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https://ntp.niehs.nih.gov/go/3764

TR 389 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            SODIUM AZIDE


NTP Experiment-Test: 05026-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 07:44:14




       Facility:  Microbiological Associates

       Chemical CAS #:  26628228

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              13            5           22                                                  
    Moribund                                          10           12           11                                                  
    Gavage Death                                                                 5                                                  
  Survivors                                                                                                                         
    Dead                                               1                                                                            
    Terminal Sacrifice                                36           43           21                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           59                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (59)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
   Intestine Large, Rectum                            (59)         (59)         (58)                                                
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (60)         (60)         (59)                                                
      Angiectasis                                      3 (5%)       1 (2%)       4 (7%)                                             
      Basophilic Focus                                 4 (7%)                    5 (8%)                                             
      Basophilic Focus, Focal                                                    1 (2%)                                             
      Basophilic Focus, Multifocal                    19 (32%)     26 (43%)     18 (31%)                                            
      Congestion                                       1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                                            1 (2%)                                                          
      Fatty Change, Diffuse                            2 (3%)       2 (3%)       1 (2%)                                             
      Fatty Change, Focal                              3 (5%)                                                                       
      Fatty Change, Multifocal                         4 (7%)       1 (2%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       1 (2%)       8 (13%)     11 (19%)                                            
      Hyperplasia, Multifocal, Nodular                 1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Inflammation, Acute, Multifocal                               1 (2%)                                                          
      Inflammation, Chronic Active, Focal                           1 (2%)                                                          
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Inflammation, Granulomatous                      2 (3%)                                                                       
      Inflammation, Granulomatous, Multifocal         24 (40%)     16 (27%)     28 (47%)                                            
      Leukocytosis                                     4 (7%)       1 (2%)                                                          
      Mixed Cell Focus                                              1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
      Necrosis, Multifocal                             4 (7%)                                                                       
      Bile Duct, Hyperplasia                          34 (57%)     37 (62%)     27 (46%)                                            
      Centrilobular, Fatty Change                      1 (2%)       2 (3%)                                                          
      Centrilobular, Necrosis                          2 (3%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis, Coagulative                          2 (3%)                                                          
      Hepatocyte, Periportal, Necrosis                 1 (2%)                                                                       
      Periportal, Fatty Change                         1 (2%)       3 (5%)                                                          
   Mesentery                                          (16)         (10)         (7)                                                 
      Fat, Necrosis, Focal                            15 (94%)      7 (70%)      7 (100%)                                           
      Fat, Necrosis, Multifocal                        1 (6%)       1 (10%)                                                         
   Pancreas                                           (60)         (60)         (58)                                                
      Ectopic Tissue                                   1 (2%)                                                                       
      Acinus, Atrophy                                 16 (27%)     13 (22%)     11 (19%)                                            
      Acinus, Cytoplasmic Alteration, Focal                                      2 (3%)                                             
      Acinus, Cytoplasmic Alteration, Multifocal       1 (2%)                                                                       
      Acinus, Hyperplasia, Focal                                    1 (2%)                                                          
   Salivary Glands                                    (59)         (60)         (59)                                                
      Inflammation, Necrotizing                        1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (57)         (57)                                                
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            2 (3%)                    2 (4%)                                             
      Ulcer                                            1 (2%)       2 (4%)       2 (4%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (60)         (57)                                                
      Degeneration, Cystic                            39 (65%)     56 (93%)     37 (65%)                                            
      Erosion                                          1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
      Lamina Propria, Fibrosis, Focal                               1 (2%)                                                          
   Tooth                                              (1)                       (1)                                                 
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (58)                                                
      Cardiomyopathy                                  20 (33%)     21 (35%)     19 (33%)                                            
      Aortic Valve, Inflammation, Chronic Active                    1 (2%)                                                          
      Aortic Valve, Inflammation, Subacute             1 (2%)                                                                       
      Artery, Degeneration                                                       1 (2%)                                             
      Myocardium, Atrium Right, Necrosis               1 (2%)                                                                       
      Myocardium, Ventricle, Necrosis                  1 (2%)                                                                       
      Pericardium, Inflammation, Necrotizing           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (58)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)                                                          
      Angiectasis                                      6 (10%)      2 (3%)       2 (3%)                                             
      Degeneration, Ballooning, Focal                  1 (2%)                                                                       
      Hyperplasia, Focal                              12 (20%)      3 (5%)       2 (3%)                                             
      Hyperplasia, Multifocal                          1 (2%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)                                                          
      Necrosis, Multifocal                             2 (3%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Vacuolization Cytoplasmic, Diffuse                            2 (3%)                                                          
      Vacuolization Cytoplasmic, Focal                 6 (10%)      6 (10%)      5 (9%)                                             
      Vacuolization Cytoplasmic, Multifocal            2 (3%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (58)         (54)         (56)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Focal                               3 (5%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                          2 (3%)       2 (4%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Bilateral, Hyperplasia, Focal                                              1 (2%)                                             
      Bilateral, Hyperplasia, Multifocal                                         1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (58)                                                
      Hyperplasia, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (60)         (60)         (59)                                                
      Angiectasis                                     10 (17%)      7 (12%)      5 (8%)                                             
      Cyst                                             9 (15%)     15 (25%)     15 (25%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Pigmentation, Hemosiderin                        2 (3%)       2 (3%)                                                          
      Pars Distalis, Hyperplasia                       3 (5%)       4 (7%)       3 (5%)                                             
      Pars Distalis, Hyperplasia, Focal                5 (8%)       3 (5%)       6 (10%)                                            
      Pars Nervosa, Hyperplasia                        1 (2%)                                                                       
   Thyroid Gland                                      (60)         (60)         (56)                                                
      Inflammation, Subacute                                        1 (2%)                                                          
      Ultimobranchial Cyst                                          2 (3%)       2 (4%)                                             
      C-Cell, Hyperplasia                              8 (13%)     10 (17%)      2 (4%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (55)         (57)         (49)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)       2 (4%)                                                          
      Duct, Ectasia                                    5 (9%)       7 (12%)      4 (8%)                                             
   Ovary                                              (60)         (60)         (59)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                             3 (5%)       3 (5%)       4 (7%)                                             
   Uterus                                             (60)         (60)         (59)                                                
      Hydrometra                                                    3 (5%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Cervix, Cyst                                     9 (15%)     12 (20%)      5 (8%)                                             
      Cervix, Hypertrophy                                           1 (2%)                                                          
      Cervix, Inflammation, Chronic Active             2 (3%)                                                                       
      Cervix, Inflammation, Suppurative                1 (2%)       2 (3%)       1 (2%)                                             
      Endometrium, Cyst                                2 (3%)       1 (2%)       3 (5%)                                             
      Endometrium, Cyst, Multiple                      1 (2%)                                                                       
      Endometrium, Hyperplasia                         1 (2%)       1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                              6 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (59)                                                
      Atrophy                                                                    3 (5%)                                             
   Lymph Node                                         (59)         (59)         (59)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Mediastinal, Congestion                          1 (2%)                                                                       
      Mediastinal, Hemorrhage                         13 (22%)      7 (12%)      9 (15%)                                            
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Mediastinal, Hyperplasia, Reticulum Cell                      1 (2%)                                                          
      Mediastinal, Inflammation, Granulomatous         2 (3%)                                                                       
      Mediastinal, Pigmentation, Hemosiderin           9 (15%)      7 (12%)      6 (10%)                                            
      Mediastinal, Sinus, Ectasia                      1 (2%)       1 (2%)                                                          
      Mesenteric, Hemorrhage                           3 (5%)       3 (5%)       2 (3%)                                             
      Mesenteric, Pigmentation, Hemosiderin                         1 (2%)                                                          
      Mesenteric, Sinus, Ectasia                       7 (12%)     14 (24%)      6 (10%)                                            
      Pancreatic, Hemorrhage                           3 (5%)       2 (3%)                                                          
      Pancreatic, Pigmentation, Hemosiderin            3 (5%)       4 (7%)       2 (3%)                                             
      Pancreatic, Sinus, Ectasia                       2 (3%)       1 (2%)                                                          
      Renal, Infiltration Cellular, Histiocyte                      1 (2%)                                                          
      Renal, Pigmentation, Hemosiderin                 1 (2%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (51)         (52)         (50)                                                
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Hyperplasia, Plasma Cell                         4 (8%)       6 (12%)      6 (12%)                                            
      Inflammation, Granulomatous                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Sinus, Ectasia                                   4 (8%)       1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (59)                                                
      Ectopic Tissue                                   2 (3%)       2 (3%)       2 (3%)                                             
      Fibrosis, Focal                                  3 (5%)       4 (7%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (5%)       3 (5%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Inflammation, Granulomatous                      2 (3%)                                                                       
      Inflammation, Necrotizing                                                  1 (2%)                                             
      Necrosis                                         2 (3%)                                                                       
      Red Pulp, Atrophy                                             1 (2%)       1 (2%)                                             
   Thymus                                             (42)         (51)         (49)                                                
      Congestion                                       1 (2%)       1 (2%)       1 (2%)                                             
      Cyst                                                          1 (2%)       2 (4%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Ectopic Tissue                                   1 (2%)       1 (2%)                                                          
      Hemorrhage                                       4 (10%)      1 (2%)       3 (6%)                                             
      Epithelial Cell, Hyperplasia                    38 (90%)     48 (94%)     35 (71%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (55)         (56)                                                
      Galactocele                                      2 (3%)                                                                       
      Hyperplasia, Multifocal, Nodular                 1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Duct, Ectasia                                    9 (16%)      7 (13%)      2 (4%)                                             
   Skin                                               (59)         (60)         (59)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (2)                                                              
      Femur, Osteopetrosis                                          1 (50%)                                                         
      Vertebra, Osteopetrosis                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Cerebrum, Gliosis                                             1 (2%)                                                          
      Cerebrum, Necrosis                                            1 (2%)      33 (57%)                                            
      Hippocampus, Necrosis                                                      3 (5%)                                             
      Thalamus, Necrosis                                                        21 (36%)                                            
   Spinal Cord                                        (58)         (60)         (58)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)                                                
      Congestion                                       6 (10%)      3 (5%)      21 (36%)                                            
      Fungus                                                        1 (2%)                                                          
      Hemorrhage                                       5 (8%)       5 (8%)       5 (8%)                                             
      Infiltration Cellular, Histiocyte               49 (82%)     51 (85%)     42 (71%)                                            
      Inflammation, Focal, Granulomatous                            1 (2%)                                                          
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
      Leukocytosis                                     1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Pigmentation                                    49 (82%)     51 (85%)     42 (71%)                                            
      Pigmentation, Diffuse, Hemosiderin                            1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          3 (5%)       3 (5%)       2 (3%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (2%)                                                          
   Nose                                               (60)         (60)         (59)                                                
      Foreign Body                                     1 (2%)                    2 (3%)                                             
      Fungus                                                        1 (2%)       2 (3%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Suppurative                        5 (8%)       4 (7%)       5 (8%)                                             
   Trachea                                            (60)         (60)         (59)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (3)          (3)                                                 
      Middle Ear, Inflammation, Suppurative                         1 (33%)                                                         
   Eye                                                (4)          (7)          (3)                                                 
      Cataract                                         1 (25%)      3 (43%)      1 (33%)                                            
      Necrosis                                         1 (25%)      2 (29%)                                                         
      Anterior Chamber, Inflammation, Suppurative      1 (25%)                                                                      
      Retina, Degeneration                             1 (25%)      2 (29%)      1 (33%)                                            
      Sclera, Metaplasia, Osseous                      1 (25%)      2 (29%)                                                         
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Infiltration Cellular, Lymphocyte                2 (100%)     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)                                                
      Concretion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)                    2 (3%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Nephropathy                                     54 (90%)     51 (85%)     23 (39%)                                            
      Pigmentation                                     1 (2%)                                                                       
   Urinary Bladder                                    (60)         (58)         (58)                                                
      Infiltration Cellular, Lymphocyte                             4 (7%)                                                          
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
      Serosa, Inflammation, Subacute                   1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Focal                   1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              16           14           26                                                  
    Moribund                                          19           17           16                                                  
    Gavage Death                                       1            2            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           27            9                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (53)         (49)                                                
      Epithelium, Hyperplasia, Focal                                1 (2%)                                                          
   Liver                                              (60)         (60)         (60)                                                
      Angiectasis                                     13 (22%)      7 (12%)     12 (20%)                                            
      Basophilic Focus                                 2 (3%)                    1 (2%)                                             
      Basophilic Focus, Focal                                       1 (2%)       4 (7%)                                             
      Basophilic Focus, Multifocal                     2 (3%)       3 (5%)       3 (5%)                                             
      Congestion                                       1 (2%)                    3 (5%)                                             
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Degeneration, Cystic                             4 (7%)                                                                       
      Eosinophilic Focus, Focal                                     1 (2%)                                                          
      Eosinophilic Focus, Multifocal                                1 (2%)                                                          
      Fatty Change, Diffuse                            1 (2%)       1 (2%)                                                          
      Fatty Change, Focal                              1 (2%)                    1 (2%)                                             
      Fatty Change, Multifocal                         1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       3 (5%)       1 (2%)       4 (7%)                                             
      Hyperplasia, Multifocal, Nodular                 1 (2%)                                                                       
      Inflammation, Granulomatous, Multifocal          4 (7%)                    1 (2%)                                             
      Leukocytosis                                     5 (8%)       3 (5%)       2 (3%)                                             
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Necrosis, Multifocal                             2 (3%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                          53 (88%)     56 (93%)     53 (88%)                                            
      Centrilobular, Hemorrhage                        1 (2%)                                                                       
      Centrilobular, Necrosis                          2 (3%)       5 (8%)       1 (2%)                                             
      Periportal, Fatty Change                         1 (2%)                                                                       
   Mesentery                                          (9)          (13)         (8)                                                 
      Inflammation, Focal, Granulomatous                            1 (8%)       1 (13%)                                            
      Necrosis, Focal                                               1 (8%)                                                          
      Artery, Inflammation, Chronic                                              1 (13%)                                            
      Fat, Necrosis, Focal                             6 (67%)     10 (77%)      5 (63%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (57)         (60)         (60)                                                
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Cytoplasmic Alteration, Multifocal                            1 (2%)                                                          
      Acinus, Atrophy                                 18 (32%)     20 (33%)     22 (37%)                                            
      Acinus, Hyperplasia, Focal                       5 (9%)                                                                       
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Duct, Ectasia                                                 1 (2%)                                                          
   Salivary Glands                                    (59)         (60)         (60)                                                
      Acinus, Atrophy                                  1 (2%)                    1 (2%)                                             
   Stomach, Forestomach                               (58)         (59)         (60)                                                
      Erosion                                                                    3 (5%)                                             
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     2 (3%)       1 (2%)       1 (2%)                                             
      Ulcer                                            5 (9%)       2 (3%)       5 (8%)                                             
   Stomach, Glandular                                 (58)         (60)         (59)                                                
      Degeneration                                                  1 (2%)                                                          
      Degeneration, Cystic                            37 (64%)     48 (80%)     35 (59%)                                            
      Erosion                                          1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            1 (2%)       1 (2%)                                                          
   Tooth                                                           (1)                                                              
      Dysplasia                                                     1 (100%)                                                        
      Peridontal Tissue, Inflammation, Suppurative                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Cardiomyopathy                                  40 (67%)     26 (43%)     36 (60%)                                            
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Artery, Myocardium, Degeneration                                           1 (2%)                                             
      Atrium, Dilatation                               1 (2%)                    1 (2%)                                             
      Atrium, Thrombosis                              10 (17%)      4 (7%)                                                          
      Epicardium, Inflammation, Chronic Active,                                                                                     
           Focal                                                                 1 (2%)                                             
      Myocardium, Degeneration, Hyaline                1 (2%)                                                                       
      Myocardium, Inflammation, Chronic, Focal                                   1 (2%)                                             
      Myocardium, Atrium, Inflammation, Chronic                     1 (2%)                                                          
      Valve, Inflammation, Suppurative                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Angiectasis                                                   2 (3%)                                                          
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                               7 (12%)      6 (10%)      5 (8%)                                             
      Hypertrophy                                                                1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Necrosis, Multifocal                                          1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                15 (25%)     15 (25%)      8 (13%)                                            
   Adrenal Gland, Medulla                             (55)         (56)         (53)                                                
      Hyperplasia, Focal                              15 (27%)     11 (20%)     11 (21%)                                            
   Parathyroid Gland                                  (41)         (43)         (43)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (59)         (60)         (60)                                                
      Angiectasis                                      3 (5%)       1 (2%)       1 (2%)                                             
      Cyst                                                          3 (5%)       2 (3%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                        4 (7%)       1 (2%)                                                          
      Pigmentation, Hemoglobin                                      1 (2%)                                                          
      Pars Distalis, Hyperplasia                       1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                4 (7%)       7 (12%)     12 (20%)                                            
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                                                                       
      Pars Nervosa, Hyperplasia                                     1 (2%)                                                          
   Thyroid Gland                                      (57)         (58)         (59)                                                
      Ultimobranchial Cyst                             1 (2%)                    4 (7%)                                             
      C-Cell, Hyperplasia                              5 (9%)       5 (9%)       1 (2%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)                                                 
      Mineralization                                                             1 (100%)                                           
      Thrombosis                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)                                                
      Spermatocele                                                               1 (2%)                                             
   Preputial Gland                                    (59)         (59)         (55)                                                
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Focal, Glandular                    1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                    20 (34%)     10 (17%)     11 (20%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                                                  2 (4%)                                             
      Duct, Ectasia                                                 1 (2%)       1 (2%)                                             
   Prostate                                           (60)         (60)         (60)                                                
      Inflammation, Chronic Active                    13 (22%)      4 (7%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   8 (13%)      9 (15%)      3 (5%)                                             
      Serosa, Inflammation, Suppurative                             1 (2%)                                                          
   Seminal Vesicle                                    (59)         (60)         (60)                                                
      Atrophy                                          1 (2%)       2 (3%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Serosa, Inflammation, Suppurative                             1 (2%)                                                          
   Testes                                             (60)         (60)         (60)                                                
      Hypospermia                                      5 (8%)       7 (12%)      1 (2%)                                             
      Arteriole, Inflammation, Necrotizing             1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  10 (17%)     11 (18%)     17 (28%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)                                                
      Atrophy                                          1 (2%)       1 (2%)       3 (5%)                                             
   Lymph Node                                         (58)         (56)         (58)                                                
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)                                                          
      Lumbar, Hemorrhage                                                         2 (3%)                                             
      Lumbar, Hyperplasia, Plasma Cell                                           1 (2%)                                             
      Lumbar, Pigmentation, Hemosiderin                                          1 (2%)                                             
      Mediastinal, Hematopoietic Cell Proliferation                 1 (2%)                                                          
      Mediastinal, Hemorrhage                          5 (9%)       9 (16%)     13 (22%)                                            
      Mediastinal, Hyperplasia, Re Cell                                          1 (2%)                                             
      Mediastinal, Infiltration Cellular, Mast Cell    1 (2%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   2 (3%)                                                                       
      Mediastinal, Pigmentation, Hemosiderin           1 (2%)       2 (4%)                                                          
      Mediastinal, Sinus, Ectasia                      2 (3%)       2 (4%)       1 (2%)                                             
      Mesenteric, Congestion                                        1 (2%)                                                          
      Mesenteric, Degeneration, Cystic                                           1 (2%)                                             
      Mesenteric, Hemorrhage                           3 (5%)       6 (11%)      3 (5%)                                             
      Mesenteric, Inflammation, Granulomatous                                    1 (2%)                                             
      Mesenteric, Sinus, Ectasia                       6 (10%)      4 (7%)       5 (9%)                                             
      Pancreatic, Hemorrhage                           1 (2%)                    1 (2%)                                             
      Pancreatic, Sinus, Ectasia                       1 (2%)                                                                       
   Lymph Node, Mandibular                             (55)         (55)         (55)                                                
      Congestion                                                                 1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                                                                       
      Hemorrhage                                       3 (5%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                                      7 (13%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Sinus, Ectasia                                   7 (13%)      9 (16%)      4 (7%)                                             
   Spleen                                             (60)         (60)         (60)                                                
      Ectopic Tissue                                   4 (7%)       2 (3%)                                                          
      Fibrosis, Diffuse                                3 (5%)       2 (3%)                                                          
      Fibrosis, Focal                                  7 (12%)      5 (8%)       4 (7%)                                             
      Fibrosis, Multifocal                             1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Re Cell                                          1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)       1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)                                                          
      Red Pulp, Atrophy                                1 (2%)       1 (2%)                                                          
   Thymus                                             (49)         (45)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Ectopic Tissue                                   1 (2%)                                                                       
      Hemorrhage                                       2 (4%)       1 (2%)       5 (10%)                                            
      Epithelial Cell, Hyperplasia                    29 (59%)     36 (80%)     40 (82%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (52)         (50)                                                
      Galactocele                                      1 (2%)                                                                       
      Hyperplasia, Nodular                                          1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)       1 (2%)                                                          
      Duct, Ectasia                                    3 (6%)       4 (8%)       2 (4%)                                             
      Fat, Necrosis                                                              1 (2%)                                             
   Skin                                               (58)         (59)         (60)                                                
      Abscess                                                                    1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (1)                       (2)                                                 
      Cranium, Fibrous Osteodystrophy                                            1 (50%)                                            
      Femur, Fibrous Osteodystrophy                                              1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)                                                
      Congestion                                                                 2 (3%)                                             
      Hemorrhage                                       7 (12%)      2 (3%)       6 (10%)                                            
      Hydrocephalus                                    1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Mineralization                                   1 (2%)                                                                       
      Brain Stem, Compression                                       1 (2%)                                                          
      Cerebrum, Inflammation, Focal, Suppurative       1 (2%)                                                                       
      Cerebrum, Necrosis                                            1 (2%)      24 (40%)                                            
      Medulla, Gliosis                                              1 (2%)                                                          
      Meninges, Hyperplasia                                                      1 (2%)                                             
      Pons, Necrosis                                                             1 (2%)                                             
      Thalamus, Gliosis                                                          1 (2%)                                             
      Thalamus, Necrosis                                            1 (2%)      25 (42%)                                            
   Spinal Cord                                        (58)         (59)         (47)                                                
      Hemorrhage                                       2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Congestion                                       6 (10%)      4 (7%)      30 (50%)                                            
      Hemorrhage                                       4 (7%)       5 (8%)      17 (28%)                                            
      Infiltration Cellular, Histiocyte               11 (18%)     15 (25%)     21 (35%)                                            
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Inflammation, Multifocal, Suppurative            1 (2%)                                                                       
      Leukocytosis                                     2 (3%)                                                                       
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Pigmentation                                     8 (13%)     15 (25%)     19 (32%)                                            
      Pigmentation, Hemoglobin                         1 (2%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          8 (13%)      7 (12%)      4 (7%)                                             
      Bronchiole, Inflammation, Suppurative            2 (3%)                                                                       
      Bronchus, Inflammation, Suppurative              1 (2%)                                                                       
      Interstitium, Inflammation                       3 (5%)       1 (2%)                                                          
      Interstitium, Inflammation, Focal                             1 (2%)                                                          
      Peribronchiolar, Foreign Body                                 1 (2%)                                                          
      Peribronchiolar, Alveolus, Inflammation,                                                                                      
           Suppurative                                 2 (3%)                                                                       
      Pleura, Fibrosis, Focal                                                    1 (2%)                                             
   Nose                                               (59)         (60)         (60)                                                
      Congestion                                       1 (2%)                    3 (5%)                                             
      Fungus                                           3 (5%)       1 (2%)                                                          
      Hemorrhage                                       4 (7%)       2 (3%)       4 (7%)                                             
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        6 (10%)      3 (5%)       3 (5%)                                             
      Sinus, Inflammation, Chronic                                  1 (2%)                                                          
      Sinus, Inflammation, Chronic Active                           1 (2%)                                                          
      Sinus, Inflammation, Suppurative                 1 (2%)                                                                       
   Trachea                                            (58)         (60)         (60)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05026-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (10)         (4)          (4)                                                 
      Cataract                                         4 (40%)      3 (75%)      2 (50%)                                            
      Necrosis                                         1 (10%)                                                                      
      Conjunctiva, Inflammation, Chronic Active        2 (20%)                                                                      
      Retina, Degeneration                             4 (40%)      4 (100%)     1 (25%)                                            
      Sclera, Metaplasia, Osseous                      5 (50%)      2 (50%)      1 (25%)                                            
   Harderian Gland                                                 (1)                                                              
      Pigmentation, Porphyrin                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                             4 (7%)       1 (2%)       1 (2%)                                             
      Inflammation, Multifocal, Suppurative            1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
      Nephropathy                                     57 (95%)     57 (95%)     53 (88%)                                            
      Pigmentation                                     3 (5%)       4 (7%)                                                          
      Pelvis, Epithelium, Hyperplasia, Focal                        1 (2%)                                                          
      Renal Tubule, Necrosis                                        1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (59)                                                
      Infiltration Cellular, Lymphocyte                3 (5%)       3 (5%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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