TR 388 Rat Pathology Tables
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4|
| 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 2 |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 2 2 1 1 2 2 2 1 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 3 4 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 3 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Mineralization | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 3 2 2 2 2 2 2|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4|
| 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 |
Hyperplasia | 3 2 2 1 2 2 2 2 2 2 2|
Hypertrophy | 2 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M M + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 3 2 3 3 2 3 3 2 2 3 2|
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 3 1 2 2 2 2 2 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 1 2 2 |
Duct, Dilatation | 4 4 4 4 4 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cervix, Diverticulum | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4|
| 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | M + M + M + + M + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 3 4 2 1 2 3 3 2 3 2 2 3 3 2 1 4 3 3 2 2 3 4 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | |
Hydrocephalus | 3 1 1 3 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 2|
Mediastinum, Perivascular, | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | 4 2 |
Lens, Cataract | 4 4 4 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 5| 6| 5| 7| 7| 6| 4| 4| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 2| 4| 5| 4| 4| 3| 9| 4| 4| 2| 5| 6| 9| 4| 4| 4| 2| 1| 4| 2| 4| 9| 4| 6| 4|
| 4| 0| 8| 0| 0| 8| 4| 7| 0| 1| 4| 6| 4| 3| 3| 4| 4| 8| 3| 1| 3| 4| 4| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 3 |
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 1 2 2 2 2 1 3 3 3 3 2 3 3 1 2 3 3 1 2 3 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| |
| 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X | 36 |
Clear Cell Focus | X X | 2 |
Degeneration, Cystic | | 1 2.0|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Chronic | 1 1 1 2 1 | 14 1.5|
Necrosis, Coagulative | 4 2 | 2 3.0|
Vacuolization Cytoplasmic | 4 3| 8 2.8|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 2 4 1 2 1 1 2 2 2 | 16 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 1 2 1| 4 1.3|
Mineralization | | 1 3.0|
Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| |
| 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 3 3 3 2 2 2 2 2 2| 30 2.2|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 2 1 2 2 2 3 2 2 2| 16 1.9|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 | 25 2.0|
Hypertrophy | 2 | 3 2.0|
Necrosis, Coagulative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1 2 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X X X X X X X X X X X | 27 |
Pars Distalis, Hyperplasia | 2 3 3 3 2 2 | 18 2.5|
Pars Intermedia, Angiectasis | 4 | 1 4.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 | 31 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia | 2 2 3 | 3 2.3|
Inflammation, Chronic Active | 2 2 4 3 3 4 | 11 2.5|
Duct, Dilatation | 4 4 4 4 4 | 11 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X| 11 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 3 | 2 3.5|
Cervix, Diverticulum | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 4 2 2 3 | 12 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| |
| 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + A + | 10 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
Femoral, Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Cyst | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 3 4 4 4 3 2 3 4 4 4 3 4 2 3 2 2 3 2 4| 48 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 11 |
Hemorrhage | 4 | 1 4.0|
Hydrocephalus | 2 3 3 2 3 | 10 2.4|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 | 7 1.7|
Mediastinum, Perivascular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 5| 5| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 4| 4| 2| 2| 6| 0| 4| 4| 6| 4| 4| 4| 5| 4| 4| 4| 4| 4| 0| 2| 4| 4| 1| 4| 5| |
| 4| 4| 6| 6| 1| 8| 5| 5| 1| 5| 5| 2| 7| 6| 6| 6| 6| 7| 7| 3| 7| 7| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 1 | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 8 |
Hemorrhage | 2 | 3 2.7|
Lens, Cataract | 4 4 4 | 6 4.0|
Retina, Atrophy | 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Mineralization | | 1 3.0|
Necrosis, Coagulative | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 4 3 2 3 3 3 2 2 2 1 1 3 4 3 2 2 3 3 1 3 3| 49 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2|
| 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + A + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + A + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + M + + + + + + + + + A +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 1 2 1 1 1 1|
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 3 4 4 4|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | |
Acinus, Atrophy | 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | 2|
Inflammation, Chronic Active | 4 2 3 |
Mineralization | |
Mucosa, Degeneration, Chronic | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 1 2 1 2 2 1 1|
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2|
| 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +|
Degeneration, Fatty | 3 2 2 1 1 1 1|
Hematocyst | |
Hyperplasia | 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Hypertrophy | 2 1 2 3 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hematocyst | X |
Hyperplasia | 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 3 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 2 2 3 1 2 2 2 2 3 2 2 3|
Follicular Cell, Hyperplasia | 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Inflammation, Chronic Active | 2 3 2 3 1 |
Duct, Dilatation | 3 3 3 4 3 3 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 4 4 |
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Prolapse | |
Cervix, Diverticulum | 4 4 |
Cervix, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2|
| 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 4 4 3 4 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + M M +|
Hyperplasia, Cystic | 3 3 3 2 2 3 2 2 4 3 3 2 2 3 3 1 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X|
Hydrocephalus | 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 6| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 0| 3| 1| 8| 4| 2| 4| 3| 0| 2|
| 0| 0| 4| 0| 8| 0| 0| 3| 3| 2| 3| 3| 3| 4| 4| 6| 1| 2| 8| 4| 8| 4| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +|
Nephropathy, Chronic | 3 2 2 1 2 2 3 3 4 3 2 2 2 2 2 1 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + A +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| |
| 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X X X | 4 |
Degeneration, Cystic | 2 2 | 2 2.0|
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 2 2 1 1 1 1 2 2 2| 17 1.4|
Necrosis, Coagulative | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 4 3.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Acinus, Atrophy | 1 1 2 2 1 2 2 1| 12 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 | 2 3.0|
Hyperkeratosis | 3 | 2 3.0|
Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 2 | 4 2.8|
Mineralization | 2 3 1 | 3 2.0|
Mucosa, Degeneration, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| |
| 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 1 2 3 2 2 2 2 2 2 2 2 2| 25 1.8|
Mineralization | 4 | 1 4.0|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 1 1 2 2 1 2 1 1 2 1 2 2| 20 1.6|
Hematocyst | X | 1 |
Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 3 3 2 3 2 2 2| 33 2.1|
Hypertrophy | 2 1 1 2 2 3 | 11 1.9|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematocyst | | 1 |
Hyperplasia | 2 2 2 2 2 1 1 | 16 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + M + + + + + + + +| 47 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | X X X X X X X X X X| 17 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2| 12 2.2|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ultimobranchial Cyst | X X | 3 |
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0|
Follicular Cell, Hyperplasia | 1 2 1 | 8 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 4 2.0|
Inflammation, Chronic Active | 2 4 2 3 2 2 | 11 2.4|
Duct, Dilatation | 3 4 4 3 4 4 | 14 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| |
| 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.0|
Cyst | X X X X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3| 5 3.2|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 2 1 | 3 1.3|
Prolapse | X | 1 |
Cervix, Diverticulum | 4 | 3 4.0|
Cervix, Inflammation, Suppurative | 4 | 2 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 4 2 3 2 3| 12 3.0|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 10 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 | 4 3.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + M M + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Cystic | 4 3 1 4 3 2 3 3 2 2 4 2 3 2 3 2 2 2 3 2 2 2 2 2 2| 45 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranium, Fibrous Osteodystrophy | X | 2 |
Femur, Fibrous Osteodystrophy | X | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 4| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 9| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 8| 9| 4| 5| 8| 9| 4| 4| |
| 4| 5| 5| 3| 5| 4| 4| 5| 5| 6| 9| 6| 6| 6| 7| 7| 7| 3| 2| 7| 8| 0| 0| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | X X X | 7 |
Hydrocephalus | 2 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 2 3 1 1 1| 11 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Mediastinum, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2| 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + | 9 |
Lens, Cataract | 4 4 4 4 4 | 7 4.0|
Retina, Atrophy | 4 4 4 4 4 4 | 8 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 2 2 2 2 1 2 3 2 1 1 3 2 3 2 2 3 2 4 2 2 1 3 2| 43 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Artery, Necrosis, Fibrinoid | 4 |
Perivascular, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 |
Necrosis, Coagulative | 3 |
Thrombosis | X |
Vacuolization Cytoplasmic | 4 3 3 4 4|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 1 2 2 2 2 |
Artery, Necrosis, Fibrinoid | 4 |
Perivascular, Inflammation, Chronic | |
Active | 3 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Hyperkeratosis | 3 2 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic Active | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 2|
Mineralization | 2 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy, Chronic | 2 2 2 1 2 2 2 2 2 1 2 2 2 2 |
Atrium, Thrombosis | X|
Ventricle, Thrombosis | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Degeneration, Fatty | 3 2 3 1 2 2 3 1 2 2 2|
Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 3 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 |
Pars Intermedia, Cyst | X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 2 1 2 2 1 1 2 1 2 1 2 1 1 2 1 1 2 1 2 2 2|
Follicular Cell, Hyperplasia | 1 1 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Duct, Dilatation | 1 4 1 2 1 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
Cyst | X X X X X X X |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic Active | 4 |
Cervix, Diverticulum | |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 4 1 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 3 4 3 2 3 2 2 3 1 4 2 2 2 3 3 1 4 4 2 2 4 3|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | |
Mediastinum, Perivascular, | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 1| 8| 0| 5| 4| 2| 3| 4| 4| 1| 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4|
| 0| 0| 0| 1| 0| 7| 0| 3| 5| 0| 0| 1| 3| 3| 3| 3| 9| 3| 6| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Lens, Cataract | 4 |
Retina, Atrophy | 3 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 3 4 1 1 2 2 2 2 3 2 2 2 3 3 2 1 4 2 3 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| |
| 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Artery, Necrosis, Fibrinoid | | 1 4.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Parasite Metazoan | X X| 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 34 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 1 1 1 2 1 1 2 1 3 2 1 1 1| 21 1.3|
Necrosis, Coagulative | 2 | 2 2.5|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | 3 2 2 2 | 9 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 1 2 2 3 1 1| 17 1.7|
Artery, Necrosis, Fibrinoid | | 1 4.0|
Perivascular, Inflammation, Chronic | | |
Active | | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 3 2.7|
Hyperkeratosis | 2 | 3 2.3|
Hyperplasia, Focal, Squamous | 4 | 1 4.0|
Inflammation, Chronic Active | 2 2 1 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 3 2.7|
Mineralization | 2 2 2 | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| |
| 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 3 2 2 2 1 2 2 1 1 2 1 2 | 27 1.8|
Atrium, Thrombosis | | 1 |
Ventricle, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atypia Cellular | X| 2 |
Degeneration, Fatty | 1 1 2 1 1 2 1 2 1 3 1 2| 23 1.8|
Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 26 2.0|
Hypertrophy | 2 2 3 | 8 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 1 2| 8 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X X X X X X X X X X X| 27 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2| 13 2.2|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2| 41 1.7|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 | 15 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 3 2.0|
Inflammation, Chronic Active | 1 1 | 9 1.0|
Duct, Dilatation | 3 | 8 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| |
| 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 3 | 3 3.0|
Cyst | X X X X X X X X X X X | 18 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 | 3 2.3|
Inflammation, Chronic Active | | 1 4.0|
Cervix, Diverticulum | 4 | 1 4.0|
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 4 2 2 2 1 | 10 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Coagulative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + + + + + + M + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 3 2 2 2 2 4 2 4 2 3 1 2 2 2 3 3 4 4 2 3 2 3 3| 50 2.6|
Inflammation, Chronic Active | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 8 |
Hydrocephalus | 3 2 2 2 3 3 3 | 9 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 2| 0| 9| 4| 4| 4| |
| 5| 5| 5| 5| 5| 2| 6| 6| 6| 6| 6| 6| 7| 6| 7| 7| 9| 7| 7| 1| 5| 6| 7| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 3| 13 1.4|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | 3 | 1 3.0|
Mediastinum, Perivascular, | | |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 5 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 7 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Lens, Cataract | 4 4 4 | 4 4.0|
Retina, Atrophy | 4 4 4 | 5 3.8|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Nephropathy, Chronic | 2 1 2 2 2 1 2 3 2 3 3 1 2 2 3 1 2 2 1 3 3 3 2| 46 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4|
| 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + A + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + A + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 2 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 |
Inflammation, Chronic | 1 2 2 1 3 2 2 2 1 1 1|
Necrosis, Coagulative | 2 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic Active | 2 2 2 2 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 1|
Mineralization | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4|
| 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 1 3 2 2 1 1 2 2 1 |
Hematocyst | X |
Hyperplasia | 2 2 3 2 1 3 2 2 2 1 2 2 2 2 1 2|
Hypertrophy | 2 2 2 2 |
Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Atypia Cellular | X |
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2|
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + A + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | 2 2 1 2 2 2 2 1 1 1 2 2 1 2 1 1 2|
Follicular Cell, Hyperplasia | 1 1 2 2 1 2 2 2 2 2 2 2 2 2 4 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 3 2 1 3 2|
Duct, Dilatation | 1 2 1 1 2 2 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Cyst | X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 3 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 2 |
Cervix, Diverticulum | 4 |
Cervix, Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 4 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4|
| 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + M + + + M + + + + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 2 4 3 2 2 4 4 2 2 1 3 2 2 4 3 3 4 2 4 3 1 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
Hydrocephalus | 2 2 3 3 2 2 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 4| 6| 4| 4| 4| 4| 4| 0| 4| 4| 3| 1| 0| 4| 4| 7| 4| 4| 4| 4| 4| 3| 4| 4|
| 7| 0| 9| 0| 0| 0| 0| 3| 3| 0| 3| 8| 8| 4| 3| 3| 2| 4| 4| 4| 4| 4| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 |
Lens, Cataract | 2 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nephropathy, Chronic | 1 2 1 2 3 3 2 2 2 4 2 2 2 3 3 2 2 4 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| |
| 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + A + + + + + + + A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + A + + + A + + + A + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + + + + + + A + + + + + + + A + + + + + +| 45 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + A + + + A + + + A + + + + + +| 43 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + A + + + A + + + A + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | | 2 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 1 3 1 1 1 1| 18 1.6|
Necrosis, Coagulative | 3 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 2 4 2 2 2 2 2| 15 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 | 3 2.0|
Hyperkeratosis | 2 2 | 3 2.0|
Inflammation, Chronic Active | 3 4 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 2 2 3 | 9 2.1|
Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| |
| 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 2 2 2 2 1 1 1 2 2 2 1 2 2 2 2 3 2 2 2 2 2| 38 1.8|
Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Fatty | 2 1 2 2 2 2 2 2 2 2 2 1 2 | 22 1.8|
Hematocyst | X | 2 |
Hyperplasia | 2 1 3 1 2 2 2 2 2 2 2 3 2 3 2 | 31 2.0|
Hypertrophy | 2 3 2 | 7 2.1|
Necrosis, Coagulative | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 2 2 2 | 14 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Atypia Cellular | | 1 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X X | 28 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 3 2 2 2 | 13 2.2|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + A + + + + + + + A + + + A + +| 44 |
Ultimobranchial Cyst | | 3 |
C-Cell, Hyperplasia | 2 2 2 2 2 1 1 1 1 2 2 2 3 1 2 1 1 1| 35 1.6|
Follicular Cell, Hyperplasia | 2 2 1 2 2 3 1 1 2 2 2 2 1 2 1 | 33 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | A + + + M + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia | 2 2 2 | 3 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 1 1 2 3| 15 2.0|
Duct, Dilatation | | 8 1.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| |
| 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 3 3.0|
Cyst | X X X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 4 | 6 3.3|
Hemorrhage | 4 4 | 3 4.0|
Inflammation, Chronic Active | | 1 2.0|
Cervix, Diverticulum | | 1 4.0|
Cervix, Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 1 4 2 4 2 4 2 2| 14 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 4 1 3 1 3 3 3 3 3 2 3 2 2 3 3 2 2 3 3 2 2 3| 47 2.6|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X X | 2 |
Femur, Fibrous Osteodystrophy | X X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 9| 4| 4| 6| 4| 4| 4| 5| 4| 4| 1| 4| 4| 4| 3| 7| 2| 4| 6| 4| 4| 4| 3| 4| 4| |
| 7| 5| 5| 1| 5| 6| 6| 4| 6| 6| 1| 6| 6| 7| 2| 1| 6| 7| 5| 7| 4| 7| 8| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | 3 | 8 2.4|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 4 1| 12 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 4 | 4 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + | 7 |
Inflammation, Chronic Active | | 1 4.0|
Lens, Cataract | 3 4 3 4 | 6 3.3|
Retina, Atrophy | 4 4 3 4 | 6 3.8|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Nephropathy, Chronic | 3 2 2 1 3 2 3 1 1 1 3 1 4 1 2 2 1 4 3 1 1 2| 43 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + A + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4|
| 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + A + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + A + A A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + A + M + + + + + + + + + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + A + A + A + + + + + + + + + + + A +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A + + A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 3 |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic | 1 1 1 1 1 1 2 1|
Leukocytosis | |
Necrosis, Coagulative | 4 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
Acinus, Atrophy | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 1 4 2 2 |
Mineralization | 1|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Caries | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4|
| 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X|
Degeneration, Fatty | 3 2 1 2 1 2 2 2 1 1 |
Hyperplasia | 2 1 2 2 3 2 2 2 2 1 2|
Hypertrophy | 1 3 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Fibrosis | |
Pars Distalis, Hyperplasia | 2 2 2 2|
Pars Distalis, Vacuolization | |
Cytoplasmic | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + A + A + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
C-Cell, Hyperplasia | 3 2 2 2 1 1 2 2 2 2 2 2 1 2 1|
Follicular Cell, Hyperplasia | 1 2 1 1 3 3 2 2 2 2 3 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 1 3 |
Duct, Dilatation | 3 3 4 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X X X X X X |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 2 |
Cervix, Diverticulum | 4 |
Cervix, Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4|
| 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + A +|
Femoral, Hyperplasia, Reticulum Cell | |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 3 2 3 2 3 2 4 4 3 2 3 3 4 3 3 4 3 2 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 2 4 3 |
Hydrocephalus | 3 2 |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Peripheral Nerve | M |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1|
Leukocytosis | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Fungus | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 7| 5| 7| 6| 7| 5| 6| 3| 7| 4| 5| 7| 6| 7| 7| 7| 4| 6| 7|
DAY ON TEST | 4| 4| 4| 0| 5| 9| 4| 8| 4| 7| 1| 9| 8| 1| 4| 3| 8| 4| 2| 4| 4| 4| 9| 8| 4|
| 0| 0| 0| 1| 1| 4| 0| 5| 3| 7| 2| 7| 5| 2| 3| 1| 7| 3| 2| 3| 3| 4| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Lens, Cataract | 4 4 4 3 3 4 |
Retina, Atrophy | 4 4 4 3 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 3 |
Nephropathy, Chronic | 1 2 2 2 3 3 4 3 2 3 4 2 3 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| |
| 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + A + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + A + + + + M + + + A + + + + + A + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + A + + + + + A + + +| 43 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + A + + + + M + + + A + + + + + + + + +| 41 |
Parasite Metazoan | X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + M + + + + + + + + + + A + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 23 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 3.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic | 1 2 2 1 2 2 2 2| 16 1.4|
Leukocytosis | X | 1 |
Necrosis, Coagulative | 4 | 3 3.3|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic Active | 3 | 2 3.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Liver | X | 1 |
Acinus, Atrophy | 2 3 1 2 1 2 2 3 1 2 2| 14 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 3 4 | 9 2.6|
Mineralization | 2 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Caries | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| |
| 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 1 3 2 2 1 2 2 2 2 2 2 1 2| 33 1.9|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atypia Cellular | | 1 |
Degeneration, Fatty | 3 3 2 1 1 2 1 3 2 3| 20 1.9|
Hyperplasia | 2 2 1 2 2 2 2 1 2 3 2 2 1 2 1 2| 27 1.9|
Hypertrophy | 2 1 3| 8 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 1 2 2 2 1| 15 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + M + + + + + + + +| 46 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X| 29 |
Pars Distalis, Fibrosis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 3 | 12 2.2|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Ultimobranchial Cyst | X X | 2 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 2 1 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2| 33 1.8|
Follicular Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2| 30 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 3 | 2 2.5|
Inflammation, Chronic Active | 2 3 2 2 2| 8 2.0|
Duct, Dilatation | 4 3 | 6 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| |
| 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 3 | 2 3.0|
Cyst | X X X X X X X X| 14 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
Cervix, Diverticulum | | 1 4.0|
Cervix, Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 2 4 | 11 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Femoral, Hyperplasia, Reticulum Cell | 3 | 1 3.0|
Femoral, Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + | 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + M + + + + M + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 4 2 1 4 4 2 3 2 2 2 2 2 4 3 2 4 4 4 3 1 2 3 3 2| 49 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | | 1 |
Femur, Fibrous Osteodystrophy | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 1| 4| 4| 4| 6| 0| 4| 3| 4| 4| 4| 4| 7| 4| 3| 4| 4| 9| 4| 4| 5| 4| 3| 4| |
| 4| 3| 4| 5| 5| 5| 5| 5| 7| 5| 1| 6| 6| 4| 6| 8| 6| 7| 8| 7| 7| 9| 7| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 4 3.3|
Hydrocephalus | 2 | 3 2.3|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
White Matter, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 2 1 1| 10 1.2|
Leukocytosis | X | 1 |
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fungus | X X | 2 |
Inflammation, Chronic Active | 3 3 | 4 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 3 4 1 | 7 2.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + | 12 |
Lens, Cataract | 4 4 4 3 4 | 11 3.7|
Retina, Atrophy | 4 4 4 4 | 10 3.9|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lacrimal Gland | +| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic | 2 2 1 1 1 2 2 2 3 2 2 3 1 2 1 3 2 2 1 2 1 2 2| 41 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4|
| 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + A + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + A + + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 2 1 2 3 1 |
Necrosis, Coagulative | |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 3 3 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 2 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Cardiomyopathy, Chronic | 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 2 3 3|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4|
| 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Necrosis, Fibrinoid | 3 |
Perivascular, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Degeneration, Fatty | 2 3 2 2 2 1 1 2 2 1 2 2 3 |
Hematocyst | X |
Hyperplasia | 3 1 2 3 2 2 1 1 2 3 2 1 2 2 1 2 2 2 3 2|
Hypertrophy, Focal | |
Hypertrophy | 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + A|
C-Cell, Hyperplasia | 2 2 1 3 2 1 3 2 3 2 2 3 2 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia | 1 3 3 2 2 3 2 2 2 1 2 1 2 2 2 2 2 2 3 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 |
Duct, Dilatation | 4 4 3 4 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | 4|
Endometrium, Hyperplasia, Cystic, | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4|
| 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Glandular | 2 4 2 1 3 2 4 1 2 |
__________________________________________________________________________|
Vagina | |
Dilatation | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 3 2 4 3 3 2 3 4 3 3 3 3 3 2 1 3 2 4 3 4 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | 2 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 4| 4| 4| 4| 4| 4| 9| 2| 0| 5| 4| 4| 2| 4| 4| 4| 9| 4| 8| 4| 0| 4| 4|
| 4| 0| 0| 0| 0| 0| 0| 3| 4| 0| 4| 7| 3| 3| 5| 3| 3| 2| 0| 3| 7| 4| 6| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + |
Inflammation, Chronic Active | 4 |
Lens, Cataract | 4 3 4 4 4 4 4 |
Retina, Atrophy | 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis, Coagulative | 3 |
Nephropathy, Chronic | 2 1 2 2 1 2 3 2 3 2 4 1 2 2 2 2 2 2 2 2 2 2 4 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| |
| 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X| 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X| 28 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 2 1 2 1 1 2 2 2 2 1 2 1 2 | 20 1.7|
Necrosis, Coagulative | 1 | 1 1.0|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Inflammation, Chronic Active | 3 4 3 | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 2 3 1 1 2 | 17 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 3.0|
Necrosis, Coagulative | | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 5 2.0|
Mineralization | 2 2 2 2 2| 6 1.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| |
| 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 |
Cardiomyopathy, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 1 1 2 1 2| 35 1.9|
Inflammation, Chronic Active | | 1 3.0|
Artery, Necrosis, Fibrinoid | | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X | 1 |
Degeneration, Fatty | 2 2 2 1 3 2 1 2 1 3 | 23 1.9|
Hematocyst | | 1 |
Hyperplasia | 3 3 3 3 2 2 3 2 2 2 2 2 2 2 2 2| 36 2.1|
Hypertrophy, Focal | 3 | 1 3.0|
Hypertrophy | 2 2 | 4 2.0|
Necrosis, Coagulative | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 2 2 2 2 2 2 | 13 1.9|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + M| 47 |
Hyperplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Pars Distalis, Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X| 31 |
Pars Distalis, Hyperplasia | 1 3 2 3 2 | 12 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 2 2 2 3 2 2 1 2 2 2 2 2 1 2 2 1 2 1 2 2| 39 2.0|
Follicular Cell, Hyperplasia | 2 3 3 2 1 2 3 2 3 2 2 2 3 3 3 1 1 2 2 1| 41 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| |
| 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + M + + + + + + + M +| 45 |
Inflammation, Chronic Active | 2 1 3 2 3 3 2 2 3 2 2| 14 2.3|
Duct, Dilatation | 3 4 4 3 4 3 3 3 | 13 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | X X X X X X| 13 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Hemorrhage | 4 | 2 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 4 1 4 2 3 | 15 2.5|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Dilatation | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M M + + M M + + + + + + M| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 2 2 2 2 3 4 4 3 3 4 3 3 4 3 4 2 3 2 2 1 4 1| 47 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 5| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 1| 4| 2| 4| 4| 4| 4| 4| 3| 4| 4| 2| 5| 6| 4| 4| 4| 4| |
| 4| 4| 4| 5| 0| 5| 5| 2| 5| 5| 5| 6| 6| 6| 6| 7| 6| 7| 1| 8| 4| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | X | 5 |
Hydrocephalus | 2 | 4 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
White Matter, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 1 1 2 | 9 1.2|
Bronchiole, Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X | 1 |
Inflammation, Chronic Active | 1 2 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 10 |
Inflammation, Chronic Active | | 1 4.0|
Lens, Cataract | 4 4 | 9 3.9|
Retina, Atrophy | 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 2 |
Necrosis, Coagulative | 2 | 2 2.5|
Nephropathy, Chronic | 2 2 3 2 2 2 4 2 2 3 3 2 3 4 2 1 2 3 2 2 2| 45 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1|
| 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 4 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 1 1 1 1 1 |
Leukocytosis | |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | 3|
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1|
| 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Degeneration, Fatty | 1 2 3 2 2 2 2 2 2 2 3 |
Hyperplasia | 3 2 2 2 2 3 3 2 2 2 2 |
Hypertrophy | 2 2 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + M + + + + M + M + M + + + + + M +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 1 2 1 1 2 3 2 2 2 1 3 3 1 2 3 1|
Follicular Cell, Hyperplasia | 2 2 2 3 1 2 3 3 2 4 2 2 3 4 4 3 1 4 3 4 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 4 |
Duct, Dilatation | 4 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 2 |
Cervix, Diverticulum | |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 2 |
__________________________________________________________________________|
Vagina | +|
Inflammation, Suppurative | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1|
| 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Cyst | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + M M + + + + M + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 3 4 2 2 4 2 3 2 2 2 3 3 2 2 3 3 3 2 2 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X |
Femur, Fibrous Osteodystrophy | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X|
Hemorrhage | |
Hydrocephalus | 3 3 3 3 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 3 |
Artery, Mediastinum, Inflammation, | |
Chronic Active | 4 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | 3 |
Mediastinum, Hemorrhage | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | X |
Hemorrhage | 3 |
Inflammation, Chronic Active | 4 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 6| 5| 7| 6| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 0| 4| 4| 7| 4| 6| 7| 4| 7| 9| 2| 2| 4| 0| 8| 4| 4| 6| 2| 4| 2| 5| 4| 3| 1|
| 5| 0| 0| 7| 7| 6| 3| 0| 9| 8| 8| 1| 3| 7| 4| 3| 3| 0| 6| 4| 6| 7| 4| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + |
Hemorrhage | |
Lens, Cataract | 3 4 4 4 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 3 2 2 3 1 2 3 2 2 2 4 1 1 2 1 2 2 1 4 1 4 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| |
| 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + A + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + A + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + A + M + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Glandular | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + + + A + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + A + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X | 16 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 2 | 3 2.7|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic | 1 2 2 2 2 2 2 2 2 | 15 1.6|
Leukocytosis | X X X | 3 |
Necrosis, Coagulative | 3 2 3 | 4 2.8|
Vacuolization Cytoplasmic | 2 2 3 | 4 2.5|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 2 3 1 3 2 2 3 | 14 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2| 6 2.0|
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3| 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| |
| 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.0|
Inflammation, Chronic Active | | 1 3.0|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 1 |
Degeneration, Fatty | 2 3 1 2 2 2 2 2 2 2 2 | 22 2.0|
Hyperplasia | 2 2 2 1 2 3 2 2 2 3 2 | 22 2.2|
Hypertrophy | 2 | 4 2.3|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + + + M + + + M + + + M + + M + +| 37 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X X X X X X X X| 17 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 | 12 2.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 2 2 2 2 1 3 1 1 1 2 2 2 1 1 | 33 1.7|
Follicular Cell, Hyperplasia | 4 2 3 4 4 4 2 2 3 3 3 4 2 2 3 2 2 2 2 3 3 2 3 | 45 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + M + + + + + + + + + + + + +| 47 |
Hyperplasia | 4 3 | 2 3.5|
Inflammation, Chronic Active | 3 2 4 2 2| 9 2.6|
Duct, Dilatation | 3 3 4 4 | 6 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| |
| 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cervix, Diverticulum | 3 4 | 2 3.5|
Cervix, Inflammation, Suppurative | 3 3 | 2 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Cyst | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + M + + + + M + + + + + + + + M| 41 |
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 2 3 2 3 2 2 3 3 2 2 4 2 2 2 2 4 4 4 2 3 2 2 2| 47 2.6|
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | | 2 |
Femur, Fibrous Osteodystrophy | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 7 |
Hemorrhage | 2| 1 2.0|
Hydrocephalus | 2 2 2 | 8 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 3 | 5 2.8|
Leukocytosis | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 4| 6| 7| 7| 7| 5| 6| 7| 7| 6| |
DAY ON TEST | 4| 4| 7| 4| 4| 2| 1| 9| 4| 4| 9| 4| 4| 4| 8| 8| 7| 3| 4| 4| 9| 9| 4| 2| 0| |
| 4| 4| 0| 5| 5| 6| 7| 0| 5| 6| 4| 6| 6| 7| 8| 7| 6| 4| 7| 7| 2| 4| 7| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Artery, Mediastinum, Inflammation, | | |
Chronic Active | | 1 4.0|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | | 1 3.0|
Mediastinum, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 1 3.0|
Fungus | X | 2 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 3 3 | 4 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 2| 4 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + +| 12 |
Hemorrhage | 4| 1 4.0|
Lens, Cataract | 3 3 4 3 4 | 9 3.6|
Retina, Atrophy | 4 4 4 4 4 | 8 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Nephropathy, Chronic | 1 1 2 4 3 1 1 2 3 1 2 2 2 2 2 3 3 3 1 4 2 2 1| 48 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1|
| 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X |
Cyst | |
Inflammation, Chronic | 1 2 1 2 1 1 2 |
Necrosis, Coagulative | 3 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 2 3 2 2 |
Inflammation, Chronic Active | |
Atrium, Thrombosis | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 2 |
Hyperplasia | 2 2 2 1 1 1 1 1 2 3 2|
Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1|
| 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Atypia Cellular | X X |
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 3 2 2 3 |
Pars Intermedia, Cyst | X |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 3 2 |
Follicular Cell, Hyperplasia | 4 2 2 3 3 3 3 3 3 3 3 3 2 2 3 3 3 3 2 2 1 3 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 2 4 2 2 |
Duct, Dilatation | 1 2 4 2 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Diverticulum | 4 |
Cervix, Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Inflammation, Chronic Active | 4 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + M + + M + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1|
| 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 4 3 3 3 4 3 2 2 3 3 2 2 3 3 3 2 2 3 3 2 3 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | |
Hydrocephalus | 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 4 3 1 1 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 1 |
Mucosa, Nasolacrimal Duct, | |
Hyperplasia | |
Nasolacrimal Duct, Dilatation | |
Nasolacrimal Duct, Hyperkeratosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 5| 6| 5| 5| 7| 5| 6| 5| 6| 7| 7| 7| 6| 4| 7| 5| 5| 7| 5| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 7| 7| 9| 7| 4| 3| 2| 9| 4| 4| 4| 4| 8| 6| 4| 4| 6| 4| 6| 1| 0| 9| 3| 1|
| 4| 3| 6| 2| 6| 0| 8| 0| 8| 2| 0| 3| 3| 4| 2| 4| 8| 5| 4| 4| 4| 6| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
250 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | |
Nephropathy, Chronic | 3 1 2 2 2 1 3 3 3 2 3 2 2 1 2 3 2 3 2 2 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| |
| 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X| 11 |
Clear Cell Focus | X | 4 |
Cyst | X | 1 |
Inflammation, Chronic | 2 2 2 3 1 1 1 2 | 15 1.6|
Necrosis, Coagulative | 2 | 4 2.3|
Vacuolization Cytoplasmic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 3 2 2 | 10 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic Active | 4 2 2 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 4 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 3 3 1 3 3 2| 27 2.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| |
| 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 2 2 2 2 2 2 2 2 | 15 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | 23 1.8|
Hypertrophy | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1 2 | 10 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + M + + + M + M + + + + M + + + + +| 42 |
Hyperplasia | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Atypia Cellular | | 2 |
Pars Distalis, Cyst | X X X X X X X X X X X X| 25 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 | 11 2.3|
Pars Intermedia, Cyst | X X | 3 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 3 2 2 2 3 2| 27 2.1|
Follicular Cell, Hyperplasia | 3 4 3 2 3 2 3 3 3 3 3 1 3 3 3 3 3 4 3 3 3 4 3| 47 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 3 2 | 8 2.3|
Duct, Dilatation | 4 4 | 9 2.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | X X X X X X X X | 16 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cervix, Diverticulum | | 1 4.0|
Cervix, Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 3 | 8 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| |
| 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Inflammation, Chronic Active | | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3| 2 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + M + + M + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 3 2 3 4 2 3 3 4 2 4 2 4 2 3 2 3 3 2 3 3 3 4 2| 49 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X | 13 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | 2 2 3 3 3 4 | 11 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X | 1 |
Inflammation, Chronic Active | 1 1 4 3 1| 10 2.1|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X | 2 |
Inflammation, Chronic Active | 3 3 4 1 | 6 2.3|
Mucosa, Nasolacrimal Duct, | | |
Hyperplasia | 4| 1 4.0|
Nasolacrimal Duct, Dilatation | 4| 1 4.0|
Nasolacrimal Duct, Hyperkeratosis | 4| 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 6| 7| 6| 6| 7| 7| 4| 6| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 1| 7| 4| 4| 4| 0| 4| 8| 0| 0| 0| 6| 7| 2| 4| 6| 4| 2| 3| 1| 4| 4| 1| 4| |
| 5| 5| 9| 4| 5| 2| 0| 1| 9| 7| 7| 7| 9| 9| 4| 6| 5| 6| 0| 8| 3| 7| 7| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
250 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + | 8 |
Lens, Cataract | 4 2 4 3 | 5 3.4|
Retina, Atrophy | 4 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis, Coagulative | 4 | 1 4.0|
Nephropathy, Chronic | 3 4 2 3 1 2 2 2 2 2 2 3 4 2 2 3 2 1 2 3 2 3 2| 47 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3|
DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0|
| 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X X X X |
Artery, Necrosis, Fibrinoid | 2 |
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 2 2 3 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X|
Inflammation, Chronic | 1 |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Acinus, Atrophy | 2 3 1 2 2 2 2 2 |
Acinus, Hyperplasia | |
Artery, Necrosis, Fibrinoid | 2 |
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Hyperkeratosis | 3 2 |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3|
DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0|
| 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 3 3 3 2 2 1 3 2 2 3 3 2 2 2 3 3 2 2 2 3 2|
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 1 2 2 |
Hyperplasia | 2 3 3 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + M + + M + + + + + + + + +|
Hyperplasia | 3 2 3 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 2 2 2 2 2 1 2 2 1 2 1 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 1 1 1 1 2 2 3 2 1 3 2 4 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3|
DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0|
| 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 |
Seminiferous Tubule, Atrophy | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
Femoral, Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst | X |
Mandibular, Hyperplasia, Plasma Cell | 2 3 |
Mediastinal, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Thrombosis | |
__________________________________________________________________________|
Thymus | + M + + + + M + M + + + + + M + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + M + + + + M M + + + + +|
Hyperplasia, Cystic | 2 2 2 1 1 4 2 2 1 1 2 3 2 3 2 2 2 2 1 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X |
Femur, Fibrous Osteodystrophy | X X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 2 |
Hydrocephalus | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 5| 6| 6| 3| 6| 6| 5| 4| 7| 7| 5| 6| 6| 3|
DAY ON TEST | 3| 3| 7| 3| 2| 0| 4| 0| 4| 4| 4| 9| 4| 2| 7| 1| 2| 1| 7| 2| 4| 8| 9| 4| 0|
| 8| 8| 6| 8| 0| 2| 2| 7| 1| 1| 1| 7| 7| 8| 2| 5| 8| 7| 2| 6| 2| 6| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 4 |
White Matter, Degeneration | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 1 2 2 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 1 4 1 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + |
Hemorrhage | |
Inflammation, Chronic Active | |
Lens, Cataract | 4 4 3 4 4 |
Retina, Atrophy | 4 4 4 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy, Chronic | 3 3 2 3 4 4 2 2 3 2 3 3 3 3 2 2 4 2 4 4 3 2 3 4 |
Artery, Necrosis, Fibrinoid | 2 |
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Urethra | + |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| |
| 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + A + + + + +| 45 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X | 7 |
Artery, Necrosis, Fibrinoid | | 1 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + M A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X| 12 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | 1 1 2 1 2 2 2 1 2 1 1 1 | 17 1.6|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 2 | 2 1.5|
Necrosis, Coagulative | 3 | 2 3.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
Acinus, Atrophy | 2 1 1 1 1 1 2 1 1 3 2 2 | 20 1.7|
Acinus, Hyperplasia | 2 | 1 2.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 3 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| |
| 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 3 3 | 4 2.8|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | 2 4 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 2 | 2 2.5|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 3 2 3 2 2 3 3 3 3 3 2 2 3 3 2 2 2 2 3 2 2| 46 2.4|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 2 | 2 2.0|
Atrium, Thrombosis | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 2 1 4 1 2 2 1 2 | 14 1.9|
Hyperplasia | 2 2 2 2 2 2 2 2 | 15 2.1|
Hypertrophy | 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2| 21 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 44 |
Hyperplasia | 4 2 3 | 8 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X | 4 |
Pars Distalis, Hyperplasia | 2 2 2 2 | 12 1.9|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 2 1 1 1 2 2 2 2 2 3 1| 29 1.8|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 2 1 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| |
| 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2| 3 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 45 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 2 3 1 1 1 3 3 3 1 2 2| 29 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Necrosis, Coagulative | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 | 9 1.1|
Seminiferous Tubule, Atrophy | 4 3 4 3 3 3 | 9 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 17 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Myelofibrosis | | 1 2.0|
Femoral, Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Cyst | | 1 |
Mandibular, Hyperplasia, Plasma Cell | | 2 2.5|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 4 2 | 6 2.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + M + + M + M M + + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| 42 |
Hyperplasia, Cystic | 3 2 2 2 1 2 1 4 3 3 1 2 1 4 2 1 2 1 1 1 1| 42 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| |
| 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | | 4 |
Femur, Fibrous Osteodystrophy | | 4 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 5 |
Hemorrhage | | 1 2.0|
Hydrocephalus | 3 3 2 | 4 2.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Hemorrhage | | 1 4.0|
White Matter, Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | | 1 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 2 1 3 2 2 1 | 9 1.8|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X | 5 |
Inflammation, Chronic Active | 4 3 3 3 1 1 3 1 2 | 15 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 1 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 11 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Lens, Cataract | 4 3 4 3 | 9 3.7|
Retina, Atrophy | 4 3 4 4 | 10 3.9|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 7| 9| 4| 9| 4| 4| 4| 0| 3| 1| 0| 3| 4| 4| 4| 4| 3| 5| 9| 1| 1| 1| 4| 7| 4| |
| 2| 2| 2| 8| 2| 3| 3| 9| 3| 2| 1| 4| 3| 4| 4| 5| 3| 5| 6| 2| 9| 9| 5| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic | 2 3 3 2 2 3 3 3 4 3 3 4 2 3 4 4 4 1 3 2 2 2 4 3 3| 49 2.9|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 1 4.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4|
| 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Perivascular, Inflammation, Chronic | |
Active | 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 2 3 1 3 3 3 1 3 2 3 |
Eosinophilic Focus | |
Inflammation, Chronic | |
Necrosis, Coagulative | 2 3 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 2 3 3 2 1 3 2 2 1 1 3 3 2 2 1 1|
Perivascular, Inflammation, Chronic | |
Active | 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Mineralization | 3 3 3 2|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 2 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4|
| 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Atrium, Thrombosis | X X X X X X X |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 3 2 2 |
Hyperplasia | 2 2 1 1 1 2 1 2 3|
Hypertrophy | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M M + + + + + + M + + + + +|
Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 2 2 2|
Pars Distalis, Vacuolization | |
Cytoplasmic | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 1 1 2 1 1 2 1 3 2 1 2 1 1 2|
Follicular Cell, Hyperplasia | 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 3 2 2 2 2 2 4 2 2 2 2 4 3 2 2 3 2 2 1 2|
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4|
| 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 4 2 4 3|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 |
Seminiferous Tubule, Atrophy | 3 3 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Necrosis | |
Mediastinal, Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M + + + + M M + + + + M + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + M + + + + + M + + + + M + +|
Hyperplasia, Cystic | 2 2 2 2 2 1 2 1 2 4 3 4 1 1 1 2 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +|
Acanthosis | |
Hyperkeratosis | |
Subcutaneous Tissue, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X |
Femur, Fibrous Osteodystrophy | X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Hydrocephalus | 2 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 7| 5| 7| 7| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 4| 1| 3| 0| 1| 8| 7| 5| 3| 2| 4| 5| 4| 1| 4| 3| 5| 4| 7| 1| 4|
| 8| 8| 8| 1| 1| 2| 7| 5| 1| 9| 7| 0| 7| 0| 2| 2| 2| 0| 3| 8| 2| 0| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Perivascular, | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic Active | 2 2 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + +|
Lens, Cataract | 4 4 4 4 4|
Retina, Atrophy | 4 4 4 4 4|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy, Chronic | 3 3 3 2 2 3 4 2 4 1 3 3 3 3 3 4 4 4 3 2 4 3 3 1 3|
Renal Tubule, Epithelium, Hyperplasia| 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| |
| 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 |
Inflammation, Chronic Active | | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | 3 | 5 2.2|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + M + + + + + + + + + + + A +| 46 |
Inflammation, Chronic Active | 4 | 1 4.0|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 4 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | 1 2 3 4 2 3 2 2| 19 2.3|
Eosinophilic Focus | X | 1 |
Inflammation, Chronic | 3 1 2 | 3 2.0|
Necrosis, Coagulative | 3 3 | 4 2.8|
Vacuolization Cytoplasmic | | 1 3.0|
Bile Duct, Hyperplasia | 3| 4 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Acinus, Atrophy | 2 1 1 3 2 2 4 3 2 2 2 1 1| 30 2.0|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 4 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.5|
Mineralization | | 4 2.8|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| |
| 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 2 2 2 1 3 2 3 2 2 2 2 3 2 2 2 2 3 2 2 3 3 | 44 2.3|
Inflammation, Chronic Active | 3 | 1 3.0|
Atrium, Thrombosis | X | 8 |
Ventricle, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 2 2 2 1 3 2 2 2 | 15 2.1|
Hyperplasia | 2 2 2 2 3 2 3 2 1 | 18 1.9|
Hypertrophy | 2 | 2 2.5|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 2 2 2 3 2 2| 21 2.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 | 5 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 1 2 2 1 | 9 1.7|
Pars Distalis, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
Pars Intermedia, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Inflammation, Chronic Active | | 1 3.0|
Ultimobranchial Cyst | X X | 3 |
C-Cell, Hyperplasia | 1 1 2 2 1 1 2 2 2 2 1 2 2 2 2 2| 33 1.6|
Follicular Cell, Hyperplasia | 1 2 1 1 2 2 | 12 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| |
| 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 3 |
Inflammation, Chronic Active | 4 | 2 3.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 2 2 3 4 2 2 3 2 3 2 2 2 2 2 4| 45 2.3|
Duct, Dilatation | 4| 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 1 1 2 2 2 3 2 2 4 2 1 3 3 4| 27 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 | 12 1.2|
Seminiferous Tubule, Atrophy | 3 4 3| 8 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | 2 | 1 2.0|
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Cyst | X X | 2 |
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Necrosis | 3 | 1 3.0|
Mediastinal, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 2 4 3 | 8 2.8|
Hematopoietic Cell Proliferation | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + M + M + + + + + + + M + M| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + M M + + + M + + + M + + + M + + + + +| 40 |
Hyperplasia, Cystic | 4 2 2 1 2 1 3 1 1 2 4 3 2 4 2 2 2| 36 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| |
| 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 4 |
Femur, Fibrous Osteodystrophy | X | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 5 |
Hemorrhage | 4 4 | 2 4.0|
Hydrocephalus | 3 2 2 | 5 2.2|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 4 1.8|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
Mediastinum, Perivascular, | | |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | 1 2 2 1 2 | 10 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 4 | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 10 |
Lens, Cataract | 2 4 | 7 3.7|
Retina, Atrophy | 4 4 4 4 | 9 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 1 3.0|
Nephropathy, Chronic | 2 3 3 3 2 3 3 3 2 3 3 2 3 3 4 4 4 2 3 4 3 3 3 3 3| 50 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 7| 5| 6| 7| 7| 4| 6| 7| 6| 7| 6| 4| 6| 5| 5| 7| 7| 7| 6| |
DAY ON TEST | 7| 3| 7| 4| 2| 7| 4| 0| 3| 0| 4| 1| 3| 4| 9| 4| 0| 3| 5| 0| 8| 4| 2| 1| 9| |
| 8| 3| 1| 3| 2| 7| 4| 7| 3| 7| 4| 6| 6| 5| 8| 5| 3| 5| 0| 1| 7| 4| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Epithelium, Hyperplasia| 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4|
| 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A A + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A A + + + M + + A + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Degeneration, Cystic | 3 2 2 2 2 4 1 2 2|
Hyperplasia | 3 |
Inflammation, Chronic | 2 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + +|
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Acinus, Atrophy | 2 1 4 1 2 2 2 2 1 1 2 2 1 1|
Acinus, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 2 2 1 2 2 2 3 3 2 3 2 3 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4|
| 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 1 2 2 2 |
Hyperplasia | 3 2 2 4 2 2 2 2 2 3|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 3 2 2 3 2 3 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 3 2|
Pars Intermedia, Cyst | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 1 2 2 2 2 1 1|
Follicular Cell, Hyperplasia | 1 2 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 2 2 2 2 2 4 3 4 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 1 1 1 2 2 2 1 2 1 1 1 1|
__________________________________________________________________________|
Seminal Vesicle | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Interstitial Cell, Hyperplasia | 1 1 1 2 |
Seminiferous Tubule, Atrophy | 3 3 3 2 4 3 2 3 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4|
| 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + I + M + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + M + + + M + + + + + + + + + + + + + M +|
Hyperplasia, Cystic | 1 1 4 4 2 2 3 2 4 2 1 3 2 3 1 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X |
Femur, Fibrous Osteodystrophy | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 4 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
Metaplasia, Osseous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 1 1 2 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | 3 3 3 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 0| 9| 3| 0| 3| 4| 4| 4| 4| 3| 3| 4| 2| 8| 5| 9| 4| 6| 3| 4| 1| 4|
| 2| 8| 4| 5| 1| 6| 3| 8| 1| 2| 1| 1| 6| 7| 2| 0| 2| 7| 2| 2| 5| 8| 3| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Chronic Active | |
Nephropathy, Chronic | 3 3 3 4 2 1 2 3 2 2 2 3 1 4 2 3 2 2 3 4 2 2 2 3 3|
Renal Tubule, Mineralization | |
Renal Tubule, Epithelium, Hyperplasia| 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| |
DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| |
| 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + A + A + + + + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + A + A + A M A + + + + A| 40 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + A + A + + + + + + + + A| 42 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + + + + A + A + + + A + M A + A| 40 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + A + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + A + + + + + + + + A| 46 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + A + M + + + + + + A + A| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + A + + + + + + A + A| 44 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 9 |
Degeneration, Cystic | 1 4 1 1 1 1 1 1 3 | 18 1.9|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 1 2 1 | 7 1.3|
Necrosis, Coagulative | 2 2 2 | 3 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 3 4 | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Acinus, Atrophy | 1 1 1 2 1 2 2 1 1 2 | 24 1.6|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 |
Acanthosis | 2 | 3 2.0|
Hyperkeratosis | 1 | 3 1.7|
Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + A + + + + + + + + +| 47 |
Inflammation, Chronic Active | 1 2 | 3 1.7|
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| |
DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| |
| 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 3 3 2 2 2 1 2 2 3 2 2 2 2 1 2 3 1 2 2 2 3 2 3| 47 2.1|
Mineralization | | 1 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 2 1 1 | 11 1.6|
Hyperplasia | 2 2 2 2 3 2 2 2 1 | 19 2.2|
Hypertrophy | 2 2 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 1 2 2 2 2 2 1 2 | 23 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Hyperplasia | 4 | 3 3.7|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Pars Distalis, Cyst | X X X X | 4 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 2 2 | 12 2.0|
Pars Intermedia, Cyst | X X X | 3 |
Rathke's Cleft, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + A + A + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 2 1 2 2 3 2 2 1 1 1 1 | 22 1.6|
Follicular Cell, Hyperplasia | 1 2 1 2 1 2 | 13 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2| 46 2.0|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| |
DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| |
| 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 1 |
Inflammation, Chronic Active | 1 2 1 3 1 3 2 2 1 1 4 | 23 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 4 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 | 9 1.1|
Seminiferous Tubule, Atrophy | 3 | 11 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Cyst | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Coagulative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + M + +| 42 |
Hyperplasia, Cystic | 3 2 1 3 2 2 1 1 1 3 3 2 2 1 1 1 2 1 1 2 1 | 39 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 3 |
Femur, Fibrous Osteodystrophy | X | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
Hemorrhage | | 1 4.0|
Hydrocephalus | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 5| 2| 4| 6| 7| 7| 6| 3| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 4| |
DAY ON TEST | 2| 7| 4| 4| 9| 0| 8| 3| 4| 4| 4| 4| 9| 6| 4| 2| 4| 1| 4| 6| 4| 7| 4| 9| 9| |
| 6| 1| 3| 3| 6| 5| 0| 0| 4| 6| 4| 4| 7| 8| 4| 8| 5| 1| 5| 0| 5| 4| 3| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 3| 5 1.6|
Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X | 1 |
Inflammation, Chronic Active | 3 2 3 2 1| 12 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 4 1 3 3 1 | 7 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 6 |
Lens, Cataract | 3 | 4 3.0|
Retina, Atrophy | 4 | 4 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Bacterium | X | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
Nephropathy, Chronic | 2 3 3 2 2 3 2 1 4 2 3 3 3 2 2 2 3 3 3 3 2 2| 47 2.5|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Epithelium, Hyperplasia| | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6|
DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1|
| 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + A + + + A|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Necrosis, Coagulative | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + M + + + A|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A|
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A|
Dilatation | 4 |
Inflammation, Chronic Active | 4 |
Metaplasia, Osseous | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 2 2 3 1 3 1 2 2 |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Chronic | 2 1 |
Leukocytosis | X |
Necrosis, Coagulative | 2 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 2 4 2 2 4 2 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
Hyperplasia | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | 1 3 3 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6|
DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1|
| 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 2 2 2 2 2 3 3 2 2 3 2 3 1 2 2 3|
Inflammation, Chronic Active | 3|
Mineralization | |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 1 2 1 1 |
Hyperplasia | 1 2 2 2 2 3 3 2|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + + + + + + M M + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hemorrhage | 3 4 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + A|
C-Cell, Hyperplasia | 2 3 2 1 2 2 2 1 3 2 1 1 1 2 2 2 2 |
Follicular Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 1 1 2 3 3 4 1 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6|
DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1|
| 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 1 1 1 1 |
Seminiferous Tubule, Atrophy | 3 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
Femoral, Myelofibrosis | 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Inflammation, | |
Suppurative | |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + M + + + M + + + + M + M + + + M +|
Hyperplasia, Cystic | 1 1 2 1 1 2 2 3 2 1 2 1 2 2 1 2 1 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperplasia, Basal Cell | 3 |
Vein, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 3 2 |
Hydrocephalus | 3 2 |
__________________________________________________________________________|
Peripheral Nerve | |
Sciatic, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 2| 5| 3| 7| 6|
DAY ON TEST | 3| 3| 5| 3| 9| 4| 4| 0| 4| 3| 3| 3| 1| 5| 4| 4| 7| 7| 4| 4| 7| 6| 9| 1| 1|
| 8| 8| 3| 8| 5| 1| 1| 3| 1| 2| 9| 2| 3| 3| 2| 2| 8| 9| 3| 3| 6| 5| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Leukocytosis | X |
Necrosis, Coagulative | 3 |
Alveolar Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fungus | X X X X X |
Inflammation, Chronic Active | 2 2 3 4 3 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 4 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + +|
Lens, Cataract | 3 3 4 2|
Retina, Atrophy | 4 4 4 4|
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 4|
Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 3 3 4 1 4 3 2 3 2 3 4 1 2 1 4 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| |
DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| |
| 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + A + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + A + + + A| 44 |
Inflammation, Chronic Active | 2 2 | 2 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A + A + + + A| 45 |
Necrosis, Coagulative | 4 | 1 4.0|
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + A + A + + + A| 43 |
Parasite Metazoan | X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + A| 47 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M A + + + + + + A + A + + + A| 43 |
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + A| 46 |
Dilatation | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Metaplasia, Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 7 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 2 2 2 1 | 13 1.9|
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Inflammation, Chronic | 1 | 3 1.3|
Leukocytosis | | 1 |
Necrosis, Coagulative | 3 4 | 4 3.0|
Bile Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 2 1 3 1 2 2 1 2 2 3 1 | 24 1.9|
Perivascular, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 2 3.0|
Hyperkeratosis | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| |
DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| |
| 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic Active | 4 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | 3 | 4 2.5|
Mineralization | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 1 2 3 3 2 2 1 2 3 3 2 3 2 2 4 2 2| 41 2.3|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 3 3 | 2 3.0|
Atrium, Thrombosis | X X X X | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 2 2 1 1 2 1 | 15 1.3|
Hyperplasia | 2 2 2 2 1 3 1 2 2 | 17 2.0|
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | 1 2 2 1 2 2 2 2 2 2 | 21 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 45 |
Hyperplasia | 4 4 | 4 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + + + A + + + +| 47 |
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia | 2 1 1 | 9 1.9|
Pars Intermedia, Cyst | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + A| 46 |
C-Cell, Hyperplasia | 2 1 2 2 2 2 1 2 1 2 2 1 2 | 30 1.8|
Follicular Cell, Hyperplasia | 3 2 2 2 1 2 2 1 2 2 2 2 2 3 | 30 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| |
DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| |
| 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
Inflammation, Chronic Active | 2 2 1 2 4 2 3 2 2 2 2 1 2 4 4| 24 2.3|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | +| 1 |
Inflammation, Chronic Active | 4| 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 1 | 7 1.1|
Seminiferous Tubule, Atrophy | 3 3 4 3 3 | 11 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | 1 | 1 1.0|
Femoral, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Inflammation, | | |
Suppurative | 4 | 1 4.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 4 2.8|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + M M + + + + + + + + + + M + + + + + + M M| 42 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + M + M + + + + M + + M M| 37 |
Hyperplasia, Cystic | 1 2 1 2 1 3 1 3 4 2 2 3 2 2 2 2 4 | 35 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Hyperplasia, Basal Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| |
DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| |
| 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Vein, Dilatation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 5 |
Hemorrhage | 3 | 3 2.7|
Hydrocephalus | 3 4 3 | 5 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Sciatic, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
White Matter, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 | 5 1.2|
Leukocytosis | | 1 |
Necrosis, Coagulative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fungus | | 5 |
Inflammation, Chronic Active | 2 1 2 2 | 11 2.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Lens, Cataract | 4 2 | 6 3.0|
Retina, Atrophy | 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 7| 5| 6| 5| 7| 6| 6| 3| 5| 6| 6| 7| 1| |
DAY ON TEST | 2| 6| 4| 3| 4| 2| 4| 9| 2| 4| 8| 2| 1| 8| 0| 0| 4| 6| 7| 8| 9| 5| 0| 4| 8| |
| 8| 1| 3| 2| 4| 2| 4| 0| 2| 5| 6| 6| 3| 5| 5| 3| 2| 4| 8| 1| 2| 7| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Coagulative | | 2 4.0|
Nephropathy, Chronic | 4 2 2 4 2 3 3 3 3 3 2 2 3 3 1 2 4 2 4 2 4 3 3 4 | 49 2.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7|
DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4|
| 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + + + + A + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + M + A + + + + + + + A + + +|
Edema | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + + + + + + A + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X|
Clear Cell Focus | X X |
Cyst | |
Degeneration, Cystic | 2 1 1 1 1 2 1 2 2 1 2 1 1|
Inflammation, Chronic | 1 |
Leukocytosis | |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 3 1 2 2 1 2 2 2 1 2|
Acinus, Hyperplasia, Focal | 3 |
Perivascular, Inflammation, Chronic | |
Active | 4 3 3 4 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7|
DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4|
| 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 3 2 2 2 2 3 2 2 3 2 3 2 2 2 2 2 3 2 2 2|
Mineralization | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 1 1 2 |
Hyperplasia | 1 1 2 2 2 2 2 2 1 2 2|
Hypertrophy | 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 2 2 1 2 1 2 2 2 2 2 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + M + + + +|
Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 2 2 2|
Pars Intermedia, Cyst | X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 2 1|
Follicular Cell, Hyperplasia | 2 1 2 2 2 2 2 3 3 1 1 2 3 3 3 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + M + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 1 2 2 1 2 2 1 3 3 2 2 2 2 2 2 2 1 2 1 2|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 1 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7|
DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4|
| 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Necrosis | 4 |
Mandibular, Cyst | X |
Mandibular, Necrosis | 4 |
Mediastinal, Cyst | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Necrosis, Coagulative | 4 |
Thrombosis | X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + M + + + + + M + + + +|
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + M + M + + + + + + + +|
Hyperplasia, Cystic | 3 2 1 2 2 2 2 3 4 2 2 1 2 2 1 2 2 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X |
Femur, Fibrous Osteodystrophy | X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 3 |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | M |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 1 1 2 |
Metaplasia, Osseous | 1 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 4| 6| 7| 4| 7|
DAY ON TEST | 3| 3| 4| 3| 1| 7| 4| 7| 4| 4| 4| 4| 0| 1| 4| 4| 2| 9| 1| 9| 6| 3| 4| 5| 4|
| 8| 8| 1| 8| 7| 8| 1| 0| 1| 1| 2| 2| 3| 5| 3| 2| 4| 6| 9| 7| 6| 4| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 2 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | 3 |
Mediastinum, Perivascular, | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 4 2 2 3 2 1 |
Nasolacrimal Duct, Hyperkeratosis | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic Active | |
Nephropathy, Chronic | 4 4 2 3 2 3 3 4 2 2 2 2 2 2 3 3 3 4 4 2 3 3 3 4 4|
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| |
DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| |
| 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + A + + + + + A + + + + + A + +| 43 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + A + + + M + + + + + + + + + +| 45 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + A + + + + + + + + + + + + + +| 44 |
Edema | 3 | 1 3.0|
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + M + + + + + + + + + +| 45 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + M + + + + + + + + + +| 47 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X | 14 |
Clear Cell Focus | | 2 |
Cyst | X | 1 |
Degeneration, Cystic | 1 3 1 2 2 2 4 | 20 1.7|
Inflammation, Chronic | | 1 1.0|
Leukocytosis | X | 1 |
Vacuolization Cytoplasmic | 2 3 | 2 2.5|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Chronic Active | 2 | 1 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 2 1 2 2 2 1 3 3 3 1 3 1 3 2| 27 2.0|
Acinus, Hyperplasia, Focal | | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | 4 | 5 3.6|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + M + + + + + + + + + + + +| 48 |
Acanthosis | 2 2 2 3 | 4 2.3|
Hyperkeratosis | 2 3 2 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| |
DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| |
| 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 3 4 4 2 2 | 6 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 4 2 3 2 2 | 6 2.5|
Mineralization | 3 | 2 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 2 2 1 2 1 2 3 2 2 2 2 3 3 2 2 2 2 2 2 2| 44 2.2|
Mineralization | | 1 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 3 1 2 1 2 2 2 | 13 1.6|
Hyperplasia | 3 2 1 2 2 2 2 3 2 2 | 21 1.9|
Hypertrophy | 2 3 2 | 5 2.0|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 2 2 2 2 2 2 1 2 2 1 2 2| 30 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + + + + +| 45 |
Hyperplasia | 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X X X | 7 |
Pars Distalis, Hemorrhage | 4 4 3 | 4 3.8|
Pars Distalis, Hyperplasia | 2 2 2 2 2 | 10 2.0|
Pars Intermedia, Cyst | X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + A + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 2 2 2 2 1 2 2 1 3 2 2 2 2 2 2 1 3| 35 1.9|
Follicular Cell, Hyperplasia | 3 2 3 2 2 1 2 2 3 2 1 1 3 3 2 2 1| 35 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| |
DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| |
| 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + A + + M + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2| 42 2.0|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 4 1 2 2 1 1 2 2 4 3 | 21 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 1 1 1 | 4 1.0|
Seminiferous Tubule, Atrophy | 4 3 3 4 4 | 8 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Inguinal, Necrosis | | 1 4.0|
Mandibular, Cyst | X X | 3 |
Mandibular, Necrosis | | 1 4.0|
Mediastinal, Cyst | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 3 2.7|
Necrosis, Coagulative | | 1 4.0|
Thrombosis | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + M A + M + + M + + + + + + M + + + + + + M M| 40 |
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + M + +| 45 |
Hyperplasia, Cystic | 2 1 2 2 2 2 2 3 2 2 4 1 2 1 1 1 2 4 1 2 2| 40 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Abscess | | 1 4.0|
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X X X X | 6 |
Femur, Fibrous Osteodystrophy | X X X X | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| |
DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| |
| 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 3 |
Hemorrhage | 2 2 | 3 2.3|
Hydrocephalus | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
White Matter, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 5 1.4|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | | 1 3.0|
Mediastinum, Perivascular, | | |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 2 3 2 3 1| 13 2.2|
Nasolacrimal Duct, Hyperkeratosis | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 3 1 2 | 8 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Lens, Cataract | 4 3 | 3 3.7|
Retina, Atrophy | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 0| 7| 6| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| |
DAY ON TEST | 9| 4| 9| 7| 4| 4| 5| 4| 5| 1| 4| 1| 9| 4| 4| 4| 0| 4| 4| 9| 4| 3| 7| 4| 4| |
| 8| 3| 6| 8| 2| 4| 3| 7| 0| 0| 2| 8| 4| 1| 4| 5| 8| 5| 0| 6| 5| 2| 1| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
83 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 4 2 3 2 3 3 2 2 3 3 3 2 2 3 3 4 3 3 3 4 4 3 3 2| 49 2.9|
Renal Tubule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05076-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENETHIOUREA Date: 04/29/97
Route: DOSED FEED Time: 17:58:07
_____________________________________________________________________________________________________________________
| 5| 7| 5| 5| 7| 3| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 0| 3| 5| 5| 3| 7| 4| 0| 8| 3| 0| 7| 1| 4| 4| 1| 4| 4| 4| 9| 4| 7| 0| 0| 4|
| 7| 8| 2| 2| 8| 1| 7| 9| 7| 8| 1| 8| 3| 1| 1| 5| 1| 2| 0| 3| 1| 8| 1| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
83 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + A + + M +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Degeneration, Cystic | 2 2 4 1 4 3 4 2 1 2 2 |
Hyperplasia | |
Inflammation, Chronic | 2 |
Necrosis, Coagulative | 1 3 4 |
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Mesentery | |