TR 392 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:12:51
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
90-DAY LOW DOSE GROUPS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 VEHICLE 3 SSAC
INCLUDE 003 VEHICLE CONTROL
INCLUDE 004 VEHICLE 3 SSAC
INCLUDE 010 0.0100% 3 SSAC
INCLUDE 012 0.0100% 3 SSAC
INCLUDE 014 0.00500% 3 SSAC
INCLUDE 016 0.00500% 3 SSAC
INCLUDE 026 0.00700% 3 SSAC
INCLUDE 028 0.00700% 3 SSAC
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:12:51
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:12:51
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 0/3 (0%) 0/2 (0%) | 0/70 (0%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 13.9% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 | 0/33 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 681 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.568N | (e) |
|FISHER EXACT | P=0.806N P=0.865N | (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/3 (0%) 0/2 (0%) | 1/70 (1%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% | 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 | 1/33 (3%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.701N | P=0.746N |
|FISHER EXACT | P=0.880N P=0.918N | P=0.921N P=0.946N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/70 (47%) 0/3 (0%) 0/2 (0%) | 20/70 (29%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 72.7% 0.0% 0.0% | 54.6% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 | 1/10 (10%) 0/0 0/0 |
|TERMINAL (d) | 22/34 (65%) 0/0 0/0 | 17/33 (52%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) --- --- | 457 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.869N P=0.968N P=0.989N | P=0.984N (e) (e) |
|COCHRAN-ARMITAGE | P=0.052N | P=0.059N |
|FISHER EXACT | P=0.159N P=0.290N | P=0.149N P=0.275N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/70 (20%) 0/3 (0%) 0/2 (0%) | 6/70 (9%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 29.4% 0.0% 0.0% | 17.2% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 | 5/33 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | 659 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.536N P=0.712N P=0.800N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.277N | P=0.318N |
|FISHER EXACT | P=0.523N P=0.647N | P=0.600N P=0.708N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 0/3 (0%) 0/2 (0%) | 6/70 (9%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 31.2% 0.0% 0.0% | 17.2% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 | 5/33 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | 659 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.535N P=0.711N P=0.799N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.257N | P=0.318N |
|FISHER EXACT | P=0.496N P=0.624N | P=0.600N P=0.708N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/70 (57%) 0/3 (0%) 0/2 (0%) | 21/70 (30%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 78.0% 0.0% 0.0% | 55.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 5/10 (50%) 0/0 0/0 | 1/10 (10%) 0/0 0/0 |
|TERMINAL (d) | 23/34 (68%) 0/0 0/0 | 17/33 (52%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | 457 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.595N P=0.769N P=0.850N | P=0.963N P=1.000N (e) |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.051N |
|FISHER EXACT | P=0.088N P=0.194N | P=0.133N P=0.254N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/70 (57%) 0/3 (0%) 0/2 (0%) | 21/70 (30%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 78.0% 0.0% 0.0% | 55.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 5/10 (50%) 0/0 0/0 | 1/10 (10%) 0/0 0/0 |
|TERMINAL (d) | 23/34 (68%) 0/0 0/0 | 17/33 (52%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | 457 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.595N P=0.769N P=0.850N | P=0.963N P=1.000N (e) |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.051N |
|FISHER EXACT | P=0.088N P=0.194N | P=0.133N P=0.254N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/70 (26%) 0/3 (0%) 0/2 (0%) | 4/70 (6%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 39.4% 0.0% 0.0% | 10.6% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 9/34 (26%) 0/0 0/0 | 3/33 (9%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.553N P=0.729N P=0.815N | P=0.851N P=0.981N P=0.992N |
|COCHRAN-ARMITAGE | P=0.205N | P=0.418N |
|FISHER EXACT | P=0.422N P=0.560N | P=0.715N P=0.797N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/70 (13%) 0/3 (0%) 0/2 (0%) | 1/70 (1%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 22.1% 0.0% 0.0% | 3.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 5/34 (15%) 0/0 0/0 | 1/33 (3%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.894N P=0.976N P=0.992N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.404N | P=0.746N |
|FISHER EXACT | P=0.670N P=0.764N | P=0.921N P=0.946N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 0/3 (0%) 0/2 (0%) | 5/70 (7%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 51.3% 0.0% 0.0% | 13.6% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 4/10 (40%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 12/34 (35%) 0/0 0/0 | 4/33 (12%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.479N P=0.659N P=0.755N | P=0.884N P=0.990N P=0.997N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.363N |
|FISHER EXACT | P=0.278N P=0.423N | P=0.655N P=0.751N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/66 (3%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | | 6.9% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | | 2/29 (7%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | (e) (e) (e) |
|INCIDENTAL TUMOR | | (e) (e) (e) |
|LOGISTIC REGRESSION | | (e) (e) (e) |
|COCHRAN-ARMITAGE | | P=0.574N |
|FISHER EXACT | | P=0.839N P=0.888N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/68 (0%) 0/3 (0%) 0/2 (0%) | 5/68 (7%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 14.6% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 0/32 (0%) 0/0 0/0 | 4/33 (12%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- | 698 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.357N |
|FISHER EXACT | (e) (e) | P=0.647N P=0.745N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/3 (0%) 0/2 (0%) | 1/69 (1%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% | 3.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 | 1/32 (3%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.701N | P=0.743N |
|FISHER EXACT | P=0.880N P=0.918N | P=0.920N P=0.945N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/3 (0%) 0/2 (0%) | 0/70 (0%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 | 0/33 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.866N P=0.959N P=0.982N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.796N | (e) |
|FISHER EXACT | P=0.919N P=0.945N | (e) (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/3 (0%) 0/2 (0%) | 3/70 (4%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% | 7.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 1/10 (10%) 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 | 2/33 (6%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 691 --- --- | 456 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.817N P=0.968N P=0.985N |
|COCHRAN-ARMITAGE | P=0.924N | P=0.488N |
|FISHER EXACT | P=0.959N P=0.972N | P=0.779N P=0.844N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/3 (0%) 0/2 (0%) | 3/70 (4%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 8.4% 0.0% 0.0% | 9.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 2/34 (6%) 0/0 0/0 | 3/33 (9%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 730 --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.701N | P=0.488N |
|FISHER EXACT | P=0.880N P=0.918N | P=0.779N P=0.844N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/3 (0%) 0/2 (0%) | 3/70 (4%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% | 9.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 | 3/33 (9%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.701N | P=0.488N |
|FISHER EXACT | P=0.880N P=0.918N | P=0.779N P=0.844N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 0/3 (0%) 0/2 (0%) | 5/70 (7%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 17.0% 0.0% 0.0% | 15.2% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 5/34 (15%) 0/0 0/0 | 5/33 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 730 --- --- | 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.518N | P=0.363N |
|FISHER EXACT | P=0.770N P=0.839N | P=0.655N P=0.751N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/3 (0%) 0/2 (0%) | 9/70 (13%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 22.9% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 | 5/33 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.828N P=0.975N P=0.990N |
|COCHRAN-ARMITAGE | (e) | P=0.221N |
|FISHER EXACT | (e) (e) | P=0.456N P=0.588N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/3 (0%) 0/2 (0%) | 9/70 (13%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 22.9% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 | 5/33 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.828N P=0.975N P=0.990N |
|COCHRAN-ARMITAGE | (e) | P=0.221N |
|FISHER EXACT | (e) (e) | P=0.456N P=0.588N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 45/70 (64%) 0/3 (0%) 0/2 (0%) | 29/70 (41%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 86.2% 0.0% 0.0% | 71.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 6/10 (60%) 0/0 0/0 | 3/10 (30%) 0/0 0/0 |
|TERMINAL (d) | 27/34 (79%) 0/0 0/0 | 22/33 (67%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.596N P=0.770N P=0.850N | P=0.647N P=0.868N P=0.922N |
|COCHRAN-ARMITAGE | P=0.008N** | P=0.016N* |
|FISHER EXACT | P=0.053N P=0.137N | P=0.049N* P=0.129N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 0/3 (0%) 0/2 (0%) | 23/70 (33%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 50.7% 0.0% 0.0% | 54.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 | 0/10 (0%) 0/0 0/0 |
|TERMINAL (d) | 11/34 (32%) 0/0 0/0 | 14/33 (42%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.513N P=0.692N P=0.784N | P=0.871N P=0.990N P=0.997N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.039N* |
|FISHER EXACT | P=0.278N P=0.423N | P=0.105N P=0.217N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00700% 0.0100% | VEHICLE 0.00500% 0.0100% |
| | 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/70 (70%) 0/3 (0%) 0/2 (0%) | 38/70 (54%) 0/6 (0%) 0/4 (0%) |
|ADJUSTED (b) | 88.9% 0.0% 0.0% | 84.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/0 | 0/1 (0%) 0/0 0/1 (0%) |
|INTERIM SACRIFICE 2 (c)| 7/10 (70%) 0/0 0/0 | 3/10 (30%) 0/0 0/0 |
|TERMINAL (d) | 28/34 (82%) 0/0 0/0 | 26/33 (79%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- | 452 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.520N P=0.699N P=0.790N | P=0.761N P=0.949N P=0.978N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.003N** |
|FISHER EXACT | P=0.033N* P=0.099N | P=0.013N* P=0.051N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 102 455
Female interim sacrifices(days): 102 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:14:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
90-DAY HIGH DOSE GROUPS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 VEHICLE 3 SSAC
INCLUDE 003 VEHICLE CONTROL
INCLUDE 004 VEHICLE 3 SSAC
INCLUDE 006 0.0200% 3 SSAC
INCLUDE 008 0.0200% 3 SSAC
INCLUDE 018 0.0275% 3 SSAC
INCLUDE 020 0.0275% 3 SSAC
INCLUDE 022 0.0140% 3 SSAC
INCLUDE 024 0.0140% 3 SSAC
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:14:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:14:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 0/70 (0%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 13.9% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 0/0 | 0/33 (0%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 681 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.181N | (e) |
|FISHER EXACT | P=0.930N P=0.503N P=0.503N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 1/70 (1%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% 0.0% | 3.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 0/0 | 1/33 (3%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.296N | P=0.565N |
|FISHER EXACT | P=0.958N P=0.666N P=0.666N | P=0.986N P=0.875N P=0.875N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/70 (47%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 20/70 (29%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 72.7% 0.0% 0.0% 0.0% | 54.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 0/0 | 1/10 (10%) 0/0 0/0 0/0 |
|TERMINAL (d) | 22/34 (65%) 0/0 0/0 0/0 | 17/33 (52%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) --- --- --- | 457 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.509N P=1.000N P=0.817N P=0.818N | P=0.905N (e) P=0.999N P=0.999N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.006N** |
|FISHER EXACT | P=0.535N P=0.003N** P=0.003N** | P=0.718N P=0.046N* P=0.046N* |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/70 (20%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 6/70 (9%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 29.4% 0.0% 0.0% 0.0% | 17.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 0/0 | 5/33 (15%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | 659 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.176N P=0.921N P=0.428N P=0.428N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.024N* | P=0.144N |
|FISHER EXACT | P=0.803N P=0.128N P=0.128N | P=0.915N P=0.436N P=0.436N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 6/70 (9%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 31.2% 0.0% 0.0% 0.0% | 17.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 4/34 (12%) 0/0 0/0 0/0 | 5/33 (15%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | 659 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.175N P=0.921N P=0.426N P=0.427N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.019N* | P=0.144N |
|FISHER EXACT | P=0.789N P=0.109N P=0.109N | P=0.915N P=0.436N P=0.436N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/70 (57%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 21/70 (30%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 78.0% 0.0% 0.0% 0.0% | 55.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 5/10 (50%) 0/0 0/0 0/0 | 1/10 (10%) 0/0 0/0 0/0 |
|TERMINAL (d) | 23/34 (68%) 0/0 0/0 0/0 | 17/33 (52%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | 457 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.222N P=0.951N P=0.490N P=0.490N | P=0.857N (e) P=0.997N P=0.997N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.004N** |
|FISHER EXACT | P=0.437N P<0.001N** P<0.001N** | P=0.704N P=0.038N* P=0.038N* |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/70 (57%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 21/70 (30%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 78.0% 0.0% 0.0% 0.0% | 55.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 5/10 (50%) 0/0 0/0 0/0 | 1/10 (10%) 0/0 0/0 0/0 |
|TERMINAL (d) | 23/34 (68%) 0/0 0/0 0/0 | 17/33 (52%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | 457 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.222N P=0.951N P=0.490N P=0.490N | P=0.857N (e) P=0.997N P=0.997N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.004N** |
|FISHER EXACT | P=0.437N P<0.001N** P<0.001N** | P=0.704N P=0.038N* P=0.038N* |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/70 (26%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 4/70 (6%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 39.4% 0.0% 0.0% 0.0% | 10.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 9/34 (26%) 0/0 0/0 0/0 | 3/33 (9%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- --- | 452 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.190N P=0.930N P=0.447N P=0.448N | P=0.732N (e) P=0.958N P=0.958N |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.230N |
|FISHER EXACT | P=0.746N P=0.065N P=0.065N | P=0.944N P=0.580N P=0.580N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/70 (13%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 1/70 (1%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 22.1% 0.0% 0.0% 0.0% | 3.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 5/34 (15%) 0/0 0/0 0/0 | 1/33 (3%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.578N P=1.000N P=0.868N P=0.869N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.074N | P=0.565N |
|FISHER EXACT | P=0.873N P=0.280N P=0.280N | P=0.986N P=0.875N P=0.875N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 5/70 (7%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 51.3% 0.0% 0.0% 0.0% | 13.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 4/10 (40%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 12/34 (35%) 0/0 0/0 0/0 | 4/33 (12%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- --- | 452 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.132N P=0.894N P=0.357N P=0.358N | P=0.769N (e) P=0.974N P=0.974N |
|COCHRAN-ARMITAGE | P=0.001N** | P=0.181N |
|FISHER EXACT | P=0.648N P=0.018N* P=0.018N* | P=0.930N P=0.503N P=0.503N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/66 (3%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | | 6.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | | 2/29 (7%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | | P=0.769N (e) (e) (e) |
|COCHRAN-ARMITAGE | | P=0.383N |
|FISHER EXACT | | P=0.970N P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/68 (0%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 5/68 (7%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 14.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 0/32 (0%) 0/0 0/0 0/0 | 4/33 (12%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 698 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.175N |
|FISHER EXACT | (e) (e) (e) | P=0.928N P=0.494N P=0.494N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 1/69 (1%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% 0.0% | 3.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 0/0 | 1/32 (3%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.296N | P=0.562N |
|FISHER EXACT | P=0.958N P=0.666N P=0.666N | P=0.986N P=0.873N P=0.873N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 0/70 (0%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 0/0 | 0/33 (0%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.565N P=0.998N P=0.854N P=0.854N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.395N | (e) |
|FISHER EXACT | P=0.972N P=0.764N P=0.764N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 0.0% | 7.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 1/10 (10%) 0/0 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 0/0 | 2/33 (6%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 691 --- --- --- | 456 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.999N (e) (e) (e) | P=0.694N (e) P=0.939N P=0.939N |
|COCHRAN-ARMITAGE | P=0.565N | P=0.296N |
|FISHER EXACT | P=0.986N P=0.875N P=0.875N | P=0.958N P=0.666N P=0.666N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 8.4% 0.0% 0.0% 0.0% | 9.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 2/34 (6%) 0/0 0/0 0/0 | 3/33 (9%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 730 --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.296N | P=0.296N |
|FISHER EXACT | P=0.958N P=0.666N P=0.666N | P=0.958N P=0.666N P=0.666N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 3/70 (4%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% 0.0% | 9.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 3/34 (9%) 0/0 0/0 0/0 | 3/33 (9%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.296N | P=0.296N |
|FISHER EXACT | P=0.958N P=0.666N P=0.666N | P=0.958N P=0.666N P=0.666N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 5/70 (7%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 17.0% 0.0% 0.0% 0.0% | 15.2% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 5/34 (15%) 0/0 0/0 0/0 | 5/33 (15%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 730 --- --- --- | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.144N | P=0.181N |
|FISHER EXACT | P=0.915N P=0.436N P=0.436N | P=0.930N P=0.503N P=0.503N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 9/70 (13%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 22.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 0/0 | 5/33 (15%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 452 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.690N (e) P=0.943N P=0.943N |
|COCHRAN-ARMITAGE | (e) | P=0.074N |
|FISHER EXACT | (e) (e) (e) | P=0.873N P=0.280N P=0.280N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 9/70 (13%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 22.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 0/34 (0%) 0/0 0/0 0/0 | 5/33 (15%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 452 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.690N (e) P=0.943N P=0.943N |
|COCHRAN-ARMITAGE | (e) | P=0.074N |
|FISHER EXACT | (e) (e) (e) | P=0.873N P=0.280N P=0.280N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 45/70 (64%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 29/70 (41%) 0/1 (0%) 0/10 (0%) 1/10 (10%) |
|ADJUSTED (b) | 86.2% 0.0% 0.0% 0.0% | 71.3% 0.0% 0.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 6/10 (60%) 0/0 0/0 0/0 | 3/10 (30%) 0/0 0/0 0/0 |
|TERMINAL (d) | 27/34 (79%) 0/0 0/0 0/0 | 22/33 (67%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- --- | 452 --- --- 97 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.314 (e) (e) P=0.450 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.314 (e) (e) P=0.450 |
|LOGISTIC REGRESSION | P=0.223N P=0.951N P=0.491N P=0.492N | P=0.434 P=0.999N P=0.782N P=0.498 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.002N** |
|FISHER EXACT | P=0.366N P<0.001N** P<0.001N** | P=0.592N P=0.008N** P=0.052N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 23/70 (33%) 0/1 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 50.7% 0.0% 0.0% 0.0% | 54.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 3/10 (30%) 0/0 0/0 0/0 | 0/10 (0%) 0/0 0/0 0/0 |
|TERMINAL (d) | 11/34 (32%) 0/0 0/0 0/0 | 14/33 (42%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 456 (I) --- --- --- | 452 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.157N P=0.912N P=0.397N P=0.397N | P=0.722N (e) P=0.965N P=0.965N |
|COCHRAN-ARMITAGE | P=0.001N** | P=0.002N** |
|FISHER EXACT | P=0.648N P=0.018N* P=0.018N* | P=0.676N P=0.026N* P=0.026N* |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | 3 SSAC 3 SSAC 3 SSAC 3 SSAC | 3 SSAC 3 SSAC 3 SSAC 3 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/70 (70%) 0/1 (0%) 0/10 (0%) 0/10 (0%) | 38/70 (54%) 0/1 (0%) 0/10 (0%) 1/10 (10%) |
|ADJUSTED (b) | 88.9% 0.0% 0.0% 0.0% | 84.0% 0.0% 0.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/3 (0%) 0/2 (0%) | 0/1 (0%) 0/1 (0%) 0/1 (0%) 0/3 (0%) |
|INTERIM SACRIFICE 2 (c)| 7/10 (70%) 0/0 0/0 0/0 | 3/10 (30%) 0/0 0/0 0/0 |
|TERMINAL (d) | 28/34 (82%) 0/0 0/0 0/0 | 26/33 (79%) 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 455 (I) --- --- --- | 452 --- --- 97 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.314 (e) (e) P=0.450 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.314 (e) (e) P=0.450 |
|LOGISTIC REGRESSION | P=0.162N P=0.916N P=0.402N P=0.403N | P=0.304 (e) P=0.889N P=0.390 |
|COCHRAN-ARMITAGE | P<0.001N** | P<0.001N** |
|FISHER EXACT | P=0.310N P<0.001N** P<0.001N** | P=0.465N P<0.001N** P=0.009N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 102 455
Female interim sacrifices(days): 102 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:20:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY LOW DOSE GROUPS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 003 VEHICLE CONTROL
INCLUDE 009 0.0100%
INCLUDE 011 0.0100%
INCLUDE 013 0.00500%
INCLUDE 015 0.00500%
INCLUDE 025 0.00700%
INCLUDE 027 0.00700%
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:20:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:20:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Islets, Pancreatic Carcinoma or Adenoma
Ovary Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
====================================================================================================
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 4/60 (7%) 4/60 (7%) 4/60 (7%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 13.9% 13.9% 12.4% 11.2% | 0.0% 0.0% 0.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 2/23 (9%) 2/28 (7%) 3/34 (9%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 681 652 682 727 | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.433N P=0.598 P=0.599N P=0.497N | P=0.299 (e) (e) P=0.512 |
|INCIDENTAL TUMOR | P=0.414N P=0.523N P=0.526N P=0.487N | P=0.299 (e) (e) P=0.512 |
|LOGISTIC REGRESSION | P=0.412N P=0.532N P=0.543N P=0.483N | P=0.299 (e) (e) P=0.512 |
|COCHRAN-ARMITAGE | P=0.418N | P=0.291 |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 3/60 (5%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 3.2% 8.9% 2.9% | 3.0% 3.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/23 (0%) 1/28 (4%) 1/34 (3%) | 1/33 (3%) 1/32 (3%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 727 668 733 (T) | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.309N P=0.435N P=0.583 P=0.304N | P=0.244N P=0.755 P=0.512N P=0.488N |
|INCIDENTAL TUMOR | P=0.291N P=0.347N P=0.643 P=0.304N | P=0.244N P=0.755 P=0.512N P=0.488N |
|LOGISTIC REGRESSION | P=0.292N P=0.365N P=0.632 P=0.304N | P=0.244N P=0.755 P=0.512N P=0.488N |
|COCHRAN-ARMITAGE | P=0.293N | P=0.247N |
|FISHER EXACT | P=0.309N P=0.660N P=0.309N | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 1/60 (2%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 8.8% 3.2% 10.8% 2.9% | 3.0% 3.1% 3.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/23 (0%) 1/28 (4%) 1/34 (3%) | 1/33 (3%) 1/32 (3%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 727 522 733 (T) | 733 (T) 733 (T) 730 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.367N P=0.435N P=0.423 P=0.304N | P=0.618N P=0.755 P=0.750 P=0.749N |
|INCIDENTAL TUMOR | P=0.376N P=0.347N P=0.532 P=0.304N | P=0.615N P=0.755 P=0.753 P=0.749N |
|LOGISTIC REGRESSION | P=0.351N P=0.365N P=0.486 P=0.304N | P=0.600N P=0.755 P=0.763 P=0.749N |
|COCHRAN-ARMITAGE | P=0.354N | P=0.635 |
|FISHER EXACT | P=0.309N P=0.500 P=0.309N | P=0.752N P=0.752N P=0.752N |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 8.4% 3.4% 7.2% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/23 (0%) 0/28 (0%) 1/34 (3%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 565 730 581 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304 P=0.251 P=0.711 P=0.318 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.299 P=0.410 P=0.754N P=0.316 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.296 P=0.301 P=0.733 P=0.309 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.293 | (e) |
|FISHER EXACT | P=0.309 P=0.752N P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.9% 3.4% 7.2% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 0/28 (0%) 1/34 (3%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 565 730 581 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107 P=0.234 P=0.451 P=0.131 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.088 P=0.337 P=0.552 P=0.130 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.096 P=0.240 P=0.477 P=0.121 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.096 | (e) |
|FISHER EXACT | P=0.248 P=0.500 P=0.122 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 2/58 (3%) |
|ADJUSTED (b) | 0.0% 4.3% 3.0% 2.2% | 0.0% 0.0% 3.2% 4.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/23 (4%) 0/28 (0%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 1/31 (3%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 723 677 | --- --- 733 (T) 669 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.325 P=0.422 P=0.472 P=0.519 | P=0.111 (e) P=0.488 P=0.264 |
|INCIDENTAL TUMOR | P=0.314 P=0.422 P=0.552 P=0.519 | P=0.113 (e) P=0.488 P=0.280 |
|LOGISTIC REGRESSION | P=0.320 P=0.422 P=0.485 P=0.501 | P=0.101 (e) P=0.488 P=0.236 |
|COCHRAN-ARMITAGE | P=0.316 | P=0.097 |
|FISHER EXACT | P=0.500 P=0.500 P=0.500 | (e) P=0.496 P=0.239 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 3/58 (5%) |
|ADJUSTED (b) | 0.0% 4.3% 6.1% 2.2% | 0.0% 0.0% 3.2% 7.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/23 (4%) 0/28 (0%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 1/31 (3%) 1/33 (3%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 723 677 | --- --- 733 (T) 669 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275 P=0.422 P=0.206 P=0.519 | P=0.047 * (e) P=0.488 P=0.137 |
|INCIDENTAL TUMOR | P=0.260 P=0.422 P=0.295 P=0.519 | P=0.048 * (e) P=0.488 P=0.144 |
|LOGISTIC REGRESSION | P=0.271 P=0.422 P=0.219 P=0.501 | P=0.043 * (e) P=0.488 P=0.123 |
|COCHRAN-ARMITAGE | P=0.267 | P=0.039 * |
|FISHER EXACT | P=0.500 P=0.248 P=0.500 | (e) P=0.496 P=0.116 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 2/60 (3%) 4/60 (7%) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 3.7% 5.7% 9.8% | 3.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/23 (0%) 0/28 (0%) 1/34 (3%) | 1/33 (3%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 732 638 618 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120 P=0.690 P=0.447 P=0.191 | P=0.204N P=0.506N P=0.512N P=0.488N |
|INCIDENTAL TUMOR | P=0.104 P=0.736N P=0.546 P=0.194 | P=0.204N P=0.506N P=0.512N P=0.488N |
|LOGISTIC REGRESSION | P=0.112 P=0.716 P=0.488 P=0.185 | P=0.204N P=0.506N P=0.512N P=0.488N |
|COCHRAN-ARMITAGE | P=0.108 | P=0.204N |
|FISHER EXACT | P=0.752N P=0.500 P=0.182 | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 6.3% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 1/28 (4%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 691 --- 698 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.497N P=0.510N P=0.459 P=0.490N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.492N P=0.362N P=0.539 P=0.481N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.498N P=0.504N P=0.485 P=0.498N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.500N | (e) |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/60 (55%) 34/60 (57%) 29/60 (48%) 23/60 (38%) | 20/60 (33%) 14/60 (23%) 19/60 (32%) 22/60 (37%) |
|ADJUSTED (b) | 72.7% 89.2% 75.7% 57.0% | 54.6% 40.9% 53.2% 51.9% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 22/34 (65%) 19/23 (83%) 19/28 (68%) 17/34 (50%) | 17/33 (52%) 12/32 (38%) 15/31 (48%) 15/35 (43%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 559 562 638 | 457 (I) 717 552 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067N P=0.062 P=0.509 P=0.055N | P=0.450 P=0.159N P=0.581 P=0.531 |
|INCIDENTAL TUMOR | P=0.025N* P=0.400 P=0.380N P=0.034N* | P=0.437 P=0.131N P=0.487N P=0.471 |
|LOGISTIC REGRESSION | P=0.020N* P=0.441 P=0.343N P=0.032N* | P=0.497 P=0.115N P=0.488N P=0.559 |
|COCHRAN-ARMITAGE | P=0.041N* | P=0.380 |
|FISHER EXACT | P=0.500 P=0.292N P=0.050N* | P=0.156N P=0.500N P=0.424 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 16/60 (27%) 13/60 (22%) 16/60 (27%) | 6/60 (10%) 11/60 (18%) 7/60 (12%) 6/60 (10%) |
|ADJUSTED (b) | 29.4% 40.8% 31.8% 34.9% | 17.2% 26.6% 19.5% 15.1% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 4/23 (17%) 4/28 (14%) 6/34 (18%) | 5/33 (15%) 4/32 (13%) 4/31 (13%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 490 455 (I) | 659 585 589 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.446 P=0.269 P=0.548 P=0.446 | P=0.478N P=0.160 P=0.468 P=0.571N |
|INCIDENTAL TUMOR | P=0.445 P=0.478N P=0.316N P=0.369 | P=0.514N P=0.235 P=0.514 P=0.582N |
|LOGISTIC REGRESSION | P=0.427 P=0.490 P=0.404N P=0.376 | P=0.493N P=0.159 P=0.505 P=0.581N |
|COCHRAN-ARMITAGE | P=0.435 | P=0.532N |
|FISHER EXACT | P=0.417 P=0.500N P=0.417 | P=0.148 P=0.500 P=0.619N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 16/60 (27%) 14/60 (23%) 16/60 (27%) | 6/60 (10%) 11/60 (18%) 7/60 (12%) 6/60 (10%) |
|ADJUSTED (b) | 31.2% 40.8% 33.7% 34.9% | 17.2% 26.6% 19.5% 15.1% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 4/23 (17%) 4/28 (14%) 6/34 (18%) | 5/33 (15%) 4/32 (13%) 4/31 (13%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 490 455 (I) | 659 585 589 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.504 P=0.336 P=0.540 P=0.522 | P=0.478N P=0.160 P=0.468 P=0.571N |
|INCIDENTAL TUMOR | P=0.519 P=0.363N P=0.296N P=0.461 | P=0.514N P=0.235 P=0.514 P=0.582N |
|LOGISTIC REGRESSION | P=0.496 P=0.583 P=0.396N P=0.462 | P=0.493N P=0.159 P=0.505 P=0.581N |
|COCHRAN-ARMITAGE | P=0.500 | P=0.532N |
|FISHER EXACT | P=0.500 P=0.500N P=0.500 | P=0.148 P=0.500 P=0.619N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 40/60 (67%) 38/60 (63%) 34/60 (57%) | 21/60 (35%) 21/60 (35%) 22/60 (37%) 24/60 (40%) |
|ADJUSTED (b) | 78.0% 90.7% 84.1% 71.8% | 55.8% 52.8% 58.4% 55.0% |
|INTERIM SACRIFICE 1 (c)| 5/10 (50%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/34 (68%) 19/23 (83%) 21/28 (75%) 21/34 (62%) | 17/33 (52%) 14/32 (44%) 16/31 (52%) 16/35 (46%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 490 455 (I) | 457 (I) 585 552 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234N P=0.102 P=0.356 P=0.207N | P=0.409 P=0.554 P=0.420 P=0.463 |
|INCIDENTAL TUMOR | P=0.126N P=0.539N P=0.401N P=0.174N | P=0.361 P=0.464N P=0.543 P=0.392 |
|LOGISTIC REGRESSION | P=0.121N P=0.546 P=0.472N P=0.149N | P=0.417 P=0.531N P=0.513 P=0.461 |
|COCHRAN-ARMITAGE | P=0.156N | P=0.323 |
|FISHER EXACT | P=0.577N P=0.424N P=0.174N | P=0.576N P=0.500 P=0.353 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 40/60 (67%) 38/60 (63%) 34/60 (57%) | 21/60 (35%) 21/60 (35%) 22/60 (37%) 24/60 (40%) |
|ADJUSTED (b) | 78.0% 90.7% 84.1% 71.8% | 55.8% 52.8% 58.4% 55.0% |
|INTERIM SACRIFICE 1 (c)| 5/10 (50%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/34 (68%) 19/23 (83%) 21/28 (75%) 21/34 (62%) | 17/33 (52%) 14/32 (44%) 16/31 (52%) 16/35 (46%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 490 455 (I) | 457 (I) 585 552 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234N P=0.102 P=0.356 P=0.207N | P=0.409 P=0.554 P=0.420 P=0.463 |
|INCIDENTAL TUMOR | P=0.126N P=0.539N P=0.401N P=0.174N | P=0.361 P=0.464N P=0.543 P=0.392 |
|LOGISTIC REGRESSION | P=0.121N P=0.546 P=0.472N P=0.149N | P=0.417 P=0.531N P=0.513 P=0.461 |
|COCHRAN-ARMITAGE | P=0.156N | P=0.323 |
|FISHER EXACT | P=0.577N P=0.424N P=0.174N | P=0.576N P=0.500 P=0.353 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/60 (30%) 12/60 (20%) 10/60 (17%) 11/60 (18%) | 4/60 (7%) 3/60 (5%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 39.4% 38.5% 29.4% 31.1% | 10.6% 9.4% 15.3% 5.7% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/10 (20%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 9/34 (26%) 6/23 (26%) 6/28 (21%) 10/34 (29%) | 3/33 (9%) 3/32 (9%) 4/31 (13%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 548 691 | 452 733 (T) 708 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.068N P=0.388N P=0.150N P=0.106N | P=0.344N P=0.514N P=0.473 P=0.315N |
|INCIDENTAL TUMOR | P=0.053N P=0.178N P=0.059N P=0.134N | P=0.363N P=0.610N P=0.424 P=0.337N |
|LOGISTIC REGRESSION | P=0.048N* P=0.147N P=0.067N P=0.096N | P=0.329N P=0.487N P=0.504 P=0.319N |
|COCHRAN-ARMITAGE | P=0.050N* | P=0.367N |
|FISHER EXACT | P=0.146N P=0.065N P=0.100N | P=0.500N P=0.500 P=0.340N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 9/60 (15%) 2/60 (3%) 7/60 (12%) | 1/60 (2%) 2/60 (3%) 6/60 (10%) 2/60 (3%) |
|ADJUSTED (b) | 22.1% 25.8% 7.1% 17.3% | 3.0% 6.3% 17.1% 5.7% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/34 (15%) 2/23 (9%) 2/28 (7%) 4/34 (12%) | 1/33 (3%) 2/32 (6%) 4/31 (13%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 490 733 (T) 562 | 733 (T) 733 (T) 622 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.188N P=0.422 P=0.052N P=0.381N | P=0.242 P=0.489 P=0.054 P=0.521 |
|INCIDENTAL TUMOR | P=0.168N P=0.457N P=0.035N* P=0.380N | P=0.230 P=0.489 P=0.071 P=0.521 |
|LOGISTIC REGRESSION | P=0.167N P=0.591 P=0.031N* P=0.388N | P=0.252 P=0.489 P=0.059 P=0.521 |
|COCHRAN-ARMITAGE | P=0.170N | P=0.223 |
|FISHER EXACT | P=0.601N P=0.027N* P=0.395N | P=0.500 P=0.057 P=0.500 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 21/60 (35%) 12/60 (20%) 17/60 (28%) | 5/60 (8%) 5/60 (8%) 10/60 (17%) 3/60 (5%) |
|ADJUSTED (b) | 51.3% 56.2% 35.8% 43.5% | 13.6% 15.6% 28.4% 8.6% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 2/10 (20%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 12/34 (35%) 8/23 (35%) 8/28 (29%) 13/34 (38%) | 4/33 (12%) 5/32 (16%) 7/31 (23%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 548 562 | 452 733 (T) 622 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* P=0.499 P=0.042N* P=0.102N | P=0.491N P=0.614 P=0.117 P=0.328N |
|INCIDENTAL TUMOR | P=0.026N* P=0.210N P=0.008N** P=0.111N | P=0.512N P=0.536 P=0.116 P=0.347N |
|LOGISTIC REGRESSION | P=0.024N* P=0.291N P=0.009N** P=0.087N | P=0.471N P=0.613N P=0.134 P=0.325N |
|COCHRAN-ARMITAGE | P=0.026N* | P=0.524N |
|FISHER EXACT | P=0.287N P=0.009N** P=0.090N | P=0.628N P=0.135 P=0.359N |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/56 (4%) 0/56 (0%) 0/55 (0%) 0/58 (0%) |
|ADJUSTED (b) | | 6.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/29 (7%) 0/28 (0%) 0/28 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.046N* P=0.246N P=0.246N P=0.210N |
|INCIDENTAL TUMOR | | P=0.046N* P=0.246N P=0.246N P=0.210N |
|LOGISTIC REGRESSION | | P=0.046N* P=0.244N P=0.246N P=0.210N |
|COCHRAN-ARMITAGE | | P=0.048N* |
|FISHER EXACT | | P=0.248N P=0.252N P=0.239N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/55 (0%) 0/59 (0%) 0/59 (0%) | 5/58 (9%) 11/60 (18%) 8/59 (14%) 4/57 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 14.6% 29.6% 24.8% 12.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/20 (0%) 0/28 (0%) 0/33 (0%) | 4/33 (12%) 7/32 (22%) 7/31 (23%) 4/33 (12%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 698 397 717 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.480N P=0.090 P=0.246 P=0.489N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.488N P=0.071 P=0.252 P=0.484N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.430N P=0.118 P=0.275 P=0.451N |
|COCHRAN-ARMITAGE | (e) | P=0.500N |
|FISHER EXACT | (e) (e) (e) | P=0.101 P=0.290 P=0.511N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.1% 0.0% | 0.0% 0.0% 4.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 0/28 (0%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 --- | --- --- 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.600 (e) P=0.466 (e) | P=0.480 (e) P=0.245 (e) |
|INCIDENTAL TUMOR | P=0.631 (e) P=0.552 (e) | P=0.451 (e) P=0.329 (e) |
|LOGISTIC REGRESSION | P=0.607 (e) P=0.482 (e) | P=0.449 (e) P=0.235 (e) |
|COCHRAN-ARMITAGE | P=0.608 | P=0.461 |
|FISHER EXACT | (e) P=0.500 (e) | (e) P=0.248 (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.1% 0.0% | 3.0% 0.0% 4.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 0/28 (0%) 0/34 (0%) | 1/33 (3%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 --- | 733 (T) --- 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.600 (e) P=0.466 (e) | P=0.482N P=0.506N P=0.498 P=0.488N |
|INCIDENTAL TUMOR | P=0.631 (e) P=0.552 (e) | P=0.501N P=0.506N P=0.587 P=0.488N |
|LOGISTIC REGRESSION | P=0.607 (e) P=0.482 (e) | P=0.500N P=0.506N P=0.501 P=0.488N |
|COCHRAN-ARMITAGE | P=0.608 | P=0.500N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.1% 0.0% | 3.0% 0.0% 4.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 0/28 (0%) 0/34 (0%) | 1/33 (3%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 --- | 733 (T) --- 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.600 (e) P=0.466 (e) | P=0.482N P=0.506N P=0.498 P=0.488N |
|INCIDENTAL TUMOR | P=0.631 (e) P=0.552 (e) | P=0.501N P=0.506N P=0.587 P=0.488N |
|LOGISTIC REGRESSION | P=0.607 (e) P=0.482 (e) | P=0.500N P=0.506N P=0.501 P=0.488N |
|COCHRAN-ARMITAGE | P=0.608 | P=0.500N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 4.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 0/28 (0%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 579 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.593N P=0.256 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.635N P=0.343 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.617N P=0.237 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.615N |
|FISHER EXACT | (e) (e) (e) | P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 1/59 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 5.6% 2.1% | 3.1% 0.0% 3.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/23 (0%) 1/28 (4%) 0/34 (0%) | 1/32 (3%) 0/32 (0%) 1/31 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 562 618 | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240N P=0.197N P=0.568N P=0.303N | P=0.372N P=0.500N P=0.755 P=0.482N |
|INCIDENTAL TUMOR | P=0.231N P=0.197N P=0.540N P=0.307N | P=0.372N P=0.500N P=0.755 P=0.482N |
|LOGISTIC REGRESSION | P=0.229N P=0.197N P=0.515N P=0.299N | P=0.372N P=0.500N P=0.755 P=0.482N |
|COCHRAN-ARMITAGE | P=0.230N | P=0.381N |
|FISHER EXACT | P=0.122N P=0.500N P=0.309N | P=0.496N P=0.748N P=0.496N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.2% 0.0% 3.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 1/28 (4%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 0/31 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 456 (I) --- 733 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140N P=0.245N P=0.534N P=0.234N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.128N P=0.166N P=0.492N P=0.229N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.132N P=0.231N P=0.493N P=0.244N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.132N | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 2/60 (3%) | |
|ADJUSTED (b) | 2.4% 4.3% 0.0% 5.4% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | |
|TERMINAL (d) | 0/34 (0%) 1/23 (4%) 0/28 (0%) 1/34 (3%) | |
|FIRST INCIDENCE (DAYS) | 671 733 (T) --- 698 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.476 P=0.718 P=0.515N P=0.514 | |
|INCIDENTAL TUMOR | P=0.477 P=0.736N P=0.448N P=0.522 | |
|LOGISTIC REGRESSION | P=0.476 P=0.756 P=0.502N P=0.506 | |
|COCHRAN-ARMITAGE | P=0.472 | |
|FISHER EXACT | P=0.752N P=0.500N P=0.500 | |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 0/51 (0%) 0/53 (0%) 0/56 (0%) | 1/58 (2%) 1/57 (2%) 2/58 (3%) 0/57 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.0% 2.1% 6.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/20 (0%) 0/24 (0%) 0/32 (0%) | 1/33 (3%) 0/31 (0%) 1/31 (3%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 733 (T) 564 730 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.466N P=0.758N P=0.482 P=0.506N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.468N P=0.643N P=0.472 P=0.506N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.472N P=0.759 P=0.497 P=0.506N |
|COCHRAN-ARMITAGE | (e) | P=0.476N |
|FISHER EXACT | (e) (e) (e) | P=0.748 P=0.500 P=0.504N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) 1/60 (2%) 1/59 (2%) | 3/60 (5%) 1/59 (2%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 2.5% 9.1% 3.6% 3.0% | 7.7% 3.2% 0.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/22 (9%) 1/28 (4%) 1/33 (3%) | 2/33 (6%) 1/31 (3%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 691 733 (T) 733 (T) 733 (T) | 456 (I) 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.603N P=0.394 P=0.727 P=0.758N | P=0.107N P=0.323N P=0.137N P=0.291N |
|INCIDENTAL TUMOR | P=0.604N P=0.477 P=0.754N P=0.753N | P=0.107N P=0.323N P=0.137N P=0.291N |
|LOGISTIC REGRESSION | P=0.600N P=0.471 P=0.752 P=0.762N | P=0.103N P=0.308N P=0.121N P=0.301N |
|COCHRAN-ARMITAGE | P=0.602N | P=0.107N |
|FISHER EXACT | P=0.494 P=0.752N P=0.748 | P=0.316N P=0.122N P=0.309N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) 1/60 (2%) 1/59 (2%) | 3/60 (5%) 1/59 (2%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 2.5% 9.1% 3.6% 3.0% | 7.7% 3.2% 0.0% 5.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/22 (9%) 1/28 (4%) 1/33 (3%) | 2/33 (6%) 1/31 (3%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 691 733 (T) 733 (T) 733 (T) | 456 (I) 733 (T) --- 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.603N P=0.394 P=0.727 P=0.758N | P=0.256N P=0.323N P=0.137N P=0.467N |
|INCIDENTAL TUMOR | P=0.604N P=0.477 P=0.754N P=0.753N | P=0.255N P=0.323N P=0.137N P=0.466N |
|LOGISTIC REGRESSION | P=0.600N P=0.471 P=0.752 P=0.762N | P=0.255N P=0.308N P=0.121N P=0.488N |
|COCHRAN-ARMITAGE | P=0.602N | P=0.266N |
|FISHER EXACT | P=0.494 P=0.752N P=0.748 | P=0.316N P=0.122N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 3/60 (5%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | | 0.0% 8.5% 0.0% 5.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/33 (0%) 2/32 (6%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 648 --- 731 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.286 P=0.119 (e) P=0.259 |
|INCIDENTAL TUMOR | | P=0.293 P=0.125 (e) P=0.269 |
|LOGISTIC REGRESSION | | P=0.288 P=0.126 (e) P=0.270 |
|COCHRAN-ARMITAGE | | P=0.267 |
|FISHER EXACT | | P=0.122 (e) P=0.248 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 4/60 (7%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | | 0.0% 10.7% 0.0% 5.4% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/33 (0%) 2/32 (6%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 648 --- 731 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.329 P=0.065 (e) P=0.259 |
|INCIDENTAL TUMOR | | P=0.338 P=0.068 (e) P=0.269 |
|LOGISTIC REGRESSION | | P=0.324 P=0.066 (e) P=0.270 |
|COCHRAN-ARMITAGE | | P=0.305 |
|FISHER EXACT | | P=0.059 (e) P=0.248 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 5/60 (8%) 0/60 (0%) 0/60 (0%) | 3/60 (5%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 8.4% 14.0% 0.0% 0.0% | 9.1% 0.0% 0.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/34 (6%) 1/23 (4%) 0/28 (0%) 0/34 (0%) | 3/33 (9%) 0/32 (0%) 0/31 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 730 457 (I) --- --- | 733 (T) --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.062N P=0.254 P=0.163N P=0.125N | P=0.092N P=0.126N P=0.132N P=0.284N |
|INCIDENTAL TUMOR | P=0.045N* P=0.463 P=0.129N P=0.117N | P=0.092N P=0.126N P=0.132N P=0.284N |
|LOGISTIC REGRESSION | P=0.052N P=0.350 P=0.146N P=0.118N | P=0.092N P=0.126N P=0.132N P=0.284N |
|COCHRAN-ARMITAGE | P=0.052N | P=0.094N |
|FISHER EXACT | P=0.359 P=0.122N P=0.122N | P=0.122N P=0.122N P=0.309N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 4/60 (7%) 5/60 (8%) | 3/60 (5%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 8.7% 11.0% 12.6% | 9.1% 0.0% 3.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/23 (0%) 1/28 (4%) 2/34 (6%) | 3/33 (9%) 0/32 (0%) 1/31 (3%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 686 562 618 | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291 P=0.546 P=0.422 P=0.366 | P=0.041N* P=0.126N P=0.327N P=0.110N |
|INCIDENTAL TUMOR | P=0.287 P=0.600N P=0.512 P=0.371 | P=0.041N* P=0.126N P=0.327N P=0.110N |
|LOGISTIC REGRESSION | P=0.284 P=0.638 P=0.485 P=0.369 | P=0.041N* P=0.126N P=0.327N P=0.110N |
|COCHRAN-ARMITAGE | P=0.279 | P=0.042N* |
|FISHER EXACT | P=0.660N P=0.500 P=0.359 | P=0.122N P=0.309N P=0.122N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 8/60 (13%) 4/60 (7%) 5/60 (8%) | 5/60 (8%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 17.0% 21.7% 11.0% 12.6% | 15.2% 0.0% 3.2% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/34 (15%) 1/23 (4%) 1/28 (4%) 2/34 (6%) | 5/33 (15%) 0/32 (0%) 1/31 (3%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 730 457 (I) 562 618 | 733 (T) --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.370N P=0.240 P=0.477N P=0.496N | P=0.021N* P=0.035N* P=0.116N P=0.089N |
|INCIDENTAL TUMOR | P=0.336N P=0.521 P=0.368N P=0.482N | P=0.021N* P=0.035N* P=0.116N P=0.089N |
|LOGISTIC REGRESSION | P=0.354N P=0.368 P=0.395N P=0.482N | P=0.021N* P=0.035N* P=0.116N P=0.089N |
|COCHRAN-ARMITAGE | P=0.359N | P=0.023N* |
|FISHER EXACT | P=0.389 P=0.372N P=0.500N | P=0.029N* P=0.103N P=0.103N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 3.6% 0.0% | 0.0% 0.0% 5.5% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/23 (0%) 1/28 (4%) 0/34 (0%) | 0/33 (0%) 0/32 (0%) 1/31 (3%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | --- --- 640 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.599 (e) P=0.461 (e) | P=0.225 (e) P=0.233 P=0.512 |
|INCIDENTAL TUMOR | P=0.599 (e) P=0.461 (e) | P=0.188 (e) P=0.321 P=0.512 |
|LOGISTIC REGRESSION | P=0.599 (e) P=0.461 (e) | P=0.223 (e) P=0.239 P=0.512 |
|COCHRAN-ARMITAGE | P=0.608 | P=0.212 |
|FISHER EXACT | (e) P=0.500 (e) | (e) P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 5/60 (8%) 4/60 (7%) 3/60 (5%) | 9/60 (15%) 6/60 (10%) 15/60 (25%) 6/60 (10%) |
|ADJUSTED (b) | 0.0% 15.5% 11.7% 8.1% | 22.9% 17.2% 39.3% 16.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/23 (9%) 2/28 (7%) 2/34 (6%) | 5/33 (15%) 4/32 (13%) 9/31 (29%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | --- 631 601 691 | 452 698 533 681 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.131 P=0.022 * P=0.052 P=0.126 | P=0.438N P=0.302N P=0.120 P=0.250N |
|INCIDENTAL TUMOR | P=0.123 P=0.035 * P=0.071 P=0.129 | P=0.463N P=0.332N P=0.107 P=0.239N |
|LOGISTIC REGRESSION | P=0.122 P=0.032 * P=0.060 P=0.125 | P=0.432N P=0.269N P=0.126 P=0.247N |
|COCHRAN-ARMITAGE | P=0.119 | P=0.490N |
|FISHER EXACT | P=0.029 * P=0.059 P=0.122 | P=0.291N P=0.127 P=0.291N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 5/60 (8%) 3/60 (5%) 3/60 (5%) | 9/60 (15%) 6/60 (10%) 13/60 (22%) 5/60 (8%) |
|ADJUSTED (b) | 0.0% 15.5% 8.3% 8.1% | 22.9% 17.2% 35.0% 13.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/23 (9%) 1/28 (4%) 2/34 (6%) | 5/33 (15%) 4/32 (13%) 8/31 (26%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | --- 631 601 691 | 452 698 533 681 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.148 P=0.022 * P=0.108 P=0.126 | P=0.300N P=0.302N P=0.223 P=0.168N |
|INCIDENTAL TUMOR | P=0.139 P=0.035 * P=0.147 P=0.129 | P=0.312N P=0.332N P=0.187 P=0.157N |
|LOGISTIC REGRESSION | P=0.138 P=0.032 * P=0.119 P=0.125 | P=0.288N P=0.269N P=0.241 P=0.165N |
|COCHRAN-ARMITAGE | P=0.135 | P=0.340N |
|FISHER EXACT | P=0.029 * P=0.122 P=0.122 | P=0.291N P=0.240 P=0.197N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 45/60 (75%) 41/60 (68%) 35/60 (58%) 32/60 (53%) | 29/60 (48%) 28/60 (47%) 27/60 (45%) 28/60 (47%) |
|ADJUSTED (b) | 86.2% 97.5% 85.1% 74.2% | 71.3% 71.2% 70.6% 64.8% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 3/10 (30%) 0/10 (0%) 0/10 (0%) | 3/10 (30%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 27/34 (79%) 22/23 (96%) 22/28 (79%) 23/34 (68%) | 22/33 (67%) 21/32 (66%) 20/31 (65%) 20/35 (57%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 548 638 | 452 397 552 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021N* P=0.170 P=0.313N P=0.024N* | P=0.339N P=0.535N P=0.529N P=0.371N |
|INCIDENTAL TUMOR | P=0.002N** P=0.408N P=0.049N* P=0.010N** | P=0.346N P=0.556N P=0.468N P=0.423N |
|LOGISTIC REGRESSION | P=0.002N** P=0.286N P=0.041N* P=0.006N** | P=0.294N P=0.439N P=0.404N P=0.364N |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.436N |
|FISHER EXACT | P=0.272N P=0.040N* P=0.011N* | P=0.500N P=0.427N P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.00500% 0.00700% 0.0100% | VEHICLE 0.00500% 0.00700% 0.0100% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 29/60 (48%) 26/60 (43%) 29/60 (48%) | 23/60 (38%) 21/60 (35%) 30/60 (50%) 16/60 (27%) |
|ADJUSTED (b) | 50.7% 62.7% 56.0% 57.6% | 54.1% 48.1% 65.6% 38.8% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 1/10 (10%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/34 (32%) 7/23 (30%) 9/28 (32%) 13/34 (38%) | 14/33 (42%) 10/32 (31%) 16/31 (52%) 11/35 (31%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 490 455 (I) | 452 579 211 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.343 P=0.129 P=0.331 P=0.354 | P=0.213N P=0.441N P=0.135 P=0.089N |
|INCIDENTAL TUMOR | P=0.284 P=0.554N P=0.444N P=0.255 | P=0.226N P=0.279N P=0.180 P=0.073N |
|LOGISTIC REGRESSION | P=0.279 P=0.380 P=0.530N P=0.253 | P=0.202N P=0.326N P=0.134 P=0.074N |
|COCHRAN-ARMITAGE | P=0.297 | P=0.261N |
|FISHER EXACT | P=0.291 P=0.500 P=0.291 | P=0.425N P=0.135 P=0.121N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/60 (82%) 52/60 (87%) 45/60 (75%) 42/60 (70%) | 38/60 (63%) 40/60 (67%) 43/60 (72%) 35/60 (58%) |
|ADJUSTED (b) | 88.9% 100.0% 91.8% 83.8% | 84.0% 86.8% 89.3% 75.8% |
|INTERIM SACRIFICE 1 (c)| 7/10 (70%) 3/10 (30%) 0/10 (0%) 1/10 (10%) | 3/10 (30%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 28/34 (82%) 23/23 (100%) 24/28 (86%) 26/34 (76%) | 26/33 (79%) 26/32 (81%) 26/31 (84%) 24/35 (69%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 490 455 (I) | 452 397 211 385 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.174N P=0.028 * P=0.419 P=0.166N | P=0.317N P=0.403 P=0.179 P=0.229N |
|INCIDENTAL TUMOR | P=0.032N* P=0.305 P=0.189N P=0.090N | P=0.359N P=0.517 P=0.280 P=0.210N |
|LOGISTIC REGRESSION | P=0.031N* P=0.274 P=0.224N P=0.083N | P=0.290N P=0.509 P=0.210 P=0.198N |
|COCHRAN-ARMITAGE | P=0.058N | P=0.434N |
|FISHER EXACT | P=0.309 P=0.253N P=0.100N | P=0.424 P=0.218 P=0.354N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 455
Female interim sacrifices(days): 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:22:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY HIGH DOSE GROUPS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 003 VEHICLE CONTROL
INCLUDE 005 0.0200%
INCLUDE 007 0.0200%
INCLUDE 017 0.0275%
INCLUDE 019 0.0275%
INCLUDE 021 0.0140%
INCLUDE 023 0.0140%
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:22:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst CHLORAMINE DATE: 09/21/94
EXPERIMENT: 05089 TEST: 02 TIME: 15:22:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: 56382B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 10599903
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Spleen Hemangiosarcoma
All Organs Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Uterus Polyp Stromal
All Organs Hemangiosarcoma
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 2/60 (3%) 1/60 (2%) 6/60 (10%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 13.9% 5.7% 2.7% 18.0% | 0.0% 0.0% 2.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 2/35 (6%) 1/37 (3%) 5/32 (16%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 681 733 (T) 733 (T) 702 | --- --- 647 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563N P=0.208N P=0.089N P=0.464 | P=0.603 (e) P=0.527 (e) |
|INCIDENTAL TUMOR | P=0.563N P=0.220N P=0.101N P=0.477 | P=0.561 (e) P=0.419 (e) |
|LOGISTIC REGRESSION | P=0.562N P=0.218N P=0.093N P=0.471 | P=0.593 (e) P=0.498 (e) |
|COCHRAN-ARMITAGE | P=0.552N | P=0.593 |
|FISHER EXACT | P=0.219N P=0.103N P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.9% 4.5% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 268 --- 491 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.498N P=0.495 P=0.453N P=0.754N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.620N P=0.687 P=0.581N P=0.749N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.563N P=0.500 P=0.460N P=0.754 |
|COCHRAN-ARMITAGE | (e) | P=0.520N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.752N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 5/60 (8%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 4/60 (7%) 4/60 (7%) |
|ADJUSTED (b) | 8.8% 9.9% 13.1% 0.0% | 3.0% 2.6% 8.5% 9.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 3/34 (9%) 2/35 (6%) 4/37 (11%) 0/32 (0%) | 1/33 (3%) 0/28 (0%) 2/42 (5%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 558 731 --- | 733 (T) 681 455 (I) 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271N P=0.508 P=0.405 P=0.131N | P=0.104 P=0.736 P=0.244 P=0.198 |
|INCIDENTAL TUMOR | P=0.287N P=0.508 P=0.373 P=0.131N | P=0.082 P=0.748N P=0.201 P=0.187 |
|LOGISTIC REGRESSION | P=0.273N P=0.497 P=0.404 P=0.130N | P=0.086 P=0.758 P=0.185 P=0.185 |
|COCHRAN-ARMITAGE | P=0.264N | P=0.083 |
|FISHER EXACT | P=0.500 P=0.359 P=0.122N | P=0.752N P=0.182 P=0.182 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 5/60 (8%) 1/60 (2%) | 1/60 (2%) 2/60 (3%) 4/60 (7%) 4/60 (7%) |
|ADJUSTED (b) | 8.8% 9.9% 13.1% 2.3% | 3.0% 5.8% 8.5% 9.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | 3/34 (9%) 2/35 (6%) 4/37 (11%) 0/32 (0%) | 1/33 (3%) 0/28 (0%) 2/42 (5%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 558 731 675 | 733 (T) 681 455 (I) 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.508 P=0.405 P=0.318N | P=0.126 P=0.465 P=0.244 P=0.198 |
|INCIDENTAL TUMOR | P=0.422N P=0.508 P=0.373 P=0.314N | P=0.093 P=0.548 P=0.201 P=0.187 |
|LOGISTIC REGRESSION | P=0.408N P=0.497 P=0.404 P=0.319N | P=0.104 P=0.492 P=0.185 P=0.185 |
|COCHRAN-ARMITAGE | P=0.395N | P=0.100 |
|FISHER EXACT | P=0.500 P=0.359 P=0.309N | P=0.500 P=0.182 P=0.182 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 0.0% 5.2% 8.4% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/35 (0%) 1/37 (3%) 1/32 (3%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- 731 691 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.167 P=0.494N P=0.532 P=0.292 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.173 P=0.494N P=0.479 P=0.312 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.164 P=0.494N P=0.530 P=0.290 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.170 | (e) |
|FISHER EXACT | P=0.500N P=0.500 P=0.309 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.2% 6.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 1/37 (3%) 1/32 (3%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 731 731 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.089 (e) P=0.261 P=0.230 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.097 (e) P=0.209 P=0.243 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.086 (e) P=0.255 P=0.221 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.093 | (e) |
|FISHER EXACT | (e) P=0.248 P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.4% 3.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 2/37 (5%) 1/32 (3%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.196 (e) P=0.257 P=0.488 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.196 (e) P=0.257 P=0.488 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.196 (e) P=0.257 P=0.488 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.204 | (e) |
|FISHER EXACT | (e) P=0.248 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.4% 6.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 2/37 (5%) 2/32 (6%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) 733 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.086 (e) P=0.257 P=0.225 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.086 (e) P=0.257 P=0.225 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.086 (e) P=0.257 P=0.225 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.093 | (e) |
|FISHER EXACT | (e) P=0.248 P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 4.1% 4.4% 3.1% | 3.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/34 (3%) 0/35 (0%) 0/37 (0%) 1/32 (3%) | 1/33 (3%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 540 586 733 (T) | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556 P=0.503 P=0.523 P=0.748 | P=0.187N P=0.533N P=0.452N P=0.488N |
|INCIDENTAL TUMOR | P=0.573 P=0.524 P=0.443 P=0.748 | P=0.187N P=0.533N P=0.452N P=0.488N |
|LOGISTIC REGRESSION | P=0.456 P=0.503 P=0.500 P=0.748 | P=0.187N P=0.533N P=0.452N P=0.488N |
|COCHRAN-ARMITAGE | P=0.561 | P=0.203N |
|FISHER EXACT | P=0.500 P=0.500 P=0.752N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/60 (55%) 28/60 (47%) 21/60 (35%) 28/60 (47%) | 20/60 (33%) 18/60 (30%) 13/60 (22%) 23/60 (38%) |
|ADJUSTED (b) | 72.7% 67.8% 45.2% 65.3% | 54.6% 53.7% 29.4% 62.1% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 1/10 (10%) 2/9 (22%) 3/9 (33%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 22/34 (65%) 22/35 (63%) 13/37 (35%) 18/32 (56%) | 17/33 (52%) 13/28 (46%) 11/42 (26%) 21/35 (60%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 457 (I) 353 456 (I) | 457 (I) 658 675 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.132N P=0.209N P=0.018N* P=0.350N | P=0.368N P=0.537 P=0.021N* P=0.434 |
|INCIDENTAL TUMOR | P=0.093N P=0.221N P=0.016N* P=0.304N | P=0.451N P=0.530N P=0.038N* P=0.393 |
|LOGISTIC REGRESSION | P=0.112N P=0.229N P=0.021N* P=0.287N | P=0.455N P=0.456N P=0.047N* P=0.397 |
|COCHRAN-ARMITAGE | P=0.094N | P=0.501 |
|FISHER EXACT | P=0.233N P=0.022N* P=0.233N | P=0.422N P=0.110N P=0.352 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 16/60 (27%) 11/60 (18%) 15/60 (25%) | 6/60 (10%) 7/60 (12%) 3/60 (5%) 5/60 (8%) |
|ADJUSTED (b) | 29.4% 32.7% 25.5% 30.6% | 17.2% 20.1% 6.9% 13.5% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 4/10 (40%) 0/9 (0%) 1/9 (11%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 5/35 (14%) 7/37 (19%) 3/32 (9%) | 5/33 (15%) 3/28 (11%) 2/42 (5%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 455 (I) 443 358 | 659 558 691 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.428 P=0.303N P=0.455 | P=0.251N P=0.415 P=0.150N P=0.460N |
|INCIDENTAL TUMOR | P=0.447N P=0.396 P=0.355N P=0.490N | P=0.329N P=0.520 P=0.196N P=0.492N |
|LOGISTIC REGRESSION | P=0.452 P=0.421 P=0.495N P=0.421 | P=0.276N P=0.482 P=0.181N P=0.468N |
|COCHRAN-ARMITAGE | P=0.515N | P=0.322N |
|FISHER EXACT | P=0.417 P=0.327N P=0.500 | P=0.500 P=0.245N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 16/60 (27%) 12/60 (20%) 15/60 (25%) | 6/60 (10%) 7/60 (12%) 3/60 (5%) 5/60 (8%) |
|ADJUSTED (b) | 31.2% 32.7% 27.4% 30.6% | 17.2% 20.1% 6.9% 13.5% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 4/10 (40%) 0/9 (0%) 1/9 (11%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/34 (12%) 5/35 (14%) 7/37 (19%) 3/32 (9%) | 5/33 (15%) 3/28 (11%) 2/42 (5%) 3/35 (9%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 455 (I) 443 358 | 659 558 691 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.489N P=0.504 P=0.304N P=0.529 | P=0.251N P=0.415 P=0.150N P=0.460N |
|INCIDENTAL TUMOR | P=0.379N P=0.472 P=0.388N P=0.389N | P=0.329N P=0.520 P=0.196N P=0.492N |
|LOGISTIC REGRESSION | P=0.513 P=0.508 P=0.507N P=0.500 | P=0.276N P=0.482 P=0.181N P=0.468N |
|COCHRAN-ARMITAGE | P=0.451N | P=0.322N |
|FISHER EXACT | P=0.500 P=0.331N P=0.583N | P=0.500 P=0.245N P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 38/60 (63%) 27/60 (45%) 38/60 (63%) | 21/60 (35%) 23/60 (38%) 15/60 (25%) 24/60 (40%) |
|ADJUSTED (b) | 78.0% 75.4% 56.2% 76.5% | 55.8% 63.0% 34.0% 63.2% |
|INTERIM SACRIFICE 1 (c)| 5/10 (50%) 5/10 (50%) 2/9 (22%) 4/9 (44%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/34 (68%) 23/35 (66%) 17/37 (46%) 21/32 (66%) | 17/33 (52%) 15/28 (54%) 13/42 (31%) 21/35 (60%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 455 (I) 353 358 | 457 (I) 558 675 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264N P=0.406N P=0.018N* P=0.549 | P=0.352N P=0.233 P=0.034N* P=0.440 |
|INCIDENTAL TUMOR | P=0.143N P=0.429N P=0.011N* P=0.351N | P=0.468N P=0.352 P=0.063N P=0.386 |
|LOGISTIC REGRESSION | P=0.183N P=0.428N P=0.013N* P=0.469N | P=0.445N P=0.369 P=0.072N P=0.398 |
|COCHRAN-ARMITAGE | P=0.165N | P=0.506 |
|FISHER EXACT | P=0.424N P=0.013N* P=0.424N | P=0.425 P=0.160N P=0.353 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 40/60 (67%) 38/60 (63%) 28/60 (47%) 38/60 (63%) | 21/60 (35%) 23/60 (38%) 15/60 (25%) 24/60 (40%) |
|ADJUSTED (b) | 78.0% 75.4% 57.4% 76.5% | 55.8% 63.0% 34.0% 63.2% |
|INTERIM SACRIFICE 1 (c)| 5/10 (50%) 5/10 (50%) 2/9 (22%) 4/9 (44%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/34 (68%) 23/35 (66%) 17/37 (46%) 21/32 (66%) | 17/33 (52%) 15/28 (54%) 13/42 (31%) 21/35 (60%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 455 (I) 353 358 | 457 (I) 558 675 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282N P=0.406N P=0.027N* P=0.549 | P=0.352N P=0.233 P=0.034N* P=0.440 |
|INCIDENTAL TUMOR | P=0.156N P=0.429N P=0.019N* P=0.351N | P=0.468N P=0.352 P=0.063N P=0.386 |
|LOGISTIC REGRESSION | P=0.200N P=0.428N P=0.021N* P=0.469N | P=0.445N P=0.369 P=0.072N P=0.398 |
|COCHRAN-ARMITAGE | P=0.180N | P=0.506 |
|FISHER EXACT | P=0.424N P=0.021N* P=0.424N | P=0.425 P=0.160N P=0.353 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/60 (30%) 17/60 (28%) 6/60 (10%) 15/60 (25%) | 4/60 (7%) 2/60 (3%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | 39.4% 41.3% 12.9% 35.6% | 10.6% 6.2% 7.0% 6.5% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 2/10 (20%) 2/9 (22%) 2/9 (22%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 9/34 (26%) 12/35 (34%) 2/37 (5%) 7/32 (22%) | 3/33 (9%) 1/28 (4%) 2/42 (5%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 455 (I) 457 (I) | 452 716 732 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.136N P=0.478N P=0.007N** P=0.426N | P=0.364N P=0.386N P=0.388N P=0.479N |
|INCIDENTAL TUMOR | P=0.128N P=0.482N P=0.008N** P=0.376N | P=0.407N P=0.420N P=0.600N P=0.447N |
|LOGISTIC REGRESSION | P=0.104N P=0.501N P=0.006N** P=0.342N | P=0.411N P=0.345N P=0.468N P=0.515N |
|COCHRAN-ARMITAGE | P=0.103N | P=0.419N |
|FISHER EXACT | P=0.500N P=0.006N** P=0.342N | P=0.340N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 6/60 (10%) 3/60 (5%) 8/60 (13%) | 1/60 (2%) 5/60 (8%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 22.1% 15.4% 7.7% 25.0% | 3.0% 15.3% 0.0% 5.2% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/34 (15%) 4/35 (11%) 2/37 (5%) 8/32 (25%) | 1/33 (3%) 3/28 (11%) 0/42 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 558 726 733 (T) | 733 (T) 658 --- 673 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.287N P=0.057N P=0.552N | P=0.576N P=0.085 P=0.452N P=0.516 |
|INCIDENTAL TUMOR | P=0.313N P=0.294N P=0.082N P=0.563N | P=0.573 P=0.100 P=0.452N P=0.500 |
|LOGISTIC REGRESSION | P=0.292N P=0.292N P=0.062N P=0.534N | P=0.599 P=0.098 P=0.452N P=0.512 |
|COCHRAN-ARMITAGE | P=0.277N | P=0.571 |
|FISHER EXACT | P=0.291N P=0.063N P=0.500N | P=0.103 P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 23/60 (38%) 9/60 (15%) 21/60 (35%) | 5/60 (8%) 7/60 (12%) 3/60 (5%) 5/60 (8%) |
|ADJUSTED (b) | 51.3% 53.6% 19.8% 51.1% | 13.6% 20.9% 7.0% 11.5% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 2/10 (20%) 2/9 (22%) 2/9 (22%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 12/34 (35%) 16/35 (46%) 4/37 (11%) 13/32 (41%) | 4/33 (12%) 4/28 (14%) 2/42 (5%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 455 (I) 457 (I) | 452 658 732 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093N P=0.410N P=0.002N** P=0.393N | P=0.378N P=0.315 P=0.249N P=0.601N |
|INCIDENTAL TUMOR | P=0.086N P=0.415N P=0.002N** P=0.349N | P=0.442N P=0.315 P=0.419N P=0.586N |
|LOGISTIC REGRESSION | P=0.067N P=0.428N P=0.001N** P=0.306N | P=0.431N P=0.363 P=0.319N P=0.629 |
|COCHRAN-ARMITAGE | P=0.062N | P=0.454N |
|FISHER EXACT | P=0.426N P=0.001N** P=0.287N | P=0.381 P=0.359N P=0.628N |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/56 (4%) 0/58 (0%) 1/57 (2%) 0/56 (0%) |
|ADJUSTED (b) | | 6.9% 0.0% 2.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/29 (7%) 0/26 (0%) 1/40 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | | 733 (T) --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.108N P=0.262N P=0.388N P=0.223N |
|INCIDENTAL TUMOR | | P=0.108N P=0.262N P=0.388N P=0.223N |
|LOGISTIC REGRESSION | | P=0.108N P=0.262N P=0.388N P=0.223N |
|COCHRAN-ARMITAGE | | P=0.133N |
|FISHER EXACT | | P=0.239N P=0.493N P=0.248N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/59 (0%) 0/59 (0%) 0/58 (0%) | 5/58 (9%) 4/58 (7%) 2/60 (3%) 6/60 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 14.6% 14.8% 4.8% 15.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 4/33 (12%) 4/27 (15%) 2/42 (5%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 698 733 (T) 733 (T) 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.478N P=0.608N P=0.133N P=0.541 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.493N P=0.584N P=0.156N P=0.548 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.514N P=0.518N P=0.150N P=0.531 |
|COCHRAN-ARMITAGE | (e) | P=0.542N |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.206N P=0.524 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/59 (0%) 0/59 (0%) 0/58 (0%) | 5/58 (9%) 4/58 (7%) 3/60 (5%) 6/60 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 14.6% 14.8% 7.1% 15.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/32 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 4/33 (12%) 4/27 (15%) 3/42 (7%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 698 733 (T) 733 (T) 457 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.519N P=0.608N P=0.235N P=0.541 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.533N P=0.584N P=0.265N P=0.548 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.555N P=0.518N P=0.260N P=0.531 |
|COCHRAN-ARMITAGE | (e) | P=0.551 |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.340N P=0.524 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 3/60 (5%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 2.2% 0.0% | 0.0% 8.0% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 1/28 (4%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 625 --- | --- 453 --- 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.589 (e) P=0.504 (e) | P=0.507 P=0.113 (e) P=0.505 |
|INCIDENTAL TUMOR | P=0.529 (e) P=0.455 (e) | P=0.452 P=0.090 (e) P=0.477 |
|LOGISTIC REGRESSION | P=0.601 (e) P=0.502 (e) | P=0.479 P=0.121 (e) P=0.504 |
|COCHRAN-ARMITAGE | P=0.593 | P=0.480 |
|FISHER EXACT | (e) P=0.500 (e) | P=0.122 (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 3/60 (5%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 2.9% 2.2% 0.0% | 3.0% 8.0% 2.4% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/35 (3%) 0/37 (0%) 0/32 (0%) | 1/33 (3%) 1/28 (4%) 1/42 (2%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 625 --- | 733 (T) 453 733 (T) 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.599 P=0.506 P=0.504 (e) | P=0.530N P=0.278 P=0.707N P=0.751N |
|INCIDENTAL TUMOR | P=0.557 P=0.506 P=0.455 (e) | P=0.574N P=0.244 P=0.707N P=0.754 |
|LOGISTIC REGRESSION | P=0.601 P=0.506 P=0.502 (e) | P=0.560N P=0.303 P=0.708N P=0.756N |
|COCHRAN-ARMITAGE | P=0.604 | P=0.569N |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.309 P=0.752N P=0.752N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 3/60 (5%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 2.9% 2.2% 0.0% | 3.0% 8.0% 2.4% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/35 (3%) 0/37 (0%) 0/32 (0%) | 1/33 (3%) 1/28 (4%) 1/42 (2%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 625 --- | 733 (T) 453 733 (T) 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.599 P=0.506 P=0.504 (e) | P=0.530N P=0.278 P=0.707N P=0.751N |
|INCIDENTAL TUMOR | P=0.557 P=0.506 P=0.455 (e) | P=0.574N P=0.244 P=0.707N P=0.754 |
|LOGISTIC REGRESSION | P=0.601 P=0.506 P=0.502 (e) | P=0.560N P=0.303 P=0.708N P=0.756N |
|COCHRAN-ARMITAGE | P=0.604 | P=0.569N |
|FISHER EXACT | P=0.500 P=0.500 (e) | P=0.309 P=0.752N P=0.752N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 1/59 (2%) 1/59 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 2.3% 0.0% 0.0% | 3.1% 3.6% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 1/32 (3%) 1/28 (4%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 648 --- --- | 733 (T) 733 (T) 675 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021N* P=0.301N P=0.106N P=0.131N | P=0.351N P=0.732 P=0.714N P=0.482N |
|INCIDENTAL TUMOR | P=0.023N* P=0.318N P=0.106N P=0.131N | P=0.373N P=0.732 P=0.749 P=0.482N |
|LOGISTIC REGRESSION | P=0.022N* P=0.308N P=0.106N P=0.130N | P=0.360N P=0.734 P=0.740N P=0.482N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.379N |
|FISHER EXACT | P=0.309N P=0.122N P=0.122N | P=0.752N P=0.748N P=0.496N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 4.2% 2.9% 0.0% 3.1% | 0.0% 0.0% 0.0% 5.7% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/35 (3%) 0/37 (0%) 1/32 (3%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 733 (T) --- 733 (T) | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268N P=0.497N P=0.246N P=0.522N | P=0.126 (e) (e) P=0.251 |
|INCIDENTAL TUMOR | P=0.271N P=0.522N P=0.291N P=0.508N | P=0.126 (e) (e) P=0.251 |
|LOGISTIC REGRESSION | P=0.256N P=0.498N P=0.225N P=0.485N | P=0.126 (e) (e) P=0.251 |
|COCHRAN-ARMITAGE | P=0.258N | P=0.112 |
|FISHER EXACT | P=0.500N P=0.248N P=0.500N | (e) (e) P=0.248 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 4.2% 2.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 1/35 (3%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 733 (T) --- --- | --- --- --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.078N P=0.497N P=0.246N P=0.254N | P=0.323 (e) (e) P=0.512 |
|INCIDENTAL TUMOR | P=0.083N P=0.522N P=0.291N P=0.241N | P=0.323 (e) (e) P=0.512 |
|LOGISTIC REGRESSION | P=0.069N P=0.498N P=0.225N P=0.199N | P=0.323 (e) (e) P=0.512 |
|COCHRAN-ARMITAGE | P=0.074N | P=0.305 |
|FISHER EXACT | P=0.500N P=0.248N P=0.248N | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 3/59 (5%) 0/60 (0%) | 3/60 (5%) 0/60 (0%) 0/59 (0%) 2/60 (3%) |
|ADJUSTED (b) | 2.5% 5.7% 8.3% 0.0% | 7.7% 0.0% 0.0% 5.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/35 (6%) 3/36 (8%) 0/32 (0%) | 2/33 (6%) 0/28 (0%) 0/42 (0%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 691 733 (T) 733 (T) --- | 456 (I) --- --- 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556N P=0.507 P=0.326 P=0.505N | P=0.222N P=0.143N P=0.096N P=0.474N |
|INCIDENTAL TUMOR | P=0.554N P=0.481 P=0.290 P=0.481N | P=0.245N P=0.143N P=0.096N P=0.495N |
|LOGISTIC REGRESSION | P=0.554N P=0.497 P=0.310 P=0.506N | P=0.249N P=0.121N P=0.126N P=0.494N |
|COCHRAN-ARMITAGE | P=0.547N | P=0.254N |
|FISHER EXACT | P=0.500 P=0.303 P=0.500N | P=0.122N P=0.125N P=0.500N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/60 (3%) 3/59 (5%) 0/60 (0%) | 3/60 (5%) 0/60 (0%) 0/59 (0%) 3/60 (5%) |
|ADJUSTED (b) | 2.5% 5.7% 8.3% 0.0% | 7.7% 0.0% 0.0% 8.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 2/35 (6%) 3/36 (8%) 0/32 (0%) | 2/33 (6%) 0/28 (0%) 0/42 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 691 733 (T) 733 (T) --- | 456 (I) --- --- 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556N P=0.507 P=0.326 P=0.505N | P=0.412N P=0.143N P=0.096N P=0.634N |
|INCIDENTAL TUMOR | P=0.554N P=0.481 P=0.290 P=0.481N | P=0.437N P=0.143N P=0.096N P=0.652N |
|LOGISTIC REGRESSION | P=0.554N P=0.497 P=0.310 P=0.506N | P=0.446N P=0.121N P=0.126N P=0.654N |
|COCHRAN-ARMITAGE | P=0.547N | P=0.457N |
|FISHER EXACT | P=0.500 P=0.303 P=0.500N | P=0.122N P=0.125N P=0.660N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 1/60 (2%) 1/60 (2%) 4/60 (7%) |
|ADJUSTED (b) | | 0.0% 2.4% 2.4% 9.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | | 0/33 (0%) 0/28 (0%) 1/42 (2%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 561 733 (T) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.040 * P=0.486 P=0.548 P=0.072 |
|INCIDENTAL TUMOR | | P=0.019 * P=0.602 P=0.548 P=0.052 |
|LOGISTIC REGRESSION | | P=0.024 * P=0.498 P=0.548 P=0.058 |
|COCHRAN-ARMITAGE | | P=0.033 * |
|FISHER EXACT | | P=0.500 P=0.500 P=0.059 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 0/60 (0%) 2/60 (3%) | 3/60 (5%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 8.4% 2.3% 0.0% 4.8% | 9.1% 0.0% 2.4% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/34 (6%) 0/35 (0%) 0/37 (0%) 1/32 (3%) | 3/33 (9%) 0/28 (0%) 1/42 (2%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 730 626 --- 358 | 733 (T) --- 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260N P=0.305N P=0.110N P=0.525N | P=0.289N P=0.151N P=0.223N P=0.473N |
|INCIDENTAL TUMOR | P=0.145N P=0.306N P=0.133N P=0.314N | P=0.289N P=0.151N P=0.223N P=0.473N |
|LOGISTIC REGRESSION | P=0.250N P=0.307N P=0.106N P=0.502N | P=0.289N P=0.151N P=0.223N P=0.473N |
|COCHRAN-ARMITAGE | P=0.253N | P=0.337N |
|FISHER EXACT | P=0.309N P=0.122N P=0.500N | P=0.122N P=0.309N P=0.500N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 3/60 (5%) 1/60 (2%) | 3/60 (5%) 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 6.4% 6.4% 3.1% | 9.1% 6.5% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/34 (9%) 0/35 (0%) 0/37 (0%) 1/32 (3%) | 3/33 (9%) 1/28 (4%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 540 586 733 (T) | 733 (T) 730 675 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297N P=0.655N P=0.627N P=0.326N | P=0.050N* P=0.562N P=0.234N P=0.110N |
|INCIDENTAL TUMOR | P=0.300N P=0.656N P=0.621 P=0.326N | P=0.060N P=0.534N P=0.277N P=0.110N |
|LOGISTIC REGRESSION | P=0.393N P=0.662N P=0.662N P=0.326N | P=0.052N P=0.500N P=0.260N P=0.110N |
|COCHRAN-ARMITAGE | P=0.290N | P=0.063N |
|FISHER EXACT | P=0.660N P=0.660N P=0.309N | P=0.500N P=0.309N P=0.122N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 4/60 (7%) 3/60 (5%) 3/60 (5%) | 5/60 (8%) 2/60 (3%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 17.0% 8.5% 6.4% 7.8% | 15.2% 6.5% 4.5% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/34 (15%) 0/35 (0%) 0/37 (0%) 2/32 (6%) | 5/33 (15%) 1/28 (4%) 1/42 (2%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 730 540 586 358 | 733 (T) 730 675 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.159N P=0.368N P=0.215N P=0.274N | P=0.085N P=0.278N P=0.137N P=0.191N |
|INCIDENTAL TUMOR | P=0.104N P=0.368N P=0.284N P=0.148N | P=0.096N P=0.258N P=0.161N P=0.191N |
|LOGISTIC REGRESSION | P=0.146N P=0.372N P=0.240N P=0.260N | P=0.089N P=0.215N P=0.158N P=0.191N |
|COCHRAN-ARMITAGE | P=0.149N | P=0.116N |
|FISHER EXACT | P=0.372N P=0.245N P=0.245N | P=0.219N P=0.219N P=0.219N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 3.6% 4.8% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 1/28 (4%) 2/42 (5%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.291 P=0.467 P=0.293 P=0.512 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.291 P=0.467 P=0.293 P=0.512 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.291 P=0.467 P=0.292 P=0.512 |
|COCHRAN-ARMITAGE | (e) | P=0.258 |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 2/60 (3%) 4/60 (7%) | 9/60 (15%) 9/60 (15%) 16/60 (27%) 7/60 (12%) |
|ADJUSTED (b) | 0.0% 8.6% 5.1% 11.8% | 22.9% 26.5% 38.1% 18.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 3/35 (9%) 1/37 (3%) 3/32 (9%) | 5/33 (15%) 5/28 (18%) 16/42 (38%) 5/35 (14%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 727 694 | 452 575 733 (T) 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.053 P=0.126 P=0.255 P=0.058 | P=0.471N P=0.509 P=0.229 P=0.359N |
|INCIDENTAL TUMOR | P=0.056 P=0.126 P=0.209 P=0.062 | P=0.540 P=0.598 P=0.113 P=0.381N |
|LOGISTIC REGRESSION | P=0.053 P=0.126 P=0.251 P=0.057 | P=0.537N P=0.583 P=0.142 P=0.371N |
|COCHRAN-ARMITAGE | P=0.058 | P=0.492 |
|FISHER EXACT | P=0.122 P=0.248 P=0.059 | P=0.601N P=0.088 P=0.395N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 2/60 (3%) 4/60 (7%) | 9/60 (15%) 8/60 (13%) 14/60 (23%) 6/60 (10%) |
|ADJUSTED (b) | 0.0% 8.6% 5.1% 11.8% | 22.9% 23.3% 33.3% 15.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 3/35 (9%) 1/37 (3%) 3/32 (9%) | 5/33 (15%) 4/28 (14%) 14/42 (33%) 4/35 (11%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 727 694 | 452 575 733 (T) 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.053 P=0.126 P=0.255 P=0.058 | P=0.347N P=0.583N P=0.364 P=0.264N |
|INCIDENTAL TUMOR | P=0.056 P=0.126 P=0.209 P=0.062 | P=0.430N P=0.496N P=0.208 P=0.279N |
|LOGISTIC REGRESSION | P=0.053 P=0.126 P=0.251 P=0.057 | P=0.403N P=0.519N P=0.255 P=0.270N |
|COCHRAN-ARMITAGE | P=0.058 | P=0.466N |
|FISHER EXACT | P=0.122 P=0.248 P=0.059 | P=0.500N P=0.177 P=0.291N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.9% 4.5% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 268 --- 491 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.498N P=0.495 P=0.453N P=0.754N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.620N P=0.687 P=0.581N P=0.749N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.563N P=0.500 P=0.460N P=0.754 |
|COCHRAN-ARMITAGE | (e) | P=0.520N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.752N |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.9% 4.5% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/35 (0%) 0/37 (0%) 0/32 (0%) | 0/33 (0%) 0/28 (0%) 0/42 (0%) 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 731 268 --- 491 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.498N P=0.495 P=0.453N P=0.754N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.620N P=0.687 P=0.581N P=0.749N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.563N P=0.500 P=0.460N P=0.754 |
|COCHRAN-ARMITAGE | (e) | P=0.520N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.752N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 45/60 (75%) 40/60 (67%) 31/60 (52%) 38/60 (63%) | 29/60 (48%) 23/60 (38%) 22/60 (37%) 36/60 (60%) |
|ADJUSTED (b) | 86.2% 84.8% 63.5% 81.9% | 71.3% 64.8% 45.6% 77.6% |
|INTERIM SACRIFICE 1 (c)| 6/10 (60%) 3/10 (30%) 4/9 (44%) 4/9 (44%) | 3/10 (30%) 0/10 (0%) 1/10 (10%) 3/10 (30%) |
|TERMINAL (d) | 27/34 (79%) 28/35 (80%) 20/37 (54%) 24/32 (75%) | 22/33 (67%) 16/28 (57%) 16/42 (38%) 25/35 (71%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 353 358 | 452 561 455 (I) 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088N P=0.221N P=0.010N** P=0.285N | P=0.479 P=0.371N P=0.022N* P=0.218 |
|INCIDENTAL TUMOR | P=0.029N* P=0.197N P=0.005N** P=0.122N | P=0.312 P=0.260N P=0.069N P=0.156 |
|LOGISTIC REGRESSION | P=0.045N* P=0.209N P=0.007N** P=0.153N | P=0.312 P=0.194N P=0.073N P=0.152 |
|COCHRAN-ARMITAGE | P=0.035N* | P=0.245 |
|FISHER EXACT | P=0.211N P=0.007N** P=0.118N | P=0.179N P=0.134N P=0.136 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.0140% 0.0200% 0.0275% | VEHICLE 0.0140% 0.0200% 0.0275% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 24/60 (40%) 19/60 (32%) 31/60 (52%) | 23/60 (38%) 25/60 (42%) 21/60 (35%) 19/60 (32%) |
|ADJUSTED (b) | 50.7% 46.5% 40.5% 62.1% | 54.1% 57.5% 47.6% 43.4% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 4/10 (40%) 0/9 (0%) 2/9 (22%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/34 (32%) 9/35 (26%) 10/37 (27%) 14/32 (44%) | 14/33 (42%) 11/28 (39%) 19/42 (45%) 11/35 (31%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 455 (I) 443 358 | 452 268 675 480 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292 P=0.488N P=0.160N P=0.172 | P=0.131N P=0.296 P=0.145N P=0.245N |
|INCIDENTAL TUMOR | P=0.299 P=0.509N P=0.221N P=0.227 | P=0.244N P=0.526 P=0.364N P=0.248N |
|LOGISTIC REGRESSION | P=0.172 P=0.496N P=0.323N P=0.178 | P=0.181N P=0.393 P=0.254N P=0.276N |
|COCHRAN-ARMITAGE | P=0.304 | P=0.239N |
|FISHER EXACT | P=0.500N P=0.172N P=0.180 | P=0.426 P=0.425N P=0.283N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/60 (82%) 50/60 (83%) 41/60 (68%) 52/60 (87%) | 38/60 (63%) 37/60 (62%) 32/60 (53%) 42/60 (70%) |
|ADJUSTED (b) | 88.9% 90.8% 77.1% 96.3% | 84.0% 83.4% 66.5% 83.7% |
|INTERIM SACRIFICE 1 (c)| 7/10 (70%) 6/10 (60%) 4/9 (44%) 5/9 (56%) | 3/10 (30%) 0/10 (0%) 1/10 (10%) 3/10 (30%) |
|TERMINAL (d) | 28/34 (82%) 30/35 (86%) 25/37 (68%) 30/32 (94%) | 26/33 (79%) 21/28 (75%) 26/42 (62%) 27/35 (77%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 353 358 | 452 268 455 (I) 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.443 P=0.544 P=0.085N P=0.228 | P=0.341N P=0.365 P=0.016N* P=0.430 |
|INCIDENTAL TUMOR | P=0.540 P=0.517 P=0.071N P=0.279 | P=0.456 P=0.508N P=0.061N P=0.321 |
|LOGISTIC REGRESSION | P=0.487 P=0.495 P=0.070N P=0.213 | P=0.526 P=0.572N P=0.061N P=0.320 |
|COCHRAN-ARMITAGE | P=0.532N | P=0.421 |
|FISHER EXACT | P=0.500 P=0.070N P=0.309 | P=0.500N P=0.177N P=0.281 |
|=================================================================================================================================|
DATE: 09/22/94 EXPERIMENT: 05089 TEST: 02 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CHLORAMINE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 455
Female interim sacrifices(days): 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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