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https://ntp.niehs.nih.gov/go/1748

TR 383 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE


NTP Experiment-Test: 05061-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: DOSED FEED                                                                                                 Time: 14:37:37




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           50           70           70           30           10           
  Scheduled Sacrifice                                 20           10           10           20           21            9           
  Early Deaths                                                                                                                      
    Moribund                                           8            5           15           29            5            1           
    Dead                                               4            3            7            8            3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           32           38           12                                     
    Dead                                               1                                                                            
  Wrong Sex                                                                                   1            1                        
  Animals Examined Microscopically                    70           50           70           69           28           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (50)         (67)         (58)         (28)         (10)         
      Autolysis                                        1 (1%)                                                                       
   Intestine Large, Colon                             (69)         (50)         (69)         (57)         (28)         (10)         
      Autolysis                                        3 (4%)                    5 (7%)       3 (5%)                                
      Parasite Metazoan                               17 (25%)     13 (26%)      9 (13%)      7 (12%)                   1 (10%)     
      Lymphoid Tissue, Hemorrhage                                                             1 (2%)                                
   Intestine Large, Rectum                            (69)         (50)         (70)         (67)         (27)         (10)         
      Atypia Cellular                                               1 (2%)       6 (9%)                                             
      Autolysis                                        4 (6%)                    6 (9%)       1 (1%)                                
      Diverticulum                                                                            1 (1%)                                
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Acute, Necrotizing                                                        3 (4%)                                
      Parasite Metazoan                               12 (17%)      4 (8%)       9 (13%)      9 (13%)                   1 (10%)     
      Ulcer                                                                                   1 (1%)                                
      Epithelium, Hyperplasia                                                    3 (4%)                                             
   Intestine Large, Cecum                             (70)         (50)         (70)         (57)         (28)         (10)         
      Autolysis                                        4 (6%)       1 (2%)       6 (9%)       4 (7%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                                             1 (1%)                                             
      Parasite Metazoan                                6 (9%)       7 (14%)      5 (7%)       2 (4%)                    2 (20%)     
   Intestine Small, Duodenum                          (70)         (50)         (69)         (56)         (28)         (10)         
      Autolysis                                        2 (3%)                    5 (7%)       1 (2%)                                
   Intestine Small, Jejunum                           (68)         (50)         (69)         (56)         (27)         (10)         
      Autolysis                                        3 (4%)       1 (2%)       8 (12%)      3 (5%)                                
   Intestine Small, Ileum                             (69)         (49)         (69)         (54)         (28)         (10)         
      Autolysis                                        3 (4%)       1 (2%)       8 (12%)      4 (7%)                                
      Parasite Metazoan                                             1 (2%)                                                          
      Ulcer                                            1 (1%)                                                                       
   Liver                                              (70)         (50)         (70)         (68)         (28)         (10)         
      Abscess                                                                                 1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Angiectasis                                      1 (1%)       1 (2%)                                 2 (7%)                   
      Autolysis                                                                  4 (6%)                                             
      Basophilic Focus                                48 (69%)     15 (30%)     22 (31%)     26 (38%)     16 (57%)      6 (60%)     
      Clear Cell Focus                                 3 (4%)      28 (56%)     39 (56%)     23 (34%)     14 (50%)      5 (50%)     
      Cyst                                                                                                              1 (10%)     
      Cytomegaly                                                                                           2 (7%)       1 (10%)     
      Cytoplasmic Alteration                                                                                            1 (10%)     
      Degeneration                                                               3 (4%)                                             
      Developmental Malformation                                                              1 (1%)                                
      Eosinophilic Focus                               9 (13%)     23 (46%)     12 (17%)      1 (1%)       3 (11%)      2 (20%)     
      Fatty Change                                     8 (11%)                   4 (6%)      14 (21%)     17 (61%)                  
      Hematopoietic Cell Proliferation                                          10 (14%)      2 (3%)       1 (4%)                   
      Hemorrhage                                                                              1 (1%)                                
      Hepatodiaphragmatic Nodule                      10 (14%)      4 (8%)       1 (1%)       1 (1%)                                
      Hepatodiaphragmatic Nodule, Multiple             1 (1%)                                                                       
      Hyperplasia, Focal                                            1 (2%)                                                          
      Infarct                                          1 (1%)                                                                       
      Inflammation, Chronic, Granulomatous             6 (9%)                                 6 (9%)       1 (4%)       2 (20%)     
      Inflammation, Chronic Active                    24 (34%)     16 (32%)     23 (33%)      7 (10%)      1 (4%)                   
      Mixed Cell Focus                                 1 (1%)      11 (22%)      5 (7%)       4 (6%)       3 (11%)      2 (20%)     
      Necrosis, Coagulative                            4 (6%)       4 (8%)      11 (16%)     17 (25%)     12 (43%)                  
      Pigmentation                                     2 (3%)      21 (42%)     57 (81%)     61 (90%)     27 (96%)     10 (100%)    
      Thrombosis                                       1 (1%)                                 1 (1%)                                
      Bile Duct, Hyperplasia                          41 (59%)     10 (20%)     65 (93%)     55 (81%)     27 (96%)     10 (100%)    
      Centrilobular, Hemorrhage                        1 (1%)                                                                       
      Centrilobular, Necrosis, Coagulative             1 (1%)                                                                       
      Periportal, Inflammation, Chronic               10 (14%)                               10 (15%)     11 (39%)      9 (90%)     
      Periportal, Inflammation, Chronic Active        31 (44%)     12 (24%)     64 (91%)     47 (69%)     17 (61%)      1 (10%)     
   Mesentery                                          (4)          (6)          (1)          (5)          (1)                       
      Fibrosis                                         2 (50%)      5 (83%)      1 (100%)     1 (20%)                               
      Inflammation, Chronic                                                                   1 (20%)                               
      Inflammation, Chronic, Granulomatous                                                                 1 (100%)                 
      Inflammation, Chronic Active                     3 (75%)      3 (50%)      1 (100%)     1 (20%)                               
      Necrosis, Coagulative                            2 (50%)      5 (83%)      1 (100%)                  1 (100%)                 
      Pigmentation                                                                            1 (20%)                               
      Polyarteritis                                                 1 (17%)                   1 (20%)                               
   Pancreas                                           (70)         (50)         (70)         (58)         (28)         (10)         
      Atrophy                                         22 (31%)     19 (38%)     16 (23%)     15 (26%)      5 (18%)      3 (30%)     
      Autolysis                                        1 (1%)                    1 (1%)       1 (2%)                                
      Cytoplasmic Alteration                                        1 (2%)       2 (3%)       1 (2%)                                
      Ectopic Liver                                                              2 (3%)                                             
      Ectopic Tissue                                   2 (3%)       1 (2%)                                 1 (4%)                   
      Infiltration Cellular, Mononuclear Cell          3 (4%)       7 (14%)      1 (1%)       1 (2%)       4 (14%)                  
      Infiltration Cellular, Mixed Cell                                          1 (1%)                                             
      Inflammation, Chronic                            9 (13%)                                1 (2%)       6 (21%)      6 (60%)     
      Inflammation, Chronic Active                    29 (41%)     24 (48%)     30 (43%)     22 (38%)      2 (7%)                   
      Polyarteritis                                                 2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vacuolization Cytoplasmic                        5 (7%)                   12 (17%)      3 (5%)                                
      Acinus, Hyperplasia                                                        1 (1%)       1 (2%)                                
      Duct, Hyperplasia                                                          1 (1%)                                             
   Pharynx                                                         (1)                       (1)                                    
      Hemorrhage                                                                              1 (100%)                              
   Salivary Glands                                    (70)         (50)         (70)         (58)         (28)         (10)         
      Infiltration Cellular, Mononuclear Cell                                                 2 (3%)                                
      Infiltration Cellular, Lymphocyte                                          1 (1%)                                             
      Duct, Submandibular Gland, Dilatation                                                                1 (4%)                   
      Parotid Gland, Atrophy                                                                               1 (4%)                   
      Parotid Gland, Inflammation, Chronic                                                                 2 (7%)                   
      Parotid Gland, Inflammation, Chronic Active                                2 (3%)       1 (2%)       2 (7%)                   
      Sublingual Gland, Inflammation, Chronic                                                                                       
          Active                                       1 (1%)                                                                       
      Submandibular Gland, Atrophy                                                                         1 (4%)                   
      Submandibular Gland, Inflammation, Chronic                                                           1 (4%)                   
      Submandibular Gland, Inflammation, Chronic                                                                                    
          Active                                       1 (1%)                    1 (1%)                    5 (18%)                  
      Submandibular Gland, Metaplasia, Squamous                                                            2 (7%)                   
      Submandibular Gland, Pigmentation                                                                    1 (4%)                   
   Stomach, Forestomach                               (69)         (50)         (70)         (67)         (28)         (10)         
      Acanthosis                                                                                           1 (4%)                   
      Autolysis                                        1 (1%)                                                                       
      Cyst Epithelial Inclusion                                                               1 (1%)                                
      Erosion                                                                    2 (3%)       3 (4%)       1 (4%)                   
      Hyperkeratosis                                   2 (3%)       7 (14%)     23 (33%)     28 (42%)      1 (4%)                   
      Hyperplasia, Basal Cell                          2 (3%)       7 (14%)     35 (50%)     29 (43%)      6 (21%)                  
      Hyperplasia, Squamous                            2 (3%)       7 (14%)     26 (37%)     33 (49%)      2 (7%)                   
      Inflammation, Chronic                                                                   1 (1%)                                
      Inflammation, Chronic Active                                  1 (2%)      13 (19%)     10 (15%)                               
      Ulcer                                            1 (1%)       2 (4%)       7 (10%)     17 (25%)      1 (4%)                   
      Muscularis, Mineralization                                                                           1 (4%)                   
   Stomach, Glandular                                 (70)         (50)         (70)         (68)         (28)         (10)         
      Autolysis                                        2 (3%)                    3 (4%)       1 (1%)                                
      Fibrosis                                                                   1 (1%)                                             
      Inflammation, Chronic                                                                                1 (4%)                   
      Inflammation, Chronic Active                     3 (4%)       1 (2%)       6 (9%)       6 (9%)                                
      Mineralization                                                                                                    1 (10%)     
      Necrosis, Coagulative                            1 (1%)                                 1 (1%)                                
      Ulcer                                                                                   1 (1%)                                
      Artery, Mineralization                                                                               1 (4%)                   
      Muscularis, Mineralization                       2 (3%)                                              2 (7%)                   
   Tongue                                                                                    (1)                                    
      Foreign Body                                                                            1 (100%)                              
      Inflammation, Chronic                                                                   1 (100%)                              
   Tooth                                              (1)          (1)                       (1)                                    
      Cyst                                                          1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                                                        (1)          
      Aorta, Inflammation, Chronic                                                                                      1 (100%)    
   Heart                                              (70)         (50)         (70)         (59)         (28)         (10)         
      Cardiomyopathy                                  63 (90%)     46 (92%)     60 (86%)     43 (73%)     18 (64%)     10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (67)         (50)         (69)         (58)         (27)         (10)         
      Angiectasis                                     30 (45%)     32 (64%)     41 (59%)     26 (45%)      3 (11%)      2 (20%)     
      Autolysis                                        1 (1%)                                 3 (5%)                                
      Hyperplasia                                      3 (4%)       4 (8%)       4 (6%)       1 (2%)                    1 (10%)     
      Hypertrophy                                      1 (1%)                                                                       
      Necrosis, Coagulative                            1 (1%)                                                                       
      Thrombosis, Multiple                             1 (1%)                                                                       
      Vacuolization Cytoplasmic                       17 (25%)     16 (32%)     35 (51%)     20 (34%)      1 (4%)                   
      Capsule, Fibrosis                                1 (1%)                                                                       
      Capsule, Hyperplasia                             1 (1%)                                                                       
      Capsule, Inflammation, Chronic                   1 (1%)                                                                       
      Zona Reticularis, Hyperplasia                                 1 (2%)                                                          
   Adrenal Medulla                                    (67)         (50)         (69)         (58)         (27)         (10)         
      Autolysis                                        1 (1%)                                 1 (2%)                                
      Hyperplasia                                     11 (16%)      5 (10%)     11 (16%)     14 (24%)      2 (7%)       1 (10%)     
   Islets, Pancreatic                                 (50)         (40)         (60)         (47)         (7)          (1)          
      Autolysis                                        1 (2%)                                                                       
   Parathyroid Gland                                  (63)         (47)         (67)         (48)         (25)         (10)         
      Hyperplasia                                                   3 (6%)       1 (1%)                                 1 (10%)     
   Pituitary Gland                                    (70)         (49)         (70)         (57)         (28)         (10)         
      Thrombosis                                       1 (1%)                                                                       
      Pars Distalis, Angiectasis                                    3 (6%)       1 (1%)                    1 (4%)       5 (50%)     
      Pars Distalis, Autolysis                                                   2 (3%)       1 (2%)                                
      Pars Distalis, Cyst                             24 (34%)     21 (43%)     23 (33%)     18 (32%)     11 (39%)      6 (60%)     
      Pars Distalis, Cyst, Multiple                                                           3 (5%)                                
      Pars Distalis, Hemorrhage                        1 (1%)                                                                       
      Pars Distalis, Hyperplasia                      14 (20%)     10 (20%)     15 (21%)      8 (14%)      2 (7%)                   
      Pars Distalis, Necrosis, Coagulative                                                    1 (2%)                                
      Pars Distalis, Pars Intermedia, Cyst                                       2 (3%)                                             
      Pars Intermedia, Cyst                            4 (6%)                    3 (4%)                    4 (14%)      1 (10%)     
      Rathke's Cleft, Cyst                                                                    1 (2%)                                
   Thyroid Gland                                      (70)         (50)         (70)         (59)         (28)         (10)         
      Autolysis                                        2 (3%)                    1 (1%)       4 (7%)                                
      Infiltration Cellular, Mononuclear Cell          1 (1%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (1%)                                             
      Ultimobranchial Cyst                             1 (1%)                    1 (1%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia                             11 (16%)      2 (4%)       3 (4%)       2 (3%)                                
      Follicle, Cyst                                                             1 (1%)                                             
      Follicular Cell, Hyperplasia                     1 (1%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (1)          (1)          (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (65)         (46)         (68)         (58)         (27)         (10)         
      Abscess                                          2 (3%)                    3 (4%)       1 (2%)                                
      Cyst                                             1 (2%)       1 (2%)                                 1 (4%)                   
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic                           10 (15%)                                3 (5%)       4 (15%)      6 (60%)     
      Inflammation, Chronic Active                    37 (57%)     21 (46%)     51 (75%)     31 (53%)     10 (37%)      1 (10%)     
      Duct, Metaplasia, Squamous                       1 (2%)                                                                       
   Ovary                                              (70)         (50)         (70)         (61)         (28)         (10)         
      Congestion                                                                              1 (2%)                                
      Cyst                                            11 (16%)      3 (6%)       5 (7%)       6 (10%)                               
      Pigmentation                                                  1 (2%)                                                          
      Periovarian Tissue, Cyst                                      4 (8%)       3 (4%)       4 (7%)       4 (14%)                  
   Uterus                                             (70)         (50)         (70)         (60)         (28)         (10)         
      Abscess                                                       6 (12%)      8 (11%)                                            
      Autolysis                                                                               1 (2%)                                
      Cyst                                             1 (1%)       5 (10%)                   3 (5%)                                
      Decidual Reaction                                                          1 (1%)                                             
      Fibrosis                                         3 (4%)                    1 (1%)       1 (2%)                                
      Hydrometra                                       8 (11%)      6 (12%)      9 (13%)     12 (20%)      6 (21%)      2 (20%)     
      Inflammation, Acute                              1 (1%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)       1 (4%)                   
      Endometrium, Hyperplasia                         5 (7%)       9 (18%)      2 (3%)       1 (2%)       1 (4%)       1 (10%)     
      Submucosa, Hyperplasia                                                                               1 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (70)         (59)         (28)         (10)         
      Autolysis                                        1 (1%)                                                                       
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (7)          (11)         (28)         (24)         (9)          (1)          
      Pigmentation                                                                            1 (4%)                                
      Iliac, Infiltration Cellular, Histiocyte                                                1 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lumbar, Hemorrhage                                                                      1 (4%)                                
      Lumbar, Infiltration Cellular, Histiocyte                                               2 (8%)                                
      Lumbar, Pigmentation                                                                    1 (4%)                                
      Mediastinal, Hemorrhage                          4 (57%)      1 (9%)       3 (11%)      3 (13%)                   1 (100%)    
      Mediastinal, Hyperplasia                         1 (14%)                                                                      
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (14%)      1 (9%)       2 (7%)       3 (13%)                               
      Mediastinal, Pigmentation                        1 (14%)      1 (9%)       2 (7%)       2 (8%)       3 (33%)                  
      Pancreatic, Depletion Lymphoid                                1 (9%)                                                          
      Pancreatic, Hemorrhage                                        2 (18%)      1 (4%)       3 (13%)                               
      Pancreatic, Hyperplasia                          2 (29%)                   5 (18%)      1 (4%)                                
      Pancreatic, Infiltration Cellular, Histiocyte    3 (43%)      8 (73%)     21 (75%)     11 (46%)      8 (89%)      1 (100%)    
      Pancreatic, Pigmentation                                      3 (27%)      1 (4%)       4 (17%)      7 (78%)      1 (100%)    
      Renal, Hemorrhage                                             1 (9%)                    1 (4%)                                
      Renal, Infiltration Cellular, Histiocyte                      1 (9%)                    1 (4%)                                
      Renal, Pigmentation                                           1 (9%)                    1 (4%)                                
   Lymph Node, Mandibular                             (66)         (49)         (66)         (53)         (27)         (9)          
      Autolysis                                                                               1 (2%)                                
      Depletion Lymphoid                                                                      1 (2%)                                
      Hemorrhage                                       8 (12%)      3 (6%)       5 (8%)       4 (8%)       3 (11%)      3 (33%)     
      Hyperplasia                                                   1 (2%)       2 (3%)       1 (2%)       1 (4%)                   
      Infiltration Cellular, Histiocyte                1 (2%)       2 (4%)       1 (2%)       9 (17%)      7 (26%)                  
      Inflammation, Chronic Active                                                            1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
   Lymph Node, Mesenteric                             (70)         (50)         (69)         (60)         (28)         (9)          
      Autolysis                                        1 (1%)                                 2 (3%)                                
      Depletion Lymphoid                               2 (3%)       1 (2%)       2 (3%)       8 (13%)      1 (4%)                   
      Hemorrhage                                                    4 (8%)       4 (6%)       3 (5%)       5 (18%)      2 (22%)     
      Infiltration Cellular, Histiocyte               69 (99%)     49 (98%)     67 (97%)     59 (98%)     28 (100%)     9 (100%)    
      Pigmentation                                    10 (14%)      7 (14%)      8 (12%)      4 (7%)      12 (43%)      8 (89%)     
   Spleen                                             (70)         (50)         (70)         (58)         (28)         (10)         
      Autolysis                                                                               1 (2%)                                
      Congestion                                                                              1 (2%)       1 (4%)                   
      Depletion Lymphoid                               8 (11%)      1 (2%)       3 (4%)       7 (12%)                               
      Fibrosis                                                      1 (2%)       1 (1%)       1 (2%)       1 (4%)                   
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      1 (1%)                                                                       
      Infiltration Cellular, Histiocyte                1 (1%)                                                                       
   Thymus                                             (62)         (41)         (61)         (55)         (22)         (10)         
      Congestion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)       1 (2%)                    1 (2%)                                
      Depletion Lymphoid                                                         1 (2%)       4 (7%)       6 (27%)      1 (10%)     
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)       2 (9%)       1 (10%)     
      Pigmentation                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (65)         (38)         (54)         (47)         (19)         (7)          
      Galactocele                                      1 (2%)                                                                       
      Hyperplasia                                     47 (72%)     29 (76%)     41 (76%)     26 (55%)      5 (26%)      4 (57%)     
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Skin                                               (70)         (49)         (70)         (60)         (28)         (10)         
      Abscess                                          1 (1%)                                 1 (2%)                                
      Cyst Epithelial Inclusion                                                  2 (3%)                                             
      Foreign Body                                                               1 (1%)                                             
      Inflammation, Chronic Active                     2 (3%)                    6 (9%)       2 (3%)                                
      Foot, Acanthosis                                                           1 (1%)                                             
      Foot, Hyperkeratosis                                                       1 (1%)                                             
      Foot, Inflammation, Chronic Active                            1 (2%)       1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (70)         (59)         (28)         (10)         
      Osteopetrosis                                    1 (1%)                                                                       
      Cranium, Osteopetrosis                                                                  1 (2%)                                
      Femur, Osteopetrosis                                                                    1 (2%)                                
      Sternum, Osteopetrosis                           1 (1%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (70)         (59)         (28)         (10)         
      Hydrocephalus                                    1 (1%)       2 (4%)                                                          
      Infarct                                                                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (70)         (64)         (28)         (10)         
      Autolysis                                        1 (1%)                                                                       
      Congestion                                                                                                        1 (10%)     
      Fibrosis                                                                   2 (3%)                                             
      Hemorrhage                                       1 (1%)                    1 (1%)                                             
      Infiltration Cellular, Histiocyte               38 (54%)     33 (66%)     53 (76%)     43 (67%)     17 (61%)      7 (70%)     
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic Active                     4 (6%)                    3 (4%)       2 (3%)       1 (4%)                   
      Polyarteritis                                                                           1 (2%)                                
      Alveolar Epithelium, Hyperplasia                                           1 (1%)       1 (2%)                                
      Alveolus, Mineralization                         1 (1%)                                                                       
      Artery, Mineralization                          31 (44%)      9 (18%)     23 (33%)     18 (28%)     12 (43%)      5 (50%)     
      Bronchiole, Epithelium, Hyperplasia              1 (1%)                                                                       
      Mediastinum, Polyarteritis                                    2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (70)         (50)         (70)         (59)         (28)         (10)         
      Autolysis                                                                               1 (2%)                                
      Foreign Body                                     1 (1%)                    4 (6%)                                             
      Inflammation, Chronic Active                     9 (13%)      8 (16%)     13 (19%)     12 (20%)      2 (7%)                   
      Metaplasia, Squamous                             1 (1%)       4 (8%)       4 (6%)       2 (3%)                                
      Arteriole, Thrombosis                                                                   1 (2%)                                
      Submucosa, Inflammation, Chronic                 1 (1%)                                                                       
   Trachea                                            (70)         (50)         (70)         (59)         (28)         (10)         
      Autolysis                                        1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (8)          (3)                                    
      External Ear, Inflammation, Acute                                          2 (25%)                                            
      Internal Ear, Inflammation, Acute                                          1 (13%)                                            
   Eye                                                (13)         (7)          (7)          (7)          (2)                       
      Phthisis Bulbi                                                1 (14%)      1 (14%)                                            
      Synechia                                         1 (8%)                                 1 (14%)                               
      Anterior Chamber, Inflammation, Acute                                                                1 (50%)                  
      Cornea, Inflammation, Acute                                                             1 (14%)                               
      Lens, Cataract                                   1 (8%)                    1 (14%)                                            
      Posterior Chamber, Inflammation, Acute                                                               1 (50%)                  
      Retina, Degeneration                             1 (8%)                    3 (43%)      1 (14%)      1 (50%)                  
   Harderian Gland                                                                                        (1)                       
      Hyperplasia                                                                                          1 (100%)                 
   Zymbal's Gland                                     (1)                       (2)                                                 
      Autolysis                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (70)         (68)         (28)         (10)         
      Abscess                                                                    1 (1%)                                             
      Autolysis                                        2 (3%)                    3 (4%)       3 (4%)                                
      Cyst                                                          1 (2%)       2 (3%)                                             
      Fibrosis                                                                   1 (1%)                    1 (4%)                   
      Fibrosis, Focal                                                                                      1 (4%)                   
      Hydronephrosis                                   3 (4%)                    2 (3%)                                             
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular                                         1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell                       9 (18%)      7 (10%)      3 (4%)       7 (25%)                  
      Inflammation, Chronic                            4 (6%)                                                                       
      Inflammation, Chronic Active                                               1 (1%)                    1 (4%)                   
      Mineralization                                   3 (4%)       1 (2%)                                 1 (4%)                   
      Mineralization, Focal                                                                                1 (4%)                   
      Nephropathy                                     60 (86%)     39 (78%)     60 (86%)     56 (82%)     18 (64%)     10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71UF       71LF         71MLF        71MHF        71HF         FEMALE          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pigmentation                                                               1 (1%)                                             
      Polyarteritis                                                 1 (2%)                                                          
      Artery, Thrombosis                                                         1 (1%)                                             
      Papilla, Necrosis, Coagulative                                                          2 (3%)       2 (7%)                   
      Pelvis, Inflammation, Chronic Active             1 (1%)       1 (2%)       4 (6%)       6 (9%)       1 (4%)                   
      Pelvis, Metaplasia, Squamous                                               3 (4%)       2 (3%)                                
      Renal Tubule, Hyperplasia                        1 (1%)      12 (24%)     23 (33%)     30 (44%)      2 (7%)       2 (20%)     
      Renal Tubule, Hyperplasia, Oncocytic                                       1 (1%)                                             
      Renal Tubule, Inflammation, Acute                1 (1%)       7 (14%)      3 (4%)                                             
      Renal Tubule, Inflammation, Chronic Active                                 2 (3%)       7 (10%)                   1 (10%)     
      Renal Tubule, Mineralization                     1 (1%)                                                                       
      Renal Tubule, Pigmentation                                   50 (100%)    70 (100%)    68 (100%)    28 (100%)    10 (100%)    
      Renal Tubule, Regeneration                       4 (6%)       5 (10%)      7 (10%)      4 (6%)       7 (25%)                  
      Transitional Epithelium, Hyperplasia            13 (19%)     16 (32%)     44 (63%)     25 (37%)      5 (18%)      1 (10%)     
      Transitional Epithelium, Mineralization          3 (4%)       4 (8%)                    2 (3%)                    1 (10%)     
   Urinary Bladder                                    (70)         (50)         (70)         (66)         (28)         (10)         
      Autolysis                                        1 (1%)                    2 (3%)                                             
      Calculus Gross Observation                                    2 (4%)                    1 (2%)                                
      Calculus Micro Observation Only                                                         1 (2%)                                
      Fibrosis                                                                   1 (1%)                                             
      Hemorrhage                                                                              2 (3%)       4 (14%)                  
      Hyperplasia, Lymphoid                           15 (21%)      2 (4%)       3 (4%)                                             
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                     1 (1%)       1 (2%)       3 (4%)       1 (2%)                                
      Necrosis                                                                                1 (2%)       1 (4%)                   
      Fat, Proliferation                                                         4 (6%)       2 (3%)       2 (7%)                   
      Transitional Epithelium, Hyperplasia             1 (1%)       2 (4%)      41 (59%)     52 (79%)     21 (75%)      4 (40%)     
      Transitional Epithelium, Infiltration                                                                                         
          Cellular, Mononuclear Cell                                                          1 (2%)                                
      Transitional Epithelium, Metaplasia, Squamous                 1 (2%)       4 (6%)       8 (12%)      3 (11%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           50           70           70           30           10           
  Scheduled Sacrifice                                 20           10           10           20           27            7           
  Early Deaths                                                                                                                      
    Moribund                                          19           15           34           33            2            3           
    Dead                                               5            1            5            7            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           24           21           10                                     
    Moribund                                           2                                                                            
    Dead                                               1                                                                            
  Animals Examined Microscopically                    70           50           69           70           30           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (67)         (50)         (69)         (61)         (30)         (10)         
      Autolysis                                        1 (1%)       1 (2%)       4 (6%)       5 (8%)                                
      Hyperplasia, Lymphoid                                                      1 (1%)                                             
      Parasite Metazoan                               19 (28%)     17 (34%)     12 (17%)      7 (11%)      1 (3%)                   
      Polyarteritis                                                 1 (2%)       1 (1%)                                             
      Ulcer                                                                      1 (1%)                                             
   Intestine Large, Rectum                            (65)         (50)         (68)         (69)         (30)         (10)         
      Atypia Cellular                                                            2 (3%)                                             
      Autolysis                                        1 (2%)                                 5 (7%)                                
      Inflammation, Chronic Active                                               1 (1%)                                             
      Parasite Metazoan                                7 (11%)      8 (16%)      9 (13%)      2 (3%)                    1 (10%)     
      Artery, Neovascularization                                                 2 (3%)                                             
      Artery, Thrombosis                                                         1 (1%)                                             
      Epithelium, Hyperplasia                                                    1 (1%)       1 (1%)                                
   Intestine Large, Cecum                             (68)         (50)         (69)         (60)         (28)         (10)         
      Atypia Cellular                                                            1 (1%)                                             
      Autolysis                                        2 (3%)       1 (2%)       3 (4%)       5 (8%)                                
      Hyperplasia, Lymphoid                                                      1 (1%)                                             
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)       1 (4%)                   
      Parasite Metazoan                                7 (10%)      8 (16%)     11 (16%)      3 (5%)       1 (4%)       3 (30%)     
      Ulcer, Acute                                                  1 (2%)                                                          
      Lymphoid Tissue, Hemorrhage                                                1 (1%)                                             
   Intestine Small, Duodenum                          (68)         (50)         (69)         (60)         (29)         (9)          
      Autolysis                                        2 (3%)       1 (2%)       3 (4%)       5 (8%)                                
      Ectopic Tissue                                                             1 (1%)                                             
      Inflammation, Chronic Active                                               1 (1%)                                             
   Intestine Small, Jejunum                           (68)         (48)         (67)         (58)         (29)         (10)         
      Autolysis                                        2 (3%)       1 (2%)       5 (7%)       6 (10%)                               
   Intestine Small, Ileum                             (68)         (50)         (67)         (59)         (29)         (10)         
      Autolysis                                        3 (4%)       1 (2%)       4 (6%)       9 (15%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Lymphoid                            1 (1%)                                 2 (3%)                                
      Inflammation, Chronic Active                                                                         1 (3%)                   
   Liver                                              (70)         (50)         (69)         (70)         (30)         (10)         
      Angiectasis                                      3 (4%)       3 (6%)                                                          
      Anisokaryosis                                                                                                     1 (10%)     
      Autolysis                                        2 (3%)                                 2 (3%)                                
      Basophilic Focus                                10 (14%)     12 (24%)     25 (36%)     28 (40%)     19 (63%)      4 (40%)     
      Clear Cell Focus                                 3 (4%)      26 (52%)     39 (57%)     38 (54%)     17 (57%)      6 (60%)     
      Cyst                                                                       1 (1%)       2 (3%)                                
      Cytomegaly                                                                              1 (1%)       2 (7%)                   
      Degeneration                                    12 (17%)      3 (6%)      12 (17%)      4 (6%)       4 (13%)                  
      Developmental Malformation                                                              1 (1%)                                
      Eosinophilic Focus                               2 (3%)      13 (26%)     14 (20%)      7 (10%)      2 (7%)                   
      Fatty Change                                    16 (23%)     11 (22%)     13 (19%)     11 (16%)     10 (33%)      9 (90%)     
      Fibrosis                                         1 (1%)                                                                       
      Hematopoietic Cell Proliferation                 2 (3%)                    4 (6%)                                             
      Hemorrhage                                                                 1 (1%)       1 (1%)       1 (3%)                   
      Hepatodiaphragmatic Nodule                       3 (4%)       2 (4%)                                              1 (10%)     
      Hyperplasia                                                                             1 (1%)                                
      Infarct                                                       1 (2%)       1 (1%)                                             
      Inflammation, Chronic                                                                   1 (1%)                                
      Inflammation, Chronic, Granulomatous             2 (3%)                                 1 (1%)                                
      Inflammation, Chronic Active                    10 (14%)      1 (2%)       4 (6%)       7 (10%)      2 (7%)                   
      Mixed Cell Focus                                 2 (3%)      17 (34%)      8 (12%)      2 (3%)       1 (3%)                   
      Necrosis, Coagulative                           10 (14%)      8 (16%)      8 (12%)     10 (14%)      4 (13%)      1 (10%)     
      Pigmentation                                     3 (4%)      20 (40%)     48 (70%)     55 (79%)     28 (93%)      8 (80%)     
      Regeneration                                     4 (6%)                                                                       
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          56 (80%)     10 (20%)     54 (78%)     60 (86%)     26 (87%)      7 (70%)     
      Periportal, Inflammation                                                                1 (1%)                                
      Periportal, Inflammation, Chronic               10 (14%)                               10 (14%)     17 (57%)      7 (70%)     
      Periportal, Inflammation, Chronic Active        11 (16%)     12 (24%)     61 (88%)     44 (63%)     11 (37%)                  
   Mesentery                                          (3)          (3)          (4)          (5)          (1)          (1)          
      Fibrosis                                                      2 (67%)      2 (50%)      2 (40%)                               
      Hemorrhage                                                                 1 (25%)      2 (40%)                   1 (100%)    
      Inflammation, Chronic                                                                                             1 (100%)    
      Inflammation, Chronic, Granulomatous                          1 (33%)                                                         
      Inflammation, Chronic Active                     1 (33%)      2 (67%)      3 (75%)      4 (80%)      1 (100%)                 
      Necrosis                                                                                1 (20%)                               
      Necrosis, Coagulative                                         2 (67%)      2 (50%)      1 (20%)      1 (100%)                 
      Polyarteritis                                                 1 (33%)                                                         
      Thrombosis                                                                                                        1 (100%)    
   Pancreas                                           (70)         (50)         (69)         (60)         (30)         (10)         
      Atrophy                                         17 (24%)     27 (54%)     29 (42%)     21 (35%)      4 (13%)      2 (20%)     
      Autolysis                                                                  2 (3%)       2 (3%)                                
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Ectopic Tissue                                   1 (1%)                                              1 (3%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                                                                          1 (3%)                   
      Infiltration Cellular, Mononuclear Cell          3 (4%)       5 (10%)      2 (3%)       3 (5%)       1 (3%)                   
      Infiltration Cellular, Mixed Cell                             1 (2%)                                 1 (3%)                   
      Inflammation, Chronic                            9 (13%)                                            11 (37%)      5 (50%)     
      Inflammation, Chronic Active                    11 (16%)     28 (56%)     45 (65%)     26 (43%)      1 (3%)                   
      Necrosis, Coagulative                            2 (3%)                                                                       
      Pigmentation                                     1 (1%)                                              1 (3%)                   
      Vacuolization Cytoplasmic                       17 (24%)      2 (4%)       6 (9%)      15 (25%)                   1 (10%)     
      Acinus, Atrophy                                  1 (1%)                                                                       
      Acinus, Hyperplasia                                                        1 (1%)       1 (2%)                                
      Artery, Fibrosis                                                           1 (1%)       1 (2%)                                
      Artery, Inflammation, Chronic Active                                                                 1 (3%)                   
      Artery, Polyarteritis                            4 (6%)       8 (16%)      4 (6%)       3 (5%)                                
      Duct, Hyperplasia                                1 (1%)                                 1 (2%)                                
   Pharynx                                                                                   (1)                                    
      Palate, Hyperkeratosis                                                                  1 (100%)                              
   Salivary Glands                                    (70)         (50)         (68)         (59)         (29)         (10)         
      Duct, Parotid Gland, Mineralization                                                                  1 (3%)                   
      Duct, Submandibular Gland, Inflammation,                                                                                      
           Acute                                                                              1 (2%)                                
      Parotid Gland, Inflammation, Chronic                                       1 (1%)                                             
      Sublingual Gland, Atrophy                                                                            1 (3%)                   
      Sublingual Gland, Pigmentation                                                                       1 (3%)                   
      Submandibular Gland, Inflammation, Chronic                                 2 (3%)                                             
      Submandibular Gland, Metaplasia, Squamous                                  1 (1%)                                             
   Stomach, Forestomach                               (69)         (49)         (69)         (69)         (30)         (10)         
      Acanthosis                                                                                           2 (7%)                   
      Erosion                                                                    1 (1%)       1 (1%)                                
      Fibrosis                                                                   1 (1%)       1 (1%)                                
      Hyperkeratosis                                   5 (7%)      18 (37%)     21 (30%)     20 (29%)      1 (3%)       2 (20%)     
      Hyperplasia, Basal Cell                         11 (16%)     18 (37%)     23 (33%)     23 (33%)      3 (10%)      2 (20%)     
      Hyperplasia, Squamous                            3 (4%)      19 (39%)     25 (36%)     26 (38%)                   2 (20%)     
      Infarct                                                                    1 (1%)                                             
      Inflammation, Chronic Active                     3 (4%)      12 (24%)     11 (16%)     11 (16%)      1 (3%)       1 (10%)     
      Ulcer                                            3 (4%)      10 (20%)     15 (22%)     16 (23%)                   2 (20%)     
      Arteriole, Mineralization                                                               1 (1%)                                
      Muscularis, Mineralization                       1 (1%)                                 1 (1%)                                
   Stomach, Glandular                                 (70)         (50)         (69)         (70)         (30)         (10)         
      Autolysis                                                                  2 (3%)       2 (3%)                                
      Inflammation, Chronic                            1 (1%)                                              1 (3%)       1 (10%)     
      Inflammation, Chronic Active                     3 (4%)       2 (4%)       2 (3%)       3 (4%)                    1 (10%)     
      Arteriole, Mineralization                                                                            1 (3%)                   
      Mucosa, Hyperplasia                                                                     1 (1%)                                
      Mucosa, Necrosis, Coagulative                    1 (1%)                                                                       
      Muscularis, Mineralization                       1 (1%)                                              1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (69)         (59)         (30)         (10)         
      Autolysis                                                     1 (2%)                                                          
      Cardiomyopathy                                  66 (94%)     46 (92%)     65 (94%)     54 (92%)     23 (77%)      8 (80%)     
      Infiltration Cellular, Mononuclear Cell                                                 1 (2%)                                
      Metaplasia, Osseous                                                        1 (1%)                                             
      Polyarteritis                                                 1 (2%)                                                          
      Thrombosis                                       2 (3%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (50)         (68)         (60)         (30)         (10)         
      Angiectasis                                      2 (3%)       5 (10%)     13 (19%)     15 (25%)      1 (3%)                   
      Autolysis                                                                               2 (3%)                                
      Hematopoietic Cell Proliferation                 2 (3%)                                 1 (2%)                                
      Hyperplasia                                      5 (7%)       1 (2%)       2 (3%)       1 (2%)                    1 (10%)     
      Necrosis, Coagulative                            1 (1%)                                                                       
      Vacuolization Cytoplasmic                       23 (33%)     18 (36%)     19 (28%)     11 (18%)      6 (20%)                  
      Bilateral, Vacuolization Cytoplasmic             1 (1%)                                                                       
   Adrenal Medulla                                    (69)         (50)         (68)         (60)         (30)         (10)         
      Autolysis                                                                               2 (3%)                                
      Fibrosis                                         1 (1%)                                                                       
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                     18 (26%)     25 (50%)     24 (35%)     21 (35%)      1 (3%)                   
      Necrosis, Coagulative                            2 (3%)                                                                       
      Bilateral, Hyperplasia                           1 (1%)                                                                       
   Islets, Pancreatic                                 (54)         (40)         (58)         (50)         (3)          (3)          
      Autolysis                                                                  1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                 2 (4%)                                
   Parathyroid Gland                                  (63)         (45)         (65)         (54)         (30)         (10)         
      Hyperplasia                                      4 (6%)      12 (27%)                   1 (2%)                                
   Pituitary Gland                                    (65)         (50)         (65)         (58)         (29)         (10)         
      Autolysis                                                                               1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Pars Distalis, Cyst                              7 (11%)      4 (8%)       8 (12%)      9 (16%)      3 (10%)      1 (10%)     
      Pars Distalis, Hyperplasia                      23 (35%)     15 (30%)     24 (37%)     32 (55%)     20 (69%)      6 (60%)     
      Pars Intermedia, Cyst                            2 (3%)       1 (2%)                    2 (3%)                                
      Pars Nervosa, Cyst                                                                      1 (2%)       1 (3%)                   
      Pars Nervosa, Hyperplasia                                                                            1 (3%)                   
   Thyroid Gland                                      (69)         (50)         (69)         (61)         (30)         (10)         
      Autolysis                                                                  2 (3%)       2 (3%)                                
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Inflammation, Chronic Active                     2 (3%)       1 (2%)       1 (1%)                                             
      Ultimobranchial Cyst                                          3 (6%)       4 (6%)       2 (3%)       1 (3%)       1 (10%)     
      C-Cell, Hyperplasia                             11 (16%)      8 (16%)      5 (7%)       4 (7%)       1 (3%)       1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                   2 (3%)       1 (2%)       7 (10%)      3 (5%)                                
      Follicular Cell, Hyperplasia                     3 (4%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (2)                                                              
      Inflammation, Chronic Active                     1 (50%)      2 (100%)                                                        
   Epididymis                                         (70)         (50)         (69)         (60)         (30)         (10)         
      Aspermia                                         1 (1%)                                                                       
      Autolysis                                                                  2 (3%)                                             
      Inflammation, Chronic                                                                                1 (3%)                   
      Inflammation, Chronic Active                     3 (4%)       2 (4%)      10 (14%)      3 (5%)                                
      Vacuolization Cytoplasmic                        1 (1%)                                 1 (2%)                    1 (10%)     
   Preputial Gland                                    (67)         (48)         (66)         (56)         (29)         (10)         
      Abscess                                          6 (9%)       1 (2%)       1 (2%)                                             
      Cyst                                             2 (3%)                    1 (2%)       1 (2%)                                
      Hyperplasia                                                                2 (3%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            7 (10%)                   1 (2%)       2 (4%)       8 (28%)      2 (20%)     
      Inflammation, Chronic Active                    57 (85%)     44 (92%)     59 (89%)     45 (80%)     17 (59%)      7 (70%)     
   Prostate                                           (70)         (50)         (68)         (59)         (30)         (10)         
      Abscess                                                       3 (6%)       1 (1%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Acute                              2 (3%)       2 (4%)                                11 (37%)      4 (40%)     
      Inflammation, Chronic                                                                                1 (3%)                   
      Inflammation, Chronic Active                    17 (24%)     22 (44%)     25 (37%)     24 (41%)      7 (23%)      4 (40%)     
      Metaplasia, Squamous                             1 (1%)      11 (22%)      6 (9%)       1 (2%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Epithelium, Hyperplasia                          8 (11%)      4 (8%)       2 (3%)       1 (2%)       1 (3%)                   
   Seminal Vesicle                                    (69)         (50)         (69)         (60)         (30)         (10)         
      Atrophy                                          1 (1%)      30 (60%)     35 (51%)     23 (38%)                               
      Autolysis                                                                  1 (1%)                                             
      Inflammation, Chronic Active                                  3 (6%)       2 (3%)       1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
   Testes                                             (70)         (50)         (69)         (68)         (30)         (10)         
      Abscess                                                                                                           1 (10%)     
      Abscess, Chronic                                                                        1 (1%)       1 (3%)                   
      Atrophy                                                                    1 (1%)       1 (1%)       1 (3%)                   
      Infarct                                                       1 (2%)                    1 (1%)       1 (3%)                   
      Infarct, Chronic                                                                        1 (1%)                                
      Inflammation, Chronic                                                      1 (1%)                    2 (7%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                                                         1 (3%)                   
      Mineralization                                                1 (2%)                                                          
      Polyarteritis                                    1 (1%)                                                                       
      Interstitial Cell, Hyperplasia                  27 (39%)     12 (24%)     32 (46%)     32 (47%)     19 (63%)      8 (80%)     
      Seminiferous Tubule, Atrophy                    43 (61%)     37 (74%)     55 (80%)     39 (57%)      7 (23%)      3 (30%)     
      Seminiferous Tubule, Mineralization              8 (11%)                   2 (3%)       6 (9%)                    2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (69)         (60)         (30)         (10)         
      Myelofibrosis                                                                                                     1 (10%)     
      Sternal, Autolysis                                                         1 (1%)                                             
      Sternal, Hypoplasia                                                                     1 (2%)                                
      Sternal, Myelofibrosis                           1 (1%)                                                                       
   Lymph Node                                         (19)         (6)          (18)         (25)         (6)          (2)          
      Deep Cervical, Hyperplasia                                                              1 (4%)                                
      Lumbar, Hyperplasia                                           1 (17%)                   1 (4%)                                
      Lumbar, Pigmentation                                                       1 (6%)                                             
      Mediastinal, Hemorrhage                          2 (11%)                   4 (22%)      2 (8%)       3 (50%)      1 (50%)     
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (17%)                   2 (8%)                                
      Mediastinal, Pigmentation                        1 (5%)                                 3 (12%)      1 (17%)                  
      Mediastinal, Sinus, Ectasia                      1 (5%)                                                                       
      Pancreatic, Hemorrhage                                                     1 (6%)                                 1 (50%)     
      Pancreatic, Hyperplasia                                       1 (17%)      1 (6%)       2 (8%)                                
      Pancreatic, Infiltration Cellular, Histiocyte                 2 (33%)     10 (56%)     23 (92%)      2 (33%)      1 (50%)     
      Pancreatic, Inflammation, Chronic Active                                   1 (6%)                                             
      Pancreatic, Pigmentation                                                                4 (16%)      3 (50%)                  
      Renal, Hemorrhage                                1 (5%)       1 (17%)                                                         
      Renal, Infiltration Cellular, Histiocyte         1 (5%)                    1 (6%)                                             
      Renal, Pigmentation                              1 (5%)       1 (17%)                                                         
   Lymph Node, Mandibular                             (70)         (50)         (64)         (59)         (27)         (8)          
      Hemorrhage                                      12 (17%)      5 (10%)      7 (11%)      8 (14%)      4 (15%)      1 (13%)     
      Hyperplasia                                     11 (16%)      7 (14%)      7 (11%)      4 (7%)                                
      Hyperplasia, Plasma Cell                                                                             1 (4%)                   
      Infiltration Cellular, Histiocyte                2 (3%)                    2 (3%)       8 (14%)      2 (7%)                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Pigmentation                                                                                         1 (4%)                   
   Lymph Node, Mesenteric                             (68)         (50)         (67)         (60)         (30)         (9)          
      Autolysis                                                                  1 (1%)                                             
      Depletion Lymphoid                               1 (1%)                                                                       
      Hemorrhage                                       1 (1%)       1 (2%)                                 2 (7%)                   
      Hyperplasia                                                                1 (1%)       2 (3%)                                
      Infiltration Cellular, Histiocyte               64 (94%)     50 (100%)    66 (99%)     60 (100%)    30 (100%)     9 (100%)    
      Pigmentation                                    10 (15%)                   1 (1%)       7 (12%)     23 (77%)      7 (78%)     
   Spleen                                             (70)         (50)         (68)         (62)         (30)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Autolysis                                                                  1 (1%)       2 (3%)                                
      Depletion Lymphoid                              12 (17%)      3 (6%)                    2 (3%)       1 (3%)                   
      Fibrosis                                         6 (9%)       3 (6%)       2 (3%)       5 (8%)                                
      Hyperplasia, Re Cell                                                       1 (1%)                                             
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Necrosis, Coagulative                            2 (3%)                                                                       
      Pigmentation                                                                            2 (3%)                                
   Thymus                                             (56)         (41)         (51)         (53)         (26)         (9)          
      Cyst                                             3 (5%)                                                                       
      Depletion Lymphoid                               3 (5%)       4 (10%)      5 (10%)     10 (19%)     20 (77%)      4 (44%)     
      Hemorrhage                                                    1 (2%)       1 (2%)       5 (9%)       1 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (29)         (34)         (29)         (15)         (7)          
      Galactocele                                      3 (8%)       1 (3%)       1 (3%)                                             
      Hyperplasia                                     25 (64%)     25 (86%)     22 (65%)     17 (59%)     14 (93%)      7 (100%)    
   Skin                                               (70)         (48)         (68)         (60)         (29)         (10)         
      Abscess                                                       2 (4%)       1 (1%)                                             
      Cyst Epithelial Inclusion                        1 (1%)                    3 (4%)                                             
      Fibrosis                                         1 (1%)                                                                       
      Inflammation, Chronic                                                                                1 (3%)                   
      Inflammation, Chronic Active                     1 (1%)                    2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (69)         (60)         (30)         (10)         
      Cranium, Abscess                                                                        1 (2%)                                
      Joint, Tarsal, Hyperostosis                                                1 (1%)                                             
      Joint, Tarsal, Inflammation, Chronic Active                                1 (1%)                                             
      Rib, Hyperostosis                                             1 (2%)                                                          
   Skeletal Muscle                                    (2)          (1)          (1)                                                 
      Fibrosis                                                                   1 (100%)                                           
      Polyarteritis                                                 1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (69)         (60)         (30)         (10)         
      Infarct                                          3 (4%)                                                                       
   Spinal Cord                                        (5)          (1)          (1)          (4)                                    
      Infarct                                          1 (20%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (69)         (62)         (30)         (10)         
      Crystals                                         1 (1%)                                                                       
      Fibrosis                                                                   3 (4%)                                             
      Foreign Body                                                                            1 (2%)                                
      Hemorrhage                                                                              2 (3%)                                
      Infiltration Cellular, Histiocyte               24 (34%)     23 (46%)     34 (49%)     26 (42%)      7 (23%)      2 (20%)     
      Inflammation, Chronic Active                                  1 (2%)       5 (7%)       3 (5%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Mineralization                                                                                       1 (3%)                   
      Necrosis, Coagulative                            1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                 7 (10%)      2 (4%)       7 (10%)      1 (2%)       1 (3%)                   
      Alveolus, Mineralization                         1 (1%)                                                                       
      Artery, Mineralization                          36 (51%)     17 (34%)     41 (59%)     34 (55%)     13 (43%)      7 (70%)     
      Artery, Thrombosis                               1 (1%)                                                                       
      Bronchiole, Epithelium, Hyperplasia                                        1 (1%)                                             
      Mediastinum, Polyarteritis                                    2 (4%)                                                          
   Nose                                               (68)         (50)         (69)         (60)         (30)         (10)         
      Autolysis                                        1 (1%)                                                                       
      Foreign Body                                                  2 (4%)       7 (10%)      1 (2%)                                
      Hemorrhage                                                                              3 (5%)                                
      Inflammation, Chronic Active                    26 (38%)     25 (50%)     27 (39%)     18 (30%)                               
      Metaplasia, Squamous                            10 (15%)      7 (14%)      7 (10%)      6 (10%)                               
      Ulcer                                            2 (3%)                                                                       
      Glands, Hyperplasia                              9 (13%)                                3 (5%)                                
      Glands, Inflammation, Acute                      3 (4%)                                              8 (27%)      3 (30%)     
      Glands, Inflammation, Chronic Active             1 (1%)                                              3 (10%)                  
      Lumen, Inflammation, Acute                                                                                        1 (10%)     
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (1%)                                              1 (3%)                   
      Respiratory Epithelium, Hyperplasia              2 (3%)                    1 (1%)       2 (3%)                                
      Respiratory Epithelium, Metaplasia, Squamous                                                         1 (3%)                   
   Trachea                                            (70)         (50)         (69)         (60)         (30)         (10)         
      Autolysis                                                                               1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       3 (4%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (4)          (7)          (2)          (1)                                    
      Acanthosis                                       1 (25%)      1 (14%)      1 (50%)                                            
      Hyperkeratosis                                   1 (25%)                                                                      
      Hyperplasia, Basal Cell                          1 (25%)      1 (14%)      1 (50%)                                            
      Inflammation, Chronic Active                     2 (50%)                                                                      
      Ulcer                                            1 (25%)                                                                      
      Submucosa, Abscess                                                                      1 (100%)                              
   Eye                                                (6)          (3)          (1)          (6)          (1)                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Cataract                                                                   1 (100%)                                           
      Synechia                                                                                1 (17%)                               
      Anterior, Synechia                               1 (17%)                                                                      
      Conjunctiva, Inflammation, Chronic Active                                                            1 (100%)                 
      Cornea, Fibrosis                                                                                     1 (100%)                 
      Cornea, Inflammation, Chronic Active             1 (17%)                                                                      
      Cornea, Neovascularization                                                                           1 (100%)                 
      Lens, Cataract                                                                          3 (50%)                               
      Retina, Degeneration                             1 (17%)                   1 (100%)     3 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (69)         (70)         (30)         (10)         
      Autolysis                                        2 (3%)                    1 (1%)       4 (6%)       1 (3%)                   
      Cyst                                             4 (6%)       3 (6%)       1 (1%)                                 1 (10%)     
      Cyst, Multiple                                   1 (1%)                                                                       
      Fibrosis, Focal                                               1 (2%)                                                          
      Granuloma                                        1 (1%)                                                                       
      Hydronephrosis                                   1 (1%)                                                                       
      Infiltration Cellular, Mononuclear Cell                       9 (18%)      9 (13%)      9 (13%)      7 (23%)                  
      Infiltration Cellular, Mixed Cell                                                                    1 (3%)                   
      Inflammation, Chronic                            4 (6%)                                                                       
      Nephropathy                                     60 (86%)     40 (80%)     59 (86%)     59 (84%)     20 (67%)     10 (100%)    
      Collecting Tubule, Mineralization                                          1 (1%)                                             
      Renal Tubule, Degeneration, Hyaline                          10 (20%)     11 (16%)     11 (16%)     10 (33%)                  
      Renal Tubule, Hyperplasia                        9 (13%)     30 (60%)     25 (36%)     21 (30%)      1 (3%)       1 (10%)     
      Renal Tubule, Hyperplasia, Oncocytic                          1 (2%)                    1 (1%)                                
      Renal Tubule, Inflammation, Chronic Active      14 (20%)     10 (20%)     22 (32%)     14 (20%)      1 (3%)                   
      Renal Tubule, Mineralization                     1 (1%)       2 (4%)      13 (19%)      4 (6%)                                
      Renal Tubule, Pigmentation                       5 (7%)      50 (100%)    68 (99%)     69 (99%)     30 (100%)     9 (90%)     
      Renal Tubule, Regeneration                      10 (14%)     10 (20%)     10 (14%)      9 (13%)     10 (33%)                  
      Transitional Epithelium, Hyperplasia            30 (43%)     40 (80%)     51 (74%)     39 (56%)     11 (37%)      1 (10%)     
   Urinary Bladder                                    (70)         (48)         (67)         (70)         (28)         (10)         
      Autolysis                                                                  1 (1%)       1 (1%)                                
      Calculus Micro Observation Only                  2 (3%)                    1 (1%)                    2 (7%)                   
      Edema                                                         1 (2%)                                                          
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       2 (3%)                                                                       
      Hyperplasia, Lymphoid                            4 (6%)                                                                       
      Inflammation, Chronic                                                      1 (1%)                    1 (4%)                   
      Inflammation, Chronic Active                     1 (1%)       3 (6%)                    5 (7%)                                
      Metaplasia, Squamous                                                                    1 (1%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Fat, Proliferation                                                                                   1 (4%)                   
      Muscularis, Mineralization                                                                           1 (4%)                   
      Serosa, Mineralization                           1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05061-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  1-AMINO 2,4-DIBROMOANTHRAQUINONE                             Date: 05/19/95  
Route: DOSED FEED                                                                                                 Time: 14:37:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATE     0.2%         0.5%         1.0%         2.0%         2.0%            
                                                   D 71 UM       71LM        71MLM        71MHM        71HM         MALE            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (1%)       5 (10%)     17 (25%)     33 (47%)      9 (32%)                  
      Transitional Epithelium, Metaplasia, Squamous                                           3 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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