TR 380 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
EPINEPHRINE HCL
NTP Experiment-Test: 05095-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 14 16 14
Dead 4 5 6
Survivors
Terminal Sacrifice 32 29 30
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (45) (17) (44)
Parasite Metazoan 3 (7%) 1 (6%) 1 (2%)
Artery, Inflammation 2 (5%)
Intestine Large, Colon (49) (20) (45)
Hemorrhage 1 (2%)
Parasite Metazoan 3 (6%) 1 (2%)
Intestine Large, Rectum (49) (20) (46)
Parasite Metazoan 1 (2%)
Intestine Small (50) (20) (44)
Muscularis, Hyperplasia 1 (2%)
Intestine Small, Duodenum (50) (20) (44)
Artery, Inflammation 1 (2%)
Intestine Small, Ileum (45) (18) (44)
Inflammation, Chronic 1 (2%)
Artery, Inflammation 1 (2%)
Intestine Small, Jejunum (48) (19) (44)
Inflammation, Chronic 1 (2%)
Artery, Inflammation 1 (2%)
Liver (50) (31) (47)
Angiectasis 2 (4%) 1 (3%) 2 (4%)
Basophilic Focus 21 (42%) 9 (29%) 22 (47%)
Basophilic Focus, Multiple 1 (3%)
Clear Cell Focus 3 (6%) 2 (6%) 3 (6%)
Developmental Malformation 2 (4%) 9 (29%) 6 (13%)
Eosinophilic Focus 3 (6%) 1 (3%) 1 (2%)
Eosinophilic Focus, Multiple 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Focal 1 (3%)
Inflammation, Granulomatous 19 (38%) 6 (19%) 21 (45%)
Inflammation, Suppurative 2 (4%)
Mixed Cell Focus 1 (2%)
Necrosis 7 (14%) 3 (10%) 3 (6%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 10 (20%) 9 (29%) 8 (17%)
Hepatocyte, Cytomegaly 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 11 (22%) 7 (23%) 11 (23%)
Mesentery (1) (2)
Inflammation, Chronic 1 (50%)
Necrosis 1 (50%)
Pancreas (49) (21) (47)
Fibrosis 1 (2%)
Acinus, Atrophy 7 (14%) 7 (33%) 11 (23%)
Artery, Inflammation 2 (4%)
Salivary Glands (50) (21) (48)
Inflammation, Suppurative 1 (2%)
Karyomegaly 1 (2%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (21) (48)
Acanthosis 1 (2%) 1 (5%) 4 (8%)
Developmental Malformation 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Suppurative 2 (4%) 4 (8%)
Ulcer 2 (4%) 1 (5%)
Stomach, Glandular (49) (21) (47)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (5%) 2 (4%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (21) (49)
Cardiomyopathy 13 (26%) 6 (29%) 20 (41%)
Mineralization 1 (5%) 2 (4%)
Thrombosis 2 (4%) 4 (8%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 1 (5%)
Myocardium, Hemorrhage 1 (2%)
Myocardium, Necrosis 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (23) (47)
Angiectasis 1 (2%)
Hemorrhage 1 (4%) 2 (4%)
Hyperplasia 13 (26%) 8 (17%)
Necrosis 2 (9%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 21 (42%) 9 (39%) 17 (36%)
Adrenal Gland, Medulla (50) (22) (47)
Hyperplasia 7 (14%) 2 (9%) 4 (9%)
Hyperplasia, Focal 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Parathyroid Gland (41) (20) (44)
Hyperplasia 1 (5%) 5 (11%)
Pituitary Gland (49) (38) (47)
Cyst 3 (8%) 1 (2%)
Pars Distalis, Angiectasis 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia 3 (6%) 1 (3%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 1 (3%)
Pars Intermedia, Angiectasis 1 (2%)
Thyroid Gland (50) (21) (47)
Ultimobranchial Cyst 1 (2%) 1 (5%) 1 (2%)
C-Cell, Hyperplasia 17 (34%) 9 (43%) 11 (23%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (21) (47)
Cyst 2 (4%)
Hyperplasia 5 (10%) 2 (10%) 1 (2%)
Inflammation, Suppurative 5 (10%) 3 (14%) 4 (9%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (22) (47)
Cyst 7 (14%) 5 (11%)
Inflammation, Chronic 1 (2%) 1 (2%)
Uterus (50) (25) (48)
Decidual Reaction 1 (2%)
Dilatation 3 (6%) 1 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (4%)
Inflammation, Suppurative 1 (2%) 2 (8%)
Metaplasia, Squamous 1 (2%)
Prolapse 1 (4%)
Endometrium, Hyperplasia 2 (4%) 1 (4%)
Vagina (2)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Neutrophilia 1 (100%)
Bone Marrow (50) (21) (47)
Fibrosis 1 (5%)
Hyperplasia 1 (2%)
Lymph Node (48) (22) (48)
Mediastinal, Hyperplasia 1 (5%)
Lymph Node, Mandibular (48) (17) (45)
Hyperplasia 1 (6%) 2 (4%)
Spleen (50) (26) (47)
Developmental Malformation 1 (4%)
Fibrosis 1 (2%) 2 (8%) 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 1 (4%) 5 (11%)
Infarct 1 (2%)
Pigmentation 1 (4%)
Thymus (50) (19) (47)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (28) (49)
Galactocele 1 (2%) 1 (4%)
Hyperplasia 1 (4%)
Skin (48) (22) (48)
Acanthosis 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Diaphragm, Developmental Malformation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (21) (49)
Compression 10 (20%) 6 (29%) 9 (18%)
Congestion 1 (2%)
Hemorrhage 6 (12%)
Thrombosis 1 (2%)
Ventricle, Dilatation 1 (2%) 1 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (21) (47)
Foreign Body 1 (5%) 5 (11%)
Inflammation, Chronic 2 (10%) 4 (9%)
Inflammation, Suppurative 12 (24%) 4 (19%) 17 (36%)
Mineralization 1 (5%)
Epithelium, Hyperplasia 2 (4%) 2 (10%) 1 (2%)
Lung (50) (23) (48)
Foreign Body 1 (4%) 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (4%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Alveolus, Edema 1 (4%)
Alveolus, Infiltration Cellular, Histiocyte 5 (10%) 7 (30%) 6 (13%)
Alveolus, Inflammation, Suppurative 3 (6%) 1 (4%) 5 (10%)
Artery, Inflammation 2 (4%)
Bronchiole, Inflammation, Suppurative 1 (4%)
Nose (50) (50) (46)
Dilatation 1 (2%)
Foreign Body 1 (2%) 5 (10%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 10 (20%) 6 (13%)
Parasite Metazoan 1 (2%)
Glands, Dilatation 4 (8%) 15 (30%) 37 (80%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 12 (24%) 13 (28%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 3 (7%)
Trachea (50) (21) (47)
Inflammation, Suppurative 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Acanthosis 1 (100%)
Inflammation, Granulomatous 1 (100%)
Eye (5) (7) (2)
Atrophy 1 (20%)
Lens, Cataract 3 (60%) 7 (100%) 2 (100%)
Lacrimal Gland (3) (1) (1)
Degeneration 1 (100%)
Inflammation, Chronic 3 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (23) (48)
Cyst 1 (2%)
Infarct 1 (2%)
Mineralization 1 (2%) 1 (4%) 3 (6%)
Nephropathy, Chronic 49 (98%) 21 (91%) 47 (98%)
Pelvis, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 17 17 13
Dead 6 5
Survivors
Terminal Sacrifice 33 26 32
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (22) (46)
Hemorrhage 1 (2%) 3 (14%)
Parasite Metazoan 5 (10%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%)
Intestine Large, Colon (50) (20) (47)
Parasite Metazoan 4 (8%) 4 (20%)
Intestine Large, Rectum (50) (20) (45)
Parasite Metazoan 7 (14%) 4 (9%)
Liver (50) (33) (49)
Angiectasis 2 (4%)
Angiectasis, Focal 1 (2%)
Basophilic Focus 17 (34%) 5 (15%) 22 (45%)
Clear Cell Focus 18 (36%) 1 (3%) 7 (14%)
Developmental Malformation 5 (10%) 4 (12%) 2 (4%)
Eosinophilic Focus 1 (2%)
Fibrosis 1 (2%)
Inflammation, Granulomatous 10 (20%) 3 (9%) 9 (18%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%) 5 (15%) 2 (4%)
Thrombosis, Multiple 1 (2%)
Bile Duct, Fibrosis 7 (14%) 2 (4%)
Bile Duct, Hyperplasia 33 (66%) 14 (42%) 27 (55%)
Hepatocyte, Vacuolization Cytoplasmic 5 (10%) 5 (15%) 7 (14%)
Mesentery (5) (5) (2)
Fibrosis 1 (20%)
Hemorrhage 1 (20%)
Inflammation, Chronic 4 (80%) 2 (40%) 2 (100%)
Necrosis 1 (20%)
Fat, Necrosis 1 (50%)
Pancreas (50) (23) (49)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Acinus, Atrophy 19 (38%) 11 (48%) 18 (37%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation 1 (4%)
Salivary Glands (50) (24) (49)
Hemorrhage 1 (4%)
Inflammation, Chronic 3 (6%) 3 (6%)
Karyomegaly 3 (6%) 4 (8%)
Stomach, Forestomach (49) (26) (48)
Acanthosis 2 (4%) 3 (12%) 3 (6%)
Diverticulum 1 (4%)
Fibrosis 1 (4%)
Hyperkeratosis 2 (4%) 3 (6%)
Inflammation, Suppurative 5 (10%) 2 (8%) 4 (8%)
Ulcer 2 (4%) 2 (8%) 1 (2%)
Muscularis, Hyperplasia 1 (2%)
Stomach, Glandular (50) (25) (48)
Atrophy 1 (2%)
Cyst 1 (2%)
Erosion 3 (6%)
Fibrosis 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 3 (6%) 2 (4%)
Inflammation, Suppurative 1 (2%) 2 (8%) 2 (4%)
Epithelium, Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (24) (50)
Cardiomyopathy 24 (48%) 7 (29%) 28 (56%)
Thrombosis 1 (2%) 2 (4%)
Atrium, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (23) (49)
Developmental Malformation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 8 (16%) 5 (10%)
Mineralization 1 (2%)
Vacuolization Cytoplasmic 19 (38%) 8 (35%) 13 (27%)
Vacuolization Nuclear 1 (2%)
Adrenal Gland, Medulla (50) (25) (48)
Hyperplasia 14 (28%) 2 (8%) 12 (25%)
Hyperplasia, Focal 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (24) (49)
Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (43) (19) (37)
Hyperplasia 1 (2%) 1 (3%)
Pituitary Gland (50) (36) (48)
Cyst 2 (6%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 3 (6%) 1 (3%) 1 (2%)
Thyroid Gland (50) (24) (49)
C-Cell, Hyperplasia 9 (18%) 3 (13%) 6 (12%)
Follicular Cell, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (46) (27) (39)
Angiectasis 1 (4%)
Inflammation, Chronic 1 (3%)
Preputial Gland (49) (25) (49)
Cyst 3 (6%) 2 (8%) 4 (8%)
Inflammation, Suppurative 9 (18%) 1 (4%) 10 (20%)
Prostate (50) (25) (49)
Hyperplasia 2 (4%)
Inflammation, Suppurative 12 (24%) 6 (24%) 8 (16%)
Seminal Vesicle (50) (24) (49)
Inflammation, Suppurative 8 (16%) 3 (13%) 7 (14%)
Testes (50) (47) (50)
Atrophy 35 (70%) 23 (49%) 41 (82%)
Mineralization 1 (2%) 1 (2%)
Artery, Inflammation 5 (10%) 2 (4%) 3 (6%)
Interstitial Cell, Hyperplasia 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (23) (49)
Atrophy 1 (2%)
Fibrosis 1 (2%)
Lymph Node (50) (28) (50)
Renal, Hyperplasia 1 (4%)
Spleen (50) (32) (49)
Developmental Malformation 1 (2%)
Fibrosis 3 (6%) 3 (9%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%)
Infarct 2 (4%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (20) (41)
Galactocele 1 (3%)
Hyperplasia 1 (2%)
Skin (50) (26) (50)
Acanthosis 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 3 (12%) 2 (4%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (1)
Diaphragm, Developmental Malformation 1 (50%) 1 (100%)
Diaphragm, Fibrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (24) (50)
Compression 9 (18%) 11 (46%) 3 (6%)
Congestion 1 (2%)
Gliosis 1 (2%)
Hemorrhage 3 (6%) 6 (25%) 6 (12%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Ventricle, Dilatation 4 (8%) 1 (4%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (24) (48)
Foreign Body 5 (10%) 3 (6%)
Hemorrhage 1 (4%)
Inflammation, Chronic 3 (6%)
Inflammation, Suppurative 14 (28%) 6 (25%) 13 (27%)
Epithelium, Hyperplasia 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (50) (29) (49)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 2 (7%) 3 (6%)
Alveolar Epithelium, Hyperplasia 2 (4%) 4 (14%) 1 (2%)
Alveolus, Edema 1 (2%) 1 (3%)
Alveolus, Fibrosis 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 6 (12%) 4 (14%) 2 (4%)
Alveolus, Inflammation, Suppurative 1 (2%) 1 (3%) 5 (10%)
Artery, Mediastinum, Inflammation 1 (2%)
Nose (50) (49) (50)
Foreign Body 4 (8%) 5 (10%) 10 (20%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 8 (16%) 9 (18%) 17 (34%)
Necrosis 1 (2%)
Glands, Dilatation 13 (26%) 19 (39%) 44 (88%)
Glands, Hyperplasia 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Hyperplasia 5 (10%) 15 (30%)
Respiratory Epithelium, Hyperplasia, Focal 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 1 (2%)
Trachea (50) (24) (49)
Inflammation, Chronic 1 (4%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (3) (3)
Cataract 1 (33%)
Lens, Cataract 4 (100%) 1 (33%) 3 (100%)
Harderian Gland (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (26) (49)
Infarct 1 (4%)
Nephropathy, Chronic 49 (98%) 26 (100%) 49 (100%)
Pelvis, Hyperplasia 1 (2%)
Pelvis, Inflammation, Suppurative 2 (4%)
Urinary Bladder (50) (22) (49)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Suppurative 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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