TR 387 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DL AMPHETAMINE SULFATE
NTP Experiment-Test: 05029-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
Facility: Microbiological Associates
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 10 4 7
Dead 7 4 6
Survivors
Terminal Sacrifice 33 42 37
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (49) (49)
Inflammation, Acute 1 (2%)
Submucosa, Hemorrhage 1 (2%)
Intestine Large, Colon (50) (50) (49)
Ulcer 1 (2%)
Intestine Small, Duodenum (50) (49) (50)
Ulcer, Chronic 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 1 (2%)
Fatty Change 12 (24%) 4 (8%) 2 (4%)
Focal Cellular Change 42 (84%) 42 (84%) 41 (82%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 9 (18%) 9 (18%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Hyperplasia, Multifocal 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Chronic, Multifocal 28 (56%) 25 (50%) 19 (38%)
Inflammation, Focal, Granulomatous 1 (2%)
Necrosis, Multifocal 1 (2%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 27 (54%) 36 (72%) 30 (60%)
Centrilobular, Necrosis, Acute 1 (2%)
Vein, Thrombosis 1 (2%)
Mesentery (6) (1) (1)
Fat, Necrosis 6 (100%) 1 (100%)
Pancreas (49) (49) (49)
Metaplasia, Focal 2 (4%)
Necrosis, Acute, Multifocal 1 (2%)
Acinus, Atrophy, Diffuse 2 (4%) 1 (2%)
Acinus, Atrophy, Focal 10 (20%) 5 (10%) 9 (18%)
Acinus, Atrophy, Multifocal 6 (12%) 1 (2%) 9 (18%)
Acinus, Focal Cellular Change 1 (2%)
Pharynx (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Palate, Ulcer 1 (100%)
Salivary Glands (48) (49) (49)
Atrophy, Diffuse 1 (2%)
Stomach, Forestomach (49) (49) (50)
Erosion, Focal 1 (2%)
Hyperplasia, Diffuse, Squamous 2 (4%) 1 (2%)
Hyperplasia, Focal, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Ulcer, Multiple 1 (2%)
Stomach, Glandular (49) (50) (50)
Erosion, Focal 2 (4%)
Ulcer 1 (2%) 1 (2%)
Tongue (1)
Abscess 1 (100%)
Tooth (1) (1)
Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Aorta, Inflammation, Chronic, Focal 1 (50%)
Artery, Thrombosis 1 (50%)
Heart (49) (50) (50)
Cardiomyopathy, Multifocal 30 (61%) 27 (54%) 28 (56%)
Inflammation, Acute, Multifocal 1 (2%)
Mineralization, Multifocal 2 (4%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (48) (50)
Degeneration, Focal 9 (18%) 6 (13%) 3 (6%)
Degeneration, Multifocal 1 (2%) 3 (6%)
Fibrosis, Focal 1 (2%)
Hematocyst 1 (2%) 4 (8%) 4 (8%)
Hematocyst, Focal 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hyperplasia, Focal 6 (12%) 7 (15%) 6 (12%)
Hyperplasia, Multifocal 5 (10%) 3 (6%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Adrenal Gland, Medulla (49) (47) (49)
Hyperplasia, Focal 2 (4%) 8 (17%) 3 (6%)
Hyperplasia, Multifocal 4 (8%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (48) (50)
Hyperplasia, Focal 1 (2%) 1 (2%)
Pituitary Gland (50) (48) (50)
Pars Distalis, Angiectasis, Focal 2 (4%) 3 (6%) 1 (2%)
Pars Distalis, Cyst 11 (22%) 4 (8%) 8 (16%)
Pars Distalis, Fibrosis 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 5 (10%) 1 (2%) 4 (8%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia, Diffuse 1 (2%)
C-Cell, Hyperplasia, Focal 4 (8%) 4 (8%) 3 (6%)
C-Cell, Hyperplasia, Multifocal 7 (14%) 1 (2%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (37) (39)
Ectasia 1 (3%)
Hyperplasia 1 (3%)
Hyperplasia, Focal 3 (8%) 2 (5%)
Inflammation, Acute, Focal 1 (3%)
Inflammation, Chronic, Focal 2 (5%) 1 (3%)
Inflammation, Chronic, Multifocal 2 (5%) 2 (5%)
Inflammation, Chronic Active, Multifocal 3 (8%)
Ovary (50) (50) (50)
Cyst 4 (8%) 4 (8%) 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Uterus (50) (50) (50)
Abscess 1 (2%)
Amyloid Deposition 1 (2%)
Dilatation 3 (6%) 4 (8%)
Cervix, Cyst 3 (6%) 1 (2%)
Cervix, Dilatation 2 (4%)
Cervix, Inflammation, Acute 1 (2%)
Cervix, Inflammation, Chronic 1 (2%)
Cervix, Inflammation, Chronic Active 3 (6%)
Cervix, Metaplasia, Squamous 3 (6%)
Endometrium, Cyst 4 (8%)
Endometrium, Cyst, Multiple 2 (4%) 4 (8%) 11 (22%)
Endometrium, Hyperplasia 1 (2%)
Endometrium, Inflammation, Focal, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Lumen, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49)
Atrophy 1 (2%) 1 (2%)
Hyperplasia 8 (16%) 2 (4%) 1 (2%)
Myelofibrosis, Focal 1 (2%)
Myelofibrosis, Multifocal 1 (2%) 2 (4%) 10 (20%)
Lymph Node (50) (50) (50)
Inflammation, Chronic 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Lymph Node, Mandibular (47) (49) (48)
Congestion 1 (2%)
Degeneration, Cystic, Focal 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (46) (49) (49)
Congestion 1 (2%) 4 (8%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 10 (22%) 3 (6%)
Spleen (50) (50) (49)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%)
Infarct 3 (6%) 2 (4%)
Pigmentation 1 (2%)
Lymphoid Follicle, Atrophy 2 (4%) 1 (2%)
Lymphoid Follicle, Hyperplasia, Focal 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (47)
Acinus, Hyperplasia, Focal 2 (4%) 1 (2%) 1 (2%)
Duct, Ectasia 27 (56%) 20 (41%) 5 (11%)
Skin (50) (50) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (4%)
Ulcer 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Hyperostosis 4 (8%) 4 (8%) 6 (12%)
Osteomalacia 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebrum, Hydrocephalus 1 (2%) 1 (2%)
Cerebrum, Infiltration Cellular, Focal,
Lymphocyte 1 (2%)
Cerebrum, Necrosis, Focal 1 (2%)
Hypothalamus, Compression 6 (12%) 7 (14%) 2 (4%)
Spinal Cord (50) (49) (49)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Lung (50) (50) (50)
Congestion 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 19 (38%) 22 (44%) 20 (40%)
Pigmentation, Multifocal 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 3 (6%)
Interstitium, Inflammation, Chronic, Diffuse 1 (2%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Peribronchial, Hyperplasia, Lymphoid 1 (2%)
Pleura, Fibrosis, Focal 1 (2%)
Pleura, Inflammation, Chronic, Focal 1 (2%)
Pleura, Inflammation, Multifocal,
Proliferative 1 (2%)
Nose (50) (50) (50)
Foreign Body 1 (2%) 1 (2%)
Fungus 2 (4%) 3 (6%) 1 (2%)
Mucosa, Cytoplasmic Alteration, Multifocal 37 (74%) 39 (78%) 34 (68%)
Mucosa, Inflammation, Acute, Multifocal 2 (4%) 2 (4%)
Mucosa, Inflammation, Chronic, Focal 1 (2%)
Mucosa, Inflammation, Chronic, Multifocal 1 (2%)
Mucosa, Inflammation, Chronic Active, Focal 1 (2%)
Mucosa, Inflammation, Chronic Active,
Multifocal 1 (2%) 4 (8%)
Mucosa, Inflammation, Multifocal, Subacute 2 (4%) 3 (6%)
Mucosa, Metaplasia, Focal, Squamous 1 (2%) 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 2 (4%) 4 (8%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Chronic
Active 4 (8%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50)
Lens, Cataract 12 (24%) 7 (14%) 36 (72%)
Retina, Atrophy 25 (50%) 17 (34%) 42 (84%)
Sclera, Metaplasia, Focal, Osseous 11 (22%) 10 (20%) 12 (24%)
Sclera, Metaplasia, Multifocal, Osseous 8 (16%) 15 (30%) 5 (10%)
Harderian Gland (2) (2)
Infiltration Cellular, Multifocal, Lymphocyte 1 (50%)
Inflammation, Acute 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Bacterium 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal 1 (2%) 1 (2%)
Nephropathy, Chronic, Multifocal 32 (64%) 18 (36%)
Papilla, Necrosis 1 (2%)
Pelvis, Mineralization, Multifocal 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%)
Urinary Bladder (50) (48) (50)
Calculus Gross Observation 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 8 11 9
Moribund 12 8 8
Survivors
Terminal Sacrifice 30 31 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (50)
Inflammation, Subacute 1 (2%)
Intestine Small, Duodenum (49) (50) (48)
Ectopic Tissue 1 (2%)
Intestine Small, Ileum (49) (49) (48)
Inflammation, Chronic, Multifocal 1 (2%)
Intestine Small, Jejunum (49) (49) (46)
Inflammation, Chronic, Focal 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 2 (4%)
Degeneration, Cystic, Focal 4 (8%) 6 (12%) 3 (6%)
Degeneration, Cystic, Multifocal 1 (2%) 2 (4%)
Fatty Change 5 (10%) 9 (18%) 6 (12%)
Focal Cellular Change 29 (58%) 23 (46%) 32 (64%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%)
Hepatodiaphragmatic Nodule 6 (12%) 4 (8%) 2 (4%)
Hyperplasia, Focal 3 (6%) 1 (2%)
Hyperplasia, Multifocal 1 (2%) 2 (4%)
Inflammation, Chronic, Multifocal 7 (14%) 2 (4%) 2 (4%)
Necrosis, Acute, Multifocal 1 (2%) 1 (2%)
Bile Duct, Hyperplasia, Multifocal 46 (92%) 47 (94%) 45 (90%)
Centrilobular, Congestion, Chronic 1 (2%)
Centrilobular, Necrosis, Acute 1 (2%) 2 (4%)
Vein, Thrombosis 1 (2%)
Mesentery (6) (5) (5)
Inflammation, Chronic, Multifocal 1 (17%)
Fat, Necrosis 4 (67%) 2 (40%) 4 (80%)
Pancreas (49) (49) (49)
Acinus, Atrophy, Diffuse 1 (2%) 2 (4%)
Acinus, Atrophy, Focal 14 (29%) 11 (22%) 7 (14%)
Acinus, Atrophy, Multifocal 11 (22%) 8 (16%) 8 (16%)
Acinus, Focal Cellular Change 1 (2%) 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (48) (50)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (48) (50) (50)
Erosion 1 (2%)
Hyperplasia, Multifocal, Squamous 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Inflammation, Subacute 1 (2%)
Ulcer 1 (2%) 2 (4%) 2 (4%)
Stomach, Glandular (50) (50) (50)
Erosion, Focal 1 (2%) 2 (4%)
Erosion, Multifocal 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Aorta, Arteriosclerosis 2 (100%)
Heart (50) (49) (50)
Cardiomyopathy, Multifocal 40 (80%) 40 (82%) 40 (80%)
Mineralization, Multifocal 1 (2%)
Atrium, Thrombosis 1 (2%) 3 (6%) 4 (8%)
Coronary Artery, Inflammation, Chronic 2 (4%)
Valve, Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (48) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Focal 6 (12%) 6 (13%) 3 (6%)
Degeneration, Multifocal 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%) 5 (10%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 4 (8%) 8 (17%) 3 (6%)
Hyperplasia, Multifocal 2 (4%) 2 (4%)
Adrenal Gland, Medulla (49) (44) (50)
Hemorrhage 1 (2%)
Hyperplasia, Focal 5 (10%) 2 (5%) 2 (4%)
Hyperplasia, Multifocal 3 (6%) 2 (5%)
Islets, Pancreatic (50) (47) (50)
Hyperplasia, Focal 1 (2%) 2 (4%)
Pituitary Gland (49) (48) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Abscess 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 3 (6%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 7 (14%) 6 (13%) 7 (14%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%) 2 (4%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia, Focal 3 (6%) 6 (12%) 5 (10%)
C-Cell, Hyperplasia, Multifocal 3 (6%) 3 (6%)
Follicle, Cyst 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Granuloma Sperm 1 (2%)
Preputial Gland (48) (47) (49)
Abscess 1 (2%) 2 (4%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Acute, Multifocal 1 (2%) 1 (2%)
Inflammation, Chronic, Diffuse 3 (6%) 1 (2%)
Inflammation, Chronic, Focal 3 (6%) 1 (2%) 5 (10%)
Inflammation, Chronic, Multifocal 15 (31%) 21 (45%) 17 (35%)
Inflammation, Chronic Active, Focal 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%) 6 (13%) 5 (10%)
Inflammation, Multifocal, Subacute 1 (2%)
Prostate (49) (49) (50)
Hyperplasia, Focal 7 (14%) 3 (6%) 3 (6%)
Hyperplasia, Multifocal 2 (4%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Focal 4 (8%) 2 (4%)
Inflammation, Chronic, Multifocal 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%) 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Epithelium, Hyperplasia, Multifocal 1 (2%)
Seminal Vesicle (49) (49) (49)
Atrophy, Diffuse 27 (55%) 30 (61%) 36 (73%)
Dilatation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Testes (50) (50) (50)
Atrophy 1 (2%)
Atrophy, Diffuse 4 (8%) 5 (10%) 1 (2%)
Atrophy, Focal 1 (2%) 1 (2%)
Granuloma Sperm 1 (2%)
Interstitial Cell, Hyperplasia, Multifocal 5 (10%) 8 (16%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 3 (6%) 6 (12%) 6 (12%)
Infiltration Cellular, Focal, Histiocyte 1 (2%)
Lymph Node (50) (50) (50)
Mediastinal, Hemorrhage 1 (2%)
Lymph Node, Mandibular (48) (45) (49)
Congestion 1 (2%) 1 (2%)
Degeneration, Cystic 3 (6%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (48) (49) (50)
Congestion 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 3 (6%) 3 (6%) 5 (10%)
Spleen (50) (49) (50)
Atrophy, Focal 1 (2%)
Congestion 1 (2%)
Fibrosis, Diffuse 1 (2%)
Fibrosis, Focal 3 (6%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 1 (2%)
Artery, Thrombosis 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (37) (44) (48)
Inflammation, Chronic 1 (3%)
Acinus, Hyperplasia, Diffuse 1 (2%)
Acinus, Hyperplasia, Focal 1 (3%) 1 (2%)
Duct, Ectasia 8 (22%) 8 (18%) 4 (8%)
Skin (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Hair Follicle, Atrophy 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Hyperostosis 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hydrocephalus 1 (2%)
Cerebellum, Necrosis, Focal 1 (2%)
Cerebrum, Necrosis, Focal 1 (2%)
Hypothalamus, Compression 3 (6%) 4 (8%) 1 (2%)
Spinal Cord (50) (50) (50)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Abscess, Multifocal 1 (2%)
Fibrosis, Focal 1 (2%)
Foreign Body 2 (4%) 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Focal, Histiocyte 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 4 (8%) 9 (18%) 6 (12%)
Inflammation, Acute, Multifocal 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 4 (8%)
Alveolar Epithelium, Hyperplasia, Multifocal 2 (4%)
Interstitium, Inflammation, Chronic,
Multifocal 2 (4%) 2 (4%)
Peribronchiolar, Hyperplasia, Lymphoid 1 (2%)
Nose (50) (50) (50)
Foreign Body 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Fungus 7 (14%) 9 (18%) 4 (8%)
Inflammation, Chronic Active, Multifocal 2 (4%)
Metaplasia, Focal, Squamous 1 (2%)
Mucosa, Cytoplasmic Alteration, Multifocal 2 (4%)
Mucosa, Foreign Body, Focal 1 (2%)
Mucosa, Inflammation, Acute, Focal 1 (2%) 1 (2%)
Mucosa, Inflammation, Acute, Multifocal 2 (4%) 2 (4%)
Mucosa, Inflammation, Chronic, Focal 2 (4%)
Mucosa, Inflammation, Chronic, Multifocal 2 (4%) 2 (4%) 1 (2%)
Mucosa, Inflammation, Chronic Active,
Multifocal 5 (10%) 8 (16%) 5 (10%)
Mucosa, Inflammation, Focal, Subacute 1 (2%)
Mucosa, Inflammation, Multifocal, Subacute 2 (4%) 2 (4%)
Mucosa, Metaplasia, Focal, Squamous 1 (2%)
Mucosa, Metaplasia, Multifocal, Squamous 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 7 (14%) 10 (20%) 6 (12%)
Nasolacrimal Duct, Inflammation, Chronic
Active 2 (4%) 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (48)
Inflammation, Chronic 1 (2%)
Anterior Chamber, Hemorrhage 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%)
Lens, Cataract 6 (12%) 10 (20%) 6 (13%)
Retina, Atrophy 14 (28%) 9 (18%) 3 (6%)
Sclera, Metaplasia, Focal, Osseous 21 (42%) 13 (26%) 14 (29%)
Sclera, Metaplasia, Multifocal, Osseous 22 (44%) 30 (60%) 26 (54%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Nephropathy, Chronic, Multifocal 47 (94%) 46 (92%) 45 (90%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 2 (4%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 3 (6%) 4 (8%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (49) (50)
Calculus Micro Observation Only 1 (2%)
Dilatation 1 (2%)
Inflammation, Hemorrhagic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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