TR 386 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05072 TETRANITROMETHANE TIME: 01:29:16
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55947
CONT: N01ES38042 CAS: 509-14-8
PATHOLOGIST: M. STEDHAM
--------------------------------------------------------------------------------
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05072 TETRANITROMETHANE TIME: 01:29:16
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55947
CONT: N01ES38042 CAS: 509-14-8
PATHOLOGIST: M. STEDHAM
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 294 401 422 483 492 545 546 563 569 604 |
| 618 618 644 644 644 646 646 649 653 658 |
| 660 661 668 671 686 694 707 708 720 723 |
| 723 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 353 486 533 535 535 541 547 556 560 591 |
| 598 605 619 619 633 633 659 661 663 674 |
| 675 675 675 681 687 687 688 692 699 707 |
| 708 724 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 46 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 497 500 506 513 518 521 532 541 546 547 |
| 547 548 548 548 549 562 562 573 576 590 |
| 601 601 604 605 609 610 618 629 632 632 |
| 638 653 653 657 659 673 674 674 685 694 |
| 696 698 706 708 710 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 94.0 92.0 88.0 80.0 56.0 36.0 |
| | |
| | |
|2 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 88.0 76.0 62.0 34.0 |
| | |
| | |
|5 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 84.0 52.0 30.0 8.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2 PPM 5 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 36.0% 34.0% 8.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=1.000 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.1 625.0 605.8 |
|NATURAL DEATHS (C) | (18.2) (14.3) ( 9.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 655.4 659.7 615.5 |
|(STANDARD ERROR) | (13.9) (11.6) (10.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 8 251 454 491 510 513 520 525 548 590 |
| 595 602 606 629 638 644 646 657 658 659 |
| 659 673 674 693 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 428 545 559 563 577 584 587 603 612 619 |
| 639 681 689 703 706 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 475 495 512 520 534 545 560 567 570 576 |
| 584 590 616 626 633 646 658 665 667 670 |
| 688 689 695 695 696 696 700 702 714 717 |
| 719 720 721 722 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 96.0 96.0 96.0 94.0 84.0 76.0 58.0 50.0 |
| | |
| | |
|2 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 84.0 78.0 68.0 |
| | |
| | |
|5 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 88.0 76.0 64.0 30.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2 PPM 5 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 68.0% 30.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.077 P=0.080N P=0.215 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 566.7 613.2 637.3 |
|NATURAL DEATHS (C) | (30.6) (18.9) (12.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 646.9 690.6 664.2 |
|(STANDARD ERROR) | (19.0) ( 9.6) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRANITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2 PPM = 2
5 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 1 233
| 1 1 12 333 2
| 1 1
90 + 1 3 3 21
| 33 22
| 3 12211
| 332 1 2 1
80 + 221 1
| 22
| 2 1 1
| 2 2
P 70 + 3 3 11
E | 2 2
R | 333 11
C | 3 3 2 2
E 60 + 33 1 1
N |
T | 33 1122
| 1 12
S 50 + 33 1 1
U | 33 11
R | 333 22111
V | 22 11
I 40 + 33 22
V | 3 3 2 2
A | 1
L | 3 3
30 + 3 3
|
| 33
| 3 3
20 +
|
| 333
|
10 + 3 3
| 3
|
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
TETRANITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2 PPM = 2
5 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 1 2 3 3 2
| 1 1 1 3 3 2 22
| 1 1 3 3 2 2
90 + 11 33 22
| 1 1 3 3
P | 1 1333 2 22
E | 1 33 1 22
R 80 + 33 2 2
C | 3 11 2 2
E | 3113 1 22 2
N | 131
T 70 + 3 3 2 2
| 113 22
S | 11 33
U | 1 1
R 60 + 3 3
V | 1 1
I | 1 13
V | 1 1
A 50 + 1
L |
| 333
| 33
40 +
|
| 33
|
30 + 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
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