TR 389 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
SODIUM AZIDE
NTP Experiment-Test: 05026-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 07:44:14
Facility: Microbiological Associates
Chemical CAS #: 26628228
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Dead 13 5 22
Moribund 10 12 11
Gavage Death 5
Survivors
Dead 1
Terminal Sacrifice 36 43 21
Wrong Sex 1
Animals Examined Microscopically 60 60 59
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (59)
Inflammation, Subacute 1 (2%)
Ulcer 1 (2%)
Intestine Large, Rectum (59) (59) (58)
Ulcer 1 (2%)
Liver (60) (60) (59)
Angiectasis 3 (5%) 1 (2%) 4 (7%)
Basophilic Focus 4 (7%) 5 (8%)
Basophilic Focus, Focal 1 (2%)
Basophilic Focus, Multifocal 19 (32%) 26 (43%) 18 (31%)
Congestion 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 2 (3%) 2 (3%) 1 (2%)
Fatty Change, Focal 3 (5%)
Fatty Change, Multifocal 4 (7%) 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 8 (13%) 11 (19%)
Hyperplasia, Multifocal, Nodular 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Inflammation, Granulomatous 2 (3%)
Inflammation, Granulomatous, Multifocal 24 (40%) 16 (27%) 28 (47%)
Leukocytosis 4 (7%) 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 4 (7%)
Bile Duct, Hyperplasia 34 (57%) 37 (62%) 27 (46%)
Centrilobular, Fatty Change 1 (2%) 2 (3%)
Centrilobular, Necrosis 2 (3%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis, Coagulative 2 (3%)
Hepatocyte, Periportal, Necrosis 1 (2%)
Periportal, Fatty Change 1 (2%) 3 (5%)
Mesentery (16) (10) (7)
Fat, Necrosis, Focal 15 (94%) 7 (70%) 7 (100%)
Fat, Necrosis, Multifocal 1 (6%) 1 (10%)
Pancreas (60) (60) (58)
Ectopic Tissue 1 (2%)
Acinus, Atrophy 16 (27%) 13 (22%) 11 (19%)
Acinus, Cytoplasmic Alteration, Focal 2 (3%)
Acinus, Cytoplasmic Alteration, Multifocal 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Salivary Glands (59) (60) (59)
Inflammation, Necrotizing 1 (2%)
Stomach, Forestomach (60) (57) (57)
Hyperplasia, Focal 1 (2%) 2 (4%)
Inflammation, Chronic 2 (3%) 2 (4%)
Ulcer 1 (2%) 2 (4%) 2 (4%)
Epithelium, Hyperplasia, Focal 1 (2%)
Stomach, Glandular (60) (60) (57)
Degeneration, Cystic 39 (65%) 56 (93%) 37 (65%)
Erosion 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic Active, Focal 1 (2%)
Ulcer 1 (2%)
Lamina Propria, Fibrosis, Focal 1 (2%)
Tooth (1) (1)
Peridontal Tissue, Inflammation, Chronic
Active 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (58)
Cardiomyopathy 20 (33%) 21 (35%) 19 (33%)
Aortic Valve, Inflammation, Chronic Active 1 (2%)
Aortic Valve, Inflammation, Subacute 1 (2%)
Artery, Degeneration 1 (2%)
Myocardium, Atrium Right, Necrosis 1 (2%)
Myocardium, Ventricle, Necrosis 1 (2%)
Pericardium, Inflammation, Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (58)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Angiectasis 6 (10%) 2 (3%) 2 (3%)
Degeneration, Ballooning, Focal 1 (2%)
Hyperplasia, Focal 12 (20%) 3 (5%) 2 (3%)
Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 2 (3%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Vacuolization Cytoplasmic, Diffuse 2 (3%)
Vacuolization Cytoplasmic, Focal 6 (10%) 6 (10%) 5 (9%)
Vacuolization Cytoplasmic, Multifocal 2 (3%) 1 (2%)
Adrenal Gland, Medulla (58) (54) (56)
Angiectasis 1 (2%)
Hyperplasia, Focal 3 (5%) 1 (2%) 1 (2%)
Hyperplasia, Multifocal 2 (3%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Bilateral, Hyperplasia, Focal 1 (2%)
Bilateral, Hyperplasia, Multifocal 1 (2%)
Islets, Pancreatic (60) (60) (58)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (60) (60) (59)
Angiectasis 10 (17%) 7 (12%) 5 (8%)
Cyst 9 (15%) 15 (25%) 15 (25%)
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 2 (3%) 2 (3%)
Pars Distalis, Hyperplasia 3 (5%) 4 (7%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 5 (8%) 3 (5%) 6 (10%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (60) (60) (56)
Inflammation, Subacute 1 (2%)
Ultimobranchial Cyst 2 (3%) 2 (4%)
C-Cell, Hyperplasia 8 (13%) 10 (17%) 2 (4%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (55) (57) (49)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Duct, Ectasia 5 (9%) 7 (12%) 4 (8%)
Ovary (60) (60) (59)
Congestion 1 (2%)
Cyst 3 (5%) 3 (5%) 4 (7%)
Uterus (60) (60) (59)
Hydrometra 3 (5%)
Inflammation, Chronic Active 1 (2%)
Cervix, Cyst 9 (15%) 12 (20%) 5 (8%)
Cervix, Hypertrophy 1 (2%)
Cervix, Inflammation, Chronic Active 2 (3%)
Cervix, Inflammation, Suppurative 1 (2%) 2 (3%) 1 (2%)
Endometrium, Cyst 2 (3%) 1 (2%) 3 (5%)
Endometrium, Cyst, Multiple 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 6 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59)
Atrophy 3 (5%)
Lymph Node (59) (59) (59)
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hemorrhage 13 (22%) 7 (12%) 9 (15%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Reticulum Cell 1 (2%)
Mediastinal, Inflammation, Granulomatous 2 (3%)
Mediastinal, Pigmentation, Hemosiderin 9 (15%) 7 (12%) 6 (10%)
Mediastinal, Sinus, Ectasia 1 (2%) 1 (2%)
Mesenteric, Hemorrhage 3 (5%) 3 (5%) 2 (3%)
Mesenteric, Pigmentation, Hemosiderin 1 (2%)
Mesenteric, Sinus, Ectasia 7 (12%) 14 (24%) 6 (10%)
Pancreatic, Hemorrhage 3 (5%) 2 (3%)
Pancreatic, Pigmentation, Hemosiderin 3 (5%) 4 (7%) 2 (3%)
Pancreatic, Sinus, Ectasia 2 (3%) 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%)
Renal, Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Lymph Node, Mandibular (51) (52) (50)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Plasma Cell 4 (8%) 6 (12%) 6 (12%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 1 (2%)
Sinus, Ectasia 4 (8%) 1 (2%) 1 (2%)
Spleen (60) (60) (59)
Ectopic Tissue 2 (3%) 2 (3%) 2 (3%)
Fibrosis, Focal 3 (5%) 4 (7%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 3 (5%)
Hemorrhage, Focal 1 (2%)
Inflammation, Granulomatous 2 (3%)
Inflammation, Necrotizing 1 (2%)
Necrosis 2 (3%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
Thymus (42) (51) (49)
Congestion 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%) 2 (4%)
Depletion Lymphoid 1 (2%)
Ectopic Tissue 1 (2%) 1 (2%)
Hemorrhage 4 (10%) 1 (2%) 3 (6%)
Epithelial Cell, Hyperplasia 38 (90%) 48 (94%) 35 (71%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (55) (56)
Galactocele 2 (3%)
Hyperplasia, Multifocal, Nodular 1 (2%)
Inflammation, Chronic Active 1 (2%)
Duct, Ectasia 9 (16%) 7 (13%) 2 (4%)
Skin (59) (60) (59)
Cyst Epithelial Inclusion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2)
Femur, Osteopetrosis 1 (50%)
Vertebra, Osteopetrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (58)
Hemorrhage 1 (2%)
Cerebrum, Gliosis 1 (2%)
Cerebrum, Necrosis 1 (2%) 33 (57%)
Hippocampus, Necrosis 3 (5%)
Thalamus, Necrosis 21 (36%)
Spinal Cord (58) (60) (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Hemorrhage 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59)
Congestion 6 (10%) 3 (5%) 21 (36%)
Fungus 1 (2%)
Hemorrhage 5 (8%) 5 (8%) 5 (8%)
Infiltration Cellular, Histiocyte 49 (82%) 51 (85%) 42 (71%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Leukocytosis 1 (2%)
Necrosis, Multifocal 1 (2%)
Pigmentation 49 (82%) 51 (85%) 42 (71%)
Pigmentation, Diffuse, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (5%) 3 (5%) 2 (3%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Nose (60) (60) (59)
Foreign Body 1 (2%) 2 (3%)
Fungus 1 (2%) 2 (3%)
Hemorrhage 1 (2%)
Inflammation 1 (2%)
Inflammation, Suppurative 5 (8%) 4 (7%) 5 (8%)
Trachea (60) (60) (59)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3) (3)
Middle Ear, Inflammation, Suppurative 1 (33%)
Eye (4) (7) (3)
Cataract 1 (25%) 3 (43%) 1 (33%)
Necrosis 1 (25%) 2 (29%)
Anterior Chamber, Inflammation, Suppurative 1 (25%)
Retina, Degeneration 1 (25%) 2 (29%) 1 (33%)
Sclera, Metaplasia, Osseous 1 (25%) 2 (29%)
Harderian Gland (2) (1) (1)
Infiltration Cellular, Lymphocyte 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59)
Concretion 1 (2%)
Cyst 1 (2%) 2 (3%)
Hydronephrosis 1 (2%)
Nephropathy 54 (90%) 51 (85%) 23 (39%)
Pigmentation 1 (2%)
Urinary Bladder (60) (58) (58)
Infiltration Cellular, Lymphocyte 4 (7%)
Serosa, Inflammation, Chronic 1 (2%)
Serosa, Inflammation, Subacute 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Dead 16 14 26
Moribund 19 17 16
Gavage Death 1 2 9
Survivors
Terminal Sacrifice 24 27 9
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (53) (49)
Epithelium, Hyperplasia, Focal 1 (2%)
Liver (60) (60) (60)
Angiectasis 13 (22%) 7 (12%) 12 (20%)
Basophilic Focus 2 (3%) 1 (2%)
Basophilic Focus, Focal 1 (2%) 4 (7%)
Basophilic Focus, Multifocal 2 (3%) 3 (5%) 3 (5%)
Congestion 1 (2%) 3 (5%)
Cytoplasmic Alteration, Focal 1 (2%)
Degeneration, Cystic 4 (7%)
Eosinophilic Focus, Focal 1 (2%)
Eosinophilic Focus, Multifocal 1 (2%)
Fatty Change, Diffuse 1 (2%) 1 (2%)
Fatty Change, Focal 1 (2%) 1 (2%)
Fatty Change, Multifocal 1 (2%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 3 (5%) 1 (2%) 4 (7%)
Hyperplasia, Multifocal, Nodular 1 (2%)
Inflammation, Granulomatous, Multifocal 4 (7%) 1 (2%)
Leukocytosis 5 (8%) 3 (5%) 2 (3%)
Necrosis, Focal 1 (2%) 1 (2%)
Necrosis, Multifocal 2 (3%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 53 (88%) 56 (93%) 53 (88%)
Centrilobular, Hemorrhage 1 (2%)
Centrilobular, Necrosis 2 (3%) 5 (8%) 1 (2%)
Periportal, Fatty Change 1 (2%)
Mesentery (9) (13) (8)
Inflammation, Focal, Granulomatous 1 (8%) 1 (13%)
Necrosis, Focal 1 (8%)
Artery, Inflammation, Chronic 1 (13%)
Fat, Necrosis, Focal 6 (67%) 10 (77%) 5 (63%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (57) (60) (60)
Cytoplasmic Alteration, Focal 1 (2%)
Cytoplasmic Alteration, Multifocal 1 (2%)
Acinus, Atrophy 18 (32%) 20 (33%) 22 (37%)
Acinus, Hyperplasia, Focal 5 (9%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Duct, Ectasia 1 (2%)
Salivary Glands (59) (60) (60)
Acinus, Atrophy 1 (2%) 1 (2%)
Stomach, Forestomach (58) (59) (60)
Erosion 3 (5%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (3%) 1 (2%) 1 (2%)
Ulcer 5 (9%) 2 (3%) 5 (8%)
Stomach, Glandular (58) (60) (59)
Degeneration 1 (2%)
Degeneration, Cystic 37 (64%) 48 (80%) 35 (59%)
Erosion 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
Tooth (1)
Dysplasia 1 (100%)
Peridontal Tissue, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
Cardiomyopathy 40 (67%) 26 (43%) 36 (60%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Artery, Myocardium, Degeneration 1 (2%)
Atrium, Dilatation 1 (2%) 1 (2%)
Atrium, Thrombosis 10 (17%) 4 (7%)
Epicardium, Inflammation, Chronic Active,
Focal 1 (2%)
Myocardium, Degeneration, Hyaline 1 (2%)
Myocardium, Inflammation, Chronic, Focal 1 (2%)
Myocardium, Atrium, Inflammation, Chronic 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 2 (3%)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 7 (12%) 6 (10%) 5 (8%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 1 (2%)
Necrosis 1 (2%)
Necrosis, Multifocal 1 (2%)
Vacuolization Cytoplasmic, Focal 15 (25%) 15 (25%) 8 (13%)
Adrenal Gland, Medulla (55) (56) (53)
Hyperplasia, Focal 15 (27%) 11 (20%) 11 (21%)
Parathyroid Gland (41) (43) (43)
Hyperplasia 1 (2%)
Pituitary Gland (59) (60) (60)
Angiectasis 3 (5%) 1 (2%) 1 (2%)
Cyst 3 (5%) 2 (3%)
Hemorrhage 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 4 (7%) 1 (2%)
Pigmentation, Hemoglobin 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 4 (7%) 7 (12%) 12 (20%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (57) (58) (59)
Ultimobranchial Cyst 1 (2%) 4 (7%)
C-Cell, Hyperplasia 5 (9%) 5 (9%) 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Mineralization 1 (100%)
Thrombosis 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60)
Spermatocele 1 (2%)
Preputial Gland (59) (59) (55)
Cyst 1 (2%)
Hyperplasia, Focal, Glandular 1 (2%) 1 (2%)
Inflammation, Chronic Active 20 (34%) 10 (17%) 11 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 2 (4%)
Duct, Ectasia 1 (2%) 1 (2%)
Prostate (60) (60) (60)
Inflammation, Chronic Active 13 (22%) 4 (7%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Epithelium, Hyperplasia, Focal 8 (13%) 9 (15%) 3 (5%)
Serosa, Inflammation, Suppurative 1 (2%)
Seminal Vesicle (59) (60) (60)
Atrophy 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Testes (60) (60) (60)
Hypospermia 5 (8%) 7 (12%) 1 (2%)
Arteriole, Inflammation, Necrotizing 1 (2%)
Interstitial Cell, Hyperplasia 10 (17%) 11 (18%) 17 (28%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (60)
Atrophy 1 (2%) 1 (2%) 3 (5%)
Lymph Node (58) (56) (58)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Lumbar, Hemorrhage 2 (3%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hemorrhage 5 (9%) 9 (16%) 13 (22%)
Mediastinal, Hyperplasia, Re Cell 1 (2%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 2 (3%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Mediastinal, Sinus, Ectasia 2 (3%) 2 (4%) 1 (2%)
Mesenteric, Congestion 1 (2%)
Mesenteric, Degeneration, Cystic 1 (2%)
Mesenteric, Hemorrhage 3 (5%) 6 (11%) 3 (5%)
Mesenteric, Inflammation, Granulomatous 1 (2%)
Mesenteric, Sinus, Ectasia 6 (10%) 4 (7%) 5 (9%)
Pancreatic, Hemorrhage 1 (2%) 1 (2%)
Pancreatic, Sinus, Ectasia 1 (2%)
Lymph Node, Mandibular (55) (55) (55)
Congestion 1 (2%)
Degeneration, Cystic 1 (2%)
Hemorrhage 3 (5%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 7 (13%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Sinus, Ectasia 7 (13%) 9 (16%) 4 (7%)
Spleen (60) (60) (60)
Ectopic Tissue 4 (7%) 2 (3%)
Fibrosis, Diffuse 3 (5%) 2 (3%)
Fibrosis, Focal 7 (12%) 5 (8%) 4 (7%)
Fibrosis, Multifocal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
Thymus (49) (45) (49)
Congestion 1 (2%)
Cyst 1 (2%)
Ectopic Tissue 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 5 (10%)
Epithelial Cell, Hyperplasia 29 (59%) 36 (80%) 40 (82%)
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INTEGUMENTARY SYSTEM
Mammary Gland (47) (52) (50)
Galactocele 1 (2%)
Hyperplasia, Nodular 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Duct, Ectasia 3 (6%) 4 (8%) 2 (4%)
Fat, Necrosis 1 (2%)
Skin (58) (59) (60)
Abscess 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (2)
Cranium, Fibrous Osteodystrophy 1 (50%)
Femur, Fibrous Osteodystrophy 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60)
Congestion 2 (3%)
Hemorrhage 7 (12%) 2 (3%) 6 (10%)
Hydrocephalus 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Mineralization 1 (2%)
Brain Stem, Compression 1 (2%)
Cerebrum, Inflammation, Focal, Suppurative 1 (2%)
Cerebrum, Necrosis 1 (2%) 24 (40%)
Medulla, Gliosis 1 (2%)
Meninges, Hyperplasia 1 (2%)
Pons, Necrosis 1 (2%)
Thalamus, Gliosis 1 (2%)
Thalamus, Necrosis 1 (2%) 25 (42%)
Spinal Cord (58) (59) (47)
Hemorrhage 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Congestion 6 (10%) 4 (7%) 30 (50%)
Hemorrhage 4 (7%) 5 (8%) 17 (28%)
Infiltration Cellular, Histiocyte 11 (18%) 15 (25%) 21 (35%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Multifocal, Suppurative 1 (2%)
Leukocytosis 2 (3%)
Necrosis, Focal 1 (2%) 1 (2%)
Pigmentation 8 (13%) 15 (25%) 19 (32%)
Pigmentation, Hemoglobin 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 8 (13%) 7 (12%) 4 (7%)
Bronchiole, Inflammation, Suppurative 2 (3%)
Bronchus, Inflammation, Suppurative 1 (2%)
Interstitium, Inflammation 3 (5%) 1 (2%)
Interstitium, Inflammation, Focal 1 (2%)
Peribronchiolar, Foreign Body 1 (2%)
Peribronchiolar, Alveolus, Inflammation,
Suppurative 2 (3%)
Pleura, Fibrosis, Focal 1 (2%)
Nose (59) (60) (60)
Congestion 1 (2%) 3 (5%)
Fungus 3 (5%) 1 (2%)
Hemorrhage 4 (7%) 2 (3%) 4 (7%)
Hyperkeratosis, Focal 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 6 (10%) 3 (5%) 3 (5%)
Sinus, Inflammation, Chronic 1 (2%)
Sinus, Inflammation, Chronic Active 1 (2%)
Sinus, Inflammation, Suppurative 1 (2%)
Trachea (58) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (10) (4) (4)
Cataract 4 (40%) 3 (75%) 2 (50%)
Necrosis 1 (10%)
Conjunctiva, Inflammation, Chronic Active 2 (20%)
Retina, Degeneration 4 (40%) 4 (100%) 1 (25%)
Sclera, Metaplasia, Osseous 5 (50%) 2 (50%) 1 (25%)
Harderian Gland (1)
Pigmentation, Porphyrin 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60)
Congestion 1 (2%)
Cyst 4 (7%) 1 (2%) 1 (2%)
Inflammation, Multifocal, Suppurative 1 (2%)
Necrosis, Focal 1 (2%)
Nephropathy 57 (95%) 57 (95%) 53 (88%)
Pigmentation 3 (5%) 4 (7%)
Pelvis, Epithelium, Hyperplasia, Focal 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (60) (60) (59)
Infiltration Cellular, Lymphocyte 3 (5%) 3 (5%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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