TR 386 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TETRANITROMETHANE
NTP Experiment-Test: 05072-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 6 3 8
Moribund Sacrifice 19 13 27
Survivors
Terminal Sacrifice 25 34 15
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (48)
Inflammation, Acute, Necrotizing 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 3 (6%) 2 (4%)
Intestine Large, Colon (50) (49) (48)
Parasite Metazoan 5 (10%) 10 (20%) 5 (10%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Muscularis, Mineralization, Multifocal 1 (2%)
Intestine Large, Rectum (49) (49) (49)
Parasite Metazoan 7 (14%) 7 (14%) 6 (12%)
Muscularis, Mineralization, Multifocal 1 (2%)
Intestine Small, Ileum (46) (49) (46)
Infiltration Cellular, Diffuse, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 3 (6%) 2 (4%)
Angiectasis, Multifocal 1 (2%)
Basophilic Focus 2 (4%) 2 (4%) 8 (16%)
Basophilic Focus, Multiple 24 (48%) 29 (58%) 15 (30%)
Basophilic Focus, Two 1 (2%) 6 (12%) 7 (14%)
Cytomegaly, Multifocal 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 2 (4%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change, Diffuse 6 (12%) 2 (4%)
Fatty Change, Focal 2 (4%)
Fatty Change, Multifocal 3 (6%) 6 (12%) 6 (12%)
Fibrosis, Multifocal 1 (2%) 1 (2%)
Granuloma, Multifocal 15 (30%) 28 (56%) 16 (32%)
Hemorrhage, Acute, Multifocal 2 (4%)
Hepatodiaphragmatic Nodule 5 (10%) 4 (8%) 5 (10%)
Hyperplasia, Nodular 1 (2%) 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Mitotic Alteration 2 (4%) 3 (6%) 1 (2%)
Mixed Cell Focus 2 (4%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mixed Cell Focus, Multiple 1 (2%)
Necrosis, Acute, Focal 1 (2%) 1 (2%)
Necrosis, Acute, Multifocal 2 (4%) 2 (4%) 2 (4%)
Necrosis, Focal, Subacute 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 2 (4%)
Bile Duct, Hyperplasia, Multifocal 10 (20%) 6 (12%) 3 (6%)
Centrilobular, Atrophy, Diffuse 2 (4%) 1 (2%)
Centrilobular, Atrophy, Multifocal 3 (6%) 2 (4%) 2 (4%)
Centrilobular, Congestion, Multifocal 1 (2%)
Centrilobular, Fatty Change, Diffuse 3 (6%) 2 (4%)
Centrilobular, Necrosis, Acute, Diffuse 1 (2%)
Centrilobular, Necrosis, Acute, Multifocal 1 (2%) 1 (2%)
Median Lobe, Hepatodiaphragmatic Nodule 1 (2%)
Periportal, Cytomegaly, Diffuse 1 (2%)
Periportal, Fatty Change, Diffuse 1 (2%) 1 (2%) 1 (2%)
Periportal, Fatty Change, Multifocal 2 (4%) 2 (4%) 2 (4%)
Periportal, Inflammation, Chronic, Multifocal 1 (2%)
Portal, Inflammation, Chronic, Multifocal 1 (2%) 1 (2%)
Serosa, Inflammation, Multifocal,
Proliferative 1 (2%)
Mesentery (4) (6) (8)
Accessory Spleen 2 (50%)
Artery, Mineralization, Multifocal 1 (17%)
Fat, Necrosis, Focal 2 (50%) 3 (50%) 3 (38%)
Fat, Necrosis, Multifocal 1 (17%) 1 (13%)
Vein, Thrombosis 1 (17%)
Pancreas (50) (50) (49)
Ectopic Tissue 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%) 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Acinus, Atrophy 2 (4%)
Acinus, Atrophy, Diffuse 1 (2%) 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Acinus, Atrophy, Multifocal 12 (24%) 8 (16%) 5 (10%)
Acinus, Hyperplasia, Focal 1 (2%) 2 (4%)
Artery, Angiectasis, Multifocal 1 (2%)
Artery, Inflammation, Chronic Active, Focal 1 (2%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%) 2 (4%)
Artery, Mineralization, Multifocal 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (50) (50)
Cytomegaly, Focal 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Duct, Hyperplasia, Focal 1 (2%) 1 (2%)
Duct, Inflammation, Chronic Active, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (49) (50)
Edema 1 (2%)
Erosion, Focal 1 (2%)
Hyperplasia, Basal Cell, Focal 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 6 (12%) 3 (6%) 4 (8%)
Necrosis, Acute, Focal 1 (2%)
Ulcer, Multifocal 1 (2%) 2 (4%)
Ulcer, Single 2 (4%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia, Diffuse 2 (4%) 1 (2%) 2 (4%)
Epithelium, Hyperplasia, Focal 2 (4%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia, Multifocal 2 (4%)
Stomach, Glandular (48) (49) (50)
Erosion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Necrosis, Focal, Subacute 1 (2%)
Mucosa, Mineralization 1 (2%)
Mucosa, Necrosis, Acute, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 34 (68%) 39 (78%) 36 (72%)
Mineralization, Multifocal 1 (2%)
Necrosis, Acute, Multifocal 1 (2%) 1 (2%)
Artery, Amyloid Deposition, Multifocal 1 (2%)
Artery, Adventitia, Hyperplasia 1 (2%)
Artery, Adventitia, Mineralization, Focal 1 (2%)
Artery, Epicardium, Thrombosis 1 (2%)
Atrium Left, Embolus, Focal 1 (2%)
Atrium Left, Inflammation, Acute, Multifocal 1 (2%)
Atrium Left, Thrombosis 1 (2%)
Epicardium, Inflammation, Chronic, Focal 1 (2%)
Mitral Valve, Degeneration, Mucoid 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Capsule, Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%) 1 (2%)
Adrenal Gland, Cortex (50) (49) (50)
Angiectasis, Focal 1 (2%)
Angiectasis, Multifocal 1 (2%) 1 (2%)
Congestion 1 (2%) 2 (4%)
Degeneration, Diffuse, Fatty 3 (6%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Degeneration, Fatty, Focal 10 (20%) 7 (14%) 9 (18%)
Degeneration, Fatty, Multifocal 1 (2%) 1 (2%) 7 (14%)
Degeneration, Focal 1 (2%)
Hyperplasia, Focal 13 (26%) 9 (18%) 4 (8%)
Hyperplasia, Multifocal 2 (4%) 5 (10%) 1 (2%)
Hypertrophy, Focal 4 (8%) 5 (10%) 2 (4%)
Hypertrophy, Multifocal 2 (4%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (43) (48) (45)
Fibrosis, Diffuse 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 4 (9%)
Hyperplasia, Multifocal 1 (2%) 1 (2%) 3 (7%)
Islets, Pancreatic (50) (50) (49)
Atrophy, Diffuse 1 (2%)
Hyperplasia, Focal 2 (4%) 2 (4%)
Hyperplasia, Multifocal 5 (10%) 6 (12%) 3 (6%)
Parathyroid Gland (44) (47) (45)
Hyperplasia, Diffuse 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 1 (2%)
Pituitary Gland (50) (48) (50)
Fibrosis, Focal 1 (2%)
Pars Distalis, Abscess, Chronic 1 (2%)
Pars Distalis, Angiectasis, Focal 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Angiectasis, Multifocal 4 (8%) 2 (4%) 5 (10%)
Pars Distalis, Cyst 5 (10%) 2 (4%) 3 (6%)
Pars Distalis, Cyst, Multiple 5 (10%) 3 (6%) 4 (8%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Hyperplasia, Focal 4 (8%) 4 (8%) 8 (16%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Intermedia, Angiectasis, Multifocal 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (49) (50) (50)
Cyst 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
C-Cell, Hyperplasia 1 (2%)
C-Cell, Hyperplasia, Focal 3 (6%) 3 (6%) 2 (4%)
C-Cell, Hyperplasia, Multifocal 11 (22%) 10 (20%) 12 (24%)
Follicular Cell, Hypertrophy, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (48) (44)
Abscess 2 (4%) 1 (2%)
Ectasia 2 (4%) 3 (6%) 6 (14%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Granulomatous, Multifocal 2 (4%) 1 (2%)
Necrosis, Acute 1 (2%)
Ovary (50) (50) (48)
Cyst 3 (6%) 5 (10%) 5 (10%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (50)
Cyst 1 (2%) 3 (6%)
Cyst, Multiple 1 (2%) 3 (6%)
Dilatation 3 (6%) 1 (2%) 4 (8%)
Fibrosis, Focal 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Prolapse 1 (2%)
Cervix, Dilatation 1 (2%)
Vagina (2) (1)
Inflammation, Chronic Active 1 (50%)
Epithelium, Hyperplasia, Multifocal 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (50)
Atrophy 1 (2%) 1 (2%)
Hyperplasia 23 (48%) 20 (40%) 25 (50%)
Myelofibrosis, Focal 1 (2%)
Lymph Node (50) (50) (50)
Hyperplasia, Plasma Cell 1 (2%)
Axillary, Hemorrhage, Acute 1 (2%)
Mediastinal, Cyst 2 (4%)
Mediastinal, Edema 1 (2%)
Mediastinal, Hemorrhage 7 (14%) 7 (14%) 9 (18%)
Mediastinal, Hyperplasia 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Inflammation, Acute 1 (2%)
Pancreatic, Hemorrhage 4 (8%) 3 (6%) 2 (4%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (49) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage, Acute 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Lymph Node, Mesenteric (47) (49) (49)
Atrophy 1 (2%)
Hemorrhage, Acute 6 (13%) 4 (8%) 6 (12%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Re Cell 1 (2%) 1 (2%) 5 (10%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Spleen (50) (50) (50)
Congestion 2 (4%) 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Fibrosis, Multifocal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 14 (28%)
Hyperplasia, Re Cell 1 (2%)
Pigmentation, Hemosiderin 6 (12%) 9 (18%) 8 (16%)
Capsule, Fibrosis, Multifocal 1 (2%)
Thymus (48) (46) (42)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%)
Epithelial Cell, Hyperplasia 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50)
Ectasia, Diffuse 1 (2%) 4 (8%)
Ectasia, Multifocal 16 (33%) 18 (36%) 19 (38%)
Fibrosis, Focal 1 (2%)
Galactocele 3 (6%)
Hyperplasia, Diffuse 10 (21%) 4 (8%) 5 (10%)
Hyperplasia, Focal 2 (4%) 3 (6%)
Hyperplasia, Multifocal 3 (6%) 3 (6%) 3 (6%)
Inflammation, Granulomatous, Multifocal 1 (2%) 1 (2%)
Mineralization, Multifocal 1 (2%)
Duct, Ectasia, Focal 2 (4%)
Duct, Ectasia, Multifocal 1 (2%)
Duct, Hyperplasia, Multifocal 1 (2%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia, Focal 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (49)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Osteopetrosis 3 (6%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 11 (22%) 12 (24%) 5 (10%)
Hemorrhage, Multifocal 2 (4%)
Hydrocephalus 5 (10%) 5 (10%) 3 (6%)
Choroid Plexus, Hyperplasia, Focal 1 (2%) 1 (2%)
Spinal Cord (1) (1)
Degeneration, Multifocal, Secondary Wallerian 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (49) (49)
Hyperplasia, Focal, Papillary 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute 2 (4%) 2 (4%)
Inflammation, Chronic 4 (8%) 4 (8%) 6 (12%)
Inflammation, Chronic Active 7 (15%) 10 (20%) 8 (16%)
Lung (50) (50) (50)
Hemorrhage, Acute, Focal 1 (2%)
Hemorrhage, Acute, Multifocal 1 (2%)
Inflammation, Acute, Multifocal, Necrotizing 1 (2%)
Inflammation, Multifocal, Necrotizing,
Subacute 1 (2%)
Alveolar Epithelium, Hyperplasia, Atypical,
Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 5 (10%)
Alveolar Epithelium, Hyperplasia, Multifocal 38 (76%) 50 (100%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 1 (2%)
Artery, Mineralization, Multifocal 1 (2%)
Bronchiole, Hyperplasia, Focal 2 (4%)
Bronchiole, Hyperplasia, Multifocal 26 (52%) 48 (96%)
Bronchiole, Alveolus, Inflammation, Acute,
Multifocal, Suppurative 2 (4%)
Bronchus, Hyperplasia, Focal, Papillary 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Interstitium, Inflammation, Chronic,
Multifocal 1 (2%)
Interstitium, Mineralization, Multifocal 1 (2%)
Nose (49) (50) (50)
Foreign Body 2 (4%)
Thrombosis, Multifocal 2 (4%) 1 (2%)
Mucosa, Erosion, Multifocal 1 (2%)
Mucosa, Foreign Body 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Chronic 2 (4%) 1 (2%)
Mucosa, Inflammation, Chronic Active 10 (20%) 7 (14%) 20 (40%)
Mucosa, Inflammation, Chronic Active,
Suppurative 3 (6%) 10 (20%)
Mucosa, Ulcer 1 (2%)
Mucosa, Ulcer, Multifocal 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 9 (18%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 3 (6%) 3 (6%) 2 (4%)
Nasolacrimal Duct, Inflammation, Chronic
Active, Suppurative 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 5 (10%) 2 (4%) 21 (42%)
Respiratory Epithelium, Hyperplasia,
Papillary 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (49) (50) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 3 (6%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Inflammation, Necrotizing, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (3)
Cataract 2 (50%) 1 (33%)
Anterior, Synechia 1 (33%)
Cornea, Neovascularization, Multifocal 1 (33%)
Posterior Chamber, Synechia 1 (25%)
Retina, Degeneration 2 (50%) 1 (33%)
Retina, Dysplasia, Focal 1 (25%)
Lacrimal Gland (2)
Ectopic Tissue 1 (50%)
Inflammation, Chronic 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Pigmentation 1 (50%)
Zymbal's Gland (1)
Ectasia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Infarct 2 (4%)
Nephropathy, Chronic 43 (86%) 47 (94%) 44 (88%)
Pigmentation, Diffuse 9 (18%) 2 (4%)
Pigmentation, Multifocal 1 (2%)
Artery, Mineralization, Multifocal 1 (2%)
Bilateral, Hydronephrosis 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Medulla, Mineralization, Multifocal 1 (2%)
Pelvis, Epithelium, Hyperplasia 1 (2%)
Pelvis, Epithelium, Mineralization 1 (2%) 3 (6%) 3 (6%)
Proximal Convoluted Renal Tubule,
Hyperplasia, Atypical, Focal 1 (2%)
Proximal Convoluted Renal Tubule, Necrosis,
Acute 2 (4%) 2 (4%)
Urinary Bladder (49) (50) (48)
Inflammation, Acute, Diffuse 1 (2%)
Serosa, Inflammation, Chronic Active 2 (4%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 27 25 39
Natural Death 5 8 7
Survivors
Terminal Sacrifice 18 17 4
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (50) (50)
Serosa, Hemorrhage, Chronic, Focal 1 (2%)
Intestine Large, Cecum (45) (49) (49)
Edema 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 4 (9%) 2 (4%)
Intestine Large, Colon (49) (47) (49)
Edema 1 (2%)
Parasite Metazoan 3 (6%) 3 (6%) 8 (16%)
Muscularis, Mineralization, Multifocal 1 (2%)
Intestine Large, Rectum (46) (48) (48)
Parasite Metazoan 4 (9%) 3 (6%) 3 (6%)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small (50) (50) (49)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Duodenum (48) (49) (48)
Ectopic Tissue 1 (2%)
Mucosa, Inflammation, Acute, Necrotizing 1 (2%)
Muscularis, Hyperplasia, Focal 1 (2%)
Intestine Small, Ileum (46) (45) (46)
Infiltration Cellular, Eosinophil, Histiocyte 1 (2%)
Mucosa, Atrophy, Diffuse 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (47) (42) (45)
Congestion 1 (2%)
Diverticulum 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 3 (6%) 3 (6%) 2 (4%)
Angiectasis, Multifocal 1 (2%) 2 (4%)
Basophilic Focus 6 (12%) 1 (2%) 4 (8%)
Basophilic Focus, Multiple 4 (8%) 5 (10%) 5 (10%)
Basophilic Focus, Two 1 (2%) 5 (10%) 6 (12%)
Clear Cell Focus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Congestion, Diffuse 1 (2%) 2 (4%)
Cytomegaly, Diffuse 1 (2%)
Cytomegaly, Multifocal 3 (6%)
Cytoplasmic Alteration, Focal 2 (4%)
Degeneration, Ballooning, Focal 3 (6%) 1 (2%) 3 (6%)
Degeneration, Ballooning, Multifocal 1 (2%) 2 (4%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change, Diffuse 2 (4%) 1 (2%) 1 (2%)
Fatty Change, Multifocal 8 (16%) 4 (8%) 3 (6%)
Fibrosis, Focal 1 (2%)
Granuloma, Multifocal 6 (12%) 4 (8%) 3 (6%)
Hemorrhage, Acute, Multifocal 2 (4%)
Hyperplasia, Multifocal, Nodular 2 (4%)
Inflammation, Multifocal, Subacute 1 (2%)
Mitotic Alteration 2 (4%) 1 (2%) 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Necrosis, Acute, Multifocal 1 (2%) 5 (10%) 6 (12%)
Necrosis, Multifocal, Subacute 4 (8%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Vacuolization Cytoplasmic, Multifocal 3 (6%)
Bile Duct, Hyperplasia, Multifocal 29 (58%) 30 (60%) 31 (62%)
Centrilobular, Atrophy, Diffuse 2 (4%) 1 (2%) 1 (2%)
Centrilobular, Atrophy, Multifocal 4 (8%) 3 (6%) 6 (12%)
Centrilobular, Congestion 1 (2%) 1 (2%)
Centrilobular, Degeneration, Diffuse 1 (2%)
Centrilobular, Degeneration, Multifocal 2 (4%)
Centrilobular, Fatty Change, Diffuse 1 (2%) 2 (4%) 1 (2%)
Centrilobular, Fatty Change, Multifocal 1 (2%) 1 (2%)
Centrilobular, Necrosis, Diffuse 1 (2%) 1 (2%)
Centrilobular, Necrosis, Multifocal 1 (2%) 2 (4%)
Median Lobe, Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 3 (6%)
Periportal, Cytomegaly, Diffuse 1 (2%)
Periportal, Fatty Change, Multifocal 1 (2%)
Portal, Fibrosis, Multifocal 2 (4%) 1 (2%) 5 (10%)
Portal, Inflammation, Chronic, Multifocal 1 (2%)
Portal, Inflammation, Granulomatous,
Multifocal 1 (2%)
Serosa, Inflammation, Chronic Active, Focal,
Proliferative 1 (2%)
Vein, Thrombosis 1 (2%) 2 (4%)
Mesentery (4) (7) (6)
Accessory Spleen 1 (14%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (17%)
Inflammation, Subacute 1 (17%)
Pigmentation 1 (25%)
Artery, Mineralization 1 (17%)
Artery, Adventitia, Inflammation, Chronic
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Active, Multifocal 1 (14%)
Fat, Necrosis, Focal 1 (25%) 2 (29%)
Pancreas (49) (48) (50)
Angiectasis, Focal 1 (2%)
Fibrosis, Focal 1 (2%)
Inflammation, Focal 1 (2%)
Pigmentation 1 (2%)
Acinus, Atrophy, Diffuse 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 3 (6%) 1 (2%)
Acinus, Atrophy, Multifocal 18 (37%) 12 (25%) 18 (36%)
Acinus, Hyperplasia, Focal 2 (4%)
Artery, Adventitia, Inflammation, Chronic
Active, Multifocal 1 (2%) 1 (2%)
Salivary Glands (50) (50) (49)
Inflammation, Chronic, Focal 1 (2%)
Duct, Inflammation, Chronic Active,
Multifocal 1 (2%)
Duct, Metaplasia, Multifocal, Squamous 1 (2%)
Parotid Gland, Inflammation, Chronic Active,
Diffuse 1 (2%)
Stomach, Forestomach (49) (49) (50)
Erosion 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hyperkeratosis, Multifocal 1 (2%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 6 (12%) 8 (16%)
Ulcer 4 (8%) 2 (4%) 4 (8%)
Epithelium, Hyperplasia, Diffuse 5 (10%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%) 3 (6%) 3 (6%)
Epithelium, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Mucosa, Mineralization, Multifocal 1 (2%)
Muscularis, Hyperplasia, Focal 1 (2%)
Stomach, Glandular (48) (47) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mucosa, Mineralization 2 (4%) 1 (2%)
Mucosa, Necrosis, Acute, Multifocal 1 (2%)
Tongue (2) (1)
Epithelium, Hyperplasia, Focal 1 (50%)
Tooth (1)
Abscess 1 (100%)
Developmental Malformation 1 (100%)
Gingiva, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (3) (2)
Inflammation, Chronic, Focal, Necrotizing 1 (50%)
Mineralization, Focal 1 (50%)
Aorta, Mineralization, Multifocal 1 (33%)
Artery, Aneurysm 1 (33%)
Artery, Arteriosclerosis, Multifocal 1 (33%)
Intima, Fibrosis, Multifocal 1 (50%)
Pulmonary Artery, Mineralization 1 (50%)
Heart (50) (50) (50)
Cardiomyopathy 45 (90%) 43 (86%) 36 (72%)
Dilatation 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Mineralization 1 (2%)
Atrium Left, Thrombosis 2 (4%) 3 (6%) 2 (4%)
Atrium Right, Dilatation 1 (2%) 2 (4%)
Epicardium, Hyperplasia 3 (6%)
Epicardium, Inflammation, Chronic, Focal 1 (2%)
Mitral Valve, Inflammation, Chronic 1 (2%)
Mitral Valve, Thrombosis 1 (2%)
Myocardium, Inflammation, Chronic, Focal 1 (2%)
Ventricle Left, Dilatation 1 (2%)
Ventricle Left, Hypertrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Capsule, Accessory Adrenal Cortical Nodule 4 (8%) 5 (10%) 8 (16%)
Adrenal Gland, Cortex (50) (49) (48)
Angiectasis, Multifocal 1 (2%)
Congestion 1 (2%) 1 (2%)
Degeneration, Diffuse, Fatty 3 (6%) 10 (20%) 14 (29%)
Degeneration, Fatty, Focal 10 (20%) 5 (10%) 2 (4%)
Degeneration, Fatty, Multifocal 3 (6%) 4 (8%) 7 (15%)
Degeneration, Multifocal 1 (2%)
Hemorrhage, Acute, Multifocal 1 (2%)
Hyperplasia, Focal 6 (12%) 4 (8%) 4 (8%)
Hyperplasia, Multifocal 1 (2%) 5 (10%) 1 (2%)
Hypertrophy, Focal 1 (2%) 2 (4%) 1 (2%)
Necrosis, Acute, Focal 1 (2%) 1 (2%)
Necrosis, Acute, Multifocal 1 (2%)
Adrenal Gland, Medulla (46) (47) (47)
Hyperplasia, Focal 7 (15%) 9 (19%) 4 (9%)
Hyperplasia, Multifocal 9 (20%) 11 (23%) 13 (28%)
Necrosis, Acute, Focal 1 (2%)
Islets, Pancreatic (49) (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 7 (15%) 2 (4%)
Hyperplasia, Multifocal 1 (2%) 3 (6%)
Parathyroid Gland (47) (48) (43)
Hyperplasia, Diffuse 3 (6%) 4 (8%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (49) (49) (48)
Fibrosis, Focal 1 (2%)
Necrosis, Subacute 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 3 (6%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 3 (6%) 1 (2%)
Pars Distalis, Cyst, Multiple 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Developmental Malformation 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 4 (8%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 3 (6%) 6 (13%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Distalis, Hypertrophy, Focal 1 (2%) 1 (2%)
Pars Distalis, Hypertrophy, Multifocal 1 (2%)
Pars Intermedia, Angiectasis, Multifocal 1 (2%)
Thyroid Gland (49) (49) (50)
C-Cell, Hyperplasia, Focal 3 (6%) 2 (4%) 5 (10%)
C-Cell, Hyperplasia, Multifocal 2 (4%) 6 (12%) 2 (4%)
Follicle, Cyst 1 (2%)
Follicle, Cyst, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Abscess, Chronic, Multiple 1 (100%)
Hyperplasia 1 (100%)
Inflammation, Chronic Active 1 (100%)
Epididymis (49) (49) (50)
Atrophy 2 (4%)
Ectasia 1 (2%)
Fibrosis 1 (2%)
Serosa, Granuloma, Multifocal 1 (2%)
Preputial Gland (49) (48) (49)
Abscess 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%)
Ectasia 3 (6%) 4 (8%) 7 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Foreign Body 3 (6%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 3 (6%)
Inflammation, Granulomatous 28 (57%) 28 (58%) 30 (61%)
Prostate (48) (50) (46)
Abscess 1 (2%) 2 (4%) 1 (2%)
Ectasia, Focal 1 (2%)
Hemorrhage, Acute 1 (2%)
Hyperplasia, Focal 6 (13%) 3 (6%) 3 (7%)
Hyperplasia, Multifocal 4 (8%) 5 (10%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 5 (10%) 1 (2%) 1 (2%)
Inflammation, Chronic Active, Suppurative 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization, Multifocal 1 (2%)
Seminal Vesicle (46) (47) (49)
Atrophy 3 (6%) 1 (2%)
Concretion 1 (2%)
Ectasia 2 (4%)
Hyperplasia 1 (2%)
Testes (50) (50) (50)
Mineralization, Focal 2 (4%) 1 (2%)
Mineralization, Multifocal 4 (8%) 3 (6%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%) 3 (6%)
Interstitial Cell, Hyperplasia 9 (18%) 16 (32%) 21 (42%)
Seminiferous Tubule, Atrophy 12 (24%) 9 (18%) 12 (24%)
Seminiferous Tubule, Degeneration 2 (4%) 1 (2%) 1 (2%)
Serosa, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49)
Hyperplasia 12 (24%) 13 (27%) 6 (12%)
Myelofibrosis, Focal 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (50) (50) (50)
Inguinal, Hemorrhage, Acute 1 (2%)
Mediastinal, Cyst 3 (6%)
Mediastinal, Cyst, Multiple 4 (8%)
Mediastinal, Hemorrhage, Acute 3 (6%) 7 (14%) 5 (10%)
Mediastinal, Hemorrhage, Subacute 2 (4%) 3 (6%) 4 (8%)
Mediastinal, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia, Re Cell 1 (2%)
Mediastinal, Pigmentation 2 (4%)
Pancreatic, Edema 1 (2%)
Pancreatic, Granuloma, Multifocal 1 (2%)
Pancreatic, Hemorrhage, Acute 1 (2%) 1 (2%)
Pancreatic, Hyperplasia 1 (2%)
Renal, Hemorrhage, Acute 1 (2%)
Lymph Node, Mandibular (48) (44) (46)
Hemorrhage, Acute 1 (2%) 2 (5%) 2 (4%)
Hemorrhage, Subacute 1 (2%)
Hyperplasia 2 (5%) 1 (2%)
Hyperplasia, Plasma Cell 7 (15%) 2 (5%) 4 (9%)
Inflammation, Chronic Active 2 (4%)
Lymph Node, Mesenteric (47) (48) (48)
Cyst 1 (2%) 1 (2%)
Hemorrhage, Acute 4 (9%) 10 (21%) 6 (13%)
Hemorrhage, Subacute 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Re Cell 1 (2%) 1 (2%) 2 (4%)
Inflammation, Subacute 1 (2%)
Spleen (50) (49) (50)
Congestion, Acute 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Fibrosis, Diffuse 1 (2%) 1 (2%)
Fibrosis, Focal 5 (10%) 6 (12%) 1 (2%)
Fibrosis, Multifocal 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 7 (14%)
Hemorrhage 1 (2%)
Hyperplasia, Focal, Re Cell 1 (2%)
Infarct 1 (2%) 1 (2%)
Necrosis, Multifocal, Subacute 1 (2%)
Pigmentation, Hemosiderin 4 (8%) 1 (2%)
Capsule, Fibrosis, Multifocal 1 (2%)
Thymus (36) (42) (43)
Atrophy 1 (2%)
Ectopic Parathyroid Gland 1 (3%) 2 (5%) 2 (5%)
Hemorrhage, Acute 2 (5%)
Epithelial Cell, Hyperplasia 1 (3%) 6 (14%) 2 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (43) (46) (47)
Ectasia, Diffuse 4 (9%) 1 (2%) 1 (2%)
Ectasia, Multifocal 11 (26%) 11 (24%) 8 (17%)
Hyperplasia, Diffuse 2 (5%) 3 (7%) 5 (11%)
Artery, Adventitia, Inflammation, Chronic
Active, Focal 1 (2%)
Skin (50) (49) (50)
Cyst Dermoid 2 (4%) 2 (4%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active, Focal,
Suppurative 1 (2%)
Forelimb, Right, Hemorrhage, Chronic, Focal,
Subacute 1 (2%)
Subcutaneous Tissue, Developmental
Malformation 1 (2%)
Tail, Inflammation, Chronic 1 (2%)
Tail, Subcutaneous Tissue, Inflammation,
Chronic, Proliferative 1 (2%)
Tail, Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (49)
Fibrous Osteodystrophy 2 (4%) 1 (2%)
Hyperostosis, Focal 1 (2%)
Necrosis, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 14 (28%) 10 (20%) 3 (6%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 4 (8%)
Hydrocephalus 6 (12%) 3 (6%) 1 (2%)
Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (47) (49) (50)
Foreign Body 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 4 (9%) 4 (8%) 2 (4%)
Inflammation, Chronic Active 9 (19%) 10 (20%) 4 (8%)
Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (50) (50) (50)
Abscess 1 (2%)
Giant Cell, Multifocal 1 (2%)
Hemorrhage, Acute, Focal 1 (2%)
Hemorrhage, Acute, Multifocal 2 (4%) 1 (2%)
Hemorrhage, Multifocal, Subacute 2 (4%)
Infiltration Cellular, Focal, Histiocyte 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal 2 (4%)
Metaplasia, Focal, Osseous 1 (2%)
Necrosis, Acute, Multifocal 1 (2%)
Pigmentation, Diffuse, Hemosiderin 1 (2%)
Pigmentation, Hemosiderin, Multifocal 2 (4%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 7 (14%)
Alveolar Epithelium, Hyperplasia, Multifocal 37 (74%) 50 (100%)
Artery, Thrombosis 1 (2%)
Artery, Adventitia, Mediastinum,
Inflammation, Chronic Active, Multifocal 1 (2%)
Artery, Mediastinum, Mineralization 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Hyperplasia, Focal 2 (4%)
Bronchiole, Hyperplasia, Multifocal 21 (42%) 45 (90%)
Bronchiole, Metaplasia, Focal, Squamous 1 (2%)
Bronchus, Hyperplasia, Focal 1 (2%)
Bronchus, Metaplasia, Squamous 1 (2%)
Bronchus, Alveolus, Inflammation, Chronic
Active, Multifocal 1 (2%)
Interstitium, Fibrosis, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Diffuse 1 (2%)
Interstitium, Inflammation, Chronic,
Multifocal 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic Active,
Diffuse 1 (2%)
Interstitium, Inflammation, Chronic Active,
Multifocal 1 (2%)
Interstitium, Mineralization, Multifocal 1 (2%) 1 (2%)
Mediastinum, Angiectasis 1 (2%)
Mediastinum, Cyst 1 (2%)
Mediastinum, Pigmentation 1 (2%)
Peribronchiolar, Perivascular, Granuloma,
Multifocal 1 (2%)
Nose (48) (49) (50)
Foreign Body 3 (6%) 10 (20%) 3 (6%)
Lumen, Exudate 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Chronic 2 (4%)
Mucosa, Inflammation, Chronic Active 9 (19%) 16 (33%) 16 (32%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mucosa, Inflammation, Chronic Active,
Suppurative 1 (2%) 4 (8%) 21 (42%)
Mucosa, Thrombosis, Multifocal 2 (4%) 3 (6%) 3 (6%)
Nasolacrimal Duct, Exudate 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 3 (6%) 2 (4%)
Nasolacrimal Duct, Inflammation, Chronic 2 (4%) 4 (8%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%) 2 (4%) 2 (4%)
Nasolacrimal Duct, Inflammation, Chronic
Active, Suppurative 1 (2%)
Olfactory Epithelium, Atrophy 3 (6%)
Olfactory Epithelium, Metaplasia 3 (6%)
Respiratory Epithelium, Hyperplasia 7 (15%) 15 (31%) 29 (58%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 13 (26%)
Trachea (50) (50) (50)
Inflammation, Chronic 1 (2%) 3 (6%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Bilateral, External Ear, Hyperkeratosis 1 (100%)
Eye (1) (3) (4)
Bilateral, Cornea, Mineralization, Multifocal 1 (100%)
Lens, Cataract 1 (33%) 2 (50%)
Retina, Degeneration 2 (67%) 2 (50%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
Zymbal's Gland (1) (2) (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst, Two 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (4%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Nephropathy, Chronic 47 (94%) 47 (94%) 49 (98%)
Pigmentation, Diffuse 4 (8%) 3 (6%) 3 (6%)
Pigmentation, Multifocal 1 (2%) 3 (6%) 1 (2%)
Artery, Thrombosis 1 (2%)
Bilateral, Hydronephrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cortex, Cyst, Multiple 2 (4%)
Cortex, Renal Tubule, Hyperplasia, Atypical,
Focal 2 (4%) 1 (2%)
Pelvis, Inflammation, Acute, Diffuse 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Proximal Convoluted Renal Tubule, Necrosis,
Acute 1 (2%)
Ureter (1) (1)
Inflammation, Chronic 1 (100%)
Urinary Bladder (49) (49) (48)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia,
Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
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