TR 382 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FURFURAL
NTP Experiment-Test: 05005-08 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 06:46:15
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund 8 11 9 7
Dead 8 8 11 11
Dosing Accident 1
Natural Death 1 1
Accident 2
Survivors
Terminal Sacrifice 32 28 29 32
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (46) (48) (43)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 1 (2%)
Intestine Small, Jejunum (48) (48) (46) (50)
Inflammation, Focal, Subacute 1 (2%)
Liver (50) (50) (50) (50)
Abscess 1 (2%) 1 (2%)
Angiectasis, Focal 1 (2%)
Focal Cellular Change 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Granuloma, Multiple 1 (2%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 4 (8%) 1 (2%) 4 (8%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis, Focal 2 (4%)
Necrosis, Multifocal 1 (2%) 3 (6%) 2 (4%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation, Multifocal 1 (2%) 1 (2%)
Serosa, Subserosa, Inflammation, Chronic,
Multifocal 6 (12%)
Serosa, Subserosa, Pigmentation, Multifocal 10 (20%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 6 (12%) 3 (6%) 14 (28%) 2 (4%)
Subserosa, Inflammation, Chronic, Multifocal 1 (2%) 2 (4%)
Subserosa, Pigmentation, Multifocal 1 (2%)
Mesentery (6) (10) (7) (11)
Abscess 1 (17%)
Inflammation, Acute, Suppurative 2 (33%) 3 (43%) 2 (18%)
Inflammation, Subacute 1 (10%) 1 (9%)
Fat, Necrosis, Focal 2 (33%) 1 (10%) 3 (43%) 7 (64%)
Fat, Necrosis, Multifocal 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (48) (50)
Infiltration Cellular, Multifocal, Lymphocyte 6 (12%) 6 (12%) 5 (10%) 10 (20%)
Inflammation, Acute, Suppurative 2 (4%) 4 (8%)
Acinus, Atrophy, Focal 1 (2%)
Acinus, Atrophy, Multifocal 1 (2%) 5 (10%) 1 (2%)
Acinus, Necrosis, Focal 1 (2%)
Duct, Cyst 2 (4%) 3 (6%)
Duct, Dilatation 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 24 (48%) 22 (44%) 21 (42%) 23 (46%)
Pigmentation, Focal, Hemosiderin 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Hyperplasia 5 (10%) 5 (10%) 3 (6%)
Inflammation, Subacute 3 (6%) 4 (8%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Erosion, Multiple 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Angiectasis, Focal 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Focal, Subacute 2 (4%) 1 (2%)
Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Degeneration, Fatty, Focal 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Focal 1 (2%) 2 (4%) 2 (4%)
Hypertrophy, Focal 1 (2%)
Capsule, Accessory Adrenal Cortical Nodule 1 (2%)
Spindle Cell, Hyperplasia, Focal 2 (4%)
Adrenal Gland, Medulla (50) (50) (50) (50)
Hyperplasia, Focal 2 (4%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Parathyroid Gland (48) (45) (45) (44)
Cyst 1 (2%)
Pituitary Gland (46) (49) (49) (49)
Pars Distalis, Angiectasis 5 (11%) 5 (10%) 6 (12%) 11 (22%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 12 (26%) 14 (29%) 9 (18%) 6 (12%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia, Focal 2 (4%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 3 (6%) 4 (8%)
Follicle, Degeneration, Cystic 14 (28%) 13 (26%) 11 (22%) 12 (24%)
Follicular Cell, Hyperplasia, Cystic, Focal 2 (4%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (49) (50) (50)
Abscess 9 (19%) 6 (12%) 15 (30%) 3 (6%)
Angiectasis 1 (2%)
Cyst 7 (15%) 11 (22%) 9 (18%) 12 (24%)
Cyst, Two 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Tubular 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 3 (6%) 1 (2%)
Cyst 1 (2%)
Hydrometra 6 (12%) 6 (12%) 3 (6%) 2 (4%)
Inflammation, Acute, Suppurative 2 (4%) 4 (8%) 8 (16%) 2 (4%)
Endometrium, Hyperplasia, Cystic 43 (86%) 42 (84%) 44 (88%) 48 (96%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2) (1) (1)
Leukocytosis 1 (50%) 1 (50%) 1 (100%) 1 (100%)
Polychromasia 1 (50%) 1 (100%)
Bone Marrow (50) (49) (49) (50)
Hyperplasia 8 (16%) 13 (27%) 11 (22%) 8 (16%)
Infiltration Cellular, Megakaryocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node (50) (50) (50) (50)
Iliac, Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Mediastinal, Inflammation, Acute, Suppurative 1 (2%) 1 (2%)
Renal, Hyperplasia, Lymphoid 2 (4%) 5 (10%) 5 (10%) 1 (2%)
Lymph Node, Mandibular (47) (47) (49) (48)
Hyperplasia, Lymphoid 1 (2%) 7 (15%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Lymph Node, Mesenteric (48) (46) (49) (48)
Angiectasis 2 (4%)
Hyperplasia, Lymphoid 12 (25%) 9 (20%) 13 (27%) 13 (27%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Spleen (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 16 (32%) 17 (34%) 19 (38%) 11 (22%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Thymus (49) (47) (44) (46)
Cyst 4 (9%) 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (48)
Duct, Cyst 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Femur, Fracture 1 (2%)
Skeletal Muscle (1) (3) (1)
Inflammation, Acute, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%)
Granuloma 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Meninges, Inflammation, Acute, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage, Focal 1 (2%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%)
Mediastinum, Foreign Body 1 (2%)
Mediastinum, Inflammation, Acute, Suppurative 3 (6%) 2 (4%) 3 (6%)
Mediastinum, Inflammation, Subacute 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 4 (8%) 5 (10%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
Hyperplasia, Melanocyte 1 (100%)
Harderian Gland (1) (1) (2)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Fibrosis, Focal 3 (6%) 2 (4%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 2 (4%)
Nephropathy, Chronic 24 (48%) 33 (66%) 33 (66%) 35 (70%)
Renal Tubule, Degeneration, Multifocal 1 (2%)
Renal Tubule, Dilatation, Multifocal 1 (2%) 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin,
Multifocal 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Infiltration Cellular, Multifocal, Lymphocyte 7 (14%) 8 (16%) 9 (18%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Dead 9 12 13 8
Moribund 6 8 12 8
Natural Death 1
Accident 1
Accidently Killed 5
Dosing Accident 2
Survivors
Terminal Sacrifice 35 28 24 27
Missing 1
Animals Examined Microscopically 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (49) (50)
Foreign Body 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Intestine Large, Cecum (49) (47) (49) (46)
Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (47) (46) (47) (45)
Perforation 1 (2%)
Liver (50) (50) (49) (50)
Angiectasis, Focal 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Congestion 1 (2%)
Developmental Malformation 1 (2%)
Embolus Tumor 1 (2%)
Fibrosis, Focal 1 (2%)
Focal Cellular Change 3 (6%) 7 (14%) 4 (8%) 5 (10%)
Focal Cellular Change, Multiple 1 (2%) 1 (2%)
Granuloma, Multiple 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Inclusion Body Intranuclear 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 2 (4%) 4 (8%) 1 (2%)
Mineralization, Focal 1 (2%) 1 (2%)
Necrosis, Focal 2 (4%) 2 (4%)
Necrosis, Multifocal 1 (2%) 2 (4%) 7 (14%) 8 (16%)
Pigmentation, Hematoidin 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%)
Biliary Tract, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Biliary Tract, Cyst Multilocular 3 (6%)
Biliary Tract, Dilatation 1 (2%) 1 (2%)
Biliary Tract, Proliferation 1 (2%)
Biliary Tract, Subserosa, Hyperplasia,
Multifocal 3 (6%) 2 (4%)
Centrilobular, Vacuolization Cytoplasmic,
Diffuse 1 (2%)
Kupffer Cell, Pigmentation, Multifocal 2 (4%)
Serosa, Subserosa, Inflammation, Chronic,
Multifocal 8 (16%) 18 (36%)
Serosa, Subserosa, Pigmentation, Multifocal 8 (16%) 18 (36%)
Sinusoid, Infiltration Cellular,
Polymorphonuclear 2 (4%) 1 (2%)
Mesentery (4) (3) (5) (5)
Inflammation, Granulomatous, Multifocal 1 (25%)
Fat, Necrosis, Focal 2 (50%) 2 (67%) 2 (40%) 4 (80%)
Pancreas (50) (50) (49) (49)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Necrosis, Multifocal 1 (2%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Acinus, Atrophy, Multifocal 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (50) (49) (50)
Infiltration Cellular, Multifocal, Lymphocyte 28 (56%) 21 (42%) 21 (43%) 24 (48%)
Inflammation, Acute, Focal, Suppurative 1 (2%)
Stomach, Forestomach (50) (49) (49) (49)
Erosion 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Hyperplasia 5 (10%) 2 (4%) 8 (16%) 6 (12%)
Inflammation, Subacute 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
Ulcer, Multiple 1 (2%) 1 (2%)
Stomach, Glandular (50) (49) (49) (49)
Erosion, Multiple 1 (2%)
Inflammation, Subacute 3 (6%) 1 (2%) 1 (2%)
Mineralization 5 (10%) 3 (6%) 2 (4%) 3 (6%)
Ulcer 1 (2%)
Tooth (27) (21) (15) (19)
Dysplasia 27 (100%) 20 (95%) 15 (100%) 19 (100%)
Inflammation, Subacute 1 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Fibrosis, Focal 1 (2%)
Inflammation, Focal, Subacute 1 (2%) 4 (8%)
Inflammation, Multifocal, Subacute 1 (2%)
Mineralization, Multifocal 1 (2%)
Atrium, Thrombosis 1 (2%)
Endothelium, Hyperplasia 1 (2%)
Pericardium, Fibrosis 1 (2%)
Pericardium, Inflammation, Subacute 1 (2%)
Valve, Bacterium 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49) (50)
Cyst 1 (2%)
Hyperplasia, Focal 7 (14%) 4 (8%) 3 (6%) 5 (10%)
Hypertrophy, Focal 2 (4%) 3 (6%) 2 (4%)
Capsule, Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Spindle Cell, Hyperplasia, Focal 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Adrenal Gland, Medulla (50) (50) (48) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 5 (10%) 4 (8%) 7 (15%) 6 (12%)
Islets, Pancreatic (50) (48) (49) (49)
Hyperplasia 14 (28%) 21 (44%) 15 (31%) 12 (24%)
Pigmentation, Hemosiderin 1 (2%)
Parathyroid Gland (43) (43) (47) (44)
Cyst 1 (2%)
Pituitary Gland (47) (45) (46) (49)
Pars Distalis, Cyst 2 (4%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 2 (4%) 2 (4%)
Pars Nervosa, Fibrosis 1 (2%)
Thyroid Gland (49) (50) (48) (50)
Ultimobranchial Cyst 1 (2%) 2 (4%)
Follicle, Cyst 6 (12%) 1 (2%) 2 (4%) 3 (6%)
Follicle, Degeneration, Cystic 17 (35%) 15 (30%) 14 (29%) 14 (28%)
Follicular Cell, Hyperplasia, Cystic, Focal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4) (5) (2) (2)
Dilatation 4 (100%) 5 (100%) 2 (100%) 1 (50%)
Inflammation, Chronic 1 (50%)
Inflammation, Subacute 1 (20%)
Epididymis (50) (50) (49) (50)
Fibrosis, Focal 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 3 (6%)
Pigmentation, Focal, Cholesterol 1 (2%)
Preputial Gland (9) (10) (14) (8)
Hyperplasia 1 (10%)
Inflammation, Subacute 7 (78%) 8 (80%) 12 (86%) 6 (75%)
Duct, Cyst 3 (33%) 8 (80%) 12 (86%) 5 (63%)
Duct, Hyperplasia 1 (7%)
Prostate (50) (50) (48) (49)
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%) 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (48) (50)
Atrophy 1 (2%)
Dilatation 7 (14%) 7 (14%) 6 (13%) 3 (6%)
Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Testes (50) (50) (49) (50)
Capsule, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2) (4) (1)
Leukocytosis 1 (100%) 2 (100%) 3 (75%) 1 (100%)
Polychromasia 2 (100%) 2 (50%)
Bone Marrow (50) (49) (49) (50)
Hyperplasia 10 (20%) 7 (14%) 10 (20%) 8 (16%)
Necrosis 1 (2%)
Lymph Node (50) (50) (49) (50)
Hyperplasia, Lymphoid 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Lymphoid 2 (4%) 4 (8%) 2 (4%)
Inguinal, Inflammation, Subacute 1 (2%)
Inguinal, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Angiectasis 2 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Renal, Angiectasis 1 (2%)
Lymph Node, Mandibular (44) (46) (47) (48)
Ectasia 1 (2%)
Hyperplasia, Lymphoid 3 (7%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 3 (6%)
Lymph Node, Mesenteric (49) (45) (49) (50)
Angiectasis 15 (31%) 18 (40%) 17 (35%) 12 (24%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 3 (6%)
Hyperplasia, Lymphoid 10 (20%) 8 (18%) 7 (14%) 10 (20%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Spleen (50) (50) (48) (49)
Atrophy 2 (4%) 3 (6%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 19 (38%) 18 (38%) 12 (24%)
Hyperplasia, Lymphoid 16 (32%) 14 (28%) 13 (27%) 16 (33%)
Necrosis 3 (6%)
Thymus (47) (42) (44) (45)
Atrophy 7 (17%) 1 (2%)
Cyst 7 (15%) 2 (5%) 8 (18%) 2 (4%)
Necrosis 4 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50)
Alopecia, Focal 3 (6%) 1 (2%)
Fibrosis, Multifocal 1 (2%)
Ulcer, Focal 1 (2%) 2 (4%)
Epidermis, Hyperplasia, Focal 5 (10%) 5 (10%) 8 (16%) 1 (2%)
Epidermis, Inflammation, Acute, Focal,
Suppurative 1 (2%) 2 (4%)
Prepuce, Developmental Malformation 2 (4%)
Sebaceous Gland, Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Cyst 2 (4%)
Subcutaneous Tissue, Edema, Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 12 (24%) 5 (10%) 8 (16%) 10 (20%)
Subcutaneous Tissue, Hemorrhage, Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Acute,
Focal, Suppurative 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Focal,
Subacute 3 (6%) 3 (6%)
Subcutaneous Tissue, Inflammation,
Granulomatous, Multifocal 1 (2%)
Subcutaneous Tissue, Metaplasia, Focal,
Osseous 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Mineralization, Focal 1 (2%)
Subcutaneous Tissue, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (49) (50)
Arthrosis, Chronic 6 (12%) 1 (2%) 2 (4%) 1 (2%)
Fracture 1 (2%)
Skeletal Muscle (1) (3) (2) (1)
Abdominal, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (49) (50)
Degeneration, Focal 1 (2%)
Edema, Focal 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Meninges, Infiltration Cellular, Multifocal,
Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Congestion 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 4 (8%) 4 (8%) 4 (8%) 6 (12%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Mediastinum, Foreign Body 2 (4%)
Mediastinum, Inflammation, Chronic 1 (2%)
Mediastinum, Inflammation, Focal, Subacute 1 (2%)
Nose (49) (50) (49) (50)
Inflammation, Acute, Suppurative 1 (2%) 4 (8%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Exudate 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%) 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Bacterium, Multifocal 1 (2%)
Fibrosis, Focal 2 (4%) 4 (8%) 3 (6%) 2 (4%)
Infiltration Cellular, Multifocal, Lymphocyte 25 (50%) 19 (38%) 25 (51%) 23 (46%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 1 (2%) 1 (2%)
Nephropathy, Chronic 37 (74%) 39 (78%) 37 (76%) 36 (72%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%) 1 (2%)
Renal Tubule, Necrosis, Multifocal 1 (2%) 1 (2%)
Urinary Bladder (49) (50) (49) (49)
Inflammation, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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