TR 388 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ETHYLENETHIOUREA DATE: 09/10/94
EXPERIMENT: 05076 TEST: 02 TIME: 02:17:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES82151 ROUTE: DOSED FEED NTP C#: 03372
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 96-45-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ETHYLENETHIOUREA DATE: 09/10/94
EXPERIMENT: 05076 TEST: 02 TIME: 02:17:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES82151 ROUTE: DOSED FEED NTP C#: 03372
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 96-45-7
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ETHYLENETHIOUREA DATE: 09/10/94
EXPERIMENT: 05076 TEST: 02 TIME: 02:17:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES82151 ROUTE: DOSED FEED NTP C#: 03372
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 96-45-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ETHYLENETHIOUREA
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma
Carcinoma or Adenoma
All Organs Hemangioma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ETHYLENETHIOUREA DATE: 09/10/94
EXPERIMENT: 05076 TEST: 02 TIME: 02:17:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES82151 ROUTE: DOSED FEED NTP C#: 03372
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 96-45-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ETHYLENETHIOUREA
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Intermedia
Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma
Carcinoma or Adenoma
All Organs Histiocytic Sarcoma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Gland: Non-medullary, Non-cortical |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/71 (3%) 0/8 (0%) 0/51 (0%) 0/99 (0%) | 0/62 (0%) 0/8 (0%) 1/36 (3%) 0/100 (0%) |
|ADJUSTED (b) | 6.5% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.7% 0.0% |
|TERMINAL (d) | 2/31 (6%) 0/1 (0%) 0/2 (0%) 0/48 (0%) | 0/35 (0%) 0/0 0/3 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- --- --- | --- --- 605 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104N P=0.965N P=0.873N P=0.149N | P=0.759N (e) P=0.596 (e) |
|INCIDENTAL TUMOR | P=0.104N P=0.965N P=0.873N P=0.149N | P=0.682N (e) P=0.419 (e) |
|LOGISTIC REGRESSION | P=0.104N P=0.965N P=0.873N P=0.149N | P=0.608N (e) P=0.388 (e) |
|COCHRAN-ARMITAGE | P=0.136N | P=0.604N |
|FISHER EXACT | P=0.807N P=0.337N P=0.173N | (e) P=0.367 (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/71 (1%) 0/8 (0%) 0/51 (0%) 3/99 (3%) | 1/61 (2%) 0/8 (0%) 0/35 (0%) 2/100 (2%) |
|ADJUSTED (b) | 3.2% 0.0% 0.0% 5.4% | 2.9% 0.0% 0.0% 3.3% |
|TERMINAL (d) | 1/31 (3%) 0/1 (0%) 0/2 (0%) 2/48 (4%) | 1/35 (3%) 0/0 0/3 (0%) 2/60 (3%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- --- 671 | 740 (T) --- --- 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303 P=0.996N P=0.967N P=0.444 | P=0.597 (e) P=0.941N P=0.684 |
|INCIDENTAL TUMOR | P=0.369 P=0.996N P=0.967N P=0.528 | P=0.597 (e) P=0.941N P=0.684 |
|LOGISTIC REGRESSION | P=0.358 P=0.996N P=0.967N P=0.529 | P=0.597 (e) P=0.941N P=0.684 |
|COCHRAN-ARMITAGE | P=0.238 | P=0.493 |
|FISHER EXACT | P=0.899N P=0.582N P=0.444 | P=0.884N P=0.635N P=0.679 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.5% 0.0% 0.7% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 1/73 (1%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 642 --- 625 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.214N P=0.541N P=0.337N P=0.263N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.189N P=0.464N P=0.490N P=0.228N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.187N P=0.531N P=0.431N P=0.236N |
|COCHRAN-ARMITAGE | (e) | P=0.205N |
|FISHER EXACT | (e) (e) (e) | P=0.600N P=0.351N P=0.249N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 3/33 (9%) 4/149 (3%) 5/100 (5%) | 4/100 (4%) 0/29 (0%) 4/150 (3%) 2/100 (2%) |
|ADJUSTED (b) | 3.2% 11.5% 3.8% 9.2% | 5.2% 0.0% 3.4% 3.3% |
|TERMINAL (d) | 1/58 (2%) 3/26 (12%) 2/95 (2%) 3/48 (6%) | 2/73 (3%) 0/21 (0%) 3/115 (3%) 2/60 (3%) |
|FIRST INCIDENCE (DAYS) | 666 743 (T) 669 694 | 698 --- 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215 P=0.169 P=0.595 P=0.189 | P=0.472N P=0.323N P=0.387N P=0.426N |
|INCIDENTAL TUMOR | P=0.448 P=0.107 P=0.660N P=0.355 | P=0.347N P=0.342N P=0.331N P=0.300N |
|LOGISTIC REGRESSION | P=0.325 P=0.142 P=0.599 P=0.261 | P=0.412N P=0.319N P=0.384N P=0.361N |
|COCHRAN-ARMITAGE | P=0.314 | P=0.379N |
|FISHER EXACT | P=0.099 P=0.546 P=0.227 | P=0.356N P=0.405N P=0.341N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 1/149 (1%) 1/100 (1%) | 1/100 (1%) 1/29 (3%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 1.1% 2.1% | 1.4% 3.8% 1.7% 1.7% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 1/95 (1%) 1/48 (2%) | 1/73 (1%) 0/21 (0%) 2/115 (2%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 743 (T) 743 (T) | 740 (T) 562 740 (T) 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293 (e) P=0.598 P=0.462 | P=0.598N P=0.463 P=0.655 P=0.717 |
|INCIDENTAL TUMOR | P=0.293 (e) P=0.598 P=0.462 | P=0.573N P=0.536 P=0.655 P=0.717 |
|LOGISTIC REGRESSION | P=0.293 (e) P=0.598 P=0.462 | P=0.537N P=0.481 P=0.655 P=0.717 |
|COCHRAN-ARMITAGE | P=0.357 | P=0.539N |
|FISHER EXACT | (e) P=0.601 P=0.503 | P=0.400 P=0.649 P=0.751N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 3/33 (9%) 5/149 (3%) 6/100 (6%) | 5/100 (5%) 1/29 (3%) 6/150 (4%) 3/100 (3%) |
|ADJUSTED (b) | 3.2% 11.5% 4.9% 11.2% | 6.5% 3.8% 5.2% 5.0% |
|TERMINAL (d) | 1/58 (2%) 3/26 (12%) 3/95 (3%) 4/48 (8%) | 3/73 (4%) 0/21 (0%) 5/115 (4%) 3/60 (5%) |
|FIRST INCIDENCE (DAYS) | 666 743 (T) 669 694 | 698 562 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.121 P=0.169 P=0.470 P=0.111 | P=0.440N P=0.569N P=0.443N P=0.463N |
|INCIDENTAL TUMOR | P=0.293 P=0.107 P=0.552 P=0.223 | P=0.327N P=0.548N P=0.395N P=0.351N |
|LOGISTIC REGRESSION | P=0.213 P=0.142 P=0.479 P=0.169 | P=0.352N P=0.557N P=0.437N P=0.394N |
|COCHRAN-ARMITAGE | P=0.209 | P=0.335N |
|FISHER EXACT | P=0.099 P=0.420 P=0.143 | P=0.593N P=0.467N P=0.360N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Heart |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/73 (0%) 0/8 (0%) 0/53 (0%) 2/100 (2%) | 0/63 (0%) 0/8 (0%) 0/38 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 0/1 (0%) 0/2 (0%) 1/48 (2%) | 0/36 (0%) 0/0 0/3 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 700 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 (e) (e) P=0.276 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.209 (e) (e) P=0.406 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.210 (e) (e) P=0.369 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.147 | (e) |
|FISHER EXACT | (e) (e) P=0.333 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 1/33 (3%) 0/149 (0%) 0/100 (0%) | 0/100 (0%) 0/29 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.4% 3.8% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/58 (3%) 1/26 (4%) 0/95 (0%) 0/48 (0%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 743 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N P=0.706 P=0.139N P=0.281N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.145N P=0.706 P=0.139N P=0.281N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.145N P=0.706 P=0.139N P=0.281N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.121N | (e) |
|FISHER EXACT | P=0.581 P=0.158N P=0.246N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/98 (4%) 1/33 (3%) 6/146 (4%) 4/99 (4%) | 2/99 (2%) 0/28 (0%) 8/150 (5%) 2/100 (2%) |
|ADJUSTED (b) | 6.4% 3.8% 5.9% 6.9% | 2.7% 0.0% 6.5% 3.3% |
|TERMINAL (d) | 3/58 (5%) 1/26 (4%) 4/95 (4%) 2/48 (4%) | 2/73 (3%) 0/20 (0%) 5/115 (4%) 2/60 (3%) |
|FIRST INCIDENCE (DAYS) | 565 743 (T) 623 685 | 740 (T) --- 605 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.462 P=0.496N P=0.564N P=0.597 | P=0.568 P=0.548N P=0.186 P=0.622 |
|INCIDENTAL TUMOR | P=0.561N P=0.505N P=0.536N P=0.552N | P=0.567N P=0.548N P=0.139 P=0.622 |
|LOGISTIC REGRESSION | P=0.589N P=0.538N P=0.551N P=0.584N | P=0.557N P=0.548N P=0.163 P=0.622 |
|COCHRAN-ARMITAGE | P=0.570 | P=0.541N |
|FISHER EXACT | P=0.629N P=0.631 P=0.634N | P=0.606N P=0.166 P=0.686N |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 1/33 (3%) 5/146 (3%) 16/99 (16%) | 0/99 (0%) 0/28 (0%) 2/150 (1%) 11/100 (11%)|
|ADJUSTED (b) | 0.0% 3.8% 5.2% 27.0% | 0.0% 0.0% 1.6% 16.2% |
|TERMINAL (d) | 0/58 (0%) 1/26 (4%) 4/95 (4%) 9/48 (19%) | 0/73 (0%) 0/20 (0%) 1/115 (1%) 7/60 (12%) |
|FIRST INCIDENCE (DAYS) | --- 743 (T) 740 618 | --- --- 653 642 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.340 P=0.098 P<0.001 ** | P<0.001 ** (e) P=0.348 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.340 P=0.111 P<0.001 ** | P<0.001 ** (e) P=0.376 P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.340 P=0.099 P<0.001 ** | P<0.001 ** (e) P=0.313 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.252 P=0.075 P<0.001 ** | (e) P=0.362 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/98 (17%) 6/33 (18%) 51/146 (35%) 24/99 (24%) | 3/99 (3%) 2/28 (7%) 102/150 (68%) 31/100 (31%)|
|ADJUSTED (b) | 26.1% 21.9% 45.8% 36.0% | 4.1% 10.0% 74.8% 43.7% |
|TERMINAL (d) | 12/58 (21%) 5/26 (19%) 37/95 (39%) 11/48 (23%) | 3/73 (4%) 2/20 (10%) 81/115 (70%) 22/60 (37%) |
|FIRST INCIDENCE (DAYS) | 351 532 526 449 | 740 (T) 740 (T) 503 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088 P=0.413N P=0.012 * P=0.111 | P<0.001 ** P=0.318 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.371 P=0.470N P=0.012 * P=0.301 | P=0.003 ** P=0.318 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.489 P=0.521N P=0.011 * P=0.395 | P=0.003 ** P=0.318 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.278 | P=0.006 ** |
|FISHER EXACT | P=0.550 P=0.002 ** P=0.155 | P=0.304 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/98 (21%) 4/33 (12%) 53/146 (36%) 90/99 (91%) | 7/99 (7%) 2/28 (7%) 83/150 (55%) 95/100 (95%)|
|ADJUSTED (b) | 32.8% 14.1% 50.5% 100.0% | 8.8% 8.0% 64.6% 98.9% |
|TERMINAL (d) | 16/58 (28%) 2/26 (8%) 44/95 (46%) 48/48 (100%)| 5/73 (7%) 0/20 (0%) 70/115 (61%) 59/60 (98%) |
|FIRST INCIDENCE (DAYS) | 520 532 535 507 | 523 529 621 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.072N P=0.033 * P<0.001 ** | P<0.001 ** P=0.652 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.089N P=0.048 * P<0.001 ** | P<0.001 ** P=0.569 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.096N P=0.056 P<0.001 ** | P<0.001 ** P=0.634N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.180N P=0.009 ** P<0.001 ** | P=0.632 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/98 (21%) 4/33 (12%) 53/146 (36%) 90/99 (91%) | 7/99 (7%) 2/28 (7%) 83/150 (55%) 95/100 (95%)|
|ADJUSTED (b) | 32.8% 14.1% 50.5% 100.0% | 8.8% 8.0% 64.6% 98.9% |
|TERMINAL (d) | 16/58 (28%) 2/26 (8%) 44/95 (46%) 48/48 (100%)| 5/73 (7%) 0/20 (0%) 70/115 (61%) 59/60 (98%) |
|FIRST INCIDENCE (DAYS) | 520 532 535 507 | 523 529 621 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.072N P=0.033 * P<0.001 ** | P<0.001 ** P=0.652 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.089N P=0.048 * P<0.001 ** | P<0.001 ** P=0.569 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.096N P=0.056 P<0.001 ** | P<0.001 ** P=0.634N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.180N P=0.009 ** P<0.001 ** | P=0.632 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/98 (34%) 9/33 (27%) 92/146 (63%) 93/99 (94%) | 9/99 (9%) 4/28 (14%) 136/150 (91%) 97/100 (97%)|
|ADJUSTED (b) | 49.3% 32.0% 78.3% 100.0% | 11.5% 17.2% 96.4% 100.0% |
|TERMINAL (d) | 25/58 (43%) 7/26 (27%) 70/95 (74%) 48/48 (100%)| 7/73 (10%) 2/20 (10%) 110/115 (96%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) | 351 532 526 449 | 523 529 503 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.097N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.324 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.137N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.239 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.152N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.343 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.325N P<0.001 ** P<0.001 ** | P=0.313 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/98 (34%) 9/33 (27%) 92/146 (63%) 93/99 (94%) | 9/99 (9%) 4/28 (14%) 136/150 (91%) 97/100 (97%)|
|ADJUSTED (b) | 49.3% 32.0% 78.3% 100.0% | 11.5% 17.2% 96.4% 100.0% |
|TERMINAL (d) | 25/58 (43%) 7/26 (27%) 70/95 (74%) 48/48 (100%)| 7/73 (10%) 2/20 (10%) 110/115 (96%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) | 351 532 526 449 | 523 529 503 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.097N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.324 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.137N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.239 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.152N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.343 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.325N P<0.001 ** P<0.001 ** | P=0.313 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/99 (11%) 10/33 (30%) 29/146 (20%) 12/99 (12%) | 5/100 (5%) 1/29 (3%) 15/150 (10%) 4/100 (4%) |
|ADJUSTED (b) | 18.6% 38.5% 29.0% 18.8% | 6.3% 4.8% 12.9% 6.7% |
|TERMINAL (d) | 10/58 (17%) 10/26 (38%) 25/95 (26%) 5/48 (10%) | 3/73 (4%) 1/21 (5%) 14/115 (12%) 4/60 (7%) |
|FIRST INCIDENCE (DAYS) | 716 743 (T) 649 641 | 491 740 (T) 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.519N P=0.054 P=0.094 P=0.407 | P=0.514N P=0.564N P=0.140 P=0.603N |
|INCIDENTAL TUMOR | P=0.236N P=0.039 * P=0.122 P=0.486N | P=0.462N P=0.620N P=0.119 P=0.573N |
|LOGISTIC REGRESSION | P=0.246N P=0.042 * P=0.122 P=0.578N | P=0.402N P=0.555N P=0.135 P=0.507N |
|COCHRAN-ARMITAGE | P=0.253N | P=0.362N |
|FISHER EXACT | P=0.012 * P=0.048 * P=0.500 | P=0.593N P=0.116 P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/33 (3%) 9/146 (6%) 2/99 (2%) | 5/100 (5%) 0/29 (0%) 4/150 (3%) 1/100 (1%) |
|ADJUSTED (b) | 1.7% 3.7% 8.5% 3.4% | 6.8% 0.0% 3.3% 1.7% |
|TERMINAL (d) | 1/58 (2%) 0/26 (0%) 6/95 (6%) 1/48 (2%) | 5/73 (7%) 0/21 (0%) 3/115 (3%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 705 562 671 | 740 (T) --- 647 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.567 P=0.071 P=0.475 | P=0.168N P=0.249N P=0.240N P=0.156N |
|INCIDENTAL TUMOR | P=0.481N P=0.421 P=0.076 P=0.572 | P=0.148N P=0.249N P=0.228N P=0.156N |
|LOGISTIC REGRESSION | P=0.542N P=0.547 P=0.064 P=0.534 | P=0.138N P=0.249N P=0.240N P=0.156N |
|COCHRAN-ARMITAGE | P=0.566N | P=0.126N |
|FISHER EXACT | P=0.439 P=0.041 * P=0.500 | P=0.274N P=0.263N P=0.106N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/99 (12%) 11/33 (33%) 35/146 (24%) 14/99 (14%) | 10/100 (10%) 1/29 (3%) 19/150 (13%) 5/100 (5%) |
|ADJUSTED (b) | 20.3% 40.7% 33.6% 21.7% | 13.0% 4.8% 16.1% 8.3% |
|TERMINAL (d) | 11/58 (19%) 10/26 (38%) 28/95 (29%) 6/48 (13%) | 8/73 (11%) 1/21 (5%) 17/115 (15%) 5/60 (8%) |
|FIRST INCIDENCE (DAYS) | 716 705 562 641 | 491 740 (T) 647 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.541 P=0.041 * P=0.040 * P=0.325 | P=0.253N P=0.237N P=0.381 P=0.237N |
|INCIDENTAL TUMOR | P=0.216N P=0.021 * P=0.054 P=0.549N | P=0.205N P=0.263N P=0.359 P=0.217N |
|LOGISTIC REGRESSION | P=0.231N P=0.026 * P=0.059 P=0.525 | P=0.164N P=0.237N P=0.376 P=0.156N |
|COCHRAN-ARMITAGE | P=0.276N | P=0.137N |
|FISHER EXACT | P=0.008 ** P=0.015 * P=0.417 | P=0.242N P=0.332 P=0.141N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 1/100 (1%) 1/29 (3%) 7/150 (5%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 1.4% 4.8% 5.3% 1.3% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 1/73 (1%) 1/21 (5%) 2/115 (2%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 740 (T) 740 (T) 440 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.470N P=0.464 P=0.121 P=0.736 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.338N P=0.464 P=0.059 P=0.715N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.360N P=0.464 P=0.044 * P=0.759 |
|COCHRAN-ARMITAGE | (e) | P=0.411N |
|FISHER EXACT | (e) (e) (e) | P=0.400 P=0.103 P=0.751N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.7% 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 2/73 (3%) 0/21 (0%) 0/115 (0%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 740 (T) --- --- 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.634N P=0.536N P=0.146N P=0.568N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.634N P=0.536N P=0.146N P=0.568N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.634N P=0.536N P=0.146N P=0.568N |
|COCHRAN-ARMITAGE | (e) | P=0.574N |
|FISHER EXACT | (e) (e) (e) | P=0.600N P=0.159N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 3/100 (3%) 1/29 (3%) 7/150 (5%) 2/100 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.1% 4.8% 5.3% 2.9% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 3/73 (4%) 1/21 (5%) 2/115 (2%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 740 (T) 740 (T) 440 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.438N P=0.684 P=0.400 P=0.573N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.323N P=0.684 P=0.289 P=0.514N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.332N P=0.684 P=0.257 P=0.524N |
|COCHRAN-ARMITAGE | (e) | P=0.362N |
|FISHER EXACT | (e) (e) (e) | P=0.644 P=0.379 P=0.500N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/75 (1%) 0/20 (0%) 3/64 (5%) 3/98 (3%) |
|ADJUSTED (b) | | 2.0% 0.0% 9.7% 4.7% |
|TERMINAL (d) | | 1/49 (2%) 0/12 (0%) 3/31 (10%) 2/59 (3%) |
|FIRST INCIDENCE (DAYS) | | 740 (T) --- 740 (T) 691 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.338 P=0.777N P=0.160 P=0.350 |
|INCIDENTAL TUMOR | | P=0.378 P=0.777N P=0.160 P=0.418 |
|LOGISTIC REGRESSION | | P=0.382 P=0.777N P=0.160 P=0.404 |
|COCHRAN-ARMITAGE | | P=0.374 |
|FISHER EXACT | | P=0.789N P=0.253 P=0.417 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/86 (0%) 0/28 (0%) 0/128 (0%) 12/80 (15%) | 21/95 (22%) 6/28 (21%) 59/144 (41%) 50/96 (52%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 23.7% | 27.3% 28.6% 48.8% 66.0% |
|TERMINAL (d) | 0/54 (0%) 0/22 (0%) 0/93 (0%) 7/40 (18%) | 17/72 (24%) 6/21 (29%) 51/112 (46%) 35/60 (58%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 669 | 587 740 (T) 569 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) (e) P<0.001 ** | P<0.001 ** P=0.591N P=0.004 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** (e) (e) P=0.001 ** | P<0.001 ** P=0.559N P=0.003 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** (e) (e) P<0.001 ** | P<0.001 ** P=0.595N P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | (e) (e) P<0.001 ** | P=0.583N P=0.002 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/86 (0%) 0/28 (0%) 0/128 (0%) 12/80 (15%) | 22/95 (23%) 7/28 (25%) 59/144 (41%) 50/96 (52%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 23.7% | 28.6% 31.0% 48.8% 66.0% |
|TERMINAL (d) | 0/54 (0%) 0/22 (0%) 0/93 (0%) 7/40 (18%) | 18/72 (25%) 6/21 (29%) 51/112 (46%) 35/60 (58%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 669 | 587 359 569 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) (e) P<0.001 ** | P<0.001 ** P=0.502 P=0.006 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** (e) (e) P=0.001 ** | P<0.001 ** P=0.586 P=0.006 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** (e) (e) P<0.001 ** | P<0.001 ** P=0.511 P=0.006 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | (e) (e) P<0.001 ** | P=0.511 P=0.003 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/86 (1%) 0/28 (0%) 0/128 (0%) 1/80 (1%) | 0/95 (0%) 2/28 (7%) 2/144 (1%) 0/96 (0%) |
|ADJUSTED (b) | 1.9% 0.0% 0.0% 2.5% | 0.0% 9.5% 1.6% 0.0% |
|TERMINAL (d) | 1/54 (2%) 0/22 (0%) 0/93 (0%) 1/40 (3%) | 0/72 (0%) 2/21 (10%) 1/112 (1%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- --- 743 (T) | --- 740 (T) 605 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.528 P=0.679N P=0.392N P=0.693 | P=0.328N P=0.037 * P=0.346 (e) |
|INCIDENTAL TUMOR | P=0.528 P=0.679N P=0.392N P=0.693 | P=0.323N P=0.037 * P=0.261 (e) |
|LOGISTIC REGRESSION | P=0.528 P=0.680N P=0.392N P=0.693 | P=0.289N P=0.037 * P=0.281 (e) |
|COCHRAN-ARMITAGE | P=0.584 | P=0.291N |
|FISHER EXACT | P=0.754N P=0.402N P=0.733 | P=0.050 P=0.362 (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 2/149 (1%) 1/100 (1%) | 0/100 (0%) 0/29 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 1.8% 2.1% | 0.0% 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 1/95 (1%) 1/48 (2%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 622 743 (T) | --- --- --- 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380 (e) P=0.364 P=0.462 | P=0.210 (e) (e) P=0.461 |
|INCIDENTAL TUMOR | P=0.395 (e) P=0.367 P=0.462 | P=0.210 (e) (e) P=0.461 |
|LOGISTIC REGRESSION | P=0.433 (e) P=0.348 P=0.462 | P=0.210 (e) (e) P=0.461 |
|COCHRAN-ARMITAGE | P=0.423 | P=0.245 |
|FISHER EXACT | (e) P=0.360 P=0.503 | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 2/149 (1%) 1/100 (1%) | 0/100 (0%) 0/29 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 1.8% 2.1% | 0.0% 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 1/95 (1%) 1/48 (2%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 622 743 (T) | --- --- --- 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380 (e) P=0.364 P=0.462 | P=0.210 (e) (e) P=0.461 |
|INCIDENTAL TUMOR | P=0.395 (e) P=0.367 P=0.462 | P=0.210 (e) (e) P=0.461 |
|LOGISTIC REGRESSION | P=0.433 (e) P=0.348 P=0.462 | P=0.210 (e) (e) P=0.461 |
|COCHRAN-ARMITAGE | P=0.423 | P=0.245 |
|FISHER EXACT | (e) P=0.360 P=0.503 | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/99 (6%) 4/33 (12%) 21/149 (14%) 10/100 (10%)| 2/100 (2%) 0/29 (0%) 1/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 9.1% 13.9% 19.1% 13.5% | 2.3% 0.0% 0.8% 1.7% |
|TERMINAL (d) | 1/58 (2%) 2/26 (8%) 11/95 (12%) 1/48 (2%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | 578 516 576 525 | 487 --- 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 P=0.355 P=0.079 P=0.240 | P=0.576N P=0.540N P=0.346N P=0.543N |
|INCIDENTAL TUMOR | P=0.268N P=0.149 P=0.139 P=0.497N | P=0.452N P=0.643N P=0.425N P=0.488N |
|LOGISTIC REGRESSION | P=0.365N P=0.269 P=0.117 P=0.590 | P=0.498N P=0.506N P=0.466N P=0.474N |
|COCHRAN-ARMITAGE | P=0.397 | P=0.528N |
|FISHER EXACT | P=0.217 P=0.035 * P=0.224 | P=0.600N P=0.351N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/33 (3%) 2/149 (1%) 0/100 (0%) | 0/100 (0%) 0/29 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 1.7% 3.8% 2.1% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/58 (2%) 1/26 (4%) 2/95 (2%) 0/48 (0%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 743 (T) 743 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311N P=0.573 P=0.668 P=0.538N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.311N P=0.573 P=0.668 P=0.538N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.311N P=0.573 P=0.668 P=0.538N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.253N | (e) |
|FISHER EXACT | P=0.439 P=0.650 P=0.497N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 609 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.190N P=0.549N P=0.144N P=0.242N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.143N P=0.486N P=0.179N P=0.144N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.162N P=0.516N P=0.215N P=0.214N |
|COCHRAN-ARMITAGE | (e) | P=0.190N |
|FISHER EXACT | (e) (e) (e) | P=0.600N P=0.159N P=0.249N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 2/149 (1%) 0/100 (0%) | 0/100 (0%) 0/29 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.1% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 2/95 (2%) 0/48 (0%) | 0/73 (0%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 743 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.707N (e) P=0.353 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.707N (e) P=0.353 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.707N (e) P=0.353 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.643N | (e) |
|FISHER EXACT | (e) P=0.360 (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/99 (10%) 5/33 (15%) 27/149 (18%) 12/100 (12%)| 2/100 (2%) 0/29 (0%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 14.6% 17.4% 24.1% 16.4% | 2.3% 0.0% 1.7% 1.7% |
|TERMINAL (d) | 2/58 (3%) 3/26 (12%) 14/95 (15%) 2/48 (4%) | 0/73 (0%) 0/21 (0%) 1/115 (1%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | 565 516 576 525 | 487 --- 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.441 P=0.486 P=0.132 P=0.429 | P=0.549N P=0.540N P=0.522N P=0.543N |
|INCIDENTAL TUMOR | P=0.098N P=0.193 P=0.252 P=0.210N | P=0.438N P=0.643N P=0.601N P=0.488N |
|LOGISTIC REGRESSION | P=0.158N P=0.341 P=0.208 P=0.292N | P=0.473N P=0.506N P=0.621N P=0.474N |
|COCHRAN-ARMITAGE | P=0.523N | P=0.492N |
|FISHER EXACT | P=0.307 P=0.058 P=0.421 | P=0.600N P=0.525N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/99 (9%) 5/33 (15%) 27/149 (18%) 12/100 (12%)| 2/100 (2%) 0/29 (0%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 13.1% 17.4% 24.1% 16.4% | 2.3% 0.0% 1.7% 1.7% |
|TERMINAL (d) | 1/58 (2%) 3/26 (12%) 14/95 (15%) 2/48 (4%) | 0/73 (0%) 0/21 (0%) 1/115 (1%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | 565 516 576 525 | 487 --- 738 740 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386 P=0.413 P=0.089 P=0.351 | P=0.549N P=0.540N P=0.522N P=0.543N |
|INCIDENTAL TUMOR | P=0.124N P=0.125 P=0.176 P=0.278N | P=0.438N P=0.643N P=0.601N P=0.488N |
|LOGISTIC REGRESSION | P=0.197N P=0.259 P=0.141 P=0.387N | P=0.473N P=0.506N P=0.621N P=0.474N |
|COCHRAN-ARMITAGE | P=0.518 | P=0.492N |
|FISHER EXACT | P=0.249 P=0.034 * P=0.332 | P=0.600N P=0.525N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 1/33 (3%) 4/149 (3%) 2/100 (2%) | 0/100 (0%) 0/29 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 4.4% 3.8% 3.8% 3.2% | 0.0% 0.0% 0.9% 0.0% |
|TERMINAL (d) | 0/58 (0%) 1/26 (4%) 1/95 (1%) 1/48 (2%) | 0/73 (0%) 0/21 (0%) 1/115 (1%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 565 743 (T) 693 618 | --- --- 740 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.471N P=0.644N P=0.526N P=0.487N | P=0.790N (e) P=0.591 (e) |
|INCIDENTAL TUMOR | P=0.185N P=0.621 P=0.368N P=0.286N | P=0.790N (e) P=0.591 (e) |
|LOGISTIC REGRESSION | P=0.401N P=0.691N P=0.555N P=0.477N | P=0.790N (e) P=0.591 (e) |
|COCHRAN-ARMITAGE | P=0.417N | P=0.755N |
|FISHER EXACT | P=0.740N P=0.580N P=0.495N | (e) P=0.600 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/74 (1%) 0/12 (0%) 1/69 (1%) 3/95 (3%) | 2/73 (3%) 0/13 (0%) 5/93 (5%) 2/99 (2%) |
|ADJUSTED (b) | 2.9% 0.0% 0.9% 5.8% | 2.3% 0.0% 6.6% 3.2% |
|TERMINAL (d) | 1/35 (3%) 0/5 (0%) 0/20 (0%) 2/47 (4%) | 0/46 (0%) 0/5 (0%) 3/58 (5%) 1/59 (2%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- 690 694 | 609 --- 621 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.229 P=0.872N P=0.767N P=0.389 | P=0.556N P=0.549N P=0.391 P=0.684N |
|INCIDENTAL TUMOR | P=0.365 P=0.872N P=0.737N P=0.485 | P=0.404N P=0.486N P=0.327 P=0.521N |
|LOGISTIC REGRESSION | P=0.347 P=0.872N P=0.755 P=0.478 | P=0.417N P=0.606N P=0.313 P=0.580N |
|COCHRAN-ARMITAGE | P=0.258 | P=0.418N |
|FISHER EXACT | P=0.860N P=0.734 P=0.409 | P=0.719N P=0.333 P=0.568N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/33 (0%) 2/149 (1%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 3.4% 0.0% 2.1% 0.0% | 2.7% 0.0% 1.7% 0.0% |
|TERMINAL (d) | 2/58 (3%) 0/26 (0%) 2/95 (2%) 0/48 (0%) | 2/73 (3%) 0/21 (0%) 2/115 (2%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- 743 (T) --- | 740 (T) --- 740 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263N P=0.427N P=0.507N P=0.281N | P=0.247N P=0.536N P=0.522N P=0.283N |
|INCIDENTAL TUMOR | P=0.263N P=0.427N P=0.507N P=0.281N | P=0.247N P=0.536N P=0.522N P=0.283N |
|LOGISTIC REGRESSION | P=0.263N P=0.427N P=0.507N P=0.281N | P=0.247N P=0.536N P=0.522N P=0.283N |
|COCHRAN-ARMITAGE | P=0.212N | P=0.210N |
|FISHER EXACT | P=0.561N P=0.524N P=0.246N | P=0.600N P=0.525N P=0.249N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/96 (1%) 1/33 (3%) 4/144 (3%) 59/99 (60%) | 1/99 (1%) 1/29 (3%) 17/149 (11%) 73/100 (73%)|
|ADJUSTED (b) | 1.8% 3.8% 4.2% 75.9% | 1.4% 4.8% 14.6% 87.7% |
|TERMINAL (d) | 1/55 (2%) 1/26 (4%) 4/95 (4%) 30/48 (63%) | 1/72 (1%) 1/21 (5%) 16/115 (14%) 50/60 (83%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 743 (T) 743 (T) 241 | 740 (T) 740 (T) 710 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.586 P=0.377 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.586 P=0.377 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.586 P=0.377 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.448 P=0.335 P<0.001 ** | P=0.403 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/96 (1%) 0/33 (0%) 0/144 (0%) 14/99 (14%) | 0/99 (0%) 0/29 (0%) 1/149 (1%) 12/100 (12%)|
|ADJUSTED (b) | 1.8% 0.0% 0.0% 24.5% | 0.0% 0.0% 0.9% 17.9% |
|TERMINAL (d) | 1/55 (2%) 0/26 (0%) 0/95 (0%) 8/48 (17%) | 0/72 (0%) 0/21 (0%) 1/115 (1%) 8/60 (13%) |
|FIRST INCIDENCE (DAYS) | 743 (T) --- --- 669 | --- --- 740 (T) 674 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.649N P=0.391N P<0.001 ** | P<0.001 ** (e) P=0.593 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.649N P=0.391N P=0.003 ** | P<0.001 ** (e) P=0.593 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.649N P=0.391N P=0.001 ** | P<0.001 ** (e) P=0.593 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.744N P=0.400N P<0.001 ** | (e) P=0.601 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/96 (2%) 1/33 (3%) 4/144 (3%) 64/99 (65%) | 1/99 (1%) 1/29 (3%) 17/149 (11%) 76/100 (76%)|
|ADJUSTED (b) | 3.6% 3.8% 4.2% 82.6% | 1.4% 4.8% 14.6% 90.3% |
|TERMINAL (d) | 2/55 (4%) 1/26 (4%) 4/95 (4%) 35/48 (73%) | 1/72 (1%) 1/21 (5%) 16/115 (14%) 52/60 (87%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 743 (T) 743 (T) 241 | 740 (T) 740 (T) 710 598 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.719 P=0.602 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.719 P=0.602 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.719 P=0.602 P<0.001 ** | P<0.001 ** P=0.467 P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.591 P=0.544 P<0.001 ** | P=0.403 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 1/149 (1%) 3/100 (3%) | 2/100 (2%) 0/29 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.8% 5.8% | 2.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 2/48 (4%) | 2/73 (3%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 662 700 | 740 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021 * (e) P=0.615 P=0.098 | P=0.210N P=0.536N P=0.146N P=0.283N |
|INCIDENTAL TUMOR | P=0.065 (e) P=0.693 P=0.151 | P=0.210N P=0.536N P=0.146N P=0.283N |
|LOGISTIC REGRESSION | P=0.034 * (e) P=0.589 P=0.132 | P=0.210N P=0.536N P=0.146N P=0.283N |
|COCHRAN-ARMITAGE | P=0.033 * | P=0.190N |
|FISHER EXACT | (e) P=0.601 P=0.125 | P=0.600N P=0.159N P=0.249N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/99 (5%) 1/33 (3%) 7/149 (5%) 7/100 (7%) | 5/100 (5%) 0/29 (0%) 11/150 (7%) 4/100 (4%) |
|ADJUSTED (b) | 8.1% 3.8% 6.7% 12.4% | 6.3% 0.0% 8.9% 6.4% |
|TERMINAL (d) | 4/58 (7%) 1/26 (4%) 4/95 (4%) 4/48 (8%) | 3/73 (4%) 0/21 (0%) 7/115 (6%) 3/60 (5%) |
|FIRST INCIDENCE (DAYS) | 565 743 (T) 623 685 | 609 --- 605 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.159 P=0.386N P=0.496N P=0.319 | P=0.567 P=0.257N P=0.361 P=0.590N |
|INCIDENTAL TUMOR | P=0.343 P=0.393N P=0.448N P=0.482 | P=0.444N P=0.231N P=0.297 P=0.474N |
|LOGISTIC REGRESSION | P=0.280 P=0.426N P=0.480N P=0.454 | P=0.492N P=0.247N P=0.298 P=0.512N |
|COCHRAN-ARMITAGE | P=0.260 | P=0.483N |
|FISHER EXACT | P=0.532N P=0.562N P=0.391 | P=0.274N P=0.323 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/99 (5%) 1/33 (3%) 8/149 (5%) 10/100 (10%)| 7/100 (7%) 0/29 (0%) 11/150 (7%) 4/100 (4%) |
|ADJUSTED (b) | 8.1% 3.8% 7.5% 17.8% | 9.0% 0.0% 8.9% 6.4% |
|TERMINAL (d) | 4/58 (7%) 1/26 (4%) 4/95 (4%) 6/48 (13%) | 5/73 (7%) 0/21 (0%) 7/115 (6%) 3/60 (5%) |
|FIRST INCIDENCE (DAYS) | 565 743 (T) 623 685 | 609 --- 605 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025 * P=0.386N P=0.579N P=0.100 | P=0.417N P=0.166N P=0.590N P=0.363N |
|INCIDENTAL TUMOR | P=0.114 P=0.393N P=0.515N P=0.214 | P=0.286N P=0.150N P=0.546 P=0.267N |
|LOGISTIC REGRESSION | P=0.068 P=0.426N P=0.573N P=0.189 | P=0.317N P=0.161N P=0.552 P=0.283N |
|COCHRAN-ARMITAGE | P=0.061 | P=0.307N |
|FISHER EXACT | P=0.532N P=0.578 P=0.146 | P=0.160N P=0.565 P=0.269N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/33 (3%) 4/149 (3%) 2/100 (2%) | 0/100 (0%) 1/29 (3%) 5/150 (3%) 4/100 (4%) |
|ADJUSTED (b) | 1.7% 3.8% 3.3% 3.2% | 0.0% 4.3% 3.6% 5.3% |
|TERMINAL (d) | 1/58 (2%) 1/26 (4%) 0/95 (0%) 0/48 (0%) | 0/73 (0%) 0/21 (0%) 1/115 (1%) 1/60 (2%) |
|FIRST INCIDENCE (DAYS) | 743 (T) 743 (T) 536 582 | --- 668 529 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.503 P=0.573 P=0.385 P=0.479 | P=0.102 P=0.248 P=0.096 P=0.056 |
|INCIDENTAL TUMOR | P=0.504N P=0.573 P=0.440 P=0.627 | P=0.229 P=0.212 P=0.046 * P=0.097 |
|LOGISTIC REGRESSION | P=0.547 P=0.573 P=0.327 P=0.530 | P=0.199 P=0.262 P=0.028 * P=0.071 |
|COCHRAN-ARMITAGE | P=0.542 | P=0.120 |
|FISHER EXACT | P=0.439 P=0.336 P=0.504 | P=0.225 P=0.076 P=0.061 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 14/99 (14%) 5/33 (15%) 26/149 (17%) 15/100 (15%)| 37/100 (37%) 9/29 (31%) 58/150 (39%) 32/100 (32%)|
|ADJUSTED (b) | 21.5% 19.2% 22.5% 22.1% | 42.5% 35.4% 42.5% 42.7% |
|TERMINAL (d) | 10/58 (17%) 5/26 (19%) 12/95 (13%) 3/48 (6%) | 24/73 (33%) 5/21 (24%) 38/115 (33%) 20/60 (33%) |
|FIRST INCIDENCE (DAYS) | 180 743 (T) 536 522 | 327 552 529 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.370 P=0.443N P=0.454 P=0.443 | P=0.488 P=0.391N P=0.532N P=0.545 |
|INCIDENTAL TUMOR | P=0.221N P=0.495N P=0.540 P=0.329N | P=0.150N P=0.317N P=0.502 P=0.229N |
|LOGISTIC REGRESSION | P=0.378N P=0.573N P=0.392 P=0.580N | P=0.250N P=0.344N P=0.385 P=0.276N |
|COCHRAN-ARMITAGE | P=0.538 | P=0.259N |
|FISHER EXACT | P=0.543 P=0.305 P=0.512 | P=0.360N P=0.448 P=0.276N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 13/99 (13%) 4/33 (12%) 22/149 (15%) 13/100 (13%)| 37/100 (37%) 8/29 (28%) 53/150 (35%) 28/100 (28%)|
|ADJUSTED (b) | 19.9% 15.4% 19.8% 19.6% | 42.5% 32.5% 40.1% 39.1% |
|TERMINAL (d) | 9/58 (16%) 4/26 (15%) 12/95 (13%) 3/48 (6%) | 24/73 (33%) 5/21 (24%) 37/115 (32%) 19/60 (32%) |
|FIRST INCIDENCE (DAYS) | 180 743 (T) 619 522 | 327 552 647 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410 P=0.359N P=0.569 P=0.528 | P=0.387N P=0.276N P=0.349N P=0.337N |
|INCIDENTAL TUMOR | P=0.247N P=0.407N P=0.511N P=0.286N | P=0.078N P=0.202N P=0.359N P=0.100N |
|LOGISTIC REGRESSION | P=0.485N P=0.480N P=0.533 P=0.511N | P=0.129N P=0.228N P=0.469N P=0.117N |
|COCHRAN-ARMITAGE | P=0.529N | P=0.125N |
|FISHER EXACT | P=0.574N P=0.434 P=0.572N | P=0.239N P=0.446N P=0.114N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.5% 0.0% 0.7% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 1/73 (1%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 642 --- 625 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.214N P=0.541N P=0.337N P=0.263N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.189N P=0.464N P=0.490N P=0.228N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.187N P=0.531N P=0.431N P=0.236N |
|COCHRAN-ARMITAGE | (e) | P=0.205N |
|FISHER EXACT | (e) (e) (e) | P=0.600N P=0.351N P=0.249N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/33 (0%) 0/149 (0%) 0/100 (0%) | 2/100 (2%) 0/29 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.5% 0.0% 0.7% 0.0% |
|TERMINAL (d) | 0/58 (0%) 0/26 (0%) 0/95 (0%) 0/48 (0%) | 1/73 (1%) 0/21 (0%) 0/115 (0%) 0/60 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 642 --- 625 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.214N P=0.541N P=0.337N P=0.263N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.189N P=0.464N P=0.490N P=0.228N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.187N P=0.531N P=0.431N P=0.236N |
|COCHRAN-ARMITAGE | (e) | P=0.205N |
|FISHER EXACT | (e) (e) (e) | P=0.600N P=0.351N P=0.249N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/99 (30%) 15/33 (45%) 78/149 (52%) 77/100 (77%)| 36/100 (36%) 9/29 (31%) 126/150 (84%) 84/100 (84%)|
|ADJUSTED (b) | 45.5% 55.4% 68.5% 91.4% | 44.1% 42.9% 89.3% 96.5% |
|TERMINAL (d) | 23/58 (40%) 14/26 (54%) 60/95 (63%) 41/48 (85%) | 28/73 (38%) 9/21 (43%) 100/115 (87%) 57/60 (95%) |
|FIRST INCIDENCE (DAYS) | 351 532 526 241 | 491 740 (T) 503 443 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.377 P=0.005 ** P<0.001 ** | P<0.001 ** P=0.413N P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.258 P=0.006 ** P<0.001 ** | P<0.001 ** P=0.437N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.231 P=0.007 ** P<0.001 ** | P<0.001 ** P=0.432N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.085 P<0.001 ** P<0.001 ** | P=0.397N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 100 PPM 333 PPM 1000 PPM | 0 PPM 100 PPM 333 PPM 1000 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/99 (47%) 16/33 (48%) 102/149 (68%) 92/100 (92%)| 55/100 (55%) 13/29 (45%) 126/150 (84%) 98/100 (98%)|
|ADJUSTED (b) | 63.2% 51.6% 76.0% 100.0% | 60.1% 44.8% 85.1% 100.0% |
|TERMINAL (d) | 31/58 (53%) 11/26 (42%) 63/95 (66%) 48/48 (100%)| 37/73 (51%) 5/21 (24%) 93/115 (81%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) | 180 516 532 507 | 327 359 440 275 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.199N P=0.040 * P<0.001 ** | P<0.001 ** P=0.292N P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.353N P=0.054 P<0.001 ** | P<0.001 ** P=0.179N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.278N P=0.032 * P<0.001 ** | P<0.001 ** P=0.194N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.539 P<0.001 ** P<0.001 ** | P=0.225N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 63/99 (64%) 25/33 (76%) 127/149 (85%) 94/100 (94%)| 69/100 (69%) 20/29 (69%) 148/150 (99%) 98/100 (98%)|
|ADJUSTED (b) | 80.7% 80.6% 92.0% 100.0% | 74.0% 69.0% 99.3% 100.0% |
|TERMINAL (d) | 43/58 (74%) 20/26 (77%) 84/95 (88%) 48/48 (100%)| 49/73 (67%) 12/21 (57%) 114/115 (99%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) | 180 516 526 241 | 327 359 440 275 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.347N P=0.046 * P<0.001 ** | P<0.001 ** P=0.539 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.502 P=0.029 * P<0.001 ** | P<0.001 ** P=0.564N P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.576N P=0.016 * P<0.001 ** | P<0.001 ** P=0.570N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.143 P<0.001 ** P<0.001 ** | P=0.583N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05076 TEST: 02 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
MALE TERMINAL SACRIFICE AT 107 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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