilatation 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 5 (10%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Prostate (59) (29) (58)
Hemorrhage 1 (2%)
Hyperplasia 7 (12%) 3 (10%) 1 (2%)
Inflammation, Acute 3 (5%) 1 (3%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Pigmentation 1 (3%)
Testes (60) (58) (60)
Atrophy 3 (5%) 2 (3%)
Interstitial Cell, Hyperplasia 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (28) (59)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Lymph Node (60) (29) (60)
Mediastinal, Giant Cell, Multiple 1 (2%)
Mediastinal, Hemorrhage 3 (5%) 1 (3%)
Mediastinal, Hyperplasia 1 (2%) 1 (2%)
Lymph Node, Mandibular (50) (28) (51)
Cyst 5 (10%) 2 (7%)
Hemorrhage 1 (2%) 1 (4%) 3 (6%)
Hyperplasia, Lymphoid 4 (8%) 3 (6%)
Spleen (59) (39) (60)
Congestion 1 (3%) 1 (2%)
Fibrosis, Focal 2 (3%) 5 (13%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%) 1 (3%) 2 (3%)
Hemorrhage 1 (2%) 1 (3%)
Hyperplasia, Nodular 1 (2%)
Necrosis 1 (2%)
Pigmentation 4 (7%) 1 (3%)
Thymus (45) (28) (48)
Congestion 1 (2%)
Hemorrhage 1 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (25) (42)
Dilatation 5 (10%) 1 (4%) 1 (2%)
Pigmentation 1 (2%)
Skin (60) (29) (59)
Cyst Epithelial Inclusion 1 (3%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Epithelium, Hyperplasia 1 (3%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (28) (60)
Sternum, Hemorrhage 1 (2%)
Skeletal Muscle (1) (2)
Cyst 1 (50%)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (27) (60)
Congestion 1 (4%)
Thrombosis, Multifocal 2 (3%)
Cerebrum, Inflammation, Chronic 1 (2%)
Meninges, Hemorrhage 1 (2%)
Meninges, Inflammation, Chronic 1 (2%)
Thalamus, Compression 1 (2%)
Spinal Cord (3)
Nerve, Demyelination 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (59) (27) (59)
Necrosis 1 (2%)
Lung (60) (60) (60)
Congestion 5 (8%) 10 (17%) 12 (20%)
Fibrosis, Focal 1 (2%) 2 (3%)
Foreign Body 3 (5%) 7 (12%)
Hemorrhage 2 (3%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Adenomatous 10 (17%) 4 (7%) 2 (3%)
Infiltration Cellular, Histiocyte 12 (20%) 18 (30%) 11 (18%)
Inflammation, Granulomatous 1 (2%)
Leukocytosis 1 (2%)
Metaplasia, Osseous 2 (3%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (2%) 2 (3%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 3 (5%)
Alveolar Epithelium, Hyperplasia 2 (3%) 1 (2%)
Alveolus, Fibrosis, Focal 1 (2%)
Interstitium, Edema 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%) 2 (3%)
Mediastinum, Hemorrhage 1 (2%)
Nose (58) (59) (59)
Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 2 (3%) 1 (2%) 1 (2%)
Olfactory Epithelium, Inflammation, Chronic 1 (2%)
Sinus, Foreign Body 1 (2%) 2 (3%) 3 (5%)
Sinus, Fungus 1 (2%) 7 (12%) 5 (8%)
Sinus, Hemorrhage 1 (2%)
Sinus, Inflammation, Acute 7 (12%) 11 (19%) 11 (19%)
Turbinate, Foreign Body 1 (2%)
Turbinate, Inflammation, Acute 1 (2%) 1 (2%)
Turbinate, Inflammation, Chronic 1 (2%) 3 (5%)
Turbinate, Metaplasia, Squamous 1 (2%)
Trachea (60) (28) (59)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (8) (8) (8)
Hemorrhage 1 (13%)
Capsule, Lens, Cataract 1 (13%)
Lens Capsule, Cataract 4 (50%) 4 (50%) 2 (25%)
Retina, Atrophy 8 (100%) 8 (100%) 5 (63%)
Sclera, Metaplasia, Osseous 4 (50%) 4 (50%) 4 (50%)
Harderian Gland (2) (1) (3)
Inflammation, Chronic 1 (100%)
Inflammation, Chronic, Focal 2 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59)
Abscess 1 (2%)
Congestion 1 (2%)
Cyst 4 (7%) 2 (3%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 52 (87%) 40 (67%) 26 (44%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Pelvis, Mineralization 1 (2%)
Renal Tubule, Atrophy, Diffuse 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 2 (3%)
Ureter (1)
Inflammation, Acute 1 (100%)
Urinary Bladder (59) (27) (59)
Hemorrhage 2 (3%) 1 (2%)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 95176-95176/95176
--multipart-boundary--