TR 386 Rat Pathology Tables
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Artery, Inflammation, Chronic Active,| |
Focal | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Parasite Metazoan | X X X X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X X X X X X X X X X|
Basophilic Focus, Two | |
Cytoplasmic Alteration, Focal | 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 3 2 4 4 |
Fatty Change, Focal | 2 4 |
Fatty Change, Multifocal | 2 2 |
Granuloma, Multifocal | 2 2 1 2 1 3 1 2|
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active, | |
Multifocal | |
Mitotic Alteration | 3 |
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X |
Necrosis, Acute, Focal | |
Necrosis, Acute, Multifocal | 2 |
Necrosis, Focal, Subacute | 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia, Multifocal | 3 2 1 2 3 |
Centrilobular, Atrophy, Diffuse | 3 2 |
Centrilobular, Atrophy, Multifocal | 4 3 |
Centrilobular, Fatty Change, Diffuse | |
Periportal, Fatty Change, Diffuse | 2 |
Periportal, Fatty Change, Multifocal | 2 2 |
Periportal, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Multifocal | |
Portal, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 3 |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | 1 2 2 2 2 4 3 2|
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic Active,| |
Multifocal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia, Focal | 2 |
Duct, Inflammation, Chronic Active, | |
Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 3 |
Ulcer, Multifocal | |
Ulcer, Single | |
Epithelium, Hyperplasia, Diffuse | 3 |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic Active | 1 |
Mucosa, Necrosis, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 2 2 2 1 2 1 1 1 1 2 3 3 2 2 3|
Atrium Left, Thrombosis | |
Epicardium, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis, Multifocal | |
Degeneration, Diffuse, Fatty | 1 2 |
Degeneration, Fatty, Focal | 2 2 2 2 3 |
Degeneration, Fatty, Multifocal | 3 |
Hyperplasia, Focal | 2 1 1 1 1|
Hyperplasia, Multifocal | 2 1 |
Hypertrophy, Focal | 2 2 1|
Hypertrophy, Multifocal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + M + + M + + + + + + + + + +|
Fibrosis, Diffuse | 1 |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Angiectasis, | |
Multifocal | 4 3 |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Cyst, Multiple | 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
Pars Intermedia, Angiectasis, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Focal, Granulomatous | 1 |
C-Cell, Hyperplasia, Focal | 3 |
C-Cell, Hyperplasia | 1 |
C-Cell, Hyperplasia, Multifocal | 4 4 3 2 1 2 3|
Follicular Cell, Hypertrophy, Diffuse| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Ectasia | |
Fibrosis | 2|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal | 3 3 |
Hyperplasia | |
Inflammation, Chronic Active, Focal | |
Inflammation, Granulomatous, | |
Multifocal | |
Necrosis, Acute | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Cyst, Multiple | 2 |
Dilatation | 3 |
Fibrosis, Focal | |
Hyperplasia | 2 |
Prolapse | X |
Cervix, Dilatation | 3 |
__________________________________________________________________________|
Vagina | |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 3 2 3 2 3 2 4 3 2 2 2 1|
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 2 3 2 |
Mediastinal, Inflammation, Acute | |
Pancreatic, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + M + + + + + + + + + + +|
Hemorrhage, Acute | 1 2|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Diffuse | 4 |
Ectasia, Multifocal | 3 1 2 2 2 3 2 2 3|
Hyperplasia, Diffuse | 2 1 1 2 |
Hyperplasia, Multifocal | 3 2 1 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X|
Hemorrhage, Multifocal | 2 3 |
Hydrocephalus | 2 2 |
Choroid Plexus, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Papillary | 2 |
Inflammation, Chronic | 2 4|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Artery, Mineralization, Multifocal | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 |
Thrombosis, Multifocal | |
Mucosa, Inflammation, Chronic Active | 3 3 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic Active,| |
Suppurative | 2 4 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 3 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Posterior Chamber, Synechia | 4 |
Retina, Degeneration | 4 |
Retina, Dysplasia, Focal | |
__________________________________________________________________________|
Lacrimal Gland | + |
Ectopic Tissue | |
Inflammation, Chronic | 2 |
Pigmentation | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 3 4 2 2 4 4 3 4 2 1 3 2 2 2 4 3 2 4 3 2 4|
Pigmentation, Diffuse | 3 2 4 2 1 |
Medulla, Mineralization, Multifocal | |
Pelvis, Epithelium, Hyperplasia | 2 |
Pelvis, Epithelium, Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Necrosis, Acute | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Diffuse | |
Serosa, Inflammation, Chronic Active | 4 |
Transitional Epithelium, Hyperplasia,| |
Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | | 1 4.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
Artery, Inflammation, Chronic Active,| | |
Focal | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + A A + + + M| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 3 2.0|
Basophilic Focus | X X | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X | 24 |
Basophilic Focus, Two | X | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 4 4| 6 3.5|
Fatty Change, Focal | | 2 3.0|
Fatty Change, Multifocal | 1 | 3 1.7|
Granuloma, Multifocal | 1 4 2 1 1 2 2 | 15 1.8|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Mitotic Alteration | 2 | 2 2.5|
Mixed Cell Focus | | 2 |
Mixed Cell Focus, Multiple | | 1 |
Necrosis, Acute, Focal | 1 | 1 1.0|
Necrosis, Acute, Multifocal | 2 | 2 2.0|
Necrosis, Focal, Subacute | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 2 1 1 1 2 | 10 1.8|
Centrilobular, Atrophy, Diffuse | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Atrophy, Multifocal | 2 | 3 3.0|
Centrilobular, Fatty Change, Diffuse | 4 4 4 | 3 4.0|
Periportal, Fatty Change, Diffuse | | 1 2.0|
Periportal, Fatty Change, Multifocal | | 2 2.0|
Periportal, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
Portal, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Accessory Spleen | X X | 2 |
Fat, Necrosis, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | | 1 3.0|
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | 1 2 1 2 | 12 2.0|
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Hyperplasia, Focal | | 1 2.0|
Duct, Inflammation, Chronic Active, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 4 1 2 2| 6 2.3|
Ulcer, Multifocal | 3 | 1 3.0|
Ulcer, Single | 1 2 | 2 1.5|
Epithelium, Hyperplasia, Diffuse | 3 | 2 3.0|
Epithelium, Hyperplasia, Focal | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Erosion | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Mucosa, Necrosis, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 3 3 3 3 3 3 1 1 1 1 2 2 2 1 | 34 2.0|
Atrium Left, Thrombosis | 4 | 1 4.0|
Epicardium, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 3 | 1 3.0|
Degeneration, Diffuse, Fatty | 2 | 3 1.7|
Degeneration, Fatty, Focal | 1 2 1 3 2 | 10 2.0|
Degeneration, Fatty, Multifocal | | 1 3.0|
Hyperplasia, Focal | 2 2 1 2 2 3 2 1 | 13 1.6|
Hyperplasia, Multifocal | | 2 1.5|
Hypertrophy, Focal | 1 | 4 1.5|
Hypertrophy, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + + + M + M + + + + + + + + + M +| 43 |
Fibrosis, Diffuse | | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | 2 | 5 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + M M + + + + + + M +| 44 |
Hyperplasia, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
Pars Distalis, Angiectasis, Focal | 4 | 1 4.0|
Pars Distalis, Angiectasis, | | |
Multifocal | 3 3 | 4 3.3|
Pars Distalis, Cyst | 2 3 3 | 5 2.6|
Pars Distalis, Cyst, Multiple | 2 2 | 5 2.0|
Pars Distalis, Hyperplasia, Focal | 3 2 2 | 4 2.3|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 2.0|
Pars Intermedia, Angiectasis, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Cyst | | 1 1.0|
Inflammation, Focal, Granulomatous | | 1 1.0|
C-Cell, Hyperplasia, Focal | 2 3 | 3 2.7|
C-Cell, Hyperplasia | | 1 1.0|
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 | 11 2.5|
Follicular Cell, Hypertrophy, Diffuse| 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + M +| 47 |
Ectasia | 4 2 | 2 3.0|
Fibrosis | | 1 2.0|
Hyperplasia, Focal | 3 | 3 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 | 2 2.0|
Necrosis, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X 3 2 | 3 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Cyst, Multiple | | 1 2.0|
Dilatation | 2 4 | 3 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Hyperplasia | | 1 2.0|
Prolapse | | 1 |
Cervix, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperplasia, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 3 2 3 3 3 3 1 2 2 2| 23 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage | 2 2 2 | 7 2.3|
Mediastinal, Inflammation, Acute | 3 | 1 3.0|
Pancreatic, Hemorrhage | 2 4 1| 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hemorrhage, Acute | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 2 | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Hemorrhage, Acute | 2 3 2 3 | 6 2.2|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Re Cell | 3 | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.0|
Depletion Lymphoid | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Pigmentation, Hemosiderin | 2 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Lymphoid | 4 | 1 4.0|
Epithelial Cell, Hyperplasia | 2 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
Ectasia, Diffuse | | 1 4.0|
Ectasia, Multifocal | 2 1 2 4 4 3 2 | 16 2.4|
Hyperplasia, Diffuse | 2 2 3 2 3 3| 10 2.1|
Hyperplasia, Multifocal | | 3 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Fibrous Osteodystrophy | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Osteopetrosis | 2 2| 3 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X| 11 |
Hemorrhage, Multifocal | | 2 2.5|
Hydrocephalus | 4 2 2 | 5 2.4|
Choroid Plexus, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
Hyperplasia, Focal, Papillary | | 1 2.0|
Inflammation, Chronic | 2 1 | 4 2.3|
Inflammation, Chronic Active | 2 2 2 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Artery, Mineralization, Multifocal | 2 | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Foreign Body | | 2 1.5|
Thrombosis, Multifocal | 3 2| 2 2.5|
Mucosa, Inflammation, Chronic Active | 2 1 2 1 | 10 1.9|
Mucosa, Inflammation, Chronic Active,| | |
Suppurative | 4 | 3 3.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 1 1 | 9 1.6|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 3 | 3 3.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | 3 | 2 3.0|
Posterior Chamber, Synechia | | 1 4.0|
Retina, Degeneration | 4 | 2 4.0|
Retina, Dysplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
Ectopic Tissue | X | 1 |
Inflammation, Chronic | | 1 2.0|
Pigmentation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 3 4 1 3 4 4 3 4 4 2 1 2 2 2 3 3 3 1 2| 43 2.7|
Pigmentation, Diffuse | 2 3 2 2| 9 2.3|
Medulla, Mineralization, Multifocal | 1 | 1 1.0|
Pelvis, Epithelium, Hyperplasia | | 1 2.0|
Pelvis, Epithelium, Mineralization | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Acute | 2 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Inflammation, Acute, Diffuse | 2| 1 2.0|
Serosa, Inflammation, Chronic Active | 3 | 2 3.5|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X X X |
Basophilic Focus, Two | X X X X X |
Fatty Change, Multifocal | 3 2 3 2 |
Fibrosis, Multifocal | 2 |
Granuloma, Multifocal | 1 2 1 2 1 2 1 1|
Hemorrhage, Acute, Multifocal | 4 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | 1 |
Mitotic Alteration | |
Mixed Cell Focus | X |
Necrosis, Acute, Focal | |
Necrosis, Acute, Multifocal | |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Atrophy, Diffuse | |
Centrilobular, Atrophy, Multifocal | 2 |
Centrilobular, Fatty Change, Diffuse | 4 |
Centrilobular, Necrosis, Acute, | |
Diffuse | |
Centrilobular, Necrosis, Acute, | |
Multifocal | 2 |
Median Lobe, Hepatodiaphragmatic | |
Nodule | |
Periportal, Fatty Change, Diffuse | |
Periportal, Fatty Change, Multifocal | 2|
Serosa, Inflammation, Multifocal, | |
Proliferative | 4 |
__________________________________________________________________________|
Mesentery | + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fat, Necrosis, Focal | |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Necrosis, Acute, Focal | 2 |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy | 1 |
Acinus, Atrophy, Multifocal | 1 2 1 |
Artery, Inflammation, Chronic Active,| |
Focal | 4 |
Artery, Inflammation, Chronic Active,| |
Multifocal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly, Focal | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Basal Cell, Focal | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 4 |
Necrosis, Acute, Focal | |
Ulcer, Multifocal | 4 |
Ulcer, Single | 2 |
Epithelium, Hyperplasia, Diffuse | 2 |
Epithelium, Hyperplasia, Focal | 3 |
Epithelium, Hyperplasia, Multifocal | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 3 2 2 3 1 1 3 3 1 1 2 2 1 1 |
Necrosis, Acute, Multifocal | 2 |
Artery, Adventitia, Hyperplasia | 3 |
Artery, Adventitia, Mineralization, | |
Focal | 2 |
Artery, Epicardium, Thrombosis | |
Atrium Left, Embolus, Focal | |
Atrium Left, Inflammation, Acute, | |
Multifocal | |
Mitral Valve, Degeneration, Mucoid | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Degeneration, Diffuse, Fatty | 2 2 |
Degeneration, Fatty, Focal | 1 4 1 1 2 1 |
Degeneration, Fatty, Multifocal | 1 2 |
Degeneration, Focal | 1 |
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | |
Hypertrophy, Focal | 3 |
Hypertrophy, Multifocal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + M + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Hyperplasia | |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M M + + +|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 3 |
Pars Distalis, Angiectasis, | |
Multifocal | 4 3 |
Pars Distalis, Cyst | 1 4 |
Pars Distalis, Cyst, Multiple | 3 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Intermedia, Angiectasis, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 2 1 1 2 3 4 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + M + + + + + + +|
Abscess | 4 |
Ectasia | 4 2 |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Granulomatous, | |
Multifocal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + I + + + + + + + + + + + + +|
Cyst | 3 2 4 |
Bilateral, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 2 |
Dilatation | 4 3 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | I |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 3 3 3 2 3 2 3 3 2 3 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Mediastinal, Cyst | 3 2 |
Mediastinal, Hemorrhage | 4 3 2 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Pancreatic, Hemorrhage | 3 4 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
Hyperplasia, Re Cell | |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 3 3 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | 3 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis, Focal | |
Fibrosis, Multifocal | 2 |
Hematopoietic Cell Proliferation | 2 4 3 2 3 3 3 4|
Hyperplasia, Re Cell | 4 |
Pigmentation, Hemosiderin | 3 2 1 |
Capsule, Fibrosis, Multifocal | 2 |
__________________________________________________________________________|
Thymus | + + M + + + M M + + + + + + + + + + + + + + + + +|
Congestion | 4|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Diffuse | 2 4 |
Ectasia, Multifocal | 2 3 1 4 3 4 4 2 |
Fibrosis, Focal | 4 |
Galactocele | X 4 |
Hyperplasia, Diffuse | 1 2 |
Hyperplasia, Focal | 4 3 |
Hyperplasia, Multifocal | |
Inflammation, Granulomatous, | |
Multifocal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Inflammation, Chronic Active, Focal | |
Inflammation, Multifocal, Subacute | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 4 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Spinal Cord | |
Degeneration, Multifocal, Secondary | |
Wallerian | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Papillary | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 2 2 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute, Multifocal | |
Inflammation, Acute, Multifocal, | |
Necrotizing | |
Inflammation, Multifocal, | |
Necrotizing, Subacute | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 4 2 4 4 4 4 2 4 4 4 2 4 3 4 3 4 4 4 4 4 4 4 4 3|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchiole, Hyperplasia, Multifocal | 4 4 2 4 4 4 4 2 4 4 4 2 4 3 4 4 4 4 4 4 4 4 4 3|
Bronchiole, Alveolus, Inflammation, | |
Acute, Multifocal, Suppurative | 3 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multifocal | |
Mucosa, Erosion, Multifocal | |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 3 2 2 3 4 1 3 4 3 1 3 2|
Mucosa, Inflammation, Chronic Active,| |
Suppurative | 4 4 3 4 |
Mucosa, Ulcer | 2 |
Mucosa, Ulcer, Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active, Suppurative | |
Olfactory Epithelium, Atrophy | |
Respiratory Epithelium, Hyperplasia | 2 2 1 1 2 3 2 2 1 2 2 1 1|
Respiratory Epithelium, Hyperplasia, | |
Papillary | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 2 2 |
Inflammation, Necrotizing, Subacute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 1 |
Nephropathy, Chronic | 2 2 1 1 4 4 1 2 3 1 3 3 4 1 1 2 3 2 1 1 |
Pigmentation, Multifocal | 2 |
Bilateral, Hydronephrosis | |
Pelvis, Epithelium, Mineralization | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X| 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + A +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 2 | 1 2.0|
Basophilic Focus | X X X 2 X X | 8 2.0|
Basophilic Focus, Multiple | X X X X X X X| 15 |
Basophilic Focus, Two | X X | 7 |
Fatty Change, Multifocal | 3 2 | 6 2.5|
Fibrosis, Multifocal | | 1 2.0|
Granuloma, Multifocal | 3 1 1 2 1 2 2 2| 16 1.6|
Hemorrhage, Acute, Multifocal | 2 | 2 3.0|
Hepatodiaphragmatic Nodule | X X X X| 5 |
Hyperplasia, Nodular | | 1 1.0|
Mitotic Alteration | 2 | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Acute, Focal | 1 | 1 1.0|
Necrosis, Acute, Multifocal | 3 3 | 2 3.0|
Bile Duct, Hyperplasia, Multifocal | 4 1 3 | 3 2.7|
Centrilobular, Atrophy, Diffuse | 2 | 1 2.0|
Centrilobular, Atrophy, Multifocal | 2 | 2 2.0|
Centrilobular, Fatty Change, Diffuse | 2 | 2 3.0|
Centrilobular, Necrosis, Acute, | | |
Diffuse | 3 | 1 3.0|
Centrilobular, Necrosis, Acute, | | |
Multifocal | | 1 2.0|
Median Lobe, Hepatodiaphragmatic | | |
Nodule | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Periportal, Fatty Change, Diffuse | 3 | 1 3.0|
Periportal, Fatty Change, Multifocal | 3 | 2 2.5|
Serosa, Inflammation, Multifocal, | | |
Proliferative | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Necrosis, Focal | 3 4 3 | 3 3.3|
Fat, Necrosis, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | X | 1 |
Necrosis, Acute, Focal | | 1 2.0|
Acinus, Atrophy, Diffuse | 2 | 2 3.0|
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy | 1 | 2 1.0|
Acinus, Atrophy, Multifocal | 2 1 | 5 1.4|
Artery, Inflammation, Chronic Active,| | |
Focal | | 1 4.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly, Focal | 2 | 1 2.0|
Inflammation, Acute, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hyperplasia, Basal Cell, Focal | | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 3 | 4 3.0|
Necrosis, Acute, Focal | 2 | 1 2.0|
Ulcer, Multifocal | 2 | 2 3.0|
Ulcer, Single | | 1 2.0|
Epithelium, Hyperplasia, Diffuse | 3 | 2 2.5|
Epithelium, Hyperplasia, Focal | | 1 3.0|
Epithelium, Hyperplasia, Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 3 1 1 3 2 1 3 2 2 2 2 1 3 2 2| 36 1.8|
Necrosis, Acute, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Adventitia, Hyperplasia | | 1 3.0|
Artery, Adventitia, Mineralization, | | |
Focal | | 1 2.0|
Artery, Epicardium, Thrombosis | 3 | 1 3.0|
Atrium Left, Embolus, Focal | 4 | 1 4.0|
Atrium Left, Inflammation, Acute, | | |
Multifocal | 3 | 1 3.0|
Mitral Valve, Degeneration, Mucoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.0|
Degeneration, Diffuse, Fatty | 2 2 | 4 2.0|
Degeneration, Fatty, Focal | 2 4 2 | 9 2.0|
Degeneration, Fatty, Multifocal | 2 2 2 3 1 | 7 1.9|
Degeneration, Focal | | 1 1.0|
Hyperplasia, Focal | 1 2 3| 4 1.8|
Hyperplasia, Multifocal | 1 | 1 1.0|
Hypertrophy, Focal | 1| 2 2.0|
Hypertrophy, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Focal | 1 2 | 4 1.5|
Hyperplasia | 1 | 1 1.0|
Hyperplasia, Multifocal | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Diffuse | | 1 4.0|
Hyperplasia, Multifocal | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
Hyperplasia, Diffuse | 2 | 1 2.0|
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | | 1 3.0|
Pars Distalis, Angiectasis, | | |
Multifocal | 4 3 2 | 5 3.2|
Pars Distalis, Cyst | 4 | 3 3.0|
Pars Distalis, Cyst, Multiple | 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2| 8 2.1|
Pars Intermedia, Angiectasis, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 4 | 2 3.0|
C-Cell, Hyperplasia, Multifocal | 2 2 3 2 | 12 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + +| 44 |
Abscess | | 1 4.0|
Ectasia | 4 2 3 2 | 6 2.8|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 3 3 | 5 3.0|
Bilateral, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 3.0|
Dilatation | 2 1 | 4 2.5|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Hyperplasia | 2 3 2 2 2 4 2 3 3 2 2 2 1| 25 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Cyst | | 2 2.5|
Mediastinal, Hemorrhage | 2 2 3 3 2 | 9 2.7|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | | 2 3.5|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage, Acute | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Hyperplasia, Plasma Cell | | 1 3.0|
Hyperplasia, Re Cell | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | 3 3 | 6 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Re Cell | 2 2 2 | 5 2.2|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 3 | 1 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Fibrosis, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 3 2 4 | 14 2.9|
Hyperplasia, Re Cell | | 1 4.0|
Pigmentation, Hemosiderin | 2 2 3 2 3 | 8 2.3|
Capsule, Fibrosis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M M + + + + + M + + + + + + M + + + +| 42 |
Congestion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia, Diffuse | 2 2 | 4 2.5|
Ectasia, Multifocal | 4 2 1 4 3 3 2 3 2 2 1 | 19 2.6|
Fibrosis, Focal | | 1 4.0|
Galactocele | 4 | 3 4.0|
Hyperplasia, Diffuse | 2 3 2 | 5 2.0|
Hyperplasia, Focal | 4 | 3 3.7|
Hyperplasia, Multifocal | 2 4 3 | 3 3.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 4.0|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Multifocal, Subacute | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Osteopetrosis | 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 5 |
Hydrocephalus | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration, Multifocal, Secondary | | |
Wallerian | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Papillary | | 1 1.0|
Inflammation, Acute | 2 2 | 2 2.0|
Inflammation, Chronic | 2 2 2 | 6 1.5|
Inflammation, Chronic Active | 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute, Multifocal | 2| 1 2.0|
Inflammation, Acute, Multifocal, | | |
Necrotizing | 4 | 1 4.0|
Inflammation, Multifocal, | | |
Necrotizing, Subacute | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 4 4 3 4 4 3 4 4 3 4 4 4 4 4 4 4 4 4 4 3 4 3 4 3 4| 50 3.7|
Bronchiole, Hyperplasia, Multifocal | 4 4 3 4 4 3 4 4 3 4 4 4 4 4 4 4 4 4 4 3 4 3 3 4| 48 3.7|
Bronchiole, Alveolus, Inflammation, | | |
Acute, Multifocal, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis, Multifocal | 2 | 1 2.0|
Mucosa, Erosion, Multifocal | 1 | 1 1.0|
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Inflammation, Chronic | 1| 1 1.0|
Mucosa, Inflammation, Chronic Active | 3 2 1 1 2 1 2 2 | 20 2.3|
Mucosa, Inflammation, Chronic Active,| | |
Suppurative | 2 4 2 4 4 2 | 10 3.3|
Mucosa, Ulcer | | 1 2.0|
Mucosa, Ulcer, Multifocal | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active, Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 2 2 1 2 1 2 | 21 1.6|
Respiratory Epithelium, Hyperplasia, | | |
Papillary | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 2.0|
Inflammation, Chronic Active | | 2 2.0|
Inflammation, Necrotizing, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 2 2.0|
Nephropathy, Chronic | 4 2 2 3 2 1 3 3 2 4 3 4 4 3 1 2 1 3 1 4 2 4 3 3| 44 2.4|
Pigmentation, Multifocal | | 1 2.0|
Bilateral, Hydronephrosis | 2 | 1 2.0|
Pelvis, Epithelium, Mineralization | 1 | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
Muscularis, Mineralization, | |
Multifocal | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
Muscularis, Mineralization, | |
Multifocal | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X |
Basophilic Focus, Two | X X X X |
Cytomegaly, Multifocal | |
Cytoplasmic Alteration, Focal | 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 3 |
Fatty Change, Multifocal | 4 1 3 |
Fibrosis, Multifocal | 1 |
Granuloma, Multifocal | 1 1 1 2 2 2 1 1 2 2 1 2 1 2 2|
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Nodular | 2 |
Mitotic Alteration | 2 2 |
Mixed Cell Focus | |
Necrosis, Acute, Multifocal | 1 1 |
Vacuolization Cytoplasmic, Multifocal| 1 |
Bile Duct, Hyperplasia, Multifocal | 2 1 2 |
Centrilobular, Atrophy, Multifocal | 3 1 |
Centrilobular, Congestion, Multifocal| 4 |
Centrilobular, Necrosis, Acute, | |
Multifocal | 2 |
Periportal, Cytomegaly, Diffuse | 2 |
Periportal, Fatty Change, Diffuse | |
Periportal, Fatty Change, Multifocal | 2 |
Portal, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Mineralization, Multifocal | 4 |
Fat, Necrosis, Focal | 3 4 3 |
Fat, Necrosis, Multifocal | 3 |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | |
Acinus, Atrophy, Multifocal | 2 2 3 2 |
Acinus, Hyperplasia, Focal | 2 |
Artery, Angiectasis, Multifocal | 3 |
Artery, Mineralization, Multifocal | 3 |
Serosa, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Duct, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 3 3 |
Ulcer, Single | 1 1 |
Epithelium, Hyperplasia, Diffuse | 2 |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Necrosis, Focal, Subacute | 4 |
Mucosa, Mineralization | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 1 2 3 2 2 1 2 1 2 2 2 2 |
Mineralization, Multifocal | 2 |
Necrosis, Acute, Multifocal | 3 |
Artery, Amyloid Deposition, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis, Multifocal | |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty, Focal | 3 3 1 2 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 1 1 1 3 1|
Hyperplasia, Multifocal | 2 1 |
Hypertrophy, Focal | 2 2 2 |
Hypertrophy, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Diffuse | 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Abscess, Chronic | |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Angiectasis, | |
Multifocal | 2 2 |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
Pars Distalis, Hyperplasia | 3 |
Pars Intermedia, Angiectasis, | |
Multifocal | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 2 |
C-Cell, Hyperplasia, Multifocal | 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + + + + + + + + + + + + + +|
Abscess | |
Ectasia | 3 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 3 3 |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | |
Hyperplasia | 2 2 |
Inflammation, Acute, Suppurative | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 3 3 2 4 2 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage, Acute | 3 |
Mediastinal, Edema | 3|
Mediastinal, Hemorrhage | 3 3 |
Pancreatic, Hemorrhage | 3 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage, Acute | 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | 4 3 |
Pigmentation, Hemosiderin | 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + M|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Multifocal | 2 3 2 4 3 3 3 2 |
Hyperplasia, Diffuse | 2 2 |
Hyperplasia, Focal | 4 |
Hyperplasia, Multifocal | 2 3 3 |
Mineralization, Multifocal | 2 |
Duct, Ectasia, Focal | 4 3 |
Duct, Ectasia, Multifocal | 4 |
Duct, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrous Osteodystrophy | 4 |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Hydrocephalus | 4 3 |
Choroid Plexus, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Papillary | |
Inflammation, Acute | 2 1 |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 2 2 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Atypical, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 3 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 4 3 4 3 4 3 4 3 3 2 4 2 3 2 2 3|
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | |
Bronchiole, Hyperplasia, Focal | 1 2 |
Bronchiole, Hyperplasia, Multifocal | 2 4 3 4 3 4 3 4 3 3 2 2 3 2 2 3|
Bronchus, Hyperplasia, Focal, | |
Papillary | |
Interstitium, Inflammation, Chronic, | |
Focal | |
Interstitium, Mineralization, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Foreign Body | 2 |
Mucosa, Inflammation, Chronic | 2 1 |
Mucosa, Inflammation, Chronic Active | 1 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 2 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Hyperplasia, | |
Papillary | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Anterior, Synechia | 4 |
Cornea, Neovascularization, | |
Multifocal | 1 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
Ectasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 4 3 3 2 4 2 4 4 3 2 3 4 2 4 4 4 1 3 4 1|
Pigmentation, Diffuse | 2 2 |
Artery, Mineralization, Multifocal | 2 |
Capsule, Inflammation, Chronic | 2 |
Pelvis, Epithelium, Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Hyperplasia, Atypical, Focal | |
Proximal Convoluted Renal Tubule, | |
Necrosis, Acute | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X | 10 |
Muscularis, Mineralization, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 7 |
Muscularis, Mineralization, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 2 2.5|
Basophilic Focus | X | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X | 29 |
Basophilic Focus, Two | X X | 6 |
Cytomegaly, Multifocal | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | 3 | 2 2.5|
Eosinophilic Focus | X X | 2 |
Fatty Change, Diffuse | | 2 2.0|
Fatty Change, Multifocal | 3 1 2| 6 2.3|
Fibrosis, Multifocal | | 1 1.0|
Granuloma, Multifocal | 1 1 3 2 2 1 1 2 3 1 3 2 1| 28 1.6|
Hepatodiaphragmatic Nodule | | 4 |
Hyperplasia, Nodular | | 1 2.0|
Mitotic Alteration | 2 | 3 2.0|
Mixed Cell Focus | X X | 2 |
Necrosis, Acute, Multifocal | | 2 1.0|
Vacuolization Cytoplasmic, Multifocal| 1 | 2 1.0|
Bile Duct, Hyperplasia, Multifocal | 1 1 1 | 6 1.3|
Centrilobular, Atrophy, Multifocal | | 2 2.0|
Centrilobular, Congestion, Multifocal| | 1 4.0|
Centrilobular, Necrosis, Acute, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Periportal, Cytomegaly, Diffuse | | 1 2.0|
Periportal, Fatty Change, Diffuse | 2 | 1 2.0|
Periportal, Fatty Change, Multifocal | 2 | 2 2.0|
Portal, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Artery, Mineralization, Multifocal | | 1 4.0|
Fat, Necrosis, Focal | | 3 3.3|
Fat, Necrosis, Multifocal | | 1 3.0|
Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Acinus, Atrophy, Multifocal | 1 1 4 1 | 8 2.0|
Acinus, Hyperplasia, Focal | 2 | 2 2.0|
Artery, Angiectasis, Multifocal | | 1 3.0|
Artery, Mineralization, Multifocal | | 1 3.0|
Serosa, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 1 | 1 1.0|
Duct, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | | 3 2.7|
Ulcer, Single | | 2 1.0|
Epithelium, Hyperplasia, Diffuse | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 2 2.5|
Necrosis, Focal, Subacute | | 1 4.0|
Mucosa, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 4 2 2 3 2 2 1 2 1 1 1 1 1 2 3 3 2 2 2 2 | 39 1.9|
Mineralization, Multifocal | | 1 2.0|
Necrosis, Acute, Multifocal | | 1 3.0|
Artery, Amyloid Deposition, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | 2 | 1 2.0|
Angiectasis, Multifocal | 2 | 1 2.0|
Congestion | | 1 3.0|
Degeneration, Fatty, Focal | 3 2 2 | 7 2.3|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hyperplasia, Focal | 1 2 2 1| 9 1.4|
Hyperplasia, Multifocal | 2 2 2 | 5 1.8|
Hypertrophy, Focal | 1 2 | 5 1.8|
Hypertrophy, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 2.5|
Hyperplasia, Multifocal | 1 2 1 3 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +| 47 |
Hyperplasia, Diffuse | | 1 3.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + + + + + + A + + + + + + + + + +| 48 |
Pars Distalis, Abscess, Chronic | 2 | 1 2.0|
Pars Distalis, Angiectasis, Focal | 3 | 1 3.0|
Pars Distalis, Angiectasis, | | |
Multifocal | | 2 2.0|
Pars Distalis, Cyst | | 2 3.0|
Pars Distalis, Cyst, Multiple | 2 1 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | | 4 2.3|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Intermedia, Angiectasis, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 3 | 3 2.7|
C-Cell, Hyperplasia, Multifocal | 1 1 1 2 | 10 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 4 3 | 2 3.5|
Ectasia | 4 3| 3 3.3|
Hyperplasia, Diffuse | 4 | 1 4.0|
Hyperplasia, Focal | | 3 2.7|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 3 | 5 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | 3 2 | 3 2.7|
Dilatation | 1 | 1 1.0|
Hyperplasia | | 2 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 2 2 2 2 2 2 1| 20 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hemorrhage, Acute | | 1 3.0|
Mediastinal, Edema | | 1 3.0|
Mediastinal, Hemorrhage | 3 3 3 4 3 | 7 3.1|
Pancreatic, Hemorrhage | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hemorrhage, Acute | 2 3 | 4 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 4 | 1 4.0|
Fibrosis, Multifocal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 2 3 3 1 | 9 2.1|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia, Multifocal | 3 3 2 2 1 2 2 4 1 3| 18 2.5|
Hyperplasia, Diffuse | 1 2 | 4 1.8|
Hyperplasia, Focal | 4 | 2 4.0|
Hyperplasia, Multifocal | | 3 2.7|
Mineralization, Multifocal | | 1 2.0|
Duct, Ectasia, Focal | | 2 3.5|
Duct, Ectasia, Multifocal | | 1 4.0|
Duct, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 4.0|
Osteopetrosis | 3 2 2 4 | 4 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X| 12 |
Hydrocephalus | 2 3 2 | 5 2.8|
Choroid Plexus, Hyperplasia, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Papillary | 2 | 1 2.0|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic | 2 1 | 4 1.8|
Inflammation, Chronic Active | 1 2 2 3 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute, Focal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Atypical, Focal | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 4 2 2 3 4 2 2 1 4 2 3 4 4 3 2 2 3 1 2 | 38 2.8|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 | 1 1.0|
Bronchiole, Hyperplasia, Focal | | 2 1.5|
Bronchiole, Hyperplasia, Multifocal | 4 2 2 2 4 3 4 4 2 2 | 26 2.9|
Bronchus, Hyperplasia, Focal, | | |
Papillary | 4 | 1 4.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
Interstitium, Mineralization, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Foreign Body | | 1 2.0|
Mucosa, Inflammation, Chronic | | 2 1.5|
Mucosa, Inflammation, Chronic Active | 1 1 | 7 1.4|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 3 2.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active, Suppurative | 2 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 2 1.0|
Respiratory Epithelium, Hyperplasia, | | |
Papillary | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 2.0|
Anterior, Synechia | | 1 4.0|
Cornea, Neovascularization, | | |
Multifocal | | 1 1.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Ectasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 4 2 3 4 4 3 3 2 1 3 4 4 4 1 3 4 4 2 4 4 3 2 4| 47 3.0|
Pigmentation, Diffuse | | 2 2.0|
Artery, Mineralization, Multifocal | | 1 2.0|
Capsule, Inflammation, Chronic | | 1 2.0|
Pelvis, Epithelium, Mineralization | 3 1 | 3 1.7|
Proximal Convoluted Renal Tubule, | | |
Hyperplasia, Atypical, Focal | 2 | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Hemorrhage, Chronic, Focal | |
__________________________________________________________________________|
Intestine Large, Cecum | + + M + A + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + + + A + + + + + + + + + + +|
Infiltration Cellular, Eosinophil, | |
Histiocyte | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + A + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Angiectasis, Multifocal | 3 |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X|
Basophilic Focus, Two | |
Clear Cell Focus | 2 |
Congestion, Diffuse | 3 |
Cytomegaly, Diffuse | |
Cytomegaly, Multifocal | 2 1 |
Degeneration, Ballooning, Focal | 2 3 |
Degeneration, Ballooning, Multifocal | |
Eosinophilic Focus | |
Fatty Change, Diffuse | 4 4 |
Fatty Change, Multifocal | 2 1 |
Fibrosis, Focal | |
Granuloma, Multifocal | 1 1 |
Mitotic Alteration | 3 3 |
Necrosis, Acute, Multifocal | 1 |
Vacuolization Cytoplasmic, Multifocal| 1 1 |
Bile Duct, Hyperplasia, Multifocal | 1 4 1 4 2 3 4 2 2 2 4 2 1 2 2 |
Centrilobular, Atrophy, Diffuse | 3 |
Centrilobular, Atrophy, Multifocal | 2 2 |
Centrilobular, Fatty Change, Diffuse | 4 |
Centrilobular, Fatty Change, | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Multifocal | |
Centrilobular, Necrosis, Diffuse | 3 |
Centrilobular, Necrosis, Multifocal | 4 |
Median Lobe, Hepatodiaphragmatic | |
Nodule | |
Periportal, Cytomegaly, Diffuse | 3 |
Periportal, Fatty Change, Multifocal | |
Portal, Fibrosis, Multifocal | 1 |
Portal, Inflammation, Chronic, | |
Multifocal | 1 |
Portal, Inflammation, Granulomatous, | |
Multifocal | |
Serosa, Inflammation, Chronic Active,| |
Focal, Proliferative | |
Vein, Thrombosis | 2 |
__________________________________________________________________________|
Mesentery | +|
Pigmentation | 4|
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 4|
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | 3 3 2 2 1 1 2 3 2 |
Artery, Adventitia, Inflammation, | |
Chronic Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2|
Parotid Gland, Inflammation, Chronic | |
Active, Diffuse | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 3 |
Ulcer | 4 3 4 |
Epithelium, Hyperplasia, Diffuse | 2 2 3 |
Epithelium, Hyperplasia, Focal | |
Muscularis, Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mucosa, Necrosis, Acute, Multifocal | |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Tooth | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Developmental Malformation | 4 |
Gingiva, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic, Focal, | |
Necrotizing | 2 |
Mineralization, Focal | |
Intima, Fibrosis, Multifocal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 1 2 3 2 2 3 2 1 3 2 3 2 2 1 3 3 3 4 2 2 3 2|
Atrium Left, Thrombosis | 4 3 |
Myocardium, Inflammation, Chronic, | |
Focal | |
Ventricle Left, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Diffuse, Fatty | 2 2 4 |
Degeneration, Fatty, Focal | 3 4 1 |
Degeneration, Fatty, Multifocal | 2 3 |
Degeneration, Multifocal | 2 |
Hyperplasia, Focal | 1 2 2 2 |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | 2|
Necrosis, Acute, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M M + + + + + + + M + M + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 |
Hyperplasia, Multifocal | 2 3 1 2 3 |
Necrosis, Acute, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + M + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 |
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Developmental | |
Malformation | |
Pars Distalis, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 3 |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 |
Fibrosis | 2 |
Serosa, Granuloma, Multifocal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 |
Inflammation, Granulomatous | 2 1 1 2 2 2 2 1 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hemorrhage, Acute | |
Hyperplasia, Focal | 1 1 |
Hyperplasia, Multifocal | 1 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 4 2 |
Inflammation, Chronic Active, | |
Suppurative | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + M + M + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Ectasia | 2 |
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 2 |
Artery, Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic Active,| |
Multifocal | |
Interstitial Cell, Hyperplasia | 1 3 1 1 |
Seminiferous Tubule, Atrophy | 2 2 2 3 3 4|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Serosa, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage, Acute | 4 2 |
Mediastinal, Hemorrhage, Subacute | |
Mediastinal, Hyperplasia, Re Cell | |
Pancreatic, Edema | 3 |
Pancreatic, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3|
Hyperplasia, Plasma Cell | 3 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + M + + M + + + + + + + + +|
Cyst | |
Hemorrhage, Acute | 2 2|
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis, Focal | 4 3 2|
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal, Re Cell | |
Infarct | |
Pigmentation, Hemosiderin | 3 2 |
__________________________________________________________________________|
Thymus | + + M + A + + + M M + M M + + M + M + + + + + M +|
Ectopic Parathyroid Gland | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + M + + M M + M + + + + + + M +|
Ectasia, Diffuse | 2 |
Ectasia, Multifocal | 2 3 |
Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Tail, Subcutaneous Tissue, | |
Inflammation, Chronic, | |
Proliferative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Necrosis, Acute | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage, Multifocal | 4 |
Hydrocephalus | 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + M + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | 3 1 2 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | 4 1 |
Metaplasia, Focal, Osseous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Bronchiole, Hyperplasia | 2|
Bronchus, Alveolus, Inflammation, | |
Chronic Active, Multifocal | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 4 |
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 2 |
Peribronchiolar, Perivascular, | |
Granuloma, Multifocal | |
__________________________________________________________________________|
Nose | + + + + A + + M + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Mucosa, Inflammation, Chronic | 1 2|
Mucosa, Inflammation, Chronic Active | 2 2 1 2 2 3 |
Mucosa, Inflammation, Chronic Active,| |
Suppurative | 3 |
Mucosa, Thrombosis, Multifocal | 2 2 |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Metaplasia | 2 3 2|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 2 2 1 4 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Bilateral, Cornea, Mineralization, | |
Multifocal | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 2 2 4 1 4 4 3 4 2 4 4 4 3 4 3 4 4 4 4 3 4 4 1|
Pigmentation, Diffuse | 4 2 2 |
Pigmentation, Multifocal | 3|
Bilateral, Hydronephrosis | 2 |
Cortex, Renal Tubule, Hyperplasia, | |
Atypical, Focal | 2 |
Pelvis, Inflammation, Acute, Diffuse | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Ureter | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia,| |
Multifocal | 4 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Hemorrhage, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic Active | 4 | 1 4.0|
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X X | 4 |
Serosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Eosinophil, | | |
Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 2| 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 2 | 3 1.7|
Angiectasis, Multifocal | | 1 3.0|
Basophilic Focus | X X X X X X | 6 |
Basophilic Focus, Multiple | X| 4 |
Basophilic Focus, Two | X | 1 |
Clear Cell Focus | | 1 2.0|
Congestion, Diffuse | | 1 3.0|
Cytomegaly, Diffuse | 3 | 1 3.0|
Cytomegaly, Multifocal | 2 | 3 1.7|
Degeneration, Ballooning, Focal | 1 | 3 2.0|
Degeneration, Ballooning, Multifocal | 3 | 1 3.0|
Eosinophilic Focus | 2 | 1 2.0|
Fatty Change, Diffuse | | 2 4.0|
Fatty Change, Multifocal | 1 2 1 2 2 1 | 8 1.5|
Fibrosis, Focal | 2 | 1 2.0|
Granuloma, Multifocal | 1 1 1 2 | 6 1.2|
Mitotic Alteration | | 2 3.0|
Necrosis, Acute, Multifocal | | 1 1.0|
Vacuolization Cytoplasmic, Multifocal| 1| 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Bile Duct, Hyperplasia, Multifocal | 2 2 1 2 1 1 3 3 2 2 1 2 1 1 | 29 2.1|
Centrilobular, Atrophy, Diffuse | 2 | 2 2.5|
Centrilobular, Atrophy, Multifocal | 2 3 | 4 2.3|
Centrilobular, Fatty Change, Diffuse | | 1 4.0|
Centrilobular, Fatty Change, | | |
Multifocal | 3 | 1 3.0|
Centrilobular, Necrosis, Diffuse | | 1 3.0|
Centrilobular, Necrosis, Multifocal | | 1 4.0|
Median Lobe, Hepatodiaphragmatic | | |
Nodule | X X | 2 |
Periportal, Cytomegaly, Diffuse | | 1 3.0|
Periportal, Fatty Change, Multifocal | 2 | 1 2.0|
Portal, Fibrosis, Multifocal | 3 | 2 2.0|
Portal, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Portal, Inflammation, Granulomatous, | | |
Multifocal | 2 | 1 2.0|
Serosa, Inflammation, Chronic Active,| | |
Focal, Proliferative | 3 | 1 3.0|
Vein, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Pigmentation | | 1 4.0|
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pigmentation | | 1 4.0|
Acinus, Atrophy, Focal | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | 2 1 3 3 3 4 3 2 3 | 18 2.4|
Artery, Adventitia, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
Parotid Gland, Inflammation, Chronic | | |
Active, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | 2 | 3 3.0|
Ulcer | 4 | 4 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia, Diffuse | 4 2 | 5 2.6|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
Muscularis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
Mucosa, Necrosis, Acute, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
Epithelium, Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 4.0|
Developmental Malformation | | 1 4.0|
Gingiva, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Inflammation, Chronic, Focal, | | |
Necrotizing | | 1 2.0|
Mineralization, Focal | 3 | 1 3.0|
Intima, Fibrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 4 3 3 2 3 1 2 2 2 1 1 2 3 2 3 2 4 2 2 2| 45 2.3|
Atrium Left, Thrombosis | | 2 3.5|
Myocardium, Inflammation, Chronic, | | |
Focal | 2| 1 2.0|
Ventricle Left, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Diffuse, Fatty | | 3 2.7|
Degeneration, Fatty, Focal | 2 1 1 1 2 1 2 | 10 1.8|
Degeneration, Fatty, Multifocal | 2 | 3 2.3|
Degeneration, Multifocal | | 1 2.0|
Hyperplasia, Focal | 2 2 | 6 1.8|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Necrosis, Acute, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Focal | 1 2 3 1 | 7 1.4|
Hyperplasia, Multifocal | 3 1 2 1 | 9 2.0|
Necrosis, Acute, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Diffuse | | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Cyst, Multiple | 2 | 1 2.0|
Pars Distalis, Developmental | | |
Malformation | X| 1 |
Pars Distalis, Hyperplasia, Focal | | 1 3.0|
Pars Distalis, Hyperplasia | 3 1 | 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | 2 | 3 2.7|
C-Cell, Hyperplasia, Multifocal | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 3 | 2 2.5|
Ectasia | | 1 3.0|
Fibrosis | | 1 2.0|
Serosa, Granuloma, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 3 4 | 3 3.0|
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 3 2.0|
Inflammation, Granulomatous | 2 2 2 2 2 1 2 2 2 3 3| 28 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Abscess | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage, Acute | 3 | 1 3.0|
Hyperplasia, Focal | 2 1 4 4| 6 2.2|
Hyperplasia, Multifocal | 2 3 | 4 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | 4 | 5 2.8|
Inflammation, Chronic Active, | | |
Suppurative | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Concretion | 2 | 1 2.0|
Ectasia | 3 | 2 2.5|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | 1 2 | 4 1.8|
Artery, Inflammation, Chronic | | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 2 1 2 | 9 1.4|
Seminiferous Tubule, Atrophy | 4 2 4 1 2 3| 12 2.7|
Seminiferous Tubule, Degeneration | 2 3 | 2 2.5|
Serosa, Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 2 2 | 12 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage, Acute | 3 | 3 3.0|
Mediastinal, Hemorrhage, Subacute | 2 2 | 2 2.0|
Mediastinal, Hyperplasia, Re Cell | 4 | 1 4.0|
Pancreatic, Edema | | 1 3.0|
Pancreatic, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Hemorrhage, Acute | | 1 3.0|
Hyperplasia, Plasma Cell | 3 3 2 2 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
Hemorrhage, Acute | 2 2 | 4 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Re Cell | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 3.0|
Fibrosis, Focal | 2 4 | 5 3.0|
Fibrosis, Multifocal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Hyperplasia, Focal, Re Cell | 3 | 1 3.0|
Infarct | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + M + + + + + + + + + + + M + + | 36 |
Ectopic Parathyroid Gland | X | 1 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Ectasia, Diffuse | 4 3 2 | 4 2.8|
Ectasia, Multifocal | 3 1 3 1 2 3 2 1 3 | 11 2.2|
Hyperplasia, Diffuse | 1| 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Tail, Subcutaneous Tissue, | | |
Inflammation, Chronic, | | |
Proliferative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X X | 14 |
Hemorrhage, Multifocal | | 1 4.0|
Hydrocephalus | 3 1 3 3 2 | 6 2.3|
Necrosis, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Foreign Body | 2 | 2 1.5|
Inflammation, Chronic | 2 2| 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 2 2 2 | 9 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Multifocal | | 2 2.5|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Bronchiole, Hyperplasia | | 1 2.0|
Bronchus, Alveolus, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 4.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 1 2.0|
Peribronchiolar, Perivascular, | | |
Granuloma, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 2 | 3 2.3|
Mucosa, Inflammation, Chronic | | 2 1.5|
Mucosa, Inflammation, Chronic Active | 1 2 3| 9 2.0|
Mucosa, Inflammation, Chronic Active,| | |
Suppurative | | 1 3.0|
Mucosa, Thrombosis, Multifocal | | 2 2.0|
Nasolacrimal Duct, Hyperplasia | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
Olfactory Epithelium, Metaplasia | | 3 2.3|
Respiratory Epithelium, Hyperplasia | 1 2| 7 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Bilateral, Cornea, Mineralization, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 4 3 4 3 4 2 4 4 4 4 3 4 2 4 4 3 4 3 1 4 4 4| 47 3.4|
Pigmentation, Diffuse | 2 | 4 2.5|
Pigmentation, Multifocal | | 1 3.0|
Bilateral, Hydronephrosis | | 1 2.0|
Cortex, Renal Tubule, Hyperplasia, | | |
Atypical, Focal | 1 | 2 1.5|
Pelvis, Inflammation, Acute, Diffuse | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Multifocal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X|
Muscularis, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Intestine Small, Ileum | + M + A + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Atrophy, Diffuse | 3 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + M + + + + + + + +|
Congestion | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X |
Basophilic Focus, Two | X X X X |
Congestion, Diffuse | 2 |
Degeneration, Ballooning, Focal | 2 |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | 1 |
Granuloma, Multifocal | 2 |
Mitotic Alteration | 2 |
Necrosis, Acute, Multifocal | 2 1 2 |
Bile Duct, Hyperplasia, Multifocal | 2 1 3 1 1 1 1 1 3 1 3 2 1 2 1 1 3|
Centrilobular, Atrophy, Diffuse | |
Centrilobular, Atrophy, Multifocal | 2 2 2 2 |
Centrilobular, Congestion | 3 |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Degeneration, | |
Multifocal | |
Centrilobular, Fatty Change, Diffuse | |
Centrilobular, Fatty Change, | |
Multifocal | |
Median Lobe, Hepatodiaphragmatic | |
Nodule | |
Portal, Fibrosis, Multifocal | 2 1 1 |
Vein, Thrombosis | X|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mesentery | + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Subacute | 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Fibrosis, Focal | |
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | 2 1 2 3 3 3 2 3 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Inflammation, Chronic Active, | |
Multifocal | 2 |
Duct, Metaplasia, Multifocal, | |
Squamous | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Multifocal | 2 |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 |
Ulcer | 2 |
Epithelium, Hyperplasia, Diffuse | |
Epithelium, Hyperplasia, Focal | 2 |
Epithelium, Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mucosa, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Pulmonary Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 2 2 1 2 2 3 2 1 2 1 2 3 |
Inflammation, Chronic Active, Focal | 2 |
Mineralization | |
Atrium Left, Thrombosis | 4 |
Atrium Right, Dilatation | 4 |
Epicardium, Hyperplasia | 4 |
Epicardium, Inflammation, Chronic, | |
Focal | 3 |
Mitral Valve, Inflammation, Chronic | 2 |
Ventricle Left, Hypertrophy, Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Degeneration, Diffuse, Fatty | 1 1 2 2 3 1 |
Degeneration, Fatty, Focal | |
Degeneration, Fatty, Multifocal | 2 1 2 2 |
Hyperplasia, Focal | 1 1 |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 1 2 3 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 4 |
Hyperplasia | |
Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + M + M + + M + + + + + + + + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Fibrosis, Focal | |
Necrosis, Subacute | 4 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
Pars Distalis, Hypertrophy, Focal | 2 |
Pars Intermedia, Angiectasis, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 3 |
C-Cell, Hyperplasia, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Cyst | |
Ectasia | 3 4 |
Hyperplasia | |
Inflammation, Granulomatous | 3 2 3 2 3 3 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + M + + + + + + + + A + +|
Abscess | |
Ectasia, Focal | |
Hyperplasia, Focal | 2 1 1 |
Hyperplasia, Multifocal | 3 1 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization, Multifocal | 2 |
Artery, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 1 3 1 4 1 2 2 1 2 2 1 |
Seminiferous Tubule, Atrophy | 3 3 3 4 3|
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | 2 2 3 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Cyst | 4 |
Mediastinal, Cyst, Multiple | 3 |
Mediastinal, Hemorrhage, Acute | 3 2 |
Mediastinal, Hemorrhage, Subacute | 3 1 |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage, Acute | 2 |
Pancreatic, Hyperplasia | 3 |
Renal, Hemorrhage, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + M + + + + + + + +|
Hemorrhage, Acute | |
Hemorrhage, Subacute | |
Hyperplasia | |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage, Acute | 3 2 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | 3 |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | 4 |
Depletion Lymphoid | 2 |
Fibrosis, Diffuse | 4|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Necrosis, Multifocal, Subacute | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + M + + M + + + + + +|
Ectopic Parathyroid Gland | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + M + + M + +|
Ectasia, Diffuse | |
Ectasia, Multifocal | 2 2 3 |
Hyperplasia, Diffuse | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Dermoid | |
Inflammation, Chronic Active, Focal, | |
Suppurative | |
Tail, Inflammation, Chronic | 3 |
Tail, Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage, Multifocal | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Abscess | |
Hemorrhage, Acute, Focal | |
Hemorrhage, Acute, Multifocal | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Necrosis, Acute, Multifocal | 4 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 4 3 4 4 4 3 4 4 4 4 4 4 2 3 3 4 4 4 4 3 4 4 4 4|
Artery, Mediastinum, Mineralization | |
Bronchiole, Hyperplasia, Multifocal | 4 4 3 4 4 4 3 4 4 4 4 4 4 3 4 4 4 4 3 4 4 4 |
Bronchus, Metaplasia, Squamous | 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
Interstitium, Mineralization, | |
Multifocal | |
Mediastinum, Angiectasis | |
Mediastinum, Cyst | 4 |
Mediastinum, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Lumen, Exudate | |
Mucosa, Inflammation, Chronic Active | 1 1 1 1 1 2 2|
Mucosa, Inflammation, Chronic Active,| |
Suppurative | 2 4 2 3 2 3 2 2 3 2 3 2 |
Mucosa, Thrombosis, Multifocal | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Atrophy | 2 1 2|
Respiratory Epithelium, Hyperplasia | 1 1 2 1 1 2 1 1 1 1 2 2 3 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 1 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Bilateral, External Ear, | |
Hyperkeratosis | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Two | 3 |
Infarct | |
Nephropathy, Chronic | 3 2 1 2 3 4 2 3 3 1 3 4 1 3 3 4 2 2 4 3 1 2 2 3|
Pigmentation, Diffuse | 4 |
Pigmentation, Multifocal | 2 |
Cortex, Renal Tubule, Hyperplasia, | |
Atypical, Focal | |
Proximal Convoluted Renal Tubule, | |
Necrosis, Acute | 2 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 8 |
Muscularis, Mineralization, | | |
Multifocal | 3| 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + +| 46 |
Mucosa, Atrophy, Diffuse | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + A + + + + + + + + +| 45 |
Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 3 | 2 2.5|
Basophilic Focus | X X X | 4 |
Basophilic Focus, Multiple | X | 5 |
Basophilic Focus, Two | X X | 6 |
Congestion, Diffuse | 2 | 2 2.0|
Degeneration, Ballooning, Focal | 4 2 | 3 2.7|
Fatty Change, Diffuse | 4 | 1 4.0|
Fatty Change, Multifocal | 2 3 | 3 2.0|
Granuloma, Multifocal | 2 1| 3 1.7|
Mitotic Alteration | | 1 2.0|
Necrosis, Acute, Multifocal | 2 2 2 | 6 1.8|
Bile Duct, Hyperplasia, Multifocal | 3 1 3 3 4 2 1 2 4 1 3 1 2 3 | 31 2.0|
Centrilobular, Atrophy, Diffuse | 3 | 1 3.0|
Centrilobular, Atrophy, Multifocal | 3 3 | 6 2.3|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Degeneration, Diffuse | 2 | 1 2.0|
Centrilobular, Degeneration, | | |
Multifocal | 3 2 | 2 2.5|
Centrilobular, Fatty Change, Diffuse | 4 | 1 4.0|
Centrilobular, Fatty Change, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Multifocal | 2 | 1 2.0|
Median Lobe, Hepatodiaphragmatic | | |
Nodule | X X X | 3 |
Portal, Fibrosis, Multifocal | 1 1| 5 1.2|
Vein, Thrombosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + +| 6 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Artery, Mineralization | 3| 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 1 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Acinus, Atrophy, Focal | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | 3 2 2 2 2 3 3 | 18 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Duct, Metaplasia, Multifocal, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis, Multifocal | | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 4 4 2 2 3 2 | 8 2.6|
Ulcer | 3 4 2 | 4 2.8|
Epithelium, Hyperplasia, Diffuse | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 3 2 | 3 2.3|
Epithelium, Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Mucosa, Mineralization | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + +| 2 |
Pulmonary Artery, Mineralization | 3| 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 4 1 2 2 1 1 2 2 2 1 2 4 2 2 2 3 2 2 4| 36 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic Active, Focal | | 1 2.0|
Mineralization | 3| 1 3.0|
Atrium Left, Thrombosis | 4 | 2 4.0|
Atrium Right, Dilatation | 4 | 2 4.0|
Epicardium, Hyperplasia | 2 2 | 3 2.7|
Epicardium, Inflammation, Chronic, | | |
Focal | | 1 3.0|
Mitral Valve, Inflammation, Chronic | | 1 2.0|
Ventricle Left, Hypertrophy, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X X X X X | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | | 1 2.0|
Degeneration, Diffuse, Fatty | 3 2 2 3 2 2 2 2 | 14 2.0|
Degeneration, Fatty, Focal | 1 2 | 2 1.5|
Degeneration, Fatty, Multifocal | 2 2 3 | 7 2.0|
Hyperplasia, Focal | 1 1 | 4 1.0|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 2 3 1 | 4 2.0|
Hyperplasia, Multifocal | 1 1 1 1 2 2 4 2 | 13 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 3.0|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Multifocal | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + M +| 43 |
Hyperplasia, Diffuse | 4| 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Fibrosis, Focal | 3 | 1 3.0|
Necrosis, Subacute | | 1 4.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Cyst, Multiple | 2 4 | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 | 6 1.8|
Pars Distalis, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Multifocal | | 1 2.0|
Pars Distalis, Hypertrophy, Focal | | 1 2.0|
Pars Intermedia, Angiectasis, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 1 | 5 1.8|
C-Cell, Hyperplasia, Multifocal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Abscess | | 1 3.0|
Atrophy | | 1 3.0|
Cyst | 2 | 1 2.0|
Ectasia | 3 3 4 2 4 | 7 3.3|
Hyperplasia | 3 2| 2 2.5|
Inflammation, Granulomatous | 2 2 1 3 2 2 1 1 2 2 3 2 2 2 2 | 30 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Abscess | 4 | 1 4.0|
Ectasia, Focal | 2 | 1 2.0|
Hyperplasia, Focal | | 3 1.3|
Hyperplasia, Multifocal | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | | 1 2.0|
Mineralization, Multifocal | | 1 2.0|
Artery, Inflammation, Chronic | 3| 1 3.0|
Interstitial Cell, Hyperplasia | 1 2 2 2 1 2 1 2 2 2 | 21 1.8|
Seminiferous Tubule, Atrophy | 1 2 2 4 3 3 2 | 12 2.8|
Seminiferous Tubule, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 3 3 | 6 2.7|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Cyst | 2 4 | 3 3.3|
Mediastinal, Cyst, Multiple | X 3 2 | 4 2.7|
Mediastinal, Hemorrhage, Acute | 2 3 3 | 5 2.6|
Mediastinal, Hemorrhage, Subacute | 2 3 | 4 2.3|
Mediastinal, Hyperplasia | | 1 3.0|
Mediastinal, Pigmentation | 2 3 | 2 2.5|
Pancreatic, Hemorrhage, Acute | | 1 2.0|
Pancreatic, Hyperplasia | | 1 3.0|
Renal, Hemorrhage, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hemorrhage, Acute | 2 4 | 2 3.0|
Hemorrhage, Subacute | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 2 2 | 4 2.3|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 1 | 1 1.0|
Hemorrhage, Acute | 2 1 | 6 1.8|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Re Cell | 3| 2 3.0|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute | | 1 4.0|
Depletion Lymphoid | | 1 2.0|
Fibrosis, Diffuse | | 1 4.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 1 | 7 1.9|
Necrosis, Multifocal, Subacute | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + M + + + M + + +| 43 |
Ectopic Parathyroid Gland | X X | 2 |
Epithelial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ectasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ectasia, Multifocal | 2 3 2 3 4| 8 2.6|
Hyperplasia, Diffuse | 2 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Dermoid | X X | 2 |
Inflammation, Chronic Active, Focal, | | |
Suppurative | 3 | 1 3.0|
Tail, Inflammation, Chronic | | 1 3.0|
Tail, Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 3 |
Hemorrhage, Multifocal | 4 3 4 2 | 4 3.3|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | 3 1 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 1 3.0|
Hemorrhage, Acute, Focal | 3| 1 3.0|
Hemorrhage, Acute, Multifocal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 3 | 1 3.0|
Necrosis, Acute, Multifocal | | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 4 4 4 4 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 50 3.8|
Artery, Mediastinum, Mineralization | 3| 1 3.0|
Bronchiole, Hyperplasia, Multifocal | 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4| 45 3.9|
Bronchus, Metaplasia, Squamous | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 3| 1 3.0|
Interstitium, Mineralization, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal | 3| 1 3.0|
Mediastinum, Angiectasis | 3 | 1 3.0|
Mediastinum, Cyst | | 1 4.0|
Mediastinum, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 | 3 1.7|
Lumen, Exudate | 2 | 1 2.0|
Mucosa, Inflammation, Chronic Active | 1 2 2 1 2 2 4 1 2| 16 1.6|
Mucosa, Inflammation, Chronic Active,| | |
Suppurative | 3 2 2 4 3 2 4 2 4 | 21 2.7|
Mucosa, Thrombosis, Multifocal | 3 4 | 3 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 3 | 2 2.0|
Olfactory Epithelium, Atrophy | | 3 1.7|
Respiratory Epithelium, Hyperplasia | 2 3 1 1 2 1 2 2 2 1 2 1 2 1| 29 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 2 2 2 | 13 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Bilateral, External Ear, | | |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Lens, Cataract | 4 4 | 2 4.0|
Retina, Degeneration | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Two | | 1 3.0|
Infarct | 2 | 1 2.0|
Nephropathy, Chronic | 1 1 3 4 2 3 2 2 2 2 3 4 3 3 2 1 4 2 3 3 2 2 3 1 4| 49 2.5|
Pigmentation, Diffuse | 3 2 | 3 3.0|
Pigmentation, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Renal Tubule, Hyperplasia, | | |
Atypical, Focal | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute, | |
Necrotizing | 2 |
Muscularis, Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + M + + + + + + + + + + + + + + A + +|
Diverticulum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Angiectasis, Multifocal | 3 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X |
Basophilic Focus, Two | X X |
Cytoplasmic Alteration, Focal | |
Degeneration, Ballooning, Focal | |
Degeneration, Ballooning, Multifocal | 3 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 |
Fatty Change, Multifocal | 2 1 1|
Granuloma, Multifocal | 1 2 |
Hemorrhage, Acute, Multifocal | 2 |
Hyperplasia, Multifocal, Nodular | 3 |
Inflammation, Multifocal, Subacute | |
Mitotic Alteration | |
Necrosis, Acute, Focal | |
Necrosis, Acute, Multifocal | 2 1 4 2|
Necrosis, Multifocal, Subacute | 4 2 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Bile Duct, Hyperplasia, Multifocal | 3 1 3 3 3 3 2 1 4 3 1 1 3 3 1 2 |
Centrilobular, Atrophy, Diffuse | |
Centrilobular, Atrophy, Multifocal | 3 3 |
Centrilobular, Congestion | 4 |
Centrilobular, Fatty Change, Diffuse | 4 4 |
Centrilobular, Necrosis, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Centrilobular, Necrosis, Multifocal | 2 |
Median Lobe, Hepatodiaphragmatic | |
Nodule | |
Portal, Fibrosis, Multifocal | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Artery, Adventitia, Inflammation, | |
Chronic Active, Multifocal | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 3|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy, Multifocal | 2 2 2 3 1 3 2 3|
Acinus, Hyperplasia, Focal | |
Artery, Adventitia, Inflammation, | |
Chronic Active, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hemorrhage, Multifocal | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 3 2 3 |
Ulcer | 2 |
Epithelium, Hyperplasia, Diffuse | |
Epithelium, Hyperplasia, Focal | 3 3 3 |
Epithelium, Hyperplasia, Multifocal | 2 |
Mucosa, Mineralization, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mucosa, Mineralization | 3 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization, Multifocal | |
Artery, Aneurysm | |
Artery, Arteriosclerosis, Multifocal | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 4 4 2 4 1 3 3 2 2 1 3 3 2 1 4 1 2 3 4|
Dilatation | 2 |
Atrium Left, Thrombosis | 4 4 |
Atrium Right, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mitral Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 3|
Congestion | |
Degeneration, Diffuse, Fatty | 2 1 3 1 2 |
Degeneration, Fatty, Focal | 1 2 |
Degeneration, Fatty, Multifocal | 3 |
Hemorrhage, Acute, Multifocal | |
Hyperplasia, Focal | 1 3|
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | |
Necrosis, Acute, Focal | 1 |
Necrosis, Acute, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 2 |
Hyperplasia, Multifocal | 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | 4 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | 4 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Developmental | |
Malformation | |
Pars Distalis, Hyperplasia, Focal | 2 4 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hypertrophy, Focal | 1 |
Pars Distalis, Hypertrophy, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 4 1 |
C-Cell, Hyperplasia, Multifocal | 1 1 1 |
Follicle, Cyst | |
Follicle, Cyst, Multiple | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Abscess, Chronic, Multiple | 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Foreign Body | 1 1 |
Hyperplasia | |
Hyperplasia, Squamous | 3 |
Inflammation, Granulomatous | 3 3 1 2 1 2 2 1 3 2 3 2 2 4 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 1 |
Inflammation, Chronic Active | |
Inflammation, Chronic Active, | |
Suppurative | 4 |
Mineralization, Multifocal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 3 |
Mineralization, Multifocal | 1 2 |
Artery, Inflammation, Chronic | |
Artery, Inflammation, Chronic Active,| |
Multifocal | |
Interstitial Cell, Hyperplasia | 2 1 2 2 1 2 |
Seminiferous Tubule, Atrophy | 2 3 2 4 1 2 |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 2 2 2 3 |
Myelofibrosis, Focal | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hemorrhage, Acute | |
Mediastinal, Hemorrhage, Acute | 3 2 3 2 4 |
Mediastinal, Hemorrhage, Subacute | |
Pancreatic, Granuloma, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + + +|
Hemorrhage, Acute | 1 |
Hyperplasia | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage, Acute | 4 3 2 |
Hemorrhage, Subacute | |
Hyperplasia | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis, Diffuse | |
Fibrosis, Focal | 4 4 3 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Infarct | |
Capsule, Fibrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + M + + M + + + + + + + +|
Atrophy | 4 |
Ectopic Parathyroid Gland | |
Hemorrhage, Acute | 1 2 |
Epithelial Cell, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + M + + + + + + + +|
Ectasia, Diffuse | 2 |
Ectasia, Multifocal | 1 3 2 2 2 4 |
Hyperplasia, Diffuse | 2 |
Artery, Adventitia, Inflammation, | |
Chronic Active, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Dermoid | X X |
Forelimb, Right, Hemorrhage, Chronic,| |
Focal, Subacute | |
Subcutaneous Tissue, Developmental | |
Malformation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 |
Hyperostosis, Focal | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage, Multifocal | |
Hydrocephalus | 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 1 2 |
Inflammation, Chronic Active | 1 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Giant Cell, Multifocal | |
Hemorrhage, Acute, Multifocal | 4 |
Hemorrhage, Multifocal, Subacute | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Pigmentation, Diffuse, Hemosiderin | |
Pigmentation, Hemosiderin, Multifocal| 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 3 4 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 4 2 4 2 4 3 4 2 2 3 4 4 4 3 3 3 4|
Artery, Thrombosis | |
Artery, Adventitia, Mediastinum, | |
Inflammation, Chronic Active, | |
Multifocal | |
Bronchiole, Hyperplasia, Focal | |
Bronchiole, Hyperplasia, Multifocal | 2 4 4 3 4 4 4 3 |
Bronchiole, Metaplasia, Focal, | |
Squamous | |
Bronchus, Hyperplasia, Focal | 4 |
Interstitium, Fibrosis, Multifocal | |
Interstitium, Inflammation, Chronic, | |
Diffuse | |
Interstitium, Inflammation, Chronic | |
Active, Diffuse | 3 |
Interstitium, Mineralization, | |
Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 3 1|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 1 2 2 3 2 1 2|
Mucosa, Inflammation, Chronic Active,| |
Suppurative | 1 2 |
Mucosa, Thrombosis, Multifocal | 2 |
Nasolacrimal Duct, Exudate | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active, Suppurative | 3 |
Respiratory Epithelium, Hyperplasia | 1 1 3 1 1 2 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + A |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infarct | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 |
Nephropathy, Chronic | 3 3 3 3 4 4 2 4 3 4 4 3 3 4 1 4 2 4 3 4 2 4 4|
Pigmentation, Diffuse | 4 3 3 |
Pigmentation, Multifocal | 2 |
Artery, Thrombosis | 2 |
Cortex, Cyst, Multiple | 3 X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Mucosa, Inflammation, Acute, | | |
Necrotizing | | 1 2.0|
Muscularis, Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + A + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + A + + + + + + A + + A + + +| 42 |
Diverticulum | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 2 | 3 2.7|
Angiectasis, Multifocal | 3 | 2 3.0|
Basophilic Focus | | 1 |
Basophilic Focus, Multiple | X X X X | 5 |
Basophilic Focus, Two | X X X | 5 |
Cytoplasmic Alteration, Focal | 3 3 | 2 3.0|
Degeneration, Ballooning, Focal | 2 | 1 2.0|
Degeneration, Ballooning, Multifocal | 3 | 2 3.0|
Eosinophilic Focus | X | 2 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Multifocal | 1 | 4 1.3|
Granuloma, Multifocal | 1 2 | 4 1.5|
Hemorrhage, Acute, Multifocal | 4 | 2 3.0|
Hyperplasia, Multifocal, Nodular | 3 | 2 3.0|
Inflammation, Multifocal, Subacute | 2 | 1 2.0|
Mitotic Alteration | 3 | 1 3.0|
Necrosis, Acute, Focal | 2 | 1 2.0|
Necrosis, Acute, Multifocal | 2 | 5 2.2|
Necrosis, Multifocal, Subacute | 3 3 | 4 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 1 1 3 3 3 1 3 1 1 1 1 2 1 3| 30 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Atrophy, Diffuse | 3 | 1 3.0|
Centrilobular, Atrophy, Multifocal | 4| 3 3.3|
Centrilobular, Congestion | | 1 4.0|
Centrilobular, Fatty Change, Diffuse | | 2 4.0|
Centrilobular, Necrosis, Diffuse | 3 | 1 3.0|
Centrilobular, Necrosis, Multifocal | 4 | 2 3.0|
Median Lobe, Hepatodiaphragmatic | | |
Nodule | X | 1 |
Portal, Fibrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Accessory Spleen | | 1 |
Artery, Adventitia, Inflammation, | | |
Chronic Active, Multifocal | 4 | 1 4.0|
Fat, Necrosis, Focal | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + M + + + + + + + + A + + + + + +| 48 |
Inflammation, Focal | | 1 3.0|
Acinus, Atrophy, Diffuse | 4 4 | 2 4.0|
Acinus, Atrophy, Focal | 2 2 | 3 1.7|
Acinus, Atrophy, Multifocal | 3 1 3 2 | 12 2.3|
Acinus, Hyperplasia, Focal | 3 2 | 2 2.5|
Artery, Adventitia, Inflammation, | | |
Chronic Active, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Erosion | | 1 2.0|
Hemorrhage, Multifocal | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 6 2.7|
Ulcer | 4 | 2 3.0|
Epithelium, Hyperplasia, Diffuse | 3 3 | 2 3.0|
Epithelium, Hyperplasia, Focal | | 3 3.0|
Epithelium, Hyperplasia, Multifocal | | 1 2.0|
Mucosa, Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + A + + + + + +| 47 |
Inflammation, Chronic Active | | 1 2.0|
Mucosa, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Aorta, Mineralization, Multifocal | 2 | 1 2.0|
Artery, Aneurysm | X | 1 |
Artery, Arteriosclerosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 3 3 3 3 2 3 2 2 4 3 2 1 3 2 2 1 3 2 3| 43 2.4|
Dilatation | | 1 2.0|
Atrium Left, Thrombosis | 3 | 3 3.7|
Atrium Right, Dilatation | 4 | 1 4.0|
Mitral Valve, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Angiectasis, Multifocal | | 1 3.0|
Congestion | 4 | 1 4.0|
Degeneration, Diffuse, Fatty | 3 2 4 2 2 | 10 2.2|
Degeneration, Fatty, Focal | 1 2 4 | 5 2.0|
Degeneration, Fatty, Multifocal | 2 2 2 | 4 2.3|
Hemorrhage, Acute, Multifocal | 3 | 1 3.0|
Hyperplasia, Focal | 3 2 | 4 2.3|
Hyperplasia, Multifocal | 2 3 2 1 | 5 2.0|
Hypertrophy, Focal | 1 1 | 2 1.0|
Necrosis, Acute, Focal | | 1 1.0|
Necrosis, Acute, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Hyperplasia, Focal | 4 1 1 2 2 | 9 1.9|
Hyperplasia, Multifocal | 2 3 2 3 2 2 1 3| 11 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + A + + + + + +| 48 |
Hyperplasia, Focal | 3 4 2 2 2 | 7 2.7|
Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia, Diffuse | 3 4 | 4 3.5|
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | 4 2 | 3 3.3|
Pars Distalis, Cyst, Multiple | 2| 1 2.0|
Pars Distalis, Developmental | | |
Malformation | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 | 3 2.7|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Distalis, Hypertrophy, Focal | | 1 1.0|
Pars Distalis, Hypertrophy, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | | 2 2.5|
C-Cell, Hyperplasia, Multifocal | 1 3 1 | 6 1.3|
Follicle, Cyst | 4 | 1 4.0|
Follicle, Cyst, Multiple | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Abscess, Chronic, Multiple | | 1 3.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 4 3 4 | 4 3.5|
Foreign Body | 1| 3 1.0|
Hyperplasia | 4 | 1 4.0|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Granulomatous | 2 3 1 3 3 2 2 2 3 2 1 2 3| 28 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 2 4.0|
Hyperplasia, Focal | 1 1 2 | 3 1.3|
Hyperplasia, Multifocal | 2 3 2 2 | 5 2.0|
Inflammation, Chronic Active | 3| 1 3.0|
Inflammation, Chronic Active, | | |
Suppurative | | 1 4.0|
Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Atrophy | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | 1 | 2 2.0|
Mineralization, Multifocal | 2 | 3 1.7|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 2 2 4 | 3 2.7|
Interstitial Cell, Hyperplasia | 2 2 2 1 1 2 1 2 2 1 | 16 1.6|
Seminiferous Tubule, Atrophy | 2 3 3 | 9 2.4|
Seminiferous Tubule, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia | 4 3 3 2 3 | 13 2.7|
Myelofibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hemorrhage, Acute | 2| 1 2.0|
Mediastinal, Hemorrhage, Acute | 3 3 | 7 2.9|
Mediastinal, Hemorrhage, Subacute | 4 2 3 | 3 3.0|
Pancreatic, Granuloma, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + M + + M + + +| 44 |
Hemorrhage, Acute | 2| 2 1.5|
Hyperplasia | 3 3 | 2 3.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Hemorrhage, Acute | 3 2 2 2 2 3 3| 10 2.6|
Hemorrhage, Subacute | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Re Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Depletion Lymphoid | 4 | 1 4.0|
Fibrosis, Diffuse | 3 | 1 3.0|
Fibrosis, Focal | 4 4 | 6 3.8|
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 4 3 | 4 2.8|
Hemorrhage | 4 | 1 4.0|
Infarct | 2 | 1 2.0|
Capsule, Fibrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + M + + + + + + + + + + + + M + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Ectopic Parathyroid Gland | X X | 2 |
Hemorrhage, Acute | | 2 1.5|
Epithelial Cell, Hyperplasia | 2 4 2 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + M + +| 46 |
Ectasia, Diffuse | | 1 2.0|
Ectasia, Multifocal | 2 3 2 4 2| 11 2.5|
Hyperplasia, Diffuse | 2 2| 3 2.0|
Artery, Adventitia, Inflammation, | | |
Chronic Active, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Cyst Dermoid | | 2 |
Forelimb, Right, Hemorrhage, Chronic,| | |
Focal, Subacute | 4 | 1 4.0|
Subcutaneous Tissue, Developmental | | |
Malformation | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Fibrous Osteodystrophy | | 2 1.5|
Hyperostosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X| 10 |
Hemorrhage, Multifocal | 3 | 1 3.0|
Hydrocephalus | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Foreign Body | 2 | 1 2.0|
Inflammation, Chronic | 1 | 4 1.5|
Inflammation, Chronic Active | 1 2 2 3 2 2 2 1| 10 1.8|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Giant Cell, Multifocal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage, Acute, Multifocal | 2 | 2 3.0|
Hemorrhage, Multifocal, Subacute | 3 2 | 2 2.5|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 1 2.0|
Pigmentation, Diffuse, Hemosiderin | 2 | 1 2.0|
Pigmentation, Hemosiderin, Multifocal| 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 4 2 2 | 7 2.9|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 4 3 4 4 2 3 2 4 4 3 3 3 4 3 4 2 2 2 3| 37 3.1|
Artery, Thrombosis | 4 | 1 4.0|
Artery, Adventitia, Mediastinum, | | |
Inflammation, Chronic Active, | | |
Multifocal | 4 | 1 4.0|
Bronchiole, Hyperplasia, Focal | 2 4 | 2 3.0|
Bronchiole, Hyperplasia, Multifocal | 3 4 2 3 2 4 4 3 3 4 3 4 2 | 21 3.3|
Bronchiole, Metaplasia, Focal, | | |
Squamous | 3 | 1 3.0|
Bronchus, Hyperplasia, Focal | | 1 4.0|
Interstitium, Fibrosis, Multifocal | 4 | 1 4.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Diffuse | | 1 3.0|
Interstitium, Mineralization, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Foreign Body | 2 1 1 2 2 2| 10 1.8|
Mucosa, Inflammation, Acute | 1 | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 1 1 2 3 2 2 1 3| 16 1.8|
Mucosa, Inflammation, Chronic Active,| | |
Suppurative | 1 1 | 4 1.3|
Mucosa, Thrombosis, Multifocal | 3 3 | 3 2.7|
Nasolacrimal Duct, Exudate | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 1 2 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05072-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic | 3 2 | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active, Suppurative | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 2 1 1 2| 15 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Infarct | 3 3 | 2 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 3.0|
Nephropathy, Chronic | 4 1 4 4 4 3 3 4 4 4 3 4 3 2 3 1 4 4 4 2 1 2 3 4| 47 3.2|
Pigmentation, Diffuse | | 3 3.3|
Pigmentation, Multifocal | 2 2 | 3 2.0|
Artery, Thrombosis | | 1 2.0|
Cortex, Cyst, Multiple | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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