TR 382 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 08 TIME: 06:59:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 08 TIME: 06:59:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 08 TIME: 06:59:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURFURAL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin: Subcutaneous Tissue Fibrosarcoma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
All Organs Malignant Tumors
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 2/48 (4%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.7% 15.8% 8.3% 3.7% | 3.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/35 (6%) 2/28 (7%) 2/24 (8%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 682 729 (T) 729 (T) | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.322N P=0.151 P=0.553 P=0.591N | P=0.254N P=0.533N P=0.526N P=0.506N |
|INCIDENTAL TUMOR | P=0.268N P=0.278 P=0.553 P=0.591N | P=0.254N P=0.533N P=0.526N P=0.506N |
|LOGISTIC REGRESSION | P=0.282N P=0.181 P=0.553 P=0.591N | P=0.254N P=0.533N P=0.526N P=0.506N |
|COCHRAN-ARMITAGE | P=0.228N | P=0.248N |
|FISHER EXACT | P=0.218 P=0.676 P=0.500N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 2/48 (4%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.6% 15.8% 8.3% 3.7% | 3.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/35 (9%) 2/28 (7%) 2/24 (8%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 682 729 (T) 729 (T) | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.214N P=0.258 P=0.670N P=0.401N | P=0.254N P=0.533N P=0.526N P=0.506N |
|INCIDENTAL TUMOR | P=0.171N P=0.416 P=0.670N P=0.401N | P=0.254N P=0.533N P=0.526N P=0.506N |
|LOGISTIC REGRESSION | P=0.179N P=0.304 P=0.670N P=0.401N | P=0.254N P=0.533N P=0.526N P=0.506N |
|COCHRAN-ARMITAGE | P=0.136N | P=0.248N |
|FISHER EXACT | P=0.357 P=0.520N P=0.309N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/49 (4%) 0/49 (0%) 1/50 (2%) | 1/50 (2%) 1/49 (2%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 6.7% 0.0% 3.2% | 3.0% 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/35 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) | 1/33 (3%) 0/27 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 703 697 --- 696 | 729 (T) 630 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.514N P=0.423 P=0.563N P=0.717 | P=0.212N P=0.732 P=0.526N P=0.506N |
|INCIDENTAL TUMOR | P=0.368N P=0.746 P=0.383N P=0.659N | P=0.161N P=0.680 P=0.526N P=0.506N |
|LOGISTIC REGRESSION | P=0.491N P=0.480 P=0.520N P=0.741 | P=0.204N P=0.752 P=0.526N P=0.506N |
|COCHRAN-ARMITAGE | P=0.458N | P=0.204N |
|FISHER EXACT | P=0.492 P=0.505N P=0.753N | P=0.747 P=0.505N P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/49 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 7.1% 3.3% 3.3% | 0.0% 0.0% 0.0% 5.6% |
|TERMINAL (d) | 0/35 (0%) 2/28 (7%) 0/24 (0%) 0/27 (0%) | 0/33 (0%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 688 724 | --- --- --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.402 P=0.190 P=0.458 P=0.469 | P=0.054 (e) (e) P=0.236 |
|INCIDENTAL TUMOR | P=0.459 P=0.190 P=0.617 P=0.594 | P=0.089 (e) (e) P=0.299 |
|LOGISTIC REGRESSION | P=0.419 P=0.190 P=0.489 P=0.469 | P=0.051 (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.460 | P=0.050 * |
|FISHER EXACT | P=0.247 P=0.495 P=0.500 | (e) (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/49 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 7.1% 7.4% 3.3% | 0.0% 3.1% 0.0% 5.6% |
|TERMINAL (d) | 0/35 (0%) 2/28 (7%) 1/24 (4%) 0/27 (0%) | 0/33 (0%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 688 724 | --- 704 --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.346 P=0.190 P=0.178 P=0.469 | P=0.147 P=0.494 (e) P=0.236 |
|INCIDENTAL TUMOR | P=0.392 P=0.190 P=0.256 P=0.594 | P=0.173 P=0.594 (e) P=0.299 |
|LOGISTIC REGRESSION | P=0.365 P=0.190 P=0.208 P=0.469 | P=0.146 P=0.488 (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.412 | P=0.143 |
|FISHER EXACT | P=0.247 P=0.242 P=0.500 | P=0.500 (e) P=0.247 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 3/49 (6%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 14.5% 10.7% 0.0% | 2.8% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/35 (3%) 1/28 (4%) 2/24 (8%) 0/27 (0%) | 0/33 (0%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 703 491 617 --- | 662 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.197N P=0.164 P=0.367 P=0.293N | P=0.255N P=0.511N P=0.511N P=0.511N |
|INCIDENTAL TUMOR | P=0.114N P=0.338 P=0.550 P=0.214N | P=0.263N P=0.406N P=0.464N P=0.545N |
|LOGISTIC REGRESSION | P=0.146N P=0.209 P=0.458 P=0.266N | P=0.248N P=0.501N P=0.500N P=0.501N |
|COCHRAN-ARMITAGE | P=0.130N | P=0.248N |
|FISHER EXACT | P=0.218 P=0.490 P=0.247N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 13/50 (26%) 11/49 (22%) 19/50 (38%) | 1/50 (2%) 3/50 (6%) 5/50 (10%) 8/50 (16%) |
|ADJUSTED (b) | 24.7% 38.8% 36.4% 56.7% | 3.0% 10.7% 14.9% 22.8% |
|TERMINAL (d) | 8/35 (23%) 9/28 (32%) 6/24 (25%) 13/27 (48%) | 1/33 (3%) 3/28 (11%) 3/29 (10%) 6/32 (19%) |
|FIRST INCIDENCE (DAYS) | 611 491 571 563 | 729 (T) 729 (T) 493 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.116 P=0.153 P=0.004 ** | P=0.008 ** P=0.247 P=0.087 P=0.017 * |
|INCIDENTAL TUMOR | P=0.008 ** P=0.153 P=0.358 P=0.010 ** | P=0.009 ** P=0.247 P=0.108 P=0.025 * |
|LOGISTIC REGRESSION | P=0.008 ** P=0.201 P=0.292 P=0.008 ** | P=0.007 ** P=0.247 P=0.100 P=0.017 * |
|COCHRAN-ARMITAGE | P=0.021 * | P=0.007 ** |
|FISHER EXACT | P=0.235 P=0.382 P=0.022 * | P=0.309 P=0.102 P=0.015 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 12/50 (24%) 6/49 (12%) 21/50 (42%) | 4/50 (8%) 0/50 (0%) 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 17.4% 31.5% 18.2% 52.7% | 12.1% 0.0% 6.1% 11.4% |
|TERMINAL (d) | 4/35 (11%) 5/28 (18%) 2/24 (8%) 9/27 (33%) | 4/33 (12%) 0/28 (0%) 1/29 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 456 433 620 456 | 729 (T) --- 611 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.107 P=0.562 P<0.001 ** | P=0.403 P=0.085N P=0.398N P=0.632 |
|INCIDENTAL TUMOR | P=0.001 ** P=0.166 P=0.274N P=0.002 ** | P=0.477 P=0.085N P=0.388N P=0.620N |
|LOGISTIC REGRESSION | P=0.001 ** P=0.157 P=0.297N P=0.001 ** | P=0.402 P=0.085N P=0.366N P=0.640 |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.400 |
|FISHER EXACT | P=0.154 P=0.516N P=0.002 ** | P=0.059N P=0.339N P=0.643N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 12/50 (24%) 6/49 (12%) 21/50 (42%) | 4/50 (8%) 0/50 (0%) 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 17.4% 31.5% 18.2% 52.7% | 12.1% 0.0% 6.1% 11.4% |
|TERMINAL (d) | 4/35 (11%) 5/28 (18%) 2/24 (8%) 9/27 (33%) | 4/33 (12%) 0/28 (0%) 1/29 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 456 433 620 456 | 729 (T) --- 611 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.107 P=0.562 P<0.001 ** | P=0.403 P=0.085N P=0.398N P=0.632 |
|INCIDENTAL TUMOR | P=0.001 ** P=0.166 P=0.274N P=0.002 ** | P=0.477 P=0.085N P=0.388N P=0.620N |
|LOGISTIC REGRESSION | P=0.001 ** P=0.157 P=0.297N P=0.001 ** | P=0.402 P=0.085N P=0.366N P=0.640 |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.400 |
|FISHER EXACT | P=0.154 P=0.516N P=0.002 ** | P=0.059N P=0.339N P=0.643N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 22/50 (44%) 17/49 (35%) 32/50 (64%) | 5/50 (10%) 3/50 (6%) 7/50 (14%) 12/50 (24%) |
|ADJUSTED (b) | 40.2% 57.5% 49.5% 75.9% | 15.2% 10.7% 20.5% 33.2% |
|TERMINAL (d) | 12/35 (34%) 13/28 (46%) 8/24 (33%) 17/27 (63%) | 5/33 (15%) 3/28 (11%) 4/29 (14%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 456 433 571 456 | 729 (T) 729 (T) 493 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.064 P=0.183 P<0.001 ** | P=0.012 * P=0.448N P=0.306 P=0.050 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.103 P=0.548N P<0.001 ** | P=0.019 * P=0.448N P=0.347 P=0.072 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.136 P=0.431 P<0.001 ** | P=0.011 * P=0.448N P=0.352 P=0.051 |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.011 * |
|FISHER EXACT | P=0.151 P=0.472 P=0.001 ** | P=0.357N P=0.380 P=0.054 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 22/50 (44%) 17/49 (35%) 32/50 (64%) | 5/50 (10%) 3/50 (6%) 7/50 (14%) 12/50 (24%) |
|ADJUSTED (b) | 40.2% 57.5% 49.5% 75.9% | 15.2% 10.7% 20.5% 33.2% |
|TERMINAL (d) | 12/35 (34%) 13/28 (46%) 8/24 (33%) 17/27 (63%) | 5/33 (15%) 3/28 (11%) 4/29 (14%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 456 433 571 456 | 729 (T) 729 (T) 493 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.064 P=0.183 P<0.001 ** | P=0.012 * P=0.448N P=0.306 P=0.050 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.103 P=0.548N P<0.001 ** | P=0.019 * P=0.448N P=0.347 P=0.072 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.136 P=0.431 P<0.001 ** | P=0.011 * P=0.448N P=0.352 P=0.051 |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.011 * |
|FISHER EXACT | P=0.151 P=0.472 P=0.001 ** | P=0.357N P=0.380 P=0.054 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 3/50 (6%) 2/49 (4%) 8/50 (16%) | 3/50 (6%) 1/50 (2%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 24.8% 9.7% 8.3% 26.7% | 9.1% 3.6% 3.4% 9.4% |
|TERMINAL (d) | 8/35 (23%) 2/28 (7%) 2/24 (8%) 6/27 (22%) | 3/33 (9%) 1/28 (4%) 1/29 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 666 668 729 (T) 576 | 729 (T) 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423 P=0.118N P=0.092N P=0.496 | P=0.525 P=0.365N P=0.352N P=0.650 |
|INCIDENTAL TUMOR | P=0.484 P=0.076N P=0.071N P=0.597 | P=0.525 P=0.365N P=0.352N P=0.650 |
|LOGISTIC REGRESSION | P=0.505 P=0.085N P=0.060N P=0.601 | P=0.525 P=0.365N P=0.352N P=0.650 |
|COCHRAN-ARMITAGE | P=0.502N | P=0.528 |
|FISHER EXACT | P=0.061N P=0.028N* P=0.500N | P=0.309N P=0.309N P=0.661N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 3/49 (6%) 6/50 (12%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 15.2% 10.6% 20.1% | 5.3% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 2/35 (6%) 3/28 (11%) 2/24 (8%) 4/27 (15%) | 0/33 (0%) 1/28 (4%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 719 433 599 662 | 620 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.150 P=0.264 P=0.505 P=0.148 | P=0.088N P=0.535N P=0.268N P=0.252N |
|INCIDENTAL TUMOR | P=0.193 P=0.355 P=0.656N P=0.228 | P=0.066N P=0.524N P=0.220N P=0.197N |
|LOGISTIC REGRESSION | P=0.191 P=0.342 P=0.614 P=0.174 | P=0.080N P=0.511N P=0.237N P=0.238N |
|COCHRAN-ARMITAGE | P=0.238 | P=0.079N |
|FISHER EXACT | P=0.357 P=0.651 P=0.243 | P=0.500N P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 8/50 (16%) 5/49 (10%) 13/50 (26%) | 5/50 (10%) 2/50 (4%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 26.9% 24.1% 18.8% 41.1% | 13.9% 7.1% 3.4% 9.4% |
|TERMINAL (d) | 8/35 (23%) 5/28 (18%) 4/24 (17%) 9/27 (33%) | 3/33 (9%) 2/28 (7%) 1/29 (3%) 3/32 (9%) |
|FIRST INCIDENCE (DAYS) | 666 433 599 576 | 620 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 P=0.570N P=0.343N P=0.137 | P=0.274N P=0.277N P=0.138N P=0.378N |
|INCIDENTAL TUMOR | P=0.179 P=0.418N P=0.201N P=0.246 | P=0.250N P=0.269N P=0.119N P=0.346N |
|LOGISTIC REGRESSION | P=0.184 P=0.442N P=0.210N P=0.197 | P=0.270N P=0.241N P=0.116N P=0.363N |
|COCHRAN-ARMITAGE | P=0.271 | P=0.264N |
|FISHER EXACT | P=0.398N P=0.140N P=0.318 | P=0.218N P=0.102N P=0.357N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/48 (4%) 1/49 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | | 6.5% 3.6% 0.0% 3.1% |
|TERMINAL (d) | | 2/31 (6%) 1/28 (4%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.301N P=0.536N P=0.253N P=0.489N |
|INCIDENTAL TUMOR | | P=0.301N P=0.536N P=0.253N P=0.489N |
|LOGISTIC REGRESSION | | P=0.301N P=0.536N P=0.253N P=0.489N |
|COCHRAN-ARMITAGE | | P=0.300N |
|FISHER EXACT | | P=0.492N P=0.237N P=0.485N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/45 (0%) 0/46 (0%) 2/49 (4%) | 7/46 (15%) 3/49 (6%) 4/49 (8%) 9/49 (18%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 5.9% | 22.6% 10.3% 13.8% 27.8% |
|TERMINAL (d) | 0/33 (0%) 0/27 (0%) 0/23 (0%) 1/27 (4%) | 7/31 (23%) 2/27 (7%) 4/29 (14%) 8/31 (26%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 464 | 729 (T) 704 729 (T) 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045 * (e) (e) P=0.213 | P=0.240 P=0.211N P=0.294N P=0.386 |
|INCIDENTAL TUMOR | P=0.046 * (e) (e) P=0.195 | P=0.260 P=0.187N P=0.294N P=0.431 |
|LOGISTIC REGRESSION | P=0.063 (e) (e) P=0.261 | P=0.224 P=0.173N P=0.294N P=0.385 |
|COCHRAN-ARMITAGE | P=0.054 | P=0.256 |
|FISHER EXACT | (e) (e) P=0.258 | P=0.134N P=0.226N P=0.447 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 0.0% 0.0% 7.4% | 0.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 0/35 (0%) 0/28 (0%) 0/24 (0%) 2/27 (7%) | 0/33 (0%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 456 --- --- 729 (T) | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231 P=0.504N P=0.509N P=0.433 | P=0.197 (e) (e) P=0.494 |
|INCIDENTAL TUMOR | P=0.225 P=0.545N P=0.500N P=0.415 | P=0.197 (e) (e) P=0.494 |
|LOGISTIC REGRESSION | P=0.269 P=0.481N P=0.540N P=0.499 | P=0.197 (e) (e) P=0.494 |
|COCHRAN-ARMITAGE | P=0.268 | P=0.191 |
|FISHER EXACT | P=0.500N P=0.505N P=0.500 | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/49 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 7.1% 0.0% 7.4% | 3.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 0/35 (0%) 2/28 (7%) 0/24 (0%) 2/27 (7%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 456 729 (T) --- 729 (T) | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410 P=0.446 P=0.509N P=0.433 | P=0.604 P=0.533N P=0.526N P=0.755 |
|INCIDENTAL TUMOR | P=0.405 P=0.423 P=0.500N P=0.415 | P=0.604 P=0.533N P=0.526N P=0.755 |
|LOGISTIC REGRESSION | P=0.464 P=0.504 P=0.540N P=0.499 | P=0.604 P=0.533N P=0.526N P=0.757 |
|COCHRAN-ARMITAGE | P=0.483 | P=0.608 |
|FISHER EXACT | P=0.500 P=0.505N P=0.500 | P=0.500N P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/49 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.1% 0.0% 0.0% | 3.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/35 (0%) 2/28 (7%) 0/24 (0%) 0/27 (0%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.190 (e) (e) | P=0.254N P=0.533N P=0.526N P=0.506N |
|INCIDENTAL TUMOR | P=0.445N P=0.190 (e) (e) | P=0.254N P=0.533N P=0.526N P=0.506N |
|LOGISTIC REGRESSION | P=0.445N P=0.190 (e) (e) | P=0.254N P=0.533N P=0.526N P=0.506N |
|COCHRAN-ARMITAGE | P=0.390N | P=0.248N |
|FISHER EXACT | P=0.247 (e) (e) | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/49 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.1% 10.7% 4.2% 7.4% | 3.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 0/35 (0%) 3/28 (11%) 1/24 (4%) 2/27 (7%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 456 729 (T) 729 (T) 729 (T) | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.422 P=0.247 P=0.714 P=0.433 | P=0.604 P=0.533N P=0.526N P=0.755 |
|INCIDENTAL TUMOR | P=0.417 P=0.231 P=0.719 P=0.415 | P=0.604 P=0.533N P=0.526N P=0.755 |
|LOGISTIC REGRESSION | P=0.481 P=0.303 P=0.756 P=0.499 | P=0.604 P=0.533N P=0.526N P=0.757 |
|COCHRAN-ARMITAGE | P=0.514 | P=0.608 |
|FISHER EXACT | P=0.309 P=0.747 P=0.500 | P=0.500N P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 2/49 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.6% 3.6% 8.3% 3.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/35 (9%) 1/28 (4%) 2/24 (8%) 1/27 (4%) | 0/33 (0%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.361N P=0.387N P=0.670N P=0.401N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.361N P=0.387N P=0.670N P=0.401N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.361N P=0.387N P=0.670N P=0.401N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.266N | (e) |
|FISHER EXACT | P=0.309N P=0.510N P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 10/49 (20%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 7.6% 18.4% 25.2% 5.9% | 5.2% 0.0% 2.9% 5.7% |
|TERMINAL (d) | 1/35 (3%) 3/28 (11%) 1/24 (4%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 611 609 459 464 | 492 --- 648 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.509 P=0.179 P=0.026 * P=0.579N | P=0.480 P=0.271N P=0.524N P=0.686 |
|INCIDENTAL TUMOR | P=0.390N P=0.366 P=0.197 P=0.480N | P=0.493 P=0.212N P=0.448N P=0.685N |
|LOGISTIC REGRESSION | P=0.432N P=0.228 P=0.154 P=0.502N | P=0.478 P=0.231N P=0.501N P=0.691 |
|COCHRAN-ARMITAGE | P=0.478N | P=0.481 |
|FISHER EXACT | P=0.243 P=0.033 * P=0.500N | P=0.247N P=0.500N P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/49 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 3.6% 2.1% 3.2% | 3.0% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 1/35 (3%) 1/28 (4%) 0/24 (0%) 0/27 (0%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 703 729 (T) 403 696 | 729 (T) --- --- 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.444N P=0.580N P=0.579N P=0.574N | P=0.603 P=0.533N P=0.526N P=0.757 |
|INCIDENTAL TUMOR | P=0.388N P=0.474N P=0.477N P=0.420N | P=0.622N P=0.533N P=0.526N P=0.701N |
|LOGISTIC REGRESSION | P=0.385N P=0.543N P=0.508N P=0.541N | P=0.608 P=0.533N P=0.526N P=0.762N |
|COCHRAN-ARMITAGE | P=0.381N | P=0.608 |
|FISHER EXACT | P=0.500N P=0.508N P=0.500N | P=0.500N P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 7/50 (14%) 13/49 (27%) 3/50 (6%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 13.0% 21.6% 34.9% 9.6% | 5.2% 0.0% 2.9% 5.7% |
|TERMINAL (d) | 3/35 (9%) 4/28 (14%) 4/24 (17%) 2/27 (7%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 611 609 459 464 | 492 --- 648 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.506 P=0.270 P=0.016 * P=0.475N | P=0.480 P=0.271N P=0.524N P=0.686 |
|INCIDENTAL TUMOR | P=0.409N P=0.465 P=0.108 P=0.395N | P=0.493 P=0.212N P=0.448N P=0.685N |
|LOGISTIC REGRESSION | P=0.427N P=0.350 P=0.102 P=0.387N | P=0.478 P=0.231N P=0.501N P=0.691 |
|COCHRAN-ARMITAGE | P=0.428N | P=0.481 |
|FISHER EXACT | P=0.380 P=0.030 * P=0.357N | P=0.247N P=0.500N P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) 11/49 (22%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 7.6% 18.4% 28.4% 5.9% | 5.2% 0.0% 2.9% 5.7% |
|TERMINAL (d) | 1/35 (3%) 3/28 (11%) 2/24 (8%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 611 609 459 464 | 492 --- 648 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.476 P=0.179 P=0.014 * P=0.579N | P=0.480 P=0.271N P=0.524N P=0.686 |
|INCIDENTAL TUMOR | P=0.430N P=0.366 P=0.117 P=0.480N | P=0.493 P=0.212N P=0.448N P=0.685N |
|LOGISTIC REGRESSION | P=0.469N P=0.228 P=0.091 P=0.502N | P=0.478 P=0.231N P=0.501N P=0.691 |
|COCHRAN-ARMITAGE | P=0.505N | P=0.481 |
|FISHER EXACT | P=0.243 P=0.018 * P=0.500N | P=0.247N P=0.500N P=0.691N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/48 (0%) 0/49 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 6.8% 0.0% 0.0% | 3.0% 2.6% 0.0% 2.4% |
|TERMINAL (d) | 1/35 (3%) 1/28 (4%) 0/24 (0%) 0/27 (0%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 703 697 --- --- | 729 (T) 630 --- 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105N P=0.610 P=0.319N P=0.293N | P=0.567N P=0.736 P=0.526N P=0.757 |
|INCIDENTAL TUMOR | P=0.067N P=0.615N P=0.212N P=0.214N | P=0.427N P=0.685 P=0.526N P=0.701N |
|LOGISTIC REGRESSION | P=0.087N P=0.664 P=0.275N P=0.266N | P=0.566N P=0.757 P=0.526N P=0.762N |
|COCHRAN-ARMITAGE | P=0.074N | P=0.565N |
|FISHER EXACT | P=0.691N P=0.258N P=0.253N | P=0.753N P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/49 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% 3.7% | 3.0% 0.0% 2.4% 15.4% |
|TERMINAL (d) | 1/35 (3%) 0/28 (0%) 0/24 (0%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 719 --- --- 729 (T) | 729 (T) --- 523 596 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.452N P=0.293N P=0.329N P=0.581N | P=0.006 ** P=0.533N P=0.741 P=0.061 |
|INCIDENTAL TUMOR | P=0.411N P=0.186N P=0.212N P=0.506N | P=0.015 * P=0.533N P=0.732N P=0.113 |
|LOGISTIC REGRESSION | P=0.432N P=0.270N P=0.293N P=0.557N | P=0.005 ** P=0.533N P=0.763 P=0.058 |
|COCHRAN-ARMITAGE | P=0.390N | P=0.005 ** |
|FISHER EXACT | P=0.247N P=0.253N P=0.500N | P=0.500N P=0.753N P=0.056 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/49 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% 3.7% | 3.0% 0.0% 2.4% 15.4% |
|TERMINAL (d) | 1/35 (3%) 0/28 (0%) 0/24 (0%) 1/27 (4%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 729 (T) | 729 (T) --- 523 596 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.551 P=0.545N P=0.575N P=0.703 | P=0.006 ** P=0.533N P=0.741 P=0.061 |
|INCIDENTAL TUMOR | P=0.551 P=0.545N P=0.575N P=0.703 | P=0.015 * P=0.533N P=0.732N P=0.113 |
|LOGISTIC REGRESSION | P=0.551 P=0.545N P=0.575N P=0.703 | P=0.005 ** P=0.533N P=0.763 P=0.058 |
|COCHRAN-ARMITAGE | P=0.607 | P=0.005 ** |
|FISHER EXACT | P=0.500N P=0.505N P=0.753N | P=0.500N P=0.753N P=0.056 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/49 (4%) 0/50 (0%) | |
|ADJUSTED (b) | 2.9% 0.0% 7.9% 0.0% | |
|TERMINAL (d) | 1/35 (3%) 0/28 (0%) 1/24 (4%) 0/27 (0%) | |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 713 --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540N P=0.545N P=0.376 P=0.552N | |
|INCIDENTAL TUMOR | P=0.503N P=0.545N P=0.479 P=0.552N | |
|LOGISTIC REGRESSION | P=0.521N P=0.545N P=0.411 P=0.552N | |
|COCHRAN-ARMITAGE | P=0.480N | |
|FISHER EXACT | P=0.500N P=0.492 P=0.500N | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 0/48 (0%) 2/50 (4%) | 2/50 (4%) 1/50 (2%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 2.9% 0.0% 0.0% 7.0% | 6.1% 3.6% 13.8% 6.3% |
|TERMINAL (d) | 1/35 (3%) 0/28 (0%) 0/24 (0%) 1/27 (4%) | 2/33 (6%) 1/28 (4%) 4/29 (14%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 728 | 729 (T) 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225 P=0.545N P=0.575N P=0.419 | P=0.431 P=0.558N P=0.277 P=0.685 |
|INCIDENTAL TUMOR | P=0.248 P=0.545N P=0.575N P=0.494 | P=0.431 P=0.558N P=0.277 P=0.685 |
|LOGISTIC REGRESSION | P=0.236 P=0.545N P=0.575N P=0.436 | P=0.431 P=0.558N P=0.277 P=0.685 |
|COCHRAN-ARMITAGE | P=0.271 | P=0.430 |
|FISHER EXACT | P=0.495N P=0.505N P=0.508 | P=0.500N P=0.329 P=0.691N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 4/49 (8%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 19.6% 12.6% 3.2% | 5.7% 2.6% 0.0% 2.4% |
|TERMINAL (d) | 1/35 (3%) 2/28 (7%) 2/24 (8%) 0/27 (0%) | 1/33 (3%) 0/28 (0%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 703 491 403 696 | 662 630 --- 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.325N P=0.056 P=0.234 P=0.574N | P=0.322N P=0.531N P=0.260N P=0.510N |
|INCIDENTAL TUMOR | P=0.198N P=0.149 P=0.376 P=0.420N | P=0.233N P=0.524N P=0.233N P=0.463N |
|LOGISTIC REGRESSION | P=0.238N P=0.078 P=0.329 P=0.541N | P=0.311N P=0.506N P=0.246N P=0.500N |
|COCHRAN-ARMITAGE | P=0.228N | P=0.311N |
|FISHER EXACT | P=0.080 P=0.329 P=0.500N | P=0.500N P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 8/50 (16%) 4/49 (8%) 1/50 (2%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 7.6% 22.7% 12.6% 3.2% | 5.7% 6.1% 2.6% 2.4% |
|TERMINAL (d) | 1/35 (3%) 3/28 (11%) 2/24 (8%) 0/27 (0%) | 1/33 (3%) 1/28 (4%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 518 491 403 696 | 662 630 574 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204N P=0.070 P=0.386 P=0.376N | P=0.324N P=0.653 P=0.533N P=0.510N |
|INCIDENTAL TUMOR | P=0.111N P=0.155 P=0.542 P=0.263N | P=0.212N P=0.662 P=0.494N P=0.463N |
|LOGISTIC REGRESSION | P=0.129N P=0.098 P=0.491 P=0.318N | P=0.315N P=0.682 P=0.499N P=0.500N |
|COCHRAN-ARMITAGE | P=0.124N | P=0.314N |
|FISHER EXACT | P=0.100 P=0.489 P=0.309N | P=0.691N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/49 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.9% 0.0% | 0.0% 6.9% 0.0% 0.0% |
|TERMINAL (d) | 0/35 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) | 0/33 (0%) 1/28 (4%) 0/29 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 638 --- | --- 719 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.589 (e) P=0.468 (e) | P=0.393N P=0.208 (e) (e) |
|INCIDENTAL TUMOR | P=0.704 (e) P=0.739 (e) | P=0.418N P=0.271 (e) (e) |
|LOGISTIC REGRESSION | P=0.612 (e) P=0.497 (e) | P=0.395N P=0.220 (e) (e) |
|COCHRAN-ARMITAGE | P=0.610 | P=0.389N |
|FISHER EXACT | (e) P=0.495 (e) | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 8/49 (16%) 4/50 (8%) | 9/50 (18%) 15/50 (30%) 9/50 (18%) 8/50 (16%) |
|ADJUSTED (b) | 13.6% 6.1% 24.9% 13.1% | 23.7% 42.1% 31.0% 21.3% |
|TERMINAL (d) | 4/35 (11%) 1/28 (4%) 3/24 (13%) 2/27 (7%) | 5/33 (15%) 8/28 (29%) 9/29 (31%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 662 647 401 662 | 576 492 729 (T) 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.339 P=0.298N P=0.132 P=0.633N | P=0.272N P=0.081 P=0.491 P=0.521N |
|INCIDENTAL TUMOR | P=0.455 P=0.200N P=0.337 P=0.512N | P=0.228N P=0.110 P=0.539 P=0.482N |
|LOGISTIC REGRESSION | P=0.415 P=0.241N P=0.253 P=0.579N | P=0.247N P=0.058 P=0.546 P=0.498N |
|COCHRAN-ARMITAGE | P=0.466 | P=0.253N |
|FISHER EXACT | P=0.218N P=0.264 P=0.500N | P=0.121 P=0.602N P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 7/49 (14%) 4/50 (8%) | 9/50 (18%) 13/50 (26%) 9/50 (18%) 8/50 (16%) |
|ADJUSTED (b) | 13.6% 6.1% 22.6% 13.1% | 23.7% 37.1% 31.0% 21.3% |
|TERMINAL (d) | 4/35 (11%) 1/28 (4%) 3/24 (13%) 2/27 (7%) | 5/33 (15%) 7/28 (25%) 9/29 (31%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 662 647 401 662 | 576 492 729 (T) 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.365 P=0.298N P=0.201 P=0.633N | P=0.324N P=0.167 P=0.491 P=0.521N |
|INCIDENTAL TUMOR | P=0.467 P=0.200N P=0.387 P=0.512N | P=0.273N P=0.216 P=0.539 P=0.482N |
|LOGISTIC REGRESSION | P=0.442 P=0.241N P=0.351 P=0.579N | P=0.301N P=0.134 P=0.546 P=0.498N |
|COCHRAN-ARMITAGE | P=0.495 | P=0.307N |
|FISHER EXACT | P=0.218N P=0.365 P=0.500N | P=0.235 P=0.602N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 24/50 (48%) 20/49 (41%) 30/50 (60%) | 16/50 (32%) 14/50 (28%) 16/50 (32%) 23/50 (46%) |
|ADJUSTED (b) | 62.8% 67.8% 66.0% 83.1% | 47.1% 48.1% 45.6% 59.6% |
|TERMINAL (d) | 21/35 (60%) 17/28 (61%) 14/24 (58%) 21/27 (78%) | 15/33 (45%) 13/28 (46%) 11/29 (38%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 518 491 571 464 | 700 704 493 442 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016 * P=0.237 P=0.312 P=0.013 * | P=0.057 P=0.563 P=0.427 P=0.088 |
|INCIDENTAL TUMOR | P=0.030 * P=0.390 P=0.566N P=0.035 * | P=0.070 P=0.580N P=0.500 P=0.124 |
|LOGISTIC REGRESSION | P=0.041 * P=0.483 P=0.490N P=0.039 * | P=0.054 P=0.521N P=0.507 P=0.094 |
|COCHRAN-ARMITAGE | P=0.158 | P=0.059 |
|FISHER EXACT | P=0.579N P=0.303N P=0.158 | P=0.414N P=0.585N P=0.109 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50. 100. 175. | VEHICLE 50. 100. 175. |
| | CONTROL MG/KG MG/KG MG/KG | CONTROL MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 31/50 (62%) 27/49 (55%) 33/50 (66%) | 22/50 (44%) 20/50 (40%) 12/50 (24%) 16/50 (32%) |
|ADJUSTED (b) | 49.7% 68.7% 62.1% 78.4% | 52.1% 53.6% 38.1% 39.6% |
|TERMINAL (d) | 13/35 (37%) 14/28 (50%) 9/24 (38%) 18/27 (67%) | 13/33 (39%) 11/28 (39%) 10/29 (34%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 456 433 401 456 | 492 492 611 526 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014 * P=0.030 * P=0.061 P=0.007 ** | P=0.096N P=0.530 P=0.083N P=0.206N |
|INCIDENTAL TUMOR | P=0.022 * P=0.108 P=0.582 P=0.010 * | P=0.034N* P=0.479N P=0.037N* P=0.105N |
|LOGISTIC REGRESSION | P=0.015 * P=0.105 P=0.491 P=0.007 ** | P=0.031N* P=0.544 P=0.041N* P=0.092N |
|COCHRAN-ARMITAGE | P=0.036 * | P=0.067N |
|FISHER EXACT | P=0.054 P=0.183 P=0.022 * | P=0.420N P=0.028N* P=0.151N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 41/50 (82%) 42/49 (86%) 43/50 (86%) | 33/50 (66%) 26/50 (52%) 24/50 (48%) 31/50 (62%) |
|ADJUSTED (b) | 84.4% 89.1% 89.4% 97.7% | 78.5% 70.0% 67.7% 73.2% |
|TERMINAL (d) | 28/35 (80%) 23/28 (82%) 19/24 (79%) 26/27 (96%) | 24/33 (73%) 17/28 (61%) 18/29 (62%) 21/32 (66%) |
|FIRST INCIDENCE (DAYS) | 456 433 401 456 | 492 492 493 442 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018 * P=0.075 P=0.015 * P=0.014 * | P=0.434N P=0.358N P=0.190N P=0.488N |
|INCIDENTAL TUMOR | P=0.013 * P=0.289 P=0.384 P=0.012 * | P=0.280N P=0.191N P=0.081N P=0.341N |
|LOGISTIC REGRESSION | P=0.011 * P=0.232 P=0.292 P=0.013 * | P=0.312N P=0.173N P=0.071N P=0.405N |
|COCHRAN-ARMITAGE | P=0.109 | P=0.412N |
|FISHER EXACT | P=0.312 P=0.166 P=0.154 | P=0.111N P=0.053N P=0.418N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 08 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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