TR 386 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TETRANITROMETHANE
NTP Experiment-Test: 05072-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 6 3 8
Moribund Sacrifice 19 13 27
Survivors
Terminal Sacrifice 25 34 15
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (48)
Intestine Large, Colon (50) (49) (48)
Intestine Large, Rectum (49) (49) (49)
Intestine Small, Duodenum (49) (49) (49)
Leiomyoma 1 (2%)
Intestine Small, Ileum (46) (49) (46)
Intestine Small, Jejunum (44) (47) (43)
Liver (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Lung 1 (2%)
Mesentery (4) (6) (8)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (13%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (13%)
Sarcoma, Metastatic, Uterus 1 (13%)
Pancreas (50) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (6%)
Mixed Tumor Malignant, Metastatic, Lung 1 (2%)
Sarcoma, Metastatic, Lung 1 (2%)
Salivary Glands (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Multiple,
Metastatic, Lung 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (6%)
Sarcoma, Multiple, Metastatic, Lung 1 (2%)
Epicardium, Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Adrenal Gland, Cortex (50) (49) (50)
Adenoma 3 (6%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 5 (10%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Lung 1 (2%)
Medulla, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 2 (4%)
Adrenal Gland, Medulla (43) (48) (45)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (5%) 3 (6%) 2 (4%)
Sarcoma, Metastatic, Lung 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (49)
Carcinoma 1 (2%)
Pituitary Gland (50) (48) (50)
Pars Distalis, Adenoma 27 (54%) 27 (56%) 24 (48%)
Pars Distalis, Adenoma, Two 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 2 (4%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50) (50)
C-Cell, Adenoma 3 (6%) 6 (12%) 4 (8%)
C-Cell, Carcinoma 3 (6%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3)
Alveolar/Bronchiolar Carcinoma, Multiple,
Metastatic, Lung 1 (33%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (33%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (48) (44)
Adenoma 1 (2%) 4 (8%)
Carcinoma 2 (4%) 1 (2%)
Ovary (50) (50) (48)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 5 (10%)
Bilateral, Carcinoma, Metastatic, Lung 1 (2%)
Bilateral, Sarcoma, Metastatic, Lung 1 (2%)
Uterus (50) (50) (50)
Deciduoma Benign 1 (2%)
Polyp Stromal 9 (18%) 8 (16%) 5 (10%)
Polyp Stromal, Two 1 (2%)
Sarcoma 2 (4%)
Sarcoma Stromal 1 (2%)
Bilateral, Polyp Stromal 2 (4%) 3 (6%)
Vagina (2) (1)
Schwannoma Malignant, Metastatic, Urinary
Bladder 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (50)
Lymph Node (50) (50) (50)
Sarcoma, Metastatic, Lung 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 5 (10%)
Mediastinal, Carcinoma, Metastatic, Lung 1 (2%)
Serosa, Mediastinal, Sarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
Lymph Node, Mandibular (49) (50) (49)
Lymph Node, Mesenteric (47) (49) (49)
Spleen (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Thymus (48) (46) (42)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 4 (10%)
Page 4
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 7 (15%) 11 (22%) 4 (8%)
Fibroadenoma, Two 1 (2%) 1 (2%) 2 (4%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basosquamous Tumor Malignant 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Subcutaneous Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic 1 (2%)
Subcutaneous Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Vulva, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Benign 1 (2%)
Astrocytoma Malignant 2 (4%)
Cerebellum, Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 11 (22%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 44 (88%)
Alveolar/Bronchiolar Carcinoma, Two 7 (14%) 3 (6%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Mixed Tumor Malignant, Multiple 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Page 5
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Site 1 (2%)
Sarcoma, Multiple 1 (2%)
Squamous Cell Carcinoma 1 (2%) 10 (20%)
Squamous Cell Carcinoma, Multiple 2 (4%)
Mediastinum, Carcinoma, Metastatic, Lung 1 (2%)
Mediastinum, Squamous Cell Carcinoma,
Metastatic, Lung 1 (2%)
Pleura, Mediastinum, Sarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Multiple,
Metastatic, Lung 2 (4%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 7 (14%)
Carcinoma, Metastatic, Lung 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Sarcoma, Metastatic, Lung 2 (4%)
Urinary Bladder (49) (50) (48)
Schwannoma Malignant 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia 1 (2%)
Leukemia Mononuclear 18 (36%) 10 (20%) 6 (12%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 49 50
Total Primary Neoplasms 84 119 137
Total Animals with Benign Neoplasms 37 42 37
Total Benign Neoplasms 57 80 56
Total Animals with Malignant Neoplasms 24 31 50
Total Malignant Neoplasms 27 39 81
Total Animals with Metastatic Neoplasms 2 20
Total Metastatic Neoplasm 2 69
Total Animals with Malignant Neoplasms 1 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 27 25 39
Natural Death 5 8 7
Survivors
Terminal Sacrifice 18 17 4
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (45) (49) (49)
Intestine Large, Colon (49) (47) (49)
Intestine Large, Rectum (46) (48) (48)
Intestine Small, Duodenum (48) (49) (48)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (46) (45) (46)
Peyer's Patch, Fibrous Histiocytoma 1 (2%)
Intestine Small, Jejunum (47) (42) (45)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50)
Adenocarcinoma, Multiple, Metastatic,
Intestine Small 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple,
Metastatic, Lung 1 (2%)
Fibrous Histiocytoma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (4) (7) (6)
Hemangioma 1 (25%)
Histiocytic Sarcoma 1 (14%)
Pancreas (49) (48) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 6 (12%)
Histiocytic Sarcoma 1 (2%)
Acinus, Adenoma 2 (4%)
Stomach, Forestomach (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Tongue (2) (1)
Page 8
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (3) (2)
Aorta, Adventitia, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (50%)
Heart (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (6%) 5 (10%)
Fibrous Histiocytoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 2 (4%)
Epicardium, Carcinoma, Metastatic, Uncertain
Primary Site 1 (2%)
Epicardium, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Capsule, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Adrenal Gland, Cortex (50) (49) (48)
Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 3 (6%)
Medulla, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%) 1 (2%)
Adrenal Gland, Medulla (46) (47) (47)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (4%)
Neuroblastoma Benign 1 (2%)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 1 (2%)
Pheochromocytoma Benign 12 (26%) 14 (30%) 7 (15%)
Pheochromocytoma Benign, Multiple 1 (2%) 3 (6%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (48) (50)
Adenoma 3 (6%) 5 (10%) 6 (12%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma 4 (8%) 3 (6%) 4 (8%)
Carcinoma, Two 1 (2%)
Parathyroid Gland (47) (48) (43)
Adenoma 1 (2%)
Pituitary Gland (49) (49) (48)
Pars Distalis, Adenoma 27 (55%) 22 (45%) 16 (33%)
Page 9
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma, Two 2 (4%) 2 (4%) 2 (4%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (49) (50)
C-Cell, Adenoma 3 (6%) 1 (2%) 3 (6%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%) 1 (50%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (49) (50)
Preputial Gland (49) (48) (49)
Carcinoma 3 (6%) 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Prostate (48) (50) (46)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Seminal Vesicle (46) (47) (49)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 19 (38%) 23 (46%) 23 (46%)
Interstitial Cell, Adenoma 14 (28%) 15 (30%) 16 (32%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49)
Lymph Node (50) (50) (50)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 3 (6%) 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (48) (44) (46)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrous Histiocytoma 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lymph Node, Mesenteric (47) (48) (48)
Histiocytic Sarcoma 1 (2%)
Page 10
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (50) (49) (50)
Hemangiosarcoma 1 (2%)
Thymus (36) (42) (43)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 4 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (43) (46) (47)
Adenoma 1 (2%)
Fibroadenoma 1 (2%) 1 (2%)
Skin (50) (49) (50)
Basal Cell Adenoma 1 (2%) 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%) 3 (6%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Periosteum, Femur, Fibrous Histiocytoma 1 (2%)
Right, Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Hindlimb, Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 11 (22%) 11 (22%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%)
Alveolar/Bronchiolar Carcinoma 18 (36%) 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 4 (8%) 35 (70%)
Page 11
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Alveolar/Bronchiolar Carcinoma, Two 4 (8%) 7 (14%)
Fibrous Histiocytoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 14 (28%)
Squamous Cell Carcinoma, Two 5 (10%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Pleura, Mediastinum, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Nose (48) (49) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2) (1)
Adenoma 1 (100%)
Carcinoma 1 (100%)
Squamous Cell Papilloma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 5 (10%)
Squamous Cell Carcinoma, Metastatic, Lung 2 (4%)
Bilateral, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Capsule, Histiocytic Sarcoma 1 (2%)
Ureter (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Urinary Bladder (49) (49) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 27 (54%) 26 (52%) 22 (44%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 3 (6%) 2 (4%) 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05072-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2 PPM 5 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 49 50
Total Primary Neoplasms 140 190 199
Total Animals with Benign Neoplasms 47 46 49
Total Benign Neoplasms 92 114 98
Total Animals with Malignant Neoplasms 38 43 50
Total Malignant Neoplasms 48 76 101
Total Animals with Metastatic Neoplasms 2 6 20
Total Metastatic Neoplasm 2 13 42
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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