TR 387 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DL AMPHETAMINE SULFATE
NTP Experiment-Test: 05029-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
Facility: Microbiological Associates
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 10 4 7
Dead 7 4 6
Survivors
Terminal Sacrifice 33 42 37
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (49) (50)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Intestine Small, Ileum (47) (50) (50)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (50)
Pancreas (49) (49) (49)
Acinus, Carcinoma 1 (2%)
Salivary Glands (48) (49) (49)
Schwannoma Malignant 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (48) (50)
Adenoma 2 (4%)
Adrenal Gland, Medulla (49) (47) (49)
Pheochromocytoma Benign 2 (4%) 3 (6%) 2 (4%)
Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (50) (48) (50)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (45) (44) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (48) (50)
Pars Distalis, Adenoma 31 (62%) 24 (50%) 19 (38%)
Pars Distalis, Carcinoma 2 (4%)
Page 2
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 5 (10%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (37) (39)
Adenoma 2 (5%) 1 (3%)
Ovary (50) (50) (50)
Uterus (50) (50) (50)
Endometrium, Polyp Stromal 10 (20%) 5 (10%) 3 (6%)
Endometrium, Polyp Stromal, Multiple 1 (2%)
Endometrium, Sarcoma Stromal 1 (2%)
Vagina (1) (1)
Sarcoma, Metastatic 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1)
Bone Marrow (50) (50) (49)
Lymph Node, Mandibular (47) (49) (48)
Lymph Node, Mesenteric (46) (49) (49)
Spleen (50) (50) (49)
Thymus (45) (47) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (47)
Adenocarcinoma 3 (6%) 1 (2%) 1 (2%)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 17 (35%) 10 (20%) 2 (4%)
Fibroadenoma, Multiple 4 (8%) 1 (2%)
Skin (50) (50) (50)
Lipoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Page 3
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebrum, Astrocytoma Malignant 1 (2%)
Pons, Carcinoma, Metastatic 1 (2%)
Spinal Cord (50) (49) (49)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (50) (48) (50)
Leiomyoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 7 (14%) 8 (16%) 7 (14%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 42 30
Total Primary Neoplasms 93 75 41
Total Animals with Benign Neoplasms 42 36 23
Total Benign Neoplasms 77 61 30
Total Animals with Malignant Neoplasms 15 14 10
Total Malignant Neoplasms 16 14 11
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 2 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 8 11 9
Moribund 12 8 8
Survivors
Terminal Sacrifice 30 31 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (49) (49) (46)
Adenocarcinoma 1 (2%)
Liver (50) (50) (50)
Carcinoma, Metastatic, Testes 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (6) (5) (5)
Fibrous Histiocytoma 1 (20%)
Pancreas (49) (49) (49)
Fibrous Histiocytoma 1 (2%)
Salivary Glands (50) (48) (50)
Schwannoma Malignant 1 (2%) 2 (4%)
Stomach, Glandular (50) (50) (50)
Tooth (1) (1)
Gingiva, Neoplasm NOS 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (48) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (44) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 17 (35%) 10 (23%) 6 (12%)
Pheochromocytoma Benign, Multiple 6 (12%) 5 (11%)
Islets, Pancreatic (50) (47) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
Parathyroid Gland (41) (39) (49)
Page 6
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 1 (3%)
Pituitary Gland (49) (48) (49)
Pars Distalis, Adenoma 15 (31%) 15 (31%) 9 (18%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 9 (18%) 4 (8%) 5 (10%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 3 (6%) 1 (2%)
Follicle, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Preputial Gland (48) (47) (49)
Adenoma 2 (4%) 5 (11%) 1 (2%)
Carcinoma 1 (2%) 2 (4%)
Prostate (49) (49) (50)
Adenoma 1 (2%)
Seminal Vesicle (49) (49) (49)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 10 (20%) 10 (20%) 4 (8%)
Interstitial Cell, Adenoma, Multiple 33 (66%) 33 (66%) 44 (88%)
Interstitial Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Lymph Node, Mandibular (48) (45) (49)
Lymph Node, Mesenteric (48) (49) (50)
Spleen (50) (49) (50)
Carcinoma, Metastatic, Testes 1 (2%)
Hemangioma 1 (2%)
Thymus (39) (45) (43)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (37) (44) (48)
Fibroadenoma 3 (8%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Diaphragm, Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebrum, Astrocytoma Malignant 1 (2%)
Spinal Cord (50) (50) (50)
Nerve, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 3 (6%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrous Histiocytoma 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Nose (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Mucosa, Squamous Cell Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (48)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Liposarcoma 1 (2%)
Urinary Bladder (50) (49) (50)
Transitional Epithelium, Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 20 (40%) 16 (32%) 18 (36%)
Mesothelioma Malignant 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05029-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 09/04/94
Route: DOSED FEED Time: 11:07:10
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE LOW M/F HIGH M/F
CONTROL 20PPM 100 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 49
Total Primary Neoplasms 140 127 110
Total Animals with Benign Neoplasms 48 45 49
Total Benign Neoplasms 107 95 79
Total Animals with Malignant Neoplasms 25 25 27
Total Malignant Neoplasms 33 31 31
Total Animals with Metastatic Neoplasms 2 3
Total Metastatic Neoplasm 3 4
Total Animals with Malignant Neoplasms 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
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