TR 383 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:07:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:07:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:07:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1-AMINO 2,4-DIBROMOANTHRAQUINONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Intestine Large: Colon/Rectum Carcinoma
Polyp Adenomatous
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Hepatocholangiocarcinoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
Urinary Bladder Carcinoma
Papilloma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:07:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1-AMINO 2,4-DIBROMOANTHRAQUINONE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Intestine Large: Colon/Rectum Carcinoma
Polyp Adenomatous
Kidney: Renal Tubule Adenoma
Carcinoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Hepatocholangiocarcinoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Squamous Cell Papilloma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Tissue NOS Sarcoma
Urinary Bladder Carcinoma
Papilloma
Squamous Cell Papilloma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/68 (0%) 0/60 (0%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/20 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 12/69 (17%) 15/50 (30%) 13/68 (19%) 7/60 (12%) 0/40 (0%) |
|ADJUSTED (b) | 36.6% 45.3% 38.7% 39.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 7/26 (27%) 7/24 (29%) 4/20 (20%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | 574 629 521 590 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.542 P=0.257 P=0.407 P=0.475 (e) |
|INCIDENTAL TUMOR | P=0.107N P=0.191 P=0.523N P=0.347N (e) |
|LOGISTIC REGRESSION | P=0.115N P=0.171 P=0.570 P=0.414N P=0.505N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.081 P=0.484 P=0.254N P=0.003N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/69 (1%) 2/50 (4%) 1/68 (1%) 0/60 (0%) 0/40 (0%) |
|ADJUSTED (b) | 3.1% 6.9% 3.2% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/20 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 653 693 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.503N P=0.470 P=0.757 P=0.615N (e) |
|INCIDENTAL TUMOR | P=0.356N P=0.472 P=0.652N P=0.485N (e) |
|LOGISTIC REGRESSION | P=0.353N P=0.440 P=0.751N P=0.570N P=0.998N |
|COCHRAN-ARMITAGE | P=0.183N |
|FISHER EXACT | P=0.380 P=0.748 P=0.535N P=0.633N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 13/69 (19%) 17/50 (34%) 14/68 (21%) 7/60 (12%) 0/40 (0%) |
|ADJUSTED (b) | 38.6% 50.0% 40.7% 39.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 7/26 (27%) 8/24 (33%) 4/20 (20%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | 574 629 521 590 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.548N P=0.200 P=0.409 P=0.547 (e) |
|INCIDENTAL TUMOR | P=0.059N P=0.133 P=0.479N P=0.252N (e) |
|LOGISTIC REGRESSION | P=0.064N P=0.231 P=0.575 P=0.332N P=0.465N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.048 * P=0.483 P=0.190N P=0.002N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/67 (4%) 2/48 (4%) 1/66 (2%) 1/56 (2%) 0/39 (0%) |
|ADJUSTED (b) | 11.0% 7.2% 2.4% 2.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/9 (0%) 0/8 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 2/25 (8%) 1/23 (4%) 0/21 (0%) 0/9 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 696 659 650 552 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.479N P=0.543N P=0.332N P=0.557N (e) |
|INCIDENTAL TUMOR | P=0.322N P=0.537N P=0.260N P=0.409N (e) |
|LOGISTIC REGRESSION | P=0.247N P=0.558N P=0.278N P=0.434N (e) |
|COCHRAN-ARMITAGE | P=0.111N |
|FISHER EXACT | P=0.655N P=0.315N P=0.380N P=0.248N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/67 (4%) 2/48 (4%) 2/66 (3%) 1/56 (2%) 1/39 (3%) |
|ADJUSTED (b) | 11.0% 7.2% 5.6% 2.5% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/9 (0%) 0/8 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/9 (0%) 0/0 0/0 0/0 1/24 (4%) |
|TERMINAL (d) | 2/25 (8%) 1/23 (4%) 0/21 (0%) 0/9 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 696 659 650 552 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.611 P=0.543N P=0.525N P=0.557N P=0.695 |
|INCIDENTAL TUMOR | P=0.559N P=0.537N P=0.415N P=0.409N P=0.695 |
|LOGISTIC REGRESSION | P=0.623N P=0.558N P=0.466N P=0.434N P=0.523 |
|COCHRAN-ARMITAGE | P=0.328N |
|FISHER EXACT | P=0.655N P=0.507N P=0.380N P=0.530N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Intestine Large: Colon/Rectum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 11/69 (16%) 17/70 (24%) 2/40 (5%) |
|ADJUSTED (b) | 0.0% 3.8% 36.6% 67.1% 7.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 1/24 (4%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 6/21 (29%) 4/10 (40%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 718 608 493 427 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.478 P<0.001 ** P<0.001 ** P=0.230 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.484 P=0.001 ** P<0.001 ** P=0.386 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.480 P=0.001 ** P<0.001 ** P=0.197 |
|COCHRAN-ARMITAGE | P=0.037 * |
|FISHER EXACT | P=0.417 P<0.001 ** P<0.001 ** P=0.130 |
|=================================================================================================================================|
| |
|Intestine Large: Colon/Rectum |
| Polyp Adenomatous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 13/50 (26%) 51/69 (74%) 46/70 (66%) 11/40 (28%) |
|ADJUSTED (b) | 0.0% 45.8% 100.0% 100.0% 41.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 6/10 (60%) 9/24 (38%) |
|TERMINAL (d) | 0/26 (0%) 9/24 (38%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 659 478 352 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P=0.008 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P=0.014 * |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/54 (4%) 2/40 (5%) 0/58 (0%) 1/50 (2%) 0/6 (0%) |
|ADJUSTED (b) | 7.7% 7.4% 0.0% 10.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/0 0/0 0/0 0/0 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/0 0/0 0/0 0/0 |
|TERMINAL (d) | 2/26 (8%) 1/24 (4%) 0/21 (0%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 675 --- 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.654N P=0.664 P=0.286N P=0.671 (e) |
|INCIDENTAL TUMOR | P=0.610N P=0.665 P=0.286N P=0.671 (e) |
|LOGISTIC REGRESSION | P=0.548N P=0.659 P=0.286N P=0.671 (e) |
|COCHRAN-ARMITAGE | P=0.316N |
|FISHER EXACT | P=0.571 P=0.230N P=0.529N P=0.808N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/70 (3%) 10/50 (20%) 11/69 (16%) 16/70 (23%) 5/40 (13%) |
|ADJUSTED (b) | 7.7% 33.6% 34.6% 69.5% 20.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 5/24 (21%) |
|TERMINAL (d) | 2/26 (8%) 6/24 (25%) 4/21 (19%) 5/10 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 618 636 456 (I) 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.012 * P=0.007 ** P<0.001 ** P=0.155 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.009 ** P=0.018 * P<0.001 ** P=0.155 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.007 ** P=0.012 * P<0.001 ** P=0.019 * |
|COCHRAN-ARMITAGE | P=0.132 |
|FISHER EXACT | P=0.003 ** P=0.008 ** P<0.001 ** P=0.059 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 2/69 (3%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 7.2% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 674 497 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.258 (e) P=0.224 P=0.482 (e) |
|INCIDENTAL TUMOR | P=0.674 (e) P=0.348 P=0.612 (e) |
|LOGISTIC REGRESSION | P=0.559 (e) P=0.252 P=0.517 (e) |
|COCHRAN-ARMITAGE | P=0.659 |
|FISHER EXACT | (e) P=0.245 P=0.500 (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/70 (3%) 10/50 (20%) 13/69 (19%) 17/70 (24%) 5/40 (13%) |
|ADJUSTED (b) | 7.7% 33.6% 39.4% 70.2% 20.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 5/24 (21%) |
|TERMINAL (d) | 2/26 (8%) 6/24 (25%) 4/21 (19%) 5/10 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 618 636 456 (I) 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.012 * P=0.002 ** P<0.001 ** P=0.155 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.009 ** P=0.008 ** P<0.001 ** P=0.155 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.007 ** P=0.004 ** P<0.001 ** P=0.019 * |
|COCHRAN-ARMITAGE | P=0.136 |
|FISHER EXACT | P=0.003 ** P=0.002 ** P<0.001 ** P=0.059 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Liver |
| Cholangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 2/69 (3%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 7.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 1/21 (5%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 650 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.651 (e) P=0.227 (e) (e) |
|INCIDENTAL TUMOR | P=0.706 (e) P=0.266 (e) (e) |
|LOGISTIC REGRESSION | P=0.743 (e) P=0.253 (e) (e) |
|COCHRAN-ARMITAGE | P=0.587N |
|FISHER EXACT | (e) P=0.245 (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 20/50 (40%) 41/69 (59%) 38/70 (54%) 17/40 (43%) |
|ADJUSTED (b) | 3.8% 71.3% 92.4% 97.2% 57.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 2/10 (20%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 4/10 (40%) 12/24 (50%) |
|TERMINAL (d) | 1/26 (4%) 16/24 (67%) 18/21 (86%) 9/10 (90%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 675 273 (I) 435 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 12/50 (24%) 55/69 (80%) 53/70 (76%) 28/40 (70%) |
|ADJUSTED (b) | 2.7% 43.5% 100.0% 100.0% 90.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 7/10 (70%) 21/24 (88%) |
|TERMINAL (d) | 0/26 (0%) 9/24 (38%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 666 650 465 436 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/70 (3%) 25/50 (50%) 58/69 (84%) 57/70 (81%) 33/40 (83%) |
|ADJUSTED (b) | 6.4% 83.1% 100.0% 100.0% 97.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 4/10 (40%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 10/10 (100%) 23/24 (96%) |
|TERMINAL (d) | 1/26 (4%) 19/24 (79%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 666 650 273 (I) 435 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/70 (3%) 25/50 (50%) 58/69 (84%) 57/70 (81%) 33/40 (83%) |
|ADJUSTED (b) | 6.4% 83.1% 100.0% 100.0% 97.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 4/10 (40%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 10/10 (100%) 23/24 (96%) |
|TERMINAL (d) | 1/26 (4%) 19/24 (79%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 666 650 273 (I) 435 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 6/69 (9%) 2/70 (3%) 1/40 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 19.1% 12.1% 3.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 2/21 (10%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 563 527 414 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.004 ** (e) P=0.019 * P=0.133 P=0.355 |
|INCIDENTAL TUMOR | P=0.134 (e) P=0.039 * P=0.186 P=0.581 |
|LOGISTIC REGRESSION | P=0.126 (e) P=0.022 * P=0.210 P=0.499 |
|COCHRAN-ARMITAGE | P=0.367 |
|FISHER EXACT | (e) P=0.013 * P=0.248 P=0.364 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 1/69 (1%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.1% 3.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 629 622 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.318 (e) P=0.532 P=0.436 (e) |
|INCIDENTAL TUMOR | P=0.621 (e) P=0.623 P=0.665 (e) |
|LOGISTIC REGRESSION | P=0.561 (e) P=0.504 P=0.480 (e) |
|COCHRAN-ARMITAGE | P=0.631 |
|FISHER EXACT | (e) P=0.496 P=0.500 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 2/50 (4%) 2/69 (3%) 4/62 (6%) 1/40 (3%) |
|ADJUSTED (b) | 1.8% 8.3% 7.2% 17.1% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 1/3 (33%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 2/24 (8%) 1/21 (5%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 729 (T) 653 456 (I) 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.277 P=0.220 P=0.219 P=0.030 * P=0.668N |
|INCIDENTAL TUMOR | P=0.470 P=0.220 P=0.266 P=0.072 P=0.668N |
|LOGISTIC REGRESSION | P=0.320 P=0.400 P=0.500 P=0.149 P=0.736N |
|COCHRAN-ARMITAGE | P=0.403 |
|FISHER EXACT | P=0.375 P=0.495 P=0.147 P=0.597 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 2/69 (3%) 1/62 (2%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 4.0% 9.5% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/3 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 720 729 (T) 435 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.434 P=0.470 P=0.192 P=0.497 (e) |
|INCIDENTAL TUMOR | P=0.657 P=0.484 P=0.192 P=0.612 (e) |
|LOGISTIC REGRESSION | P=0.630 P=0.480 P=0.192 P=0.499 (e) |
|COCHRAN-ARMITAGE | P=0.542N |
|FISHER EXACT | P=0.417 P=0.245 P=0.470 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 3/50 (6%) 4/69 (6%) 5/62 (8%) 1/40 (3%) |
|ADJUSTED (b) | 1.8% 12.0% 16.5% 18.6% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 1/3 (33%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 2/24 (8%) 3/21 (14%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 720 653 435 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.191 P=0.105 P=0.046 * P=0.017 * P=0.668N |
|INCIDENTAL TUMOR | P=0.448 P=0.109 P=0.056 P=0.047 * P=0.668N |
|LOGISTIC REGRESSION | P=0.311 P=0.220 P=0.196 P=0.085 P=0.736N |
|COCHRAN-ARMITAGE | P=0.478 |
|FISHER EXACT | P=0.195 P=0.178 P=0.079 P=0.597 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 1/69 (1%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 674 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.858 (e) P=0.506 (e) (e) |
|INCIDENTAL TUMOR | P=0.895 (e) P=0.596 (e) (e) |
|LOGISTIC REGRESSION | P=0.864 (e) P=0.513 (e) (e) |
|COCHRAN-ARMITAGE | P=0.708N |
|FISHER EXACT | (e) P=0.496 (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 1/50 (2%) 0/69 (0%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 3.1% 4.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 729 (T) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.526N P=0.740 P=0.506N P=0.615N (e) |
|INCIDENTAL TUMOR | P=0.450N P=0.742 P=0.404N P=0.485N (e) |
|LOGISTIC REGRESSION | P=0.451N P=0.737 P=0.486N P=0.568N P=0.998N |
|COCHRAN-ARMITAGE | P=0.253N |
|FISHER EXACT | P=0.662 P=0.504N P=0.500N P=0.636N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 1/50 (2%) 0/69 (0%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 3.1% 4.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 729 (T) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.526N P=0.740 P=0.506N P=0.615N (e) |
|INCIDENTAL TUMOR | P=0.450N P=0.742 P=0.404N P=0.485N (e) |
|LOGISTIC REGRESSION | P=0.451N P=0.737 P=0.486N P=0.568N P=0.998N |
|COCHRAN-ARMITAGE | P=0.253N |
|FISHER EXACT | P=0.662 P=0.504N P=0.500N P=0.636N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 1/50 (2%) 1/69 (1%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 3.1% 4.2% 2.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 729 (T) 674 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.607N P=0.740 P=0.760 P=0.615N (e) |
|INCIDENTAL TUMOR | P=0.494N P=0.742 P=0.652N P=0.485N (e) |
|LOGISTIC REGRESSION | P=0.484N P=0.737 P=0.747N P=0.568N P=0.998N |
|COCHRAN-ARMITAGE | P=0.248N |
|FISHER EXACT | P=0.662 P=0.748 P=0.500N P=0.636N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/69 (0%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/70 (4%) 0/50 (0%) 0/69 (0%) 0/60 (0%) 0/40 (0%) |
|ADJUSTED (b) | 9.3% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/0 0/24 (0%) |
|TERMINAL (d) | 2/26 (8%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.065N P=0.255N P=0.286N P=0.465N P=0.326N |
|INCIDENTAL TUMOR | P=0.065N P=0.255N P=0.286N P=0.465N P=0.326N |
|LOGISTIC REGRESSION | P=0.104N P=0.174N P=0.116N P=0.162N P=0.522N |
|COCHRAN-ARMITAGE | P=0.103N |
|FISHER EXACT | P=0.195N P=0.125N P=0.153N P=0.254N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/65 (34%) 14/50 (28%) 10/65 (15%) 10/58 (17%) 1/39 (3%) |
|ADJUSTED (b) | 57.0% 40.8% 33.0% 51.1% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/8 (13%) 0/0 0/0 0/0 1/23 (4%) |
|TERMINAL (d) | 10/25 (40%) 6/24 (25%) 4/21 (19%) 4/10 (40%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 604 608 577 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.229N P=0.190N P=0.041N* P=0.430N P=0.511N |
|INCIDENTAL TUMOR | P=0.010N* P=0.217N P=0.003N** P=0.039N* P=0.511N |
|LOGISTIC REGRESSION | P=0.010N** P=0.184N P=0.005N** P=0.015N* P=0.183N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.321N P=0.012N* P=0.029N* P<0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/65 (34%) 15/50 (30%) 10/65 (15%) 10/58 (17%) 1/39 (3%) |
|ADJUSTED (b) | 57.0% 42.3% 33.0% 51.1% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/8 (13%) 0/0 0/0 0/0 1/23 (4%) |
|TERMINAL (d) | 10/25 (40%) 6/24 (25%) 4/21 (19%) 4/10 (40%) 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) 604 608 577 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.210N P=0.248N P=0.041N* P=0.430N P=0.511N |
|INCIDENTAL TUMOR | P=0.007N** P=0.308N P=0.003N** P=0.039N* P=0.511N |
|LOGISTIC REGRESSION | P=0.007N** P=0.261N P=0.005N** P=0.015N* P=0.183N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.408N P=0.012N* P=0.029N* P<0.001N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 0/50 (0%) 0/69 (0%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 2/26 (8%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.391N P=0.255N P=0.286N P=0.465N (e) |
|INCIDENTAL TUMOR | P=0.391N P=0.255N P=0.286N P=0.465N (e) |
|LOGISTIC REGRESSION | P=0.391N P=0.255N P=0.286N P=0.465N (e) |
|COCHRAN-ARMITAGE | P=0.188N |
|FISHER EXACT | P=0.338N P=0.252N P=0.248N P=0.403N |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/70 (4%) 0/50 (0%) 1/69 (1%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 11.5% 0.0% 4.3% 5.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 3/26 (12%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 720 679 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.693N P=0.134N P=0.386N P=0.627N (e) |
|INCIDENTAL TUMOR | P=0.589N P=0.134N P=0.319N P=0.565N (e) |
|LOGISTIC REGRESSION | P=0.593N P=0.134N P=0.351N P=0.503N (e) |
|COCHRAN-ARMITAGE | P=0.189N |
|FISHER EXACT | P=0.195N P=0.315N P=0.310N P=0.254N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/70 (7%) 3/50 (6%) 6/69 (9%) 4/70 (6%) 0/40 (0%) |
|ADJUSTED (b) | 18.0% 10.1% 22.5% 17.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 4/26 (15%) 1/24 (4%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 629 693 527 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.259 P=0.403N P=0.394 P=0.377 (e) |
|INCIDENTAL TUMOR | P=0.577N P=0.435N P=0.570 P=0.593 (e) |
|LOGISTIC REGRESSION | P=0.580 P=0.425N P=0.493 P=0.589 (e) |
|COCHRAN-ARMITAGE | P=0.085N |
|FISHER EXACT | P=0.556N P=0.490 P=0.500N P=0.099N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 0/50 (0%) 3/69 (4%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 12.9% 3.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 0/24 (0%) 1/21 (5%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 646 --- 715 631 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.511 P=0.257N P=0.437 P=0.707N (e) |
|INCIDENTAL TUMOR | P=0.701N P=0.258N P=0.591 P=0.504N (e) |
|LOGISTIC REGRESSION | P=0.701 P=0.277N P=0.520 P=0.581N P=0.945N |
|COCHRAN-ARMITAGE | P=0.281N |
|FISHER EXACT | P=0.338N P=0.493 P=0.500N P=0.403N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 4/70 (6%) 3/50 (6%) 5/69 (7%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 10.7% 11.1% 17.0% 3.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 1/24 (4%) 1/21 (5%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 562 675 465 631 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.494N P=0.550N P=0.493 P=0.351N (e) |
|INCIDENTAL TUMOR | P=0.101N P=0.616N P=0.593N P=0.086N (e) |
|LOGISTIC REGRESSION | P=0.142N P=0.622N P=0.529 P=0.223N P=0.421N |
|COCHRAN-ARMITAGE | P=0.044N* |
|FISHER EXACT | P=0.620 P=0.491 P=0.183N P=0.159N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 3/50 (6%) 2/69 (3%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 4.7% 11.1% 4.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 562 675 465 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.293N P=0.456 P=0.638N P=0.304N (e) |
|INCIDENTAL TUMOR | P=0.064N P=0.378 P=0.534N P=0.080N (e) |
|LOGISTIC REGRESSION | P=0.102N P=0.391 P=0.684 P=0.247N P=0.525N |
|COCHRAN-ARMITAGE | P=0.072N |
|FISHER EXACT | P=0.344 P=0.685 P=0.248N P=0.403N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 3/50 (6%) 1/69 (1%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 2.3% 11.1% 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 562 675 685 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.403N P=0.272 P=0.732N P=0.529N (e) |
|INCIDENTAL TUMOR | P=0.208N P=0.239 P=0.634N P=0.335N (e) |
|LOGISTIC REGRESSION | P=0.223N P=0.228 P=0.760N P=0.499N P=0.711N |
|COCHRAN-ARMITAGE | P=0.122N |
|FISHER EXACT | P=0.195 P=0.748 P=0.500N P=0.636N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 2/50 (4%) 5/69 (7%) 2/70 (3%) 0/40 (0%) |
|ADJUSTED (b) | 3.8% 7.7% 18.9% 10.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 1/24 (4%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 700 693 674 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.171 P=0.469 P=0.079 P=0.278 (e) |
|INCIDENTAL TUMOR | P=0.330 P=0.472 P=0.133 P=0.411 (e) |
|LOGISTIC REGRESSION | P=0.445 P=0.465 P=0.099 P=0.357 (e) |
|COCHRAN-ARMITAGE | P=0.290N |
|FISHER EXACT | P=0.375 P=0.101 P=0.500 P=0.636N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 3/50 (6%) 5/69 (7%) 3/70 (4%) 0/40 (0%) |
|ADJUSTED (b) | 6.9% 10.1% 18.9% 12.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 1/24 (4%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 629 693 527 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.196 P=0.463 P=0.177 P=0.274 (e) |
|INCIDENTAL TUMOR | P=0.607 P=0.422 P=0.291 P=0.489 (e) |
|LOGISTIC REGRESSION | P=0.494 P=0.426 P=0.224 P=0.399 P=1.000N |
|COCHRAN-ARMITAGE | P=0.206N |
|FISHER EXACT | P=0.344 P=0.215 P=0.500 P=0.403N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 3/50 (6%) 5/69 (7%) 3/70 (4%) 0/40 (0%) |
|ADJUSTED (b) | 6.9% 10.1% 18.9% 12.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 1/24 (4%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 692 629 693 527 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.196 P=0.463 P=0.177 P=0.274 (e) |
|INCIDENTAL TUMOR | P=0.607 P=0.422 P=0.291 P=0.489 (e) |
|LOGISTIC REGRESSION | P=0.494 P=0.426 P=0.224 P=0.399 P=1.000N |
|COCHRAN-ARMITAGE | P=0.206N |
|FISHER EXACT | P=0.344 P=0.215 P=0.500 P=0.403N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 2/50 (4%) 0/69 (0%) 2/70 (3%) 1/40 (3%) |
|ADJUSTED (b) | 0.0% 7.7% 0.0% 15.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 1/24 (4%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 700 --- 702 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.123 P=0.220 (e) P=0.099 P=0.674 |
|INCIDENTAL TUMOR | P=0.159 P=0.222 (e) P=0.147 P=0.674 |
|LOGISTIC REGRESSION | P=0.067 P=0.213 (e) P=0.129 P=0.460 |
|COCHRAN-ARMITAGE | P=0.324 |
|FISHER EXACT | P=0.172 (e) P=0.248 P=0.364 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 2/50 (4%) 0/69 (0%) 1/70 (1%) 1/40 (3%) |
|ADJUSTED (b) | 0.0% 7.7% 0.0% 5.6% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 1/24 (4%) |
|TERMINAL (d) | 0/26 (0%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 700 --- 702 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.296 P=0.220 (e) P=0.398 P=0.674 |
|INCIDENTAL TUMOR | P=0.356 P=0.222 (e) P=0.515 P=0.674 |
|LOGISTIC REGRESSION | P=0.189 P=0.213 (e) P=0.420 P=0.460 |
|COCHRAN-ARMITAGE | P=0.407 |
|FISHER EXACT | P=0.172 (e) P=0.500 P=0.364 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 46/70 (66%) 37/50 (74%) 55/69 (80%) 47/68 (69%) 7/40 (18%) |
|ADJUSTED (b) | 97.8% 100.0% 100.0% 100.0% 28.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 5/8 (63%) 6/24 (25%) |
|TERMINAL (d) | 25/26 (96%) 24/24 (100%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 421 604 521 456 (I) 447 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.410N P=0.021 * P<0.001 ** P=0.637 |
|INCIDENTAL TUMOR | P=0.496N P=0.600N P=0.115 P=0.020 * P=0.484N |
|LOGISTIC REGRESSION | P=0.372 P=0.404N P=0.286 P=0.162 P=0.634N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.222 P=0.048 * P=0.404 P<0.001N** |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/69 (14%) 5/50 (10%) 3/69 (4%) 3/61 (5%) 0/40 (0%) |
|ADJUSTED (b) | 27.8% 20.8% 11.6% 23.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/1 (0%) 0/24 (0%) |
|TERMINAL (d) | 4/25 (16%) 5/24 (21%) 1/21 (5%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | 427 729 (T) 702 671 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.088N P=0.251N P=0.092N P=0.329N P=0.212N |
|INCIDENTAL TUMOR | P=0.020N* P=0.414N P=0.037N* P=0.144N P=0.039N* |
|LOGISTIC REGRESSION | P=0.029N* P=0.243N P=0.029N* P=0.085N P=0.094N |
|COCHRAN-ARMITAGE | P=0.004N** |
|FISHER EXACT | P=0.331N P=0.039N* P=0.062N P=0.008N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/69 (14%) 5/50 (10%) 3/69 (4%) 3/61 (5%) 0/40 (0%) |
|ADJUSTED (b) | 27.8% 20.8% 11.6% 23.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/1 (0%) 0/24 (0%) |
|TERMINAL (d) | 4/25 (16%) 5/24 (21%) 1/21 (5%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | 427 729 (T) 702 671 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.088N P=0.251N P=0.092N P=0.329N P=0.212N |
|INCIDENTAL TUMOR | P=0.020N* P=0.414N P=0.037N* P=0.144N P=0.039N* |
|LOGISTIC REGRESSION | P=0.029N* P=0.243N P=0.029N* P=0.085N P=0.094N |
|COCHRAN-ARMITAGE | P=0.004N** |
|FISHER EXACT | P=0.331N P=0.039N* P=0.062N P=0.008N** |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/69 (0%) 0/50 (0%) 2/69 (3%) 1/61 (2%) 1/40 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 6.9% 10.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/25 (0%) 0/24 (0%) 1/21 (5%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 636 729 (T) 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.027 * (e) P=0.236 P=0.318 P=0.500 |
|INCIDENTAL TUMOR | P=0.048 * (e) P=0.284 P=0.318 P=0.500 |
|LOGISTIC REGRESSION | P=0.174 (e) P=0.258 P=0.318 P=0.500 |
|COCHRAN-ARMITAGE | P=0.234 |
|FISHER EXACT | (e) P=0.248 P=0.469 P=0.367 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/69 (3%) 3/50 (6%) 1/69 (1%) 3/61 (5%) 0/40 (0%) |
|ADJUSTED (b) | 8.0% 12.5% 2.1% 18.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/24 (0%) |
|TERMINAL (d) | 2/25 (8%) 3/24 (13%) 0/21 (0%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 623 577 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.281 P=0.481 P=0.519N P=0.205 (e) |
|INCIDENTAL TUMOR | P=0.464 P=0.481 P=0.470N P=0.337 (e) |
|LOGISTIC REGRESSION | P=0.532 P=0.481 P=0.466N P=0.346 (e) |
|COCHRAN-ARMITAGE | P=0.269N |
|FISHER EXACT | P=0.350 P=0.500N P=0.442 P=0.399N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/69 (3%) 3/50 (6%) 3/69 (4%) 4/61 (7%) 1/40 (3%) |
|ADJUSTED (b) | 8.0% 12.5% 8.8% 27.7% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/24 (0%) |
|TERMINAL (d) | 2/25 (8%) 3/24 (13%) 1/21 (5%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 623 577 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.016 * P=0.481 P=0.482 P=0.079 P=0.500 |
|INCIDENTAL TUMOR | P=0.056 P=0.481 P=0.563 P=0.149 P=0.500 |
|LOGISTIC REGRESSION | P=0.195 P=0.481 P=0.544 P=0.181 P=0.699 |
|COCHRAN-ARMITAGE | P=0.545N |
|FISHER EXACT | P=0.350 P=0.500 P=0.283 P=0.697N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Tissue NOS |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/69 (0%) 0/70 (0%) 0/40 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/48 (0%) 1/67 (1%) 4/70 (6%) 1/38 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 4.3% 24.5% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 1/24 (4%) |
|TERMINAL (d) | 0/26 (0%) 0/22 (0%) 0/21 (0%) 1/10 (10%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 720 674 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.004 ** (e) P=0.454 P=0.012 * P=0.674 |
|INCIDENTAL TUMOR | P=0.011 * (e) P=0.586 P=0.039 * P=0.674 |
|LOGISTIC REGRESSION | P=0.002 ** (e) P=0.491 P=0.021 * P=0.451 |
|COCHRAN-ARMITAGE | P=0.084 |
|FISHER EXACT | (e) P=0.489 P=0.060 P=0.352 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/48 (2%) 2/67 (3%) 8/70 (11%) 4/38 (11%) |
|ADJUSTED (b) | 0.0% 3.7% 9.5% 40.3% 14.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 1/9 (11%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 3/24 (13%) |
|TERMINAL (d) | 0/26 (0%) 0/22 (0%) 2/21 (10%) 2/10 (20%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 700 729 (T) 493 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.479 P=0.192 P<0.001 ** P=0.160 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.484 P=0.192 P=0.004 ** P=0.160 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.459 P=0.192 P=0.002 ** P=0.051 |
|COCHRAN-ARMITAGE | P=0.002 ** |
|FISHER EXACT | P=0.407 P=0.237 P=0.003 ** P=0.014 * |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/48 (0%) 0/67 (0%) 0/70 (0%) 1/38 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 1/24 (4%) |
|TERMINAL (d) | 0/26 (0%) 0/22 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- 456 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.412 (e) (e) (e) P=0.674 |
|INCIDENTAL TUMOR | P=0.412 (e) (e) (e) P=0.674 |
|LOGISTIC REGRESSION | P=0.144 (e) (e) (e) P=0.451 |
|COCHRAN-ARMITAGE | P=0.089 |
|FISHER EXACT | (e) (e) (e) P=0.352 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/48 (0%) 0/67 (0%) 0/70 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/22 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|ADJUSTED (b) | |
|INTERIM SACRIFICE 1 (c)| |
|INTERIM SACRIFICE 2 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE (DAYS) | |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | |
|INCIDENTAL TUMOR | |
|LOGISTIC REGRESSION | |
|COCHRAN-ARMITAGE | |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|ADJUSTED (b) | |
|INTERIM SACRIFICE 1 (c)| |
|INTERIM SACRIFICE 2 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE (DAYS) | |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | |
|INCIDENTAL TUMOR | |
|LOGISTIC REGRESSION | |
|COCHRAN-ARMITAGE | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 1/50 (2%) 0/69 (0%) 1/70 (1%) 0/40 (0%) |
|ADJUSTED (b) | 3.8% 2.6% 0.0% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 0/24 (0%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 629 --- 435 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.699N P=0.746 P=0.543N P=0.658 (e) |
|INCIDENTAL TUMOR | P=0.412N P=0.690 P=0.543N P=0.736 (e) |
|LOGISTIC REGRESSION | P=0.456N P=0.718 P=0.543N P=0.758 (e) |
|COCHRAN-ARMITAGE | P=0.410N |
|FISHER EXACT | P=0.662 P=0.504N P=0.752N P=0.636N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/70 (36%) 5/50 (10%) 3/69 (4%) 3/70 (4%) 0/40 (0%) |
|ADJUSTED (b) | 59.0% 18.8% 11.7% 6.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 0/24 (0%) |
|TERMINAL (d) | 9/26 (35%) 4/24 (17%) 2/21 (10%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 514 604 650 456 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** P=0.003N** (e) |
|INCIDENTAL TUMOR | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P=0.419N |
|LOGISTIC REGRESSION | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P=0.084N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 1/50 (2%) 1/69 (1%) 2/70 (3%) 1/40 (3%) |
|ADJUSTED (b) | 3.8% 4.2% 3.6% 3.6% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/10 (10%) 0/24 (0%) |
|TERMINAL (d) | 1/26 (4%) 1/24 (4%) 0/21 (0%) 0/10 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 702 436 400 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.311 P=0.745 P=0.729 P=0.393 P=0.362 |
|INCIDENTAL TUMOR | P=0.554 P=0.745 P=0.734N P=0.459 P=0.581 |
|LOGISTIC REGRESSION | P=0.392 P=0.745 P=0.763N P=0.513 P=0.566 |
|COCHRAN-ARMITAGE | P=0.424 |
|FISHER EXACT | P=0.662 P=0.748 P=0.500 P=0.597 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 57/70 (81%) 40/50 (80%) 60/69 (87%) 57/70 (81%) 30/40 (75%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% 90.6% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 2/10 (20%) 0/10 (0%) 5/10 (50%) |
|INTERIM SACRIFICE 2 (c)| 7/10 (70%) 0/0 0/0 10/10 (100%) 21/24 (88%) |
|TERMINAL (d) | 26/26 (100%) 24/24 (100%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 273 (I) 604 273 (I) 352 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.225N P=0.059 P<0.001 ** P=0.005 ** |
|INCIDENTAL TUMOR | P=0.024 * P=0.500N P=0.500 P=0.252 P=0.062 |
|LOGISTIC REGRESSION | P=0.023N* P=0.586N P=0.427N P=0.308N P=0.027N* |
|COCHRAN-ARMITAGE | P=0.226N |
|FISHER EXACT | P=0.512N P=0.255 P=0.586N P=0.287N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 29/70 (41%) 24/50 (48%) 57/69 (83%) 55/70 (79%) 29/40 (73%) |
|ADJUSTED (b) | 67.0% 71.7% 100.0% 100.0% 90.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 8/10 (80%) 21/24 (88%) |
|TERMINAL (d) | 12/26 (46%) 15/24 (63%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 514 604 465 435 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.398N P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.562N P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.447N P<0.001 ** P<0.001 ** P=0.013 * |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P=0.298 P<0.001 ** P<0.001 ** P=0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71 UM 71LM 71MLM 71MHM MALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 57/70 (81%) 40/50 (80%) 61/69 (88%) 58/70 (83%) 36/40 (90%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 2/10 (20%) 0/10 (0%) 6/10 (60%) |
|INTERIM SACRIFICE 2 (c)| 7/10 (70%) 0/0 0/0 10/10 (100%) 24/24 (100%) |
|TERMINAL (d) | 26/26 (100%) 24/24 (100%) 21/21 (100%) 10/10 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 273 (I) 604 273 (I) 352 273 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.225N P=0.048 * P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.500N P=0.301 P=0.145 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.041N* P=0.586N P=0.681 P=0.431N P=0.066N |
|COCHRAN-ARMITAGE | P=0.156 |
|FISHER EXACT | P=0.512N P=0.181 P=0.500 P=0.179 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 32
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/67 (3%) 1/50 (2%) 0/69 (0%) 0/58 (0%) 0/37 (0%) |
|ADJUSTED (b) | 5.2% 3.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/20 (0%) |
|TERMINAL (d) | 1/35 (3%) 1/32 (3%) 0/37 (0%) 0/11 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 708 729 (T) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.311N P=0.549N P=0.228N P=0.479N (e) |
|INCIDENTAL TUMOR | P=0.190N P=0.559N P=0.154N P=0.244N (e) |
|LOGISTIC REGRESSION | P=0.246N P=0.554N P=0.204N P=0.373N (e) |
|COCHRAN-ARMITAGE | P=0.141N |
|FISHER EXACT | P=0.609N P=0.241N P=0.285N P=0.413N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/67 (3%) 3/50 (6%) 1/69 (1%) 3/58 (5%) 0/37 (0%) |
|ADJUSTED (b) | 5.7% 9.4% 2.7% 9.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/1 (100%) 0/20 (0%) |
|TERMINAL (d) | 2/35 (6%) 3/32 (9%) 1/37 (3%) 0/11 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 462 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.607 P=0.459 P=0.481N P=0.106 (e) |
|INCIDENTAL TUMOR | P=0.554N P=0.459 P=0.481N P=0.311 (e) |
|LOGISTIC REGRESSION | P=0.692N P=0.459 P=0.481N P=0.560 (e) |
|COCHRAN-ARMITAGE | P=0.288N |
|FISHER EXACT | P=0.363 P=0.489N P=0.432 P=0.413N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 33
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/67 (0%) 0/50 (0%) 0/69 (0%) 0/58 (0%) 0/37 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/35 (0%) 0/32 (0%) 0/37 (0%) 0/11 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/67 (3%) 3/50 (6%) 2/69 (3%) 3/58 (5%) 0/37 (0%) |
|ADJUSTED (b) | 5.7% 9.4% 4.6% 9.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/1 (100%) 0/20 (0%) |
|TERMINAL (d) | 2/35 (6%) 3/32 (9%) 1/37 (3%) 0/11 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 660 462 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.568 P=0.459 P=0.665N P=0.106 (e) |
|INCIDENTAL TUMOR | P=0.532N P=0.459 P=0.612N P=0.311 (e) |
|LOGISTIC REGRESSION | P=0.660N P=0.459 P=0.638N P=0.560 (e) |
|COCHRAN-ARMITAGE | P=0.276N |
|FISHER EXACT | P=0.363 P=0.679N P=0.432 P=0.413N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 34
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/65 (8%) 3/46 (7%) 3/68 (4%) 2/58 (3%) 0/37 (0%) |
|ADJUSTED (b) | 13.3% 10.0% 7.4% 10.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/3 (0%) 0/20 (0%) |
|TERMINAL (d) | 4/36 (11%) 3/30 (10%) 2/38 (5%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 708 729 (T) 696 610 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.613N P=0.465N P=0.330N P=0.664 (e) |
|INCIDENTAL TUMOR | P=0.337N P=0.495N P=0.225N P=0.377N (e) |
|LOGISTIC REGRESSION | P=0.344N P=0.489N P=0.268N P=0.414N (e) |
|COCHRAN-ARMITAGE | P=0.050N |
|FISHER EXACT | P=0.562N P=0.334N P=0.269N P=0.099N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/65 (8%) 3/46 (7%) 3/68 (4%) 2/58 (3%) 0/37 (0%) |
|ADJUSTED (b) | 13.3% 10.0% 7.4% 10.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/3 (0%) 0/20 (0%) |
|TERMINAL (d) | 4/36 (11%) 3/30 (10%) 2/38 (5%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 708 729 (T) 696 610 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.613N P=0.465N P=0.330N P=0.664 (e) |
|INCIDENTAL TUMOR | P=0.337N P=0.495N P=0.225N P=0.377N (e) |
|LOGISTIC REGRESSION | P=0.344N P=0.489N P=0.268N P=0.414N (e) |
|COCHRAN-ARMITAGE | P=0.050N |
|FISHER EXACT | P=0.562N P=0.334N P=0.269N P=0.099N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 35
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Intestine Large: Colon/Rectum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 2/50 (4%) 21/70 (30%) 8/69 (12%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 45.1% 46.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 2/32 (6%) 14/38 (37%) 4/12 (33%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 606 625 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.201 P<0.001 ** P<0.001 ** (e) |
|INCIDENTAL TUMOR | P<0.001 ** P=0.201 P<0.001 ** P=0.001 ** (e) |
|LOGISTIC REGRESSION | P=0.002 ** P=0.201 P<0.001 ** P<0.001 ** (e) |
|COCHRAN-ARMITAGE | P=0.449N |
|FISHER EXACT | P=0.172 P<0.001 ** P=0.003 ** (e) |
|=================================================================================================================================|
| |
|Intestine Large: Colon/Rectum |
| Polyp Adenomatous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 28/50 (56%) 53/70 (76%) 45/69 (65%) 8/38 (21%) |
|ADJUSTED (b) | 0.0% 77.7% 100.0% 100.0% 35.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 6/20 (30%) |
|TERMINAL (d) | 0/38 (0%) 24/32 (75%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 616 582 462 (I) 306 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P=0.009 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P=0.062 |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P=0.002 ** |
|COCHRAN-ARMITAGE | P=0.103 |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 36
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/40 (3%) 0/60 (0%) 0/47 (0%) 0/8 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/0 0/0 0/0 0/0 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/0 0/0 |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.899N P=0.466 (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.899N P=0.466 (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.899N P=0.466 (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.670N |
|FISHER EXACT | P=0.444 (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 3/50 (6%) 16/70 (23%) 16/68 (24%) 6/38 (16%) |
|ADJUSTED (b) | 0.0% 8.0% 36.0% 69.7% 27.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 5/20 (25%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 11/38 (29%) 6/12 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 601 625 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.093 P<0.001 ** P<0.001 ** P=0.065 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.072 P<0.001 ** P<0.001 ** P=0.065 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.071 P<0.001 ** P<0.001 ** P=0.010 * |
|COCHRAN-ARMITAGE | P=0.004 ** |
|FISHER EXACT | P=0.070 P<0.001 ** P<0.001 ** P=0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 37
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 2/68 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 12.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 702 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.032 * (e) (e) P=0.069 (e) |
|INCIDENTAL TUMOR | P=0.100 (e) (e) P=0.184 (e) |
|LOGISTIC REGRESSION | P=0.062 (e) (e) P=0.115 (e) |
|COCHRAN-ARMITAGE | P=0.401 |
|FISHER EXACT | (e) (e) P=0.241 (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 3/50 (6%) 16/70 (23%) 16/68 (24%) 6/38 (16%) |
|ADJUSTED (b) | 0.0% 8.0% 36.0% 69.7% 27.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 5/20 (25%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 11/38 (29%) 6/12 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 601 625 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.093 P<0.001 ** P<0.001 ** P=0.065 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.072 P<0.001 ** P<0.001 ** P=0.065 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.071 P<0.001 ** P<0.001 ** P=0.010 * |
|COCHRAN-ARMITAGE | P=0.004 ** |
|FISHER EXACT | P=0.070 P<0.001 ** P<0.001 ** P=0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 38
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Cholangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 1/68 (1%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 719 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.294 (e) (e) P=0.310 (e) |
|INCIDENTAL TUMOR | P=0.574 (e) (e) P=0.665 (e) |
|LOGISTIC REGRESSION | P=0.348 (e) (e) P=0.369 (e) |
|COCHRAN-ARMITAGE | P=0.587 |
|FISHER EXACT | (e) (e) P=0.493 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 28/50 (56%) 47/70 (67%) 37/68 (54%) 18/38 (47%) |
|ADJUSTED (b) | 0.0% 75.5% 83.7% 85.9% 73.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 8/10 (80%) 14/20 (70%) |
|TERMINAL (d) | 0/38 (0%) 23/32 (72%) 29/38 (76%) 8/12 (67%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 575 418 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 39
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 12/50 (24%) 57/70 (81%) 51/68 (75%) 22/38 (58%) |
|ADJUSTED (b) | 0.0% 37.5% 98.3% 100.0% 87.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 6/10 (60%) 17/20 (85%) |
|TERMINAL (d) | 0/38 (0%) 12/32 (38%) 37/38 (97%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 575 460 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 33/50 (66%) 59/70 (84%) 56/68 (82%) 27/38 (71%) |
|ADJUSTED (b) | 0.0% 89.1% 100.0% 100.0% 92.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 9/10 (90%) 18/20 (90%) |
|TERMINAL (d) | 0/38 (0%) 28/32 (88%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 575 418 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 40
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 33/50 (66%) 59/70 (84%) 56/68 (82%) 27/38 (71%) |
|ADJUSTED (b) | 0.0% 89.1% 100.0% 100.0% 92.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 9/10 (90%) 18/20 (90%) |
|TERMINAL (d) | 0/38 (0%) 28/32 (88%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 575 418 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 11/70 (16%) 13/68 (19%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 27.1% 56.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 9/38 (24%) 5/12 (42%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 670 600 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** (e) P<0.001 ** P<0.001 ** (e) |
|INCIDENTAL TUMOR | P<0.001 ** (e) P=0.001 ** P<0.001 ** (e) |
|LOGISTIC REGRESSION | P<0.001 ** (e) P=0.001 ** P<0.001 ** (e) |
|COCHRAN-ARMITAGE | P=0.184 |
|FISHER EXACT | (e) P<0.001 ** P<0.001 ** (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 41
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 2/70 (3%) 0/68 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 2/38 (5%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.613 (e) P=0.238 (e) (e) |
|INCIDENTAL TUMOR | P=0.613 (e) P=0.238 (e) (e) |
|LOGISTIC REGRESSION | P=0.613 (e) P=0.238 (e) (e) |
|COCHRAN-ARMITAGE | P=0.599N |
|FISHER EXACT | (e) P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 3/50 (6%) 1/70 (1%) 0/64 (0%) 0/38 (0%) |
|ADJUSTED (b) | 2.5% 9.4% 1.9% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/5 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 3/32 (9%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 716 729 (T) 647 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.476N P=0.244 P=0.739N P=0.695N (e) |
|INCIDENTAL TUMOR | P=0.260N P=0.234 P=0.584N P=0.335N (e) |
|LOGISTIC REGRESSION | P=0.307N P=0.229 P=0.746N P=0.619N (e) |
|COCHRAN-ARMITAGE | P=0.133N |
|FISHER EXACT | P=0.195 P=0.752N P=0.522N P=0.648N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 42
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 1/64 (2%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 5.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/5 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 702 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.326 (e) (e) P=0.352 (e) |
|INCIDENTAL TUMOR | P=0.574 (e) (e) P=0.665 (e) |
|LOGISTIC REGRESSION | P=0.416 (e) (e) P=0.417 (e) |
|COCHRAN-ARMITAGE | P=0.583 |
|FISHER EXACT | (e) (e) P=0.478 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/70 (1%) 3/50 (6%) 1/70 (1%) 1/64 (2%) 0/38 (0%) |
|ADJUSTED (b) | 2.5% 9.4% 1.9% 5.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/5 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 3/32 (9%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 716 729 (T) 647 702 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.693 P=0.244 P=0.739N P=0.559 (e) |
|INCIDENTAL TUMOR | P=0.478N P=0.234 P=0.584N P=0.568N (e) |
|LOGISTIC REGRESSION | P=0.584N P=0.229 P=0.746N P=0.660 (e) |
|COCHRAN-ARMITAGE | P=0.218N |
|FISHER EXACT | P=0.195 P=0.752N P=0.729 P=0.648N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 43
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 5.3% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 2/38 (5%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.387N P=0.277N P=0.238N P=0.513N (e) |
|INCIDENTAL TUMOR | P=0.387N P=0.277N P=0.238N P=0.513N (e) |
|LOGISTIC REGRESSION | P=0.387N P=0.277N P=0.238N P=0.513N (e) |
|COCHRAN-ARMITAGE | P=0.191N |
|FISHER EXACT | P=0.338N P=0.248N P=0.252N P=0.418N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 22/70 (31%) 10/50 (20%) 9/70 (13%) 5/69 (7%) 0/38 (0%) |
|ADJUSTED (b) | 53.0% 29.1% 20.7% 22.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 19/38 (50%) 8/32 (25%) 6/38 (16%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 659 582 610 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.027N* P=0.055N P=0.008N** P=0.150N P=0.362N |
|INCIDENTAL TUMOR | P<0.001N** P=0.058N P=0.003N** P=0.011N* P=0.362N |
|LOGISTIC REGRESSION | P<0.001N** P=0.057N P=0.002N** P=0.004N** P=0.385N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.117N P=0.007N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 44
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 22/70 (31%) 10/50 (20%) 9/70 (13%) 5/69 (7%) 0/38 (0%) |
|ADJUSTED (b) | 53.0% 29.1% 20.7% 22.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 19/38 (50%) 8/32 (25%) 6/38 (16%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 659 582 610 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.027N* P=0.055N P=0.008N** P=0.150N P=0.362N |
|INCIDENTAL TUMOR | P<0.001N** P=0.058N P=0.003N** P=0.011N* P=0.362N |
|LOGISTIC REGRESSION | P<0.001N** P=0.057N P=0.002N** P=0.004N** P=0.385N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.117N P=0.007N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 24/70 (34%) 10/50 (20%) 9/70 (13%) 5/69 (7%) 0/38 (0%) |
|ADJUSTED (b) | 58.0% 29.1% 20.7% 22.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 21/38 (55%) 8/32 (25%) 6/38 (16%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 659 582 610 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.014N* P=0.024N* P=0.003N** P=0.102N P=0.362N |
|INCIDENTAL TUMOR | P<0.001N** P=0.025N* P<0.001N** P=0.006N** P=0.362N |
|LOGISTIC REGRESSION | P<0.001N** P=0.025N* P<0.001N** P=0.002N** P=0.406N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.065N P=0.002N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 45
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 0/70 (0%) 2/69 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 0.0% 10.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- 559 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.124 P=0.466 (e) P=0.116 (e) |
|INCIDENTAL TUMOR | P=0.240 P=0.466 (e) P=0.216 (e) |
|LOGISTIC REGRESSION | P=0.379 P=0.466 (e) P=0.206 (e) |
|COCHRAN-ARMITAGE | P=0.580 |
|FISHER EXACT | P=0.417 (e) P=0.245 (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 2/70 (3%) 0/58 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/1 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 1/38 (3%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 691 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.646 (e) P=0.250 (e) (e) |
|INCIDENTAL TUMOR | P=0.780 (e) P=0.321 (e) (e) |
|LOGISTIC REGRESSION | P=0.720 (e) P=0.262 (e) (e) |
|COCHRAN-ARMITAGE | P=0.608N |
|FISHER EXACT | (e) P=0.248 (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 46
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 34/70 (49%) 19/49 (39%) 32/70 (46%) 13/57 (23%) 4/38 (11%) |
|ADJUSTED (b) | 75.2% 55.6% 62.3% 55.7% 15.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 0/0 1/20 (5%) |
|TERMINAL (d) | 27/38 (71%) 17/32 (53%) 19/38 (50%) 4/11 (36%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 616 575 512 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.149 P=0.060N P=0.510N P=0.431 P=0.339 |
|INCIDENTAL TUMOR | P=0.021N* P=0.071N P=0.153N P=0.018N* P=0.500N |
|LOGISTIC REGRESSION | P=0.105N P=0.061N P=0.171N P=0.008N** P=0.667N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.192N P=0.433N P=0.002N** P<0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 34/70 (49%) 19/49 (39%) 32/70 (46%) 13/57 (23%) 4/38 (11%) |
|ADJUSTED (b) | 75.2% 55.6% 62.3% 55.7% 15.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 0/0 1/20 (5%) |
|TERMINAL (d) | 27/38 (71%) 17/32 (53%) 19/38 (50%) 4/11 (36%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 616 575 512 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.149 P=0.060N P=0.510N P=0.431 P=0.339 |
|INCIDENTAL TUMOR | P=0.021N* P=0.071N P=0.153N P=0.018N* P=0.500N |
|LOGISTIC REGRESSION | P=0.105N P=0.061N P=0.171N P=0.008N** P=0.667N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.192N P=0.433N P=0.002N** P<0.001N** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 47
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 48
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 3/70 (4%) 3/69 (4%) 0/38 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 7.9% 19.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 1/38 (3%) 0/32 (0%) 3/38 (8%) 2/12 (17%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 637 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.015 * P=0.534N P=0.305 P=0.056 (e) |
|INCIDENTAL TUMOR | P=0.038 * P=0.534N P=0.305 P=0.118 (e) |
|LOGISTIC REGRESSION | P=0.065 P=0.534N P=0.305 P=0.156 (e) |
|COCHRAN-ARMITAGE | P=0.614 |
|FISHER EXACT | P=0.583N P=0.310 P=0.304 P=0.648N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 2/50 (4%) 0/70 (0%) 1/69 (1%) 0/38 (0%) |
|ADJUSTED (b) | 5.3% 6.0% 0.0% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/10 (10%) 0/20 (0%) |
|TERMINAL (d) | 2/38 (5%) 1/32 (3%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 670 --- 462 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.265N P=0.625 P=0.238N P=0.731 (e) |
|INCIDENTAL TUMOR | P=0.208N P=0.615 P=0.238N P=0.731 (e) |
|LOGISTIC REGRESSION | P=0.267N P=0.607 P=0.238N P=0.542N (e) |
|COCHRAN-ARMITAGE | P=0.177N |
|FISHER EXACT | P=0.555 P=0.248N P=0.505N P=0.418N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 49
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/70 (4%) 2/50 (4%) 0/70 (0%) 1/69 (1%) 0/38 (0%) |
|ADJUSTED (b) | 7.5% 6.0% 0.0% 1.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/10 (10%) 0/20 (0%) |
|TERMINAL (d) | 2/38 (5%) 1/32 (3%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 704 670 --- 462 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.181N P=0.591N P=0.122N P=0.596N (e) |
|INCIDENTAL TUMOR | P=0.100N P=0.608N P=0.080N P=0.423N (e) |
|LOGISTIC REGRESSION | P=0.163N P=0.610N P=0.103N P=0.363N (e) |
|COCHRAN-ARMITAGE | P=0.103N |
|FISHER EXACT | P=0.656N P=0.122N P=0.315N P=0.268N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 704 --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.688N P=0.554N P=0.495N P=0.669N (e) |
|INCIDENTAL TUMOR | P=0.426N P=0.567N P=0.348N P=0.335N (e) |
|LOGISTIC REGRESSION | P=0.592N P=0.551N P=0.480N P=0.587N P=1.000N |
|COCHRAN-ARMITAGE | P=0.412N |
|FISHER EXACT | P=0.583N P=0.500N P=0.504N P=0.648N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 50
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 704 --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.688N P=0.554N P=0.495N P=0.669N (e) |
|INCIDENTAL TUMOR | P=0.426N P=0.567N P=0.348N P=0.335N (e) |
|LOGISTIC REGRESSION | P=0.592N P=0.551N P=0.480N P=0.587N P=1.000N |
|COCHRAN-ARMITAGE | P=0.412N |
|FISHER EXACT | P=0.583N P=0.500N P=0.504N P=0.648N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 3/70 (4%) 3/69 (4%) 0/38 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 7.9% 19.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 1/38 (3%) 0/32 (0%) 3/38 (8%) 2/12 (17%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 637 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.015 * P=0.534N P=0.305 P=0.056 (e) |
|INCIDENTAL TUMOR | P=0.038 * P=0.534N P=0.305 P=0.118 (e) |
|LOGISTIC REGRESSION | P=0.065 P=0.534N P=0.305 P=0.156 (e) |
|COCHRAN-ARMITAGE | P=0.614 |
|FISHER EXACT | P=0.583N P=0.310 P=0.304 P=0.648N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 51
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 3/70 (4%) 3/69 (4%) 0/38 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 7.9% 19.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 1/38 (3%) 0/32 (0%) 3/38 (8%) 2/12 (17%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 637 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.015 * P=0.534N P=0.305 P=0.056 (e) |
|INCIDENTAL TUMOR | P=0.038 * P=0.534N P=0.305 P=0.118 (e) |
|LOGISTIC REGRESSION | P=0.065 P=0.534N P=0.305 P=0.156 (e) |
|COCHRAN-ARMITAGE | P=0.614 |
|FISHER EXACT | P=0.583N P=0.310 P=0.304 P=0.648N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/70 (1%) 0/50 (0%) 3/70 (4%) 3/69 (4%) 0/38 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 7.9% 19.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 1/38 (3%) 0/32 (0%) 3/38 (8%) 2/12 (17%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 637 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.015 * P=0.534N P=0.305 P=0.056 (e) |
|INCIDENTAL TUMOR | P=0.038 * P=0.534N P=0.305 P=0.118 (e) |
|LOGISTIC REGRESSION | P=0.065 P=0.534N P=0.305 P=0.156 (e) |
|COCHRAN-ARMITAGE | P=0.614 |
|FISHER EXACT | P=0.583N P=0.310 P=0.304 P=0.648N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 52
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 1/70 (1%) 2/69 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 2.4% 10.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 714 600 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.099 P=0.466 P=0.510 P=0.104 (e) |
|INCIDENTAL TUMOR | P=0.312 P=0.466 P=0.652 P=0.216 (e) |
|LOGISTIC REGRESSION | P=0.292 P=0.466 P=0.522 P=0.191 (e) |
|COCHRAN-ARMITAGE | P=0.612 |
|FISHER EXACT | P=0.417 P=0.500 P=0.245 (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 1/69 (1%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 8.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.268 (e) (e) P=0.271 (e) |
|INCIDENTAL TUMOR | P=0.268 (e) (e) P=0.271 (e) |
|LOGISTIC REGRESSION | P=0.268 (e) (e) P=0.271 (e) |
|COCHRAN-ARMITAGE | P=0.588 |
|FISHER EXACT | (e) (e) P=0.496 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 53
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|ADJUSTED (b) | |
|INTERIM SACRIFICE 1 (c)| |
|INTERIM SACRIFICE 2 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE (DAYS) | |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | |
|INCIDENTAL TUMOR | |
|LOGISTIC REGRESSION | |
|COCHRAN-ARMITAGE | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/70 (7%) 5/50 (10%) 5/70 (7%) 1/59 (2%) 0/38 (0%) |
|ADJUSTED (b) | 13.2% 15.6% 12.7% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/20 (0%) |
|TERMINAL (d) | 5/38 (13%) 5/32 (16%) 4/38 (11%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 714 719 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.489N P=0.519 P=0.627N P=0.509N (e) |
|INCIDENTAL TUMOR | P=0.337N P=0.519 P=0.584N P=0.350N (e) |
|LOGISTIC REGRESSION | P=0.380N P=0.519 P=0.604N P=0.421N (e) |
|COCHRAN-ARMITAGE | P=0.022N* |
|FISHER EXACT | P=0.406 P=0.628N P=0.149N P=0.109N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 54
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/70 (7%) 5/50 (10%) 6/70 (9%) 1/59 (2%) 0/38 (0%) |
|ADJUSTED (b) | 13.2% 15.6% 15.2% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/20 (0%) |
|TERMINAL (d) | 5/38 (13%) 5/32 (16%) 5/38 (13%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 714 719 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.552N P=0.519 P=0.503 P=0.509N (e) |
|INCIDENTAL TUMOR | P=0.399N P=0.519 P=0.547 P=0.350N (e) |
|LOGISTIC REGRESSION | P=0.439N P=0.519 P=0.530 P=0.421N (e) |
|COCHRAN-ARMITAGE | P=0.022N* |
|FISHER EXACT | P=0.406 P=0.500 P=0.149N P=0.109N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 1/70 (1%) 2/59 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 2.2% 12.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 691 664 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.093 P=0.466 P=0.518 P=0.083 (e) |
|INCIDENTAL TUMOR | P=0.259 P=0.466 P=0.652 P=0.184 (e) |
|LOGISTIC REGRESSION | P=0.238 P=0.466 P=0.517 P=0.155 (e) |
|COCHRAN-ARMITAGE | P=0.596 |
|FISHER EXACT | P=0.417 P=0.500 P=0.207 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 55
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 0/59 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 1/50 (2%) 1/70 (1%) 2/59 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 2.2% 12.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 1/32 (3%) 0/38 (0%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 691 664 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.093 P=0.466 P=0.518 P=0.083 (e) |
|INCIDENTAL TUMOR | P=0.259 P=0.466 P=0.652 P=0.184 (e) |
|LOGISTIC REGRESSION | P=0.238 P=0.466 P=0.517 P=0.155 (e) |
|COCHRAN-ARMITAGE | P=0.596 |
|FISHER EXACT | P=0.417 P=0.500 P=0.207 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 56
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Tissue NOS |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/70 (3%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 3.5% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 268 --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.227N P=0.301N P=0.221N P=0.270N P=0.622N |
|INCIDENTAL TUMOR | P=0.039N* P=0.557N P=0.388N P=0.227N P=0.282N |
|LOGISTIC REGRESSION | P=0.138N P=0.317N P=0.276N P=0.217N P=0.234N |
|COCHRAN-ARMITAGE | P=0.191N |
|FISHER EXACT | P=0.338N P=0.248N P=0.252N P=0.418N |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 8/70 (11%) 18/66 (27%) 6/38 (16%) |
|ADJUSTED (b) | 0.0% 0.0% 19.5% 57.2% 27.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 5/20 (25%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 6/38 (16%) 4/12 (33%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 670 367 299 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.006 ** P<0.001 ** P=0.044 * |
|INCIDENTAL TUMOR | P<0.001 ** (e) P=0.010 ** P<0.001 ** P=0.093 |
|LOGISTIC REGRESSION | P<0.001 ** (e) P=0.008 ** P<0.001 ** P=0.009 ** |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | (e) P=0.003 ** P<0.001 ** P=0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 57
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 2/50 (4%) 7/70 (10%) 10/66 (15%) 2/38 (5%) |
|ADJUSTED (b) | 0.0% 6.3% 17.6% 40.6% 8.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 1/10 (10%) 1/20 (5%) |
|TERMINAL (d) | 0/38 (0%) 2/32 (6%) 6/38 (16%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 691 462 (I) 426 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.201 P=0.010 * P<0.001 ** P=0.207 |
|INCIDENTAL TUMOR | P=0.001 ** P=0.201 P=0.013 * P=0.005 ** P=0.638 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.201 P=0.012 * P<0.001 ** P=0.198 |
|COCHRAN-ARMITAGE | P=0.075 |
|FISHER EXACT | P=0.172 P=0.007 ** P<0.001 ** P=0.122 |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 1/70 (1%) 2/66 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.6% 3.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 2/10 (20%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 1/38 (3%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) 462 (I) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.563N (e) P=0.500 P=0.234 (e) |
|INCIDENTAL TUMOR | P=0.563N (e) P=0.500 P=0.234 (e) |
|LOGISTIC REGRESSION | P=0.515 (e) P=0.500 P=0.251 (e) |
|COCHRAN-ARMITAGE | P=0.467 |
|FISHER EXACT | (e) P=0.500 P=0.234 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 58
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 1/70 (1%) 2/66 (3%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.6% 12.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 1/38 (3%) 1/12 (8%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) 673 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.033 * (e) P=0.500 P=0.080 (e) |
|INCIDENTAL TUMOR | P=0.072 (e) P=0.500 P=0.175 (e) |
|LOGISTIC REGRESSION | P=0.086 (e) P=0.500 P=0.138 (e) |
|COCHRAN-ARMITAGE | P=0.467 |
|FISHER EXACT | (e) P=0.500 P=0.234 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 9/70 (13%) 15/50 (30%) 8/70 (11%) 6/69 (9%) 2/38 (5%) |
|ADJUSTED (b) | 21.6% 41.4% 17.8% 18.9% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 1/10 (10%) 2/20 (10%) |
|TERMINAL (d) | 7/38 (18%) 11/32 (34%) 5/38 (13%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 600 279 (I) 462 (I) 462 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.500N P=0.030 * P=0.588N P=0.402 P=0.737 |
|INCIDENTAL TUMOR | P=0.073N P=0.023 * P=0.500N P=0.291N P=0.737 |
|LOGISTIC REGRESSION | P=0.147N P=0.026 * P=0.445N P=0.400N P=0.602 |
|COCHRAN-ARMITAGE | P=0.015N* |
|FISHER EXACT | P=0.019 * P=0.500N P=0.303N P=0.182N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 59
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 9/70 (13%) 15/50 (30%) 9/70 (13%) 6/69 (9%) 2/38 (5%) |
|ADJUSTED (b) | 21.6% 41.4% 20.3% 18.9% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 1/10 (10%) 2/20 (10%) |
|TERMINAL (d) | 7/38 (18%) 11/32 (34%) 6/38 (16%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 600 279 (I) 462 (I) 462 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.530N P=0.030 * P=0.517 P=0.402 P=0.737 |
|INCIDENTAL TUMOR | P=0.085N P=0.023 * P=0.604 P=0.291N P=0.737 |
|LOGISTIC REGRESSION | P=0.158N P=0.026 * P=0.541N P=0.400N P=0.602 |
|COCHRAN-ARMITAGE | P=0.014N* |
|FISHER EXACT | P=0.019 * P=0.599N P=0.303N P=0.182N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 2/70 (3%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.5% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 1/38 (3%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 649 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.661 (e) P=0.256 (e) (e) |
|INCIDENTAL TUMOR | P=0.786 (e) P=0.321 (e) (e) |
|LOGISTIC REGRESSION | P=0.762 (e) P=0.256 (e) (e) |
|COCHRAN-ARMITAGE | P=0.598N |
|FISHER EXACT | (e) P=0.248 (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 60
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 9/70 (13%) 1/50 (2%) 5/70 (7%) 1/69 (1%) 0/38 (0%) |
|ADJUSTED (b) | 21.5% 3.0% 10.0% 3.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 6/38 (16%) 0/32 (0%) 1/38 (3%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 620 689 601 662 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.154N P=0.026N* P=0.177N P=0.162N (e) |
|INCIDENTAL TUMOR | P=0.004N** P=0.025N* P=0.062N P=0.016N* (e) |
|LOGISTIC REGRESSION | P=0.026N* P=0.026N* P=0.152N P=0.039N* P=0.732N |
|COCHRAN-ARMITAGE | P=0.007N** |
|FISHER EXACT | P=0.031N* P=0.199N P=0.009N** P=0.017N* |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/70 (0%) 0/50 (0%) 0/70 (0%) 0/69 (0%) 0/38 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/10 (0%) 0/20 (0%) |
|TERMINAL (d) | 0/38 (0%) 0/32 (0%) 0/38 (0%) 0/12 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) |
|FISHER EXACT | (e) (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 61
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 45/70 (64%) 40/50 (80%) 61/70 (87%) 54/69 (78%) 25/38 (66%) |
|ADJUSTED (b) | 91.8% 100.0% 100.0% 100.0% 92.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 3/10 (30%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 8/10 (80%) 18/20 (90%) |
|TERMINAL (d) | 34/38 (89%) 32/32 (100%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 462 (I) 600 279 (I) 418 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.223 P=0.005 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.030 * P=0.005 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.017 * P=0.037 * P=0.001 ** P=0.001 ** P=0.067 |
|COCHRAN-ARMITAGE | P=0.420N |
|FISHER EXACT | P=0.047 * P=0.001 ** P=0.051 P=0.524 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 16/70 (23%) 15/50 (30%) 60/70 (86%) 55/69 (80%) 23/38 (61%) |
|ADJUSTED (b) | 33.6% 45.5% 100.0% 100.0% 88.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 9/10 (90%) 17/20 (85%) |
|TERMINAL (d) | 8/38 (21%) 14/32 (44%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 268 689 575 367 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.420 P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.317 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.317 P<0.001 ** P<0.001 ** P=0.013 * |
|COCHRAN-ARMITAGE | P<0.001 ** |
|FISHER EXACT | P=0.251 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 01 PAGE 62
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE RATS(FISCHER344) -- 1-AMINO 2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|DOSE | UNTREATE 0.2% 0.5% 1.0% 2.0% |
| | D 71UF 71LF 71MLF 71MHF FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 48/70 (69%) 40/50 (80%) 61/70 (87%) 58/69 (84%) 30/38 (79%) |
|ADJUSTED (b) | 92.2% 100.0% 100.0% 100.0% 96.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 4/10 (40%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 9/10 (90%) 19/20 (95%) |
|TERMINAL (d) | 34/38 (89%) 32/32 (100%) 38/38 (100%) 12/12 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 268 600 279 (I) 367 279 (I) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.430 P=0.025 * P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.086 P=0.035 * P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.014 * P=0.120 P=0.011 * P=0.002 ** P=0.098 |
|COCHRAN-ARMITAGE | P=0.158 |
|FISHER EXACT | P=0.117 P=0.007 ** P=0.025 * P=0.178 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 273 456
Female interim sacrifices(days): 279 462
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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