TR 388 Mouse Pathology Tables
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + M + + + + + + A A + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A A + A + + +|
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | |
Lipoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Lymphoma Malignant Lymphocytic | X X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | |
Femoral, Lymphoma Malignant | |
Histiocytic | |
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
Femoral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X |
Mandibular, Lymphoma Malignant Mixed | X X X X X X X|
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Thoracic | + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + + M M A A + M + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M M M + + + M + + + + M M M M + + +|
Adenocarcinoma | X |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|
| 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
Mediastinum, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Renal Tubule, Adenoma, Multiple | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + A + + A + + + + + + + + + A| 41 |
__________________________________________________________________________|____________|
Intestine Large | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + A + + A + + + + + + + + + +| 44 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + + + + + + A + + A + + + + + + + + + +| 46 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | X X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 6 |
Hemangiosarcoma | X | 1 |
Lipoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X X X | 10 |
Pars Distalis, Carcinoma | X | 1 |
Pars Distalis, Lymphoma Malignant | | |
Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | X | 1 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hemangiosarcoma | X | 1 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Femoral, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X X| 5 |
Mandibular, Lymphoma Malignant Mixed | X X X X X X X | 14 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X| 2 |
Mediastinal, Lymphoma Malignant Mixed| X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + +| 14 |
Lymphoma Malignant Lymphocytic | X X X| 3 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Thoracic | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X| 5 |
Lymphoma Malignant Mixed | X X X X X X | 12 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + M + M + + + + + + M +| 39 |
Lymphoma Malignant Lymphocytic | X X| 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M M M + M + + + + + + + + + + + + + + + + M| 35 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Lymphoma Malignant Lymphocytic | X X| 4 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinum, Lymphoma Malignant Mixed| X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3| |
DAY ON TEST | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2| |
| 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X X| 4 |
Lymphoma Malignant Mixed | X X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Renal Tubule, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X| 5 |
Lymphoma Malignant Mixed | X X X X X X X | 14 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A A M + A + + + |
Lymphoma Malignant Mixed, Moderate | |
__________________________________________________________________________|
Intestine Large | A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + |
__________________________________________________________________________|
Intestine Small | A A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + |
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
Peyer's Patch, Lymphoma Malignant | |
Mixed | |
Peyer's Patch, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
Hemangioma | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | A A + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + A A + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + A A + + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | A A + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | A + A + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + |
Hemangioma | |
Luteoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Femoral, Lymphoma Malignant Mixed | X |
Femoral, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | A + M + M + I M |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|
| 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
Cranium, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | A + + + + + + + |
__________________________________________________________________________|
Trachea | A + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | X |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 13 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A A | 7 |
Lymphoma Malignant Mixed, Moderate | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 12 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X X | 2 |
Peyer's Patch, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | X | 1 |
Hemangioma | X | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X| 5 |
Hepatocellular Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 11 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 13 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 11 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 13 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 13 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 13 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Pars Distalis, Adenoma | X X X X X X X| 11 |
Pars Distalis, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 26 |
Hemangioma | X | 1 |
Luteoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 33 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 13 |
Femoral, Lymphoma Malignant Mixed | | 1 |
Femoral, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 18 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | X | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant Mixed | X X X X | 6 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X | 4 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X X X X | 5 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 10 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 23 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + M + | 7 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 13 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + | 13 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 13 |
Cranium, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 13 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Mediastinum, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenocarcinoma | | 1 |
Adenoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5| |
| 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
0 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 12 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 12 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X X X X | 11 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X|
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Femoral, Histiocytic Sarcoma, Single | X |
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X X |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Histiocytic Sarcoma, | |
Single | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| X X|
Pancreatic, Lymphoma Malignant Mixed | X |
Popliteal, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
Histiocytic Sarcoma, Single | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + M + M + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 8 |
__________________________________________________________________________|____________|
Gallbladder | + | 8 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 10 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + | 28 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + | 8 |
__________________________________________________________________________|____________|
Stomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 28 |
Pars Distalis, Adenoma | X | 6 |
Pars Distalis, Carcinoma | | 1 |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 29 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 20 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 8 |
Femoral, Histiocytic Sarcoma, Single | | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 15 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Histiocytic Sarcoma, | | |
Single | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Popliteal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 8 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 13 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Thymus | M | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 8 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 8 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 29 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | | 1 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Nose | + | 8 |
__________________________________________________________________________|____________|
Trachea | + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| | |
DAY ON TEST | 5| 5| 1| 5| | |
| 0| 0| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
100 PPM | 3| 3| 3| 3| | L |
1-1 | 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 8 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 8 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 29 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X |
Hepatocellular Adenoma | X X X X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
Follicular Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cystadenoma, Papillary | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Leiomyosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Femoral, Histiocytic Sarcoma, Single | |
Femoral, Lymphoma Malignant | |
Femoral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Mandibular, Histiocytic Sarcoma, | |
Single | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant | |
Mandibular, Lymphoma Malignant Mixed | X X X |
Mandibular, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Leiomyosarcoma, | |
Metastatic, Intestine Large | X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Hemangiosarcoma | X X |
Histiocytic Sarcoma, Single | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Thymus | + + + + M |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Histiocytic Sarcoma, Single | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | |
Adenoma | |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|
| 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 8 |
__________________________________________________________________________|____________|
Gallbladder | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 9 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 8 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 4 |
Hepatocellular Carcinoma | X X X X X X X X X | 14 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X| 15 |
Hepatocellular Adenoma | X X X X X X X X X | 19 |
Hepatocellular Adenoma, Multiple | X X X X X X| 14 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A | 7 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 8 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 11 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X X X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Adenoma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 15 |
Cystadenoma, Papillary | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 19 |
Leiomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 8 |
Femoral, Histiocytic Sarcoma, Single | X | 1 |
Femoral, Lymphoma Malignant | X | 1 |
Femoral, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 19 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Mandibular, Histiocytic Sarcoma, | | |
Single | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Lymphoma Malignant | X | 1 |
Mandibular, Lymphoma Malignant Mixed | X | 4 |
Mandibular, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mediastinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 3 |
Pancreatic, Leiomyosarcoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Metastatic, Intestine Large | | 1 |
Renal, Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 12 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 28 |
Hemangiosarcoma | X| 3 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X | 7 |
__________________________________________________________________________|____________|
Thymus | + M M + | 6 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 8 |
Adenocarcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
Histiocytic Sarcoma, Single | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 7 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| |
| 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
Adenocarcinoma | X X | 2 |
Adenoma | X | 1 |
Bilateral, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 11 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 9 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
Peyer's Patch, Lymphoma Malignant | |
Peyer's Patch, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Carcinoma, Multiple | X X X X X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X|
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Lymphoma Malignant | |
Mixed | |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + +|
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
Femoral, Lymphoma Malignant | |
Femoral, Lymphoma Malignant Mixed | |
Femoral, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + +|
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Hemangiosarcoma, | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Liver | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X X X |
Mandibular, Lymphoma Malignant Mixed | X X X X|
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X X |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + M + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|
| 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Gallbladder | + A + + A M + A | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + A | 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + A | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 19 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Peyer's Patch, Lymphoma Malignant | X | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X | 2 |
Hemangiosarcoma, Multiple | | 1 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X| 20 |
Hepatocellular Adenoma | X X X X X X X X X X | 17 |
Hepatocellular Adenoma, Multiple | X X X X X | 17 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A | 16 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M | 15 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + | 17 |
Lymphoma Malignant Lymphocytic | X | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 16 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 16 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | X X X X X X X | 14 |
Pars Distalis, Lymphoma Malignant | | |
Mixed | X | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X X | 3 |
Follicular Cell, Adenoma, Multiple | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 24 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 20 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 16 |
Femoral, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | X | 2 |
Femoral, Lymphoma Malignant | X | 1 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
Femoral, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + A + + + + + + + + + + +| 25 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Hemangiosarcoma, | | |
Metastatic, Liver | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 5 |
Mandibular, Lymphoma Malignant Mixed | X X X | 7 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 4 |
Mediastinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X| 3 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X X | 3 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + | 14 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 31 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X X X X X X X X| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | + M + + + M + M | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 16 |
Adenocarcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 16 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 2 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Histiocytic Sarcoma, Single | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X| 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5| |
| 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + A | 13 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant Mixed | X X X X X X X X X| 17 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + A M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + |
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X|
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
Corticomedullary Junction, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + I + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
Follicular Cell, Adenoma, Multiple | X X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + |
Cystadenoma, Papillary | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Single | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Axillary, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mandibular, Histiocytic Sarcoma, | |
Single | |
Mandibular, Lymphoma Malignant Mixed | X X X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant Mixed| X X X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | M + + + M + M + M M |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M |
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
Lumbar, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Histiocytic Sarcoma, Single | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|
| 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
333 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 14 |
__________________________________________________________________________|____________|
Gallbladder | A A A A | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + A A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small | + A A + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A A | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + | 13 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X | 9 |
Hepatocellular Carcinoma, Multiple | X X X X | 14 |
Hepatocellular Adenoma | X X X X X X X X| 14 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X | 21 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A A + | 13 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + A | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | I + + A | 12 |
Corticomedullary Junction, Lymphoma | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | I + + A | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + A | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A A + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X X X X X X X X| 26 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Adenoma, Multiple | X X X X X X| 9 |
Follicular Cell, Carcinoma | X| 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + +| 25 |
Cystadenoma, Papillary | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + A | 20 |
Histiocytic Sarcoma, Single | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + | 13 |
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + A | 19 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 2 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mandibular, Histiocytic Sarcoma, | | |
Single | X | 1 |
Mandibular, Lymphoma Malignant Mixed | | 3 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
Mediastinal, Lymphoma Malignant Mixed| X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 2 |
Renal, Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 9 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + M| 34 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Thymus | M M M M | 5 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + | 11 |
Adenocarcinoma | X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + | 15 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 2 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 14 |
Lumbar, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 14 |
Histiocytic Sarcoma, Single | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5| |
| 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Nose | M + + + | 13 |
__________________________________________________________________________|____________|
Trachea | M + + A | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 15 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + A A A | 11 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M + + + + + M + + A M + + + + + + + + M + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X|
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + + M + + M + M M M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X|
Follicular Cell, Carcinoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X X|
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Single | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + I + + + + + +|
Femoral, Histiocytic Sarcoma, Single | |
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
Femoral, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Histiocytic Sarcoma, | |
Single | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X X |
Mandibular, Lymphoma Malignant Mixed | X X X|
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X|
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | X|
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + M + + + M M + M M + M M M M + M + M M M M M + M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + M + M + M M + + M + + + + + M M +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
Subcutaneous Tissue, Mast Cell Tumor | |
Benign | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + M + A + M + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Hepatoblastoma | X | 2 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Hepatocellular Adenoma | X X X X X X| 11 |
Hepatocellular Adenoma, Multiple | X | 3 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + + M M M + + + M + + M + + M M + + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 26 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | X X X | 4 |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X | 31 |
Follicular Cell, Carcinoma | X X X X | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X | 2 |
Granulosa Cell Tumor Benign | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X | 3 |
Periovarian Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Histiocytic Sarcoma, Single | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Histiocytic Sarcoma, Single | X | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Femoral, Lymphoma Malignant Mixed | X | 2 |
Femoral, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + M + M + + + + + + + + + + A + + + + + + + + + +| 47 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Histiocytic Sarcoma, | | |
Single | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X X | 6 |
Mandibular, Lymphoma Malignant Mixed | X | 4 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 3 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 6 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + M + M M + + + + + M + M + M M M + M + M M +| 23 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M + M M M + + + + M + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
Subcutaneous Tissue, Mast Cell Tumor | | |
Benign | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 7 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 6 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5| |
| 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X X | 6 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + A + + + + + A + + M + + + M M + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Lymphoma Malignant | |
Lymphocytic | X |
Peyer's Patch, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X X X X X |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M M M M + M M + + + + + M + + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X X X X X X X |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X X X X |
Follicular Cell, Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cystadenoma, Papillary | |
Yolk Sac Carcinoma | X|
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Histiocytic Sarcoma, | |
Single | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X X |
Mandibular, Lymphoma Malignant Mixed | X X X X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Histiocytic Sarcoma, | |
Single | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X X |
Mediastinal, Lymphoma Malignant Mixed| X X X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Histiocytic Sarcoma, Single | |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M M I M + + + M + + M M + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + + + + M + + + + + M + M + + + + + + M|
Adenocarcinoma | |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatoblastoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
Histiocytic Sarcoma, Single | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | X |
Adenoma | X |
Histiocytic Sarcoma, Single | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Renal Tubule, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|
| 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + M + + + + + + + M + + + + M + + M + + + + +| 39 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Peyer's Patch, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | X X | 8 |
Hepatoblastoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Hepatocellular Adenoma | X X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X X X| 7 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Single | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + M M + M M + M M M + + + M + + + M + + +| 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 24 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | X X X X X | 12 |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X X X X X X | 26 |
Follicular Cell, Carcinoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
Cystadenoma, Papillary | X| 1 |
Yolk Sac Carcinoma | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 3 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Histiocytic Sarcoma, | | |
Single | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X | 5 |
Mandibular, Lymphoma Malignant Mixed | X X X | 7 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Histiocytic Sarcoma, | | |
Single | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 3 |
Mediastinal, Lymphoma Malignant Mixed| X X | 5 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Histiocytic Sarcoma, Single | X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 9 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma, Single | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + M + + M + + M + M M + + + + M + M + M + +| 33 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M + + + M + + + M + + + + + + + M + + + +| 37 |
Adenocarcinoma | X | 1 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatoblastoma, Metastatic, Liver | X X X X | 4 |
Hepatocellular Carcinoma, Multiple, | | |
Metastatic, Liver | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 5 |
Histiocytic Sarcoma, Single | X X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5| |
| 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenocarcinoma | | 1 |
Adenoma | | 1 |
Histiocytic Sarcoma, Single | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Renal Tubule, Adenocarcinoma | X| 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Lymphoma Malignant Mixed | X X X X | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + A + + M A M M + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + A + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + A A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + A + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pharynx | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + +|
Pulp, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Subcapsular, Adenoma | |
Spindle Cell, Subcapsular, Adenoma, | |
Multiple | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + M + + + + + + +|
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + + M + + M + M M M + + M + M M + + M M M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|
| 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + A + + + + + + + + + + M + M + + + + + +| 40 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + A + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + M + A + + + + + + + + + + + + + + + + + + +| 44 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + A + + + + + + + + + + + + + + + + + + +| 45 |
Adenocarcinoma | X| 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X X| 2 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X | 9 |
Hepatocellular Carcinoma, Multiple | X X | 4 |
Hepatocellular Adenoma | X X X X X X X X | 8 |
Hepatocellular Adenoma, Multiple | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Pulp, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Subcapsular, Adenoma | X | 1 |
Spindle Cell, Subcapsular, Adenoma, | | |
Multiple | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + M + M + + + + I + + + + + M + + + + + + + +| 44 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 14 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + M + + + M I I + M + + + + + M| 29 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X| 4 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X | 10 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5| |
| 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 4 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + M A A A A A A + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + |
Adenocarcinoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Mesentery | + |
Fibrosarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + M + + + + + M + + + + M M M + +|
Axillary, Sarcoma, Metastatic | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M + + M M + + + + + M M |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Alveolar/Bronchiolar Adenoma | X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|
| 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + A A + | 12 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + M + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + A + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + M + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + A M + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + M + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + + A + + | 20 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X | 6 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X | 2 |
Hepatocellular Adenoma, Multiple | X | 4 |
Histiocytic Sarcoma | X| 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + | 24 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 23 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + M + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + M + + + + + + | 25 |
Axillary, Sarcoma, Metastatic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 11 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + | 25 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________|____________|
Thymus | + M + M + + M M M M | 11 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + + +| 26 |
Subcutaneous Tissue, Fibrosarcoma | X | 5 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
| 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + A + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + | 21 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X| 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
Periesophageal Tissue, Sarcoma, | |
Metastatic, Skin | |
__________________________________________________________________________|
Gallbladder | A + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A |
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + A |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Stomach | + + + + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | M M + + + + + + + + + I I + + + + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Deep Cervical, Sarcoma, Metastatic, | |
Skin | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M + M + + M + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|
| 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 8 |
Periesophageal Tissue, Sarcoma, | | |
Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Gallbladder | A + | 6 |
__________________________________________________________________________|____________|
Intestine Large | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 10 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 33 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X | 4 |
Hepatocellular Adenoma, Multiple | X | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 8 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 33 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 8 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + + | 8 |
__________________________________________________________________________|____________|
Testes | + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 15 |
Deep Cervical, Sarcoma, Metastatic, | | |
Skin | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 7 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | M M | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 1| 2| 2| 1| 3| 3| 3| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| | L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibrosarcoma | X | 4 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 33 |
Alveolar/Bronchiolar Adenoma | X X X X X | 10 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 8 |
__________________________________________________________________________|____________|
Trachea | + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 33 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + + |
__________________________________________________________________________|
Gallbladder | M A A + + + A A + + A |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X X X X |
Hepatocellular Adenoma | X X X X|
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + A |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + A + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + A |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + A |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + A |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + M + + + M M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + + + |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + |
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + A |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M M + + M M M M + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|
| 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + A |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Gallbladder | A + M + + A + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 18 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Hemangiosarcoma | X X | 2 |
Hemangiosarcoma, Multiple | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X X X X X X| 11 |
Hepatocellular Carcinoma, Multiple | X X X | 8 |
Hepatocellular Adenoma | X X X X X X X X| 12 |
Hepatocellular Adenoma, Multiple | X X | 4 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 17 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M M I + M + + + +| 42 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 18 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 20 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 18 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 22 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Mandibular, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 21 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M M | 11 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 23 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 6 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + +| 3 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 21 |
Hepatocellular Carcinoma, Metastatic,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5| |
| 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M M + M + + + + |
__________________________________________________________________________|
Gallbladder | + + M M + M + A A + |
__________________________________________________________________________|
Intestine Large | + + + + + M + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + M M + M + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + M + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + M + |
__________________________________________________________________________|
Intestine Small | + + + M + M + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + M M + M + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + M M + M + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A M + M + + + + |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + M M + M + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + M M + M + + + + |
__________________________________________________________________________|
Salivary Glands | + + M M + M + + + + |
__________________________________________________________________________|
Stomach | + + M M + M + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + M M + M + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M M + M + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + M M + M + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M M + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + M M + M + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + + M M + M I + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + M M + M + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M M + M + + + + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + M M + M + + + + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + M M M + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + I + I + A + |
Femoral, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node | + + M M + M + + + + + + +|
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mandibular, Histiocytic Sarcoma | |
Mandibular, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + M M + M + + + + + + + + + |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M M + M + + M M |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M |
__________________________________________________________________________|
Skin | + + M M + M + + + + + + + + + + |
Schwannoma Malignant | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + I + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + M M + M + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + M + + M + + + + |
__________________________________________________________________________|
Trachea | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + M M + M + + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Urinary Bladder | + + M M + M + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 16 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma, Multiple | X | 2 |
Hepatocellular Carcinoma | X X X | 7 |
Hepatocellular Carcinoma, Multiple | X X X X | 8 |
Hepatocellular Adenoma | X X X X X X X X | 12 |
Hepatocellular Adenoma, Multiple | X X X | 3 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 105
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + +| 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I I + + + + + + + + + + + + + + I + + + + +| 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + +| 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + I| 13 |
Femoral, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 20 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mandibular, Histiocytic Sarcoma | X | 1 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + | 8 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 106
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 24 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + M| 11 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + +| 25 |
Schwannoma Malignant | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X X| 6 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 2 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | X | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + I + + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 11 |
Alveolar/Bronchiolar Adenoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 107
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1| |
| 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + +| 17 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 108
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M M A + + A|
__________________________________________________________________________|
Intestine Large | + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatoblastoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X X X|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + I|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + I|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + I|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M|
Axillary, Fibrosarcoma, Metastatic, | |
Skin | |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Inguinal, Hepatoblastoma, Metastatic,| |
Liver | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X X|
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + A|
Submucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|
| 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
333 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenocarcinoma | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | A + + + A + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Gallbladder | A + + A + + + + + A +| 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + +| 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A + + + + A A +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + M + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + A + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + A A +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A A +| 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + +| 18 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | X X | 3 |
Hepatoblastoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X X X X| 12 |
Hepatocellular Carcinoma, Multiple | X X | 7 |
Hepatocellular Adenoma | X X X X X X X X X X | 14 |
Hepatocellular Adenoma, Multiple | X | 6 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + A + +| 17 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M M + + + + +| 17 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + +| 22 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + +| 18 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 113
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + A + +| 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + +| 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + +| 19 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + +| 19 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + +| 19 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + +| 22 |
Axillary, Fibrosarcoma, Metastatic, | | |
Skin | X | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | X | 1 |
Inguinal, Hepatoblastoma, Metastatic,| | |
Liver | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 114
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 24 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Thymus | M M + A + M + + M M +| 11 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Subcutaneous Tissue, Fibrosarcoma | X X X X | 8 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | X| 3 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 38 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + +| 19 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X| 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 115
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7| |
DAY ON TEST | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4| |
| 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
333 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + +| 18 |
Submucosa, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
Adenocarcinoma | X | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + +| 19 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + +| 16 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 116
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M M + + + A + A + + + + M + + M + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + A + A + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + A + + + + + + M|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma | |
Hepatoblastoma | X X |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X|
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + A + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Lymphoma | |
Malignant Lymphocytic | |
Pulp, Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M + + + M M + M M M M M + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + I + + + I + I + + + + + + M + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Follicular Cell, Adenoma | X X X X X |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X |
Follicular Cell, Carcinoma, Multiple | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X |
Femoral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + + + + + M + + + + + + +|
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Sarcoma, Metastatic, Skin| |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | M M + M + + M + + M + M + M M + M + M M M + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Sarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|
| 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X|
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Thyroid Gland | |
Fibrosarcoma, Metastatic, Skin | X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatoblastoma, Metastatic, | |
Uncertain Primary Site | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Hemangioma | X |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A M M + + + + + + A M + M + A + + + + A M + M + +| 33 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A A + + + A + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + A A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A A + + + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A + + + + + + + + + +| 44 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma | X | 1 |
Hepatoblastoma | X X| 4 |
Hepatoblastoma, Multiple | X X | 2 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X| 42 |
Hepatocellular Adenoma | X X | 4 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A A + + + A + + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 121
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + +| 4 |
Peridontal Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Pulp, Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A A + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + M + + + + + + M + + + + + + M + M +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A M + + + + + + + + M M + + + +| 41 |
Pars Distalis, Adenoma | X X | 8 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Follicular Cell, Adenoma | X X X | 8 |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X| 18 |
Follicular Cell, Carcinoma, Multiple | X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 122
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Femoral, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Sarcoma, Metastatic, Skin| X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 7 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M M M + M M + M I M + M I M M M I M M M + + M M M| 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Basosquamous Tumor Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 123
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibrosarcoma | X X X | 5 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 4 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X| 2 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatoblastoma, Metastatic, Liver | X | 2 |
Hepatoblastoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X X X | 11 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Hemangioma | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 124
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5| |
| 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + | 18 |
Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urethra | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 125
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + A A + + M M M M M + + A + M M + M A M +|
__________________________________________________________________________|
Intestine Large | + A + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A A + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + A A + + + M + + + + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small | + A + + + A + + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A M + + + + M + A + + A + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A A + + + + + + A + + A + A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatoblastoma | X X X |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X X|
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X |
Hepatocellular Adenoma | X X X X|
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Glandular | + A + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + A + + M + M + + M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + I + M + A + M M + + + + + + + + + M + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Follicular Cell, Adenoma | X X X X X X X X|
Follicular Cell, Adenoma, Multiple | X X X X X |
Follicular Cell, Carcinoma | X X X X |
Follicular Cell, Carcinoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + A + + + + + + + + + M + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + A + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + M + M A M M M M + + M M M M M M M + M M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + A + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
Carcinoma, Metastatic, Thyroid Gland | X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Fibrosarcoma, Metastatic, Skin | X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
Adenocarcinoma | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 128
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|
| 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 129
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + M M A M M + + + + A + M + M| 27 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A A + + + + + + + + A + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A A + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A A + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + A A + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A A + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A + + + + + + A + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X X | 2 |
Hemangiosarcoma, Multiple | | 1 |
Hepatoblastoma | X X X X | 7 |
Hepatoblastoma, Multiple | X X X | 3 |
Hepatocellular Carcinoma | X | 5 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X| 40 |
Hepatocellular Adenoma | X X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X | 6 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 130
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + M M + + + + + + M + + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + M + + + + + M + + I + + + M + + + + + + +| 39 |
Pars Distalis, Adenoma | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Follicular Cell, Adenoma | X X X | 11 |
Follicular Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X| 22 |
Follicular Cell, Carcinoma | X X X X | 8 |
Follicular Cell, Carcinoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inguinal, Lymphoma Malignant Mixed | X| 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | X| 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 131
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Lymphoma Malignant Mixed | X| 1 |
Mediastinal, Lymphoma Malignant Mixed| X| 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X| 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X X| 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + +| 5 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________|____________|
Thymus | + M + + I M M M M M M I M A M M M + + + + + I + M| 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X | 6 |
Carcinoma, Metastatic, Thyroid Gland | X | 2 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatoblastoma, Metastatic, Liver | X X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 132
NTP Experiment-Test: 05076-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/15/97
Route: DOSED FEED Time: 14:20:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9| |
| 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1000 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 6 |
Adenocarcinoma | X | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X| 3 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 133
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