TR 383 Rat Pathology Tables
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
9 Month Stop Exposure with 6 Month Recovery
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: 25005 Interval Sacrifice
Removal Date Range: 10/10/84 - 11/09/84
Treatment Groups: Exclude 001 UNTREATED 71 UM
Exclude 002 0.2% 71LM
Exclude 003 0.5% 71MLM
Exclude 004 1.0% 71MHM
Exclude 006 SENTINELMALE
Exclude 007 UNTREATED 71UF
Exclude 008 0.2% 71LF
Exclude 009 0.5% 71MLF
Exclude 010 1.0% 71MHF
Exclude 012 SENTINEL FEMALE
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 2| 4| 2| 2| 4| 4| 4| 4| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
2.0% | 8| 8| 9| 9| 9| 0| 0| 3| 3| 3| 4| | L |
71HF | 1| 2| 1| 2| 4| 1| 2| 1| 2| 3| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + + | 10 |
Polyp Adenomatous, Multiple | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + | 11 |
Hepatocellular Carcinoma | X X X X X X X | 7 |
Hepatocellular Carcinoma, Multiple | X X X X | 4 |
Hepatocellular Adenoma | X X X | 3 |
Hepatocellular Adenoma, Multiple | X X X X X X | 6 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 11 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 2| 4| 2| 2| 4| 4| 4| 4| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
2.0% | 8| 8| 9| 9| 9| 0| 0| 3| 3| 3| 4| | L |
71HF | 1| 2| 1| 2| 4| 1| 2| 1| 2| 3| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + I + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M M + + + M M | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
Renal Tubule, Adenoma | X | 1 |
Renal Tubule, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 11 |
Carcinoma | X X X X | 4 |
Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 2| 4| 4| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 1| 1| 1| 1| 1| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 9 |
Polyp Adenomatous | X X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 9 |
Hepatocellular Carcinoma | X X X | 3 |
Hepatocellular Carcinoma, Multiple | X X X | 3 |
Hepatocellular Adenoma | X X X X | 4 |
Hepatocellular Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 9 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 9 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 9 |
Polyp Stromal | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 2| 4| 4| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 1| 1| 1| 1| 1| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M + M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 9 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 9 |
Renal Tubule, Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 9 |
Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 8| 7| 7| 7| 8| 6| 6| 7| 6| 8| 6| 7| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| | A |
2.0% | 3| 3| 3| 3| 5| 5| 5| 6| 6| 6| 8| 8| 9| 9| 0| 0| 0| | L |
71HM | 1| 2| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 1| 2| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 17 |
Adenocarcinoma | X | 1 |
Polyp Adenomatous | X X X X X X | 6 |
Polyp Adenomatous, Multiple | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 17 |
Hepatocellular Carcinoma | X X X X X X | 6 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X | 10 |
Hepatocellular Adenoma | X X | 2 |
Hepatocellular Adenoma, Multiple | X X X X X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 17 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + | 16 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 17 |
Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 7| 6| 8| 7| 7| 7| 8| 6| 6| 7| 6| 8| 6| 7| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| | A |
2.0% | 3| 3| 3| 3| 5| 5| 5| 6| 6| 6| 8| 8| 9| 9| 0| 0| 0| | L |
71HM | 1| 2| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 1| 2| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 17 |
Interstitial Cell, Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Thymus | + + + M + + M + + + M + + + M + + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M + M M M M + M + M M M | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + M | 16 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 17 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 17 |
Renal Tubule, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 17 |
Papilloma | X X X | 3 |
Squamous Cell Carcinoma | X | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 6| 8| 6| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 7 |
Polyp Adenomatous | X | 1 |
Polyp Adenomatous, Multiple | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Hepatocellular Carcinoma | X X X X | 4 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 7 |
Interstitial Cell, Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05061-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/23/97
Route: DOSED FEED Time: 18:13:52
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 6| 8| 6| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + M + + | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 7 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 7 |
Renal Tubule, Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
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